Role of inflammation and tumor microenvironment in the development of gastrointestinal cancers: what induced pluripotent stem cells can do?

abstract：:Throughout life, different types of stem cells participate in tissue generation, maintenance, plasticity, and repair. Their abilities to secrete growth factors, to proliferate and differentiate into several cell lineages, and to migrate and home into the damaged tissues have made them attractive candidates for cell th...

journal_title：Current stem cell research & therapy

authors： Ghorbani A,Naderi-Meshkin H

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Articular cartilage defects often result in pain, loss of function and finally osteoarthritis. Developing cell-based therapies for cartilage repair is a major goal of orthopaedic research. Autologous chondrocyte implantation is currently the gold standard cell-based surgical procedure for the treatment of la...

journal_title：Current stem cell research & therapy

authors： Kubosch EJ,Lang G,Furst D,Kubosch D,Izadpanah K,Rolauffs B,Sudkamp NP,Schmal H

更新日期：2018-02-23 00:00:00

abstract：:Adipose-derived stem cells are adult stem cells which are easy to obtain and multi-potent. Stem-cell therapy has become a promising new treatment for many diseases, and plays an increasingly important role in the field of tissue repair, regeneration and reconstruction. The physicochemical properties of the extracellul...

journal_title：Current stem cell research & therapy

authors： Wang L,Li Y,Zhang M,Huang K,Peng S,Xiao J

更新日期：2021-01-01 00:00:00

abstract：:Exosomes and biomimetic nanoparticles have great potential to develop into a wide-scale therapeutic platform within the regenerative medicine industry. Exosomes, a subgroup of EVs with diameter ranging from 30-100 nm, have recently gained attention as an innovative approach for the treatment of various diseases, inclu...

journal_title：Current stem cell research & therapy

authors： Stine SJ,Popowski KD,Su T,Cheng K

更新日期：2020-01-01 00:00:00

abstract：:COVID-19 pandemic is a global health crisis in the 21st Century. There are currently no approved vaccine and no particular antiviral treatment for coronavirus disease. As COVID-19 has had a broad range of illnesses, it is necessary to find a safe and effective therapeutic method for COVID-19. An attractive approach fo...

journal_title：Current stem cell research & therapy

authors： Abbaspanah B,Abroun S,Zarrabi M,Mozdgir A,Mollanouri M

更新日期：2020-10-12 00:00:00

abstract：:Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality globally, and traditional pharmaceutical and surgical interventions delay the progression of CVDs. Recently, stem cell therapy has emerged as a promising candidate for treating and preventing heart failure. Increasing efforts have been dev...

journal_title：Current stem cell research & therapy

authors： Luo L,Li TS

更新日期：2020-01-01 00:00:00

abstract：:Protein kinases (PKs) mediate the reversible conversion of substrate proteins to phosphorylated forms, a key process in controlling intracellular signaling transduction cascades. Pluripotency is, among others, characterized by specifically expressed PKs forming a highly interconnected regulatory network that culminate...

journal_title：Current stem cell research & therapy

authors： Shoni M,Lui KO,Vavvas DG,Muto MG,Berkowitz RS,Vlahos N,Ng SW

更新日期：2014-01-01 00:00:00

abstract：:Notch signaling mediates the fates of numerous cells in both invertebrates and vertebrates. In the immune system, Notch signalling contributes to the generation of hematopoietic stem cells (HSCs), the promotion of HSC self-renewal, T lineage commitment, intrathymic T cell development, and peripheral lymphocyte differe...

journal_title：Current stem cell research & therapy

authors： Nagase H,Koh CS,Nakayama K

更新日期：2011-06-01 00:00:00

abstract：AIMS:A systematic review and meta-analysis were performed to explore the clinical outcome of the transplantation of stem cells from various human tissue sources in cirrhotic patients. METHODS:The relevant papers were searched via PubMed, EMBASE, and Cochrane Library databases. Changes in liver function before and afte...

journal_title：Current stem cell research & therapy

authors： Qi X,Guo X,Su C

更新日期：2015-01-01 00:00:00

abstract：:Regenerative medicine (RM) is an interdisciplinary field that uses different approaches to accelerate the repair and regeneration or replace damaged or diseased human cells or tissues to achieve normal tissue function. These approaches include the stimulation of the body's own repair processes, transplantation of prog...

journal_title：Current stem cell research & therapy

authors： Asgharzad S,Alizadeh A,Arab S

更新日期：2021-01-12 00:00:00

abstract：:Treatment of metastatic melanoma is a challenge for clinicians as most agents have failed to demonstrate improved survival in phase III trials. Despite the immunogenicity of this tumor entity, different immunological interventions including cytokine therapy, vaccination, biochemotherapy or allogeneic hematopoietic cel...

journal_title：Current stem cell research & therapy

authors： Zeiser R,Schnitzler M,Andrlova H,Hellige T,Meiss F

更新日期：2012-05-01 00:00:00

abstract：:Exosomes and microvesicles, which are released by most of the cells, play important roles in intracellular correspondence by transferring DNA, messenger RNA, micro RNA, and other types of RNA and proteins. Exosomes and microvesicles may contribute to the distribution of cancers and diseases through delivering the path...

journal_title：Current stem cell research & therapy

authors： Bakhshandeh B,Kamaleddin MA,Aalishah K

更新日期：2017-01-01 00:00:00

abstract：:Recent interest in developing new regenerative medicine- and tissue engineering-based treatments has motivated researchers to develop strategies for manipulating stem cells to optimize outcomes in these potentially, game-changing treatments. Cells communicate with each other, and with their surrounding tissues and org...

journal_title：Current stem cell research & therapy

authors： Heng W,Bhavsar M,Han Z,Barker JH

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Today, coronary artery disease is still one of the most important causes of mortality despite advanced surgical methods, pharmacotherapies and organ transplantation. These treatment modalities are intended to prevent further progression of myocardial infarction and do not involve the repair of the damaged pa...

journal_title：Current stem cell research & therapy

authors： Aslan A,Allahverdiyev AM,Bagirova M,Abamor ES

更新日期：2018-01-01 00:00:00

abstract：:Imbalance between free radicals and antioxidants causes oxidative stress by the accumulation of reactive oxygen species (ROS) in the tissues and organs. Oxidative stress occurs in many damage conditions, and the increase of ROS and reduction of antioxidants enhances inflammation, apoptosis, fibrosis and may worsen the...

journal_title：Current stem cell research & therapy

authors： Sahan OB,Gunel-Ozcan A

更新日期：2020-11-24 00:00:00

abstract：:Tendon, the crucial element of the musculoskeletal system, when damaged, never restores the biological and biomechanical properties completely. Recently, tissue engineering and regenerative medicine have enabled the differentiation of postnatal somatic stem cells or mesenchymal stem cells (MSCs) to different cell line...

journal_title：Current stem cell research & therapy

authors： Uysal AC,Mizuno H

更新日期：2010-06-01 00:00:00

abstract：:Cell repair/replacing strategies for neurodegenerative diseases such as Parkinson's disease depend on well-characterized dopaminergic neuronal candidates that are healthy and show promising effect on the rejuvenation of degenerated area of the brain. Therefore, it is imperative to develop innovative therapeutic strate...

journal_title：Current stem cell research & therapy

authors： Venkatesh K,Sen D

更新日期：2017-01-01 00:00:00

abstract：:Haematopoietic stem cell transplantation (HSCT) is a curative treatment of many hematological disorders. However, although significant advances have been made in donor-recipient matching or conditioning regimens, HSCT is associated with a risk of post transplant complications. Those include generation of toxic lesions...

journal_title：Current stem cell research & therapy

authors： Bogunia-Kubik K,Wysoczanska B,Lange A

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:The exposure of lung to noxious agents or gasses leads to injury, which further enhances repair mechanisms by promoting the proliferation and differentiation of lung stem cells. These cells could help preserve the anatomical structure and the function of the organ. Unfortunately in many lung diseases, 'this ...

journal_title：Current stem cell research & therapy

authors： Esendagli D,Gunel-Ozcan A

更新日期：2017-01-01 00:00:00

abstract：:The liver is a vital organ for life and the only internal organ that is capable of natural regeneration. Although the liver has high regeneration capacity, excessive hepatocyte death can lead to liver failure. Various factors can lead to liver damage including drug abuse, some natural products, alcohol, hepatitis, and...

journal_title：Current stem cell research & therapy

authors： Anwar I,Ashfaq UA,Shokat Z

更新日期：2020-01-01 00:00:00

abstract：:Due to the nature of articular cartilage of being poorly vascularized the capabilities of self repair are limited. Mesenchymal stem cells transplantation is a modern technique which has been developed after the high success rates obtained by microfracturing and drilling techniques which promote the release of growth f...

journal_title：Current stem cell research & therapy

authors： Martinelli N,Bonifacini C,Longo UG,Marinozzi A,Florio P,Khan WS,Denaro V

更新日期：2013-05-01 00:00:00

abstract：:Intervertebral disc (IVD) degeneration is one of the leading causes of low back pain, which affects a large proportion of the global population at a huge socioeconomic burden. Current treatments focus primarily on symptomatic pain relief or surgery, but offer relatively poor long-term efficacy as they fail to address ...

journal_title：Current stem cell research & therapy

authors： Clarke LE,Richardson SM,Hoyland JA

更新日期：2015-01-01 00:00:00

abstract：:Applications of regenerative medicine technology may offer new therapies for patients with injuries, end-stage organ failure, or other clinical problems. Currently, patients suffering from diseased and injured organs can be treated with transplanted organs. However, there is a shortage of donor organs that is worsenin...

journal_title：Current stem cell research & therapy

authors： Atala A

更新日期：2008-01-01 00:00:00

abstract：:Recent studies have shown that treatments involving injection of stem cells into animals with damaged cardiac tissue result in improved cardiac functionality. Clinical trials have reported conflicting results concerning the recellularization of post-infarct collagen scars. No clear mechanism has so far emerged to full...

journal_title：Current stem cell research & therapy

authors： Li SC,Acevedo J,Wang L,Jiang H,Luo J,Pestell RG,Loudon WG,Chang AC

更新日期：2012-01-01 00:00:00

abstract：:Intervertebral disc (IVD) disorders, especially degenerative disc disease, reduce the quality of life, and are short of effective therapy. A new direction for treatment of chronic tissue and organ diseases is to promote regeneration by harnessing endogenous repair mechanisms. In this review, we discuss the potential o...

journal_title：Current stem cell research & therapy

authors： Li Z,Peroglio M,Alini M,Grad S

更新日期：2015-01-01 00:00:00

abstract：:Due to the advent of less-toxic reduced intensity conditioning regimens (RIT), allogeneic hematopoietic cell transplantation (allo-HCT) is currently widely used to treat chemotherapy-resistant hematological diseases, particularly in older patients,which are the fastest growing group of patients receiving allo-HCT. How...

journal_title：Current stem cell research & therapy

authors： Toubai T,Tanaka J,Paczesny S,Shono Y,Reddy P,Imamura M

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Periodontitis is a multifactorial infectious disease that affects a large population worldwide. Oral microorganisms and susceptible host have been proposed to be the prerequisite for the development of periodontitis. Recently, the involvement of epigenetic modifications in the development of periodontitis ha...

journal_title：Current stem cell research & therapy

authors： Luo Y,Peng X,Duan D,Liu C,Xu X,Zhou X

更新日期：2018-01-01 00:00:00

abstract：:Stem cells have been long looked at as possible therapeutic vehicles for different health related problems. Among the different existing stem cell populations, Adipose- derived Stem Cells (ASCs) have been gathering attention in the last 10 years. When compared to other stem cells populations and sources, ASCs can be e...

journal_title：Current stem cell research & therapy

authors： Salgado AJ,Reis RL,Sousa NJ,Gimble JM

更新日期：2010-06-01 00:00:00

abstract：INTRODUCTION:Retinitis pigmentosa (RP), an inherited disease characterized by progressive loss of photoreceptors and retinal pigment epithelium, is a leading genetic cause of blindness. Cell transplantation to replace lost photoreceptors is a potential therapeutic strategy, but technical limitations have prevented clin...

journal_title：Current stem cell research & therapy

authors： Peng Y,Zhang Y,Huang B,Luo Y,Zhang M,Li K,Li W,Wen W,Tang S

更新日期：2014-03-01 00:00:00

abstract：:In contrast to their almost unlimited potential for expansion in vivo and despite years of dedicated research and optimization of expansion protocols, the expansion of Hematopoietic Stem Cells (HSCs) in vitro remains remarkably limited. Increased understanding of the mechanisms that are involved in maintenance, expans...

journal_title：Current stem cell research & therapy

authors： Aerts-Kaya F

更新日期：2020-02-24 00:00:00