Hepatocyte Growth Factor and Insulin-like Growth Factor-1 based Cellular Therapies for Oxidative Stress Injury.

abstract：:Connections between inflammation and cancer are a rapidly developing field. Some gastrointestinal tract cancers arise from infection, chronic irritation, and ensuing inflammation. Cellular effectors and mediators are important constituents of the tumor microenvironment, including neoplastic, stromal, and migratory hem...

journal_title：Current stem cell research & therapy

authors： Zhang L,Song X,Mohri Y,Qiao L

更新日期：2015-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSC) can be obtained from human bone marrow aspirates and, thanks to their differentiation potential and excellent in vitro culture properties, represent an attractive cell line for the regeneration of mesenchymal tissue. Both in vitro and in vivo, they can differentiate into cartilage, bone, t...

journal_title：Current stem cell research & therapy

authors： Niemeyer P,Krause U,Kasten P,Kreuz PC,Henle P,Südkam NP,Mehlhorn A

更新日期：2006-01-01 00:00:00

abstract：:Reduced-intensity stem cell transplantation (RIST) has opened a new era for hematopoietic stem cell transplantation (HSCT). It was developed based on the knowledge that graft-versus-tumor (GVT) effect is the main anti-tumor effect in allogeneic HSCT. Because RIST is associated with less morbidity and mortality, it can...

journal_title：Current stem cell research & therapy

authors： Kato K,Khaled Y,Mineishi S

更新日期：2007-05-01 00:00:00

abstract：:Defects in articular cartilage injury and chronic osteoarthritis are very widespread and common, and the ability of injured cartilage to repair itself is limited. Stem cell-based cartilage tissue engineering provides a promising therapeutic option for articular cartilage damage. However, the application of the techniq...

journal_title：Current stem cell research & therapy

authors： Chen Y,Ouyang X,Wu Y,Guo S,Xie Y,Wang G

更新日期：2020-01-01 00:00:00

abstract：:The liver is a vital organ for life and the only internal organ that is capable of natural regeneration. Although the liver has high regeneration capacity, excessive hepatocyte death can lead to liver failure. Various factors can lead to liver damage including drug abuse, some natural products, alcohol, hepatitis, and...

journal_title：Current stem cell research & therapy

authors： Anwar I,Ashfaq UA,Shokat Z

更新日期：2020-01-01 00:00:00

abstract：:The pressing demand to elucidate the biology of human embryonic stem (ES) cells and to realize their therapeutic potential has greatly promoted the progresses in the optimization of the culture systems used for this highly promising cell type. These progresses include the characterization of exogenous regulators of pl...

journal_title：Current stem cell research & therapy

authors： Lin G,Xu RH

更新日期：2010-09-01 00:00:00

abstract：:Recent studies have shown that treatments involving injection of stem cells into animals with damaged cardiac tissue result in improved cardiac functionality. Clinical trials have reported conflicting results concerning the recellularization of post-infarct collagen scars. No clear mechanism has so far emerged to full...

journal_title：Current stem cell research & therapy

authors： Li SC,Acevedo J,Wang L,Jiang H,Luo J,Pestell RG,Loudon WG,Chang AC

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The urinary bladder and urethra comprise the lower urinary tracts. Pathological conditions that affect both structures necessitate reconstructive urological intervention with autologous tissue sources that cause neuromechanical and metabolic complications. Stem-cell therapies may offer an attractive alternat...

journal_title：Current stem cell research & therapy

authors： Davis NF,Cunnane EM,Mulvihill JJ,Quinlan MR,Bolton DM,Walsh MT,Jack GS

更新日期：2018-01-01 00:00:00

abstract：:Mesenchymal stem cells are multipotent stromal cells residing within the connective tissue of most organs. Their surface phenotype has been well described. Most commonly, mesenchymal stem cells demonstrate the ability to differentiate into mesenchymal tissues (bone, catailge, fat, etc...), however, under the proper co...

journal_title：Current stem cell research & therapy

authors： Grange S

更新日期：2012-03-01 00:00:00

abstract：:Exosomes and microvesicles, which are released by most of the cells, play important roles in intracellular correspondence by transferring DNA, messenger RNA, micro RNA, and other types of RNA and proteins. Exosomes and microvesicles may contribute to the distribution of cancers and diseases through delivering the path...

journal_title：Current stem cell research & therapy

authors： Bakhshandeh B,Kamaleddin MA,Aalishah K

更新日期：2017-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have the self-renewal ability and the ability to produce multiple differentiation. Elucidating the genetic circuits that govern MSC self-renewal and differentiation is necessary to improve our comprehension of MSCs and their role in regenerative medicine. microRNAs (miRNAs) play important...

journal_title：Current stem cell research & therapy

authors： Huang C,Gou S,Wang L,Huang K,Liu L,Zhao W,Zheng L,Xiao J

更新日期：2016-01-01 00:00:00

abstract：:Human mesenchymal stem cells (hMSCs) are multipotent non-hematopoietic precursor cells with the ability to differentiate into several tissue types. The use of hMSCs has gained significant importance in cancer therapies as well as a large number of degenerative disease therapies due to their homing abilities. However, ...

journal_title：Current stem cell research & therapy

authors： Serakinci N,Kalkan R,Tulay P

更新日期：2016-01-01 00:00:00

abstract：:Despite the numerous recent advances made in conventional anticancer therapies, metastasis and recurrence still remain the major problems in cancer management. The current treatment modalities kill the bulk of the tumor, leaving cancer stem cells behind and therefore, the agents specifically targeting this cancer init...

journal_title：Current stem cell research & therapy

authors： Sak K,Everaus H

更新日期：2015-01-01 00:00:00

abstract：:The intestinal mucosa has an amazing regenerative capacity, enabling rapid restoration of its physiological functions following injury. The ability to do this resides with the epithelial stem cells located within glandular invaginations in the mucosal surface. Recent advances toward the isolation and characterization ...

journal_title：Current stem cell research & therapy

authors： Day RM

更新日期：2006-01-01 00:00:00

abstract：:Type 1 diabetes mellitus is an autoimmune disease against pancreatic β cells. The autoimmune response begins months or years before the clinical presentation. At the time of hyperglycemic symptoms a small amount of β cell mass still remains. The main therapeutic option to type 1 diabetes mellitus is daily insulin inje...

journal_title：Current stem cell research & therapy

authors： Couri CE,Voltarelli JC

更新日期：2011-03-01 00:00:00

abstract：:Intervertebral disc (IVD) degeneration is one of the leading causes of low back pain, which affects a large proportion of the global population at a huge socioeconomic burden. Current treatments focus primarily on symptomatic pain relief or surgery, but offer relatively poor long-term efficacy as they fail to address ...

journal_title：Current stem cell research & therapy

authors： Clarke LE,Richardson SM,Hoyland JA

更新日期：2015-01-01 00:00:00

abstract：:Angiogenesis is a complex process in which capillaries are produced from blood vessels that already exists. Endothelial cells (ECs) and endothelial progenitor cells (EPCs) are pivotal for this process and for the maintenance/restorage of the endothelium. Decreased numbers and dysfunction of these cells have been relat...

journal_title：Current stem cell research & therapy

authors： Sun K,Huang R,Wu S,Chen Z,Deng S,Zhou J,Xie J

更新日期：2016-01-01 00:00:00

abstract：: ...

journal_title：Current stem cell research & therapy

authors： Yoo JJ

更新日期：2019-01-01 00:00:00

abstract：:In this review we focus on epidermal stem cells in the normal regeneration of the skin as well as in wounded and psoriatic skin. Furthermore, we discuss current data supporting the idea of cancer stem cells in the pathogenesis of skin carcinoma and malignant melanoma. Epidermal stem cells present in the basal layer of...

journal_title：Current stem cell research & therapy

authors： Kamstrup M,Faurschou A,Gniadecki R,Wulf HC

更新日期：2008-05-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by loss of dopaminergic neurons, oxidative stress and neuroinflammation. The classical therapeutic approach with L-DOPA is not able to control motor symptoms in the long term, thus new disease-modifying or neuroprotective treatments are urgently required in order to match such...

journal_title：Current stem cell research & therapy

authors： Conese M,Cassano R,Gavini E,Trapani G,Rassu G,Sanna E,Di Gioia S,Trapani A

更新日期：2019-01-01 00:00:00

abstract：:Tendon and ligament injuries are common, and repair slowly with reduced biomechanical properties. With increasing financial demands on the health service and patients to recover from tendon and ligament injuries faster, and with less morbidity, health professionals are exploring new treatment options. Tissue engineeri...

journal_title：Current stem cell research & therapy

authors： Dhinsa BS,Mahapatra AN,Khan WS

更新日期：2015-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been isolated not only from bone marrow, but also from many other tissues such as adipose tissue, skeletal muscle, liver, brain and pancreas. Because MSC were found to have the ability to differentiate into cells of multiple organs and systems such as bone, fat, cartilage, muscle, ne...

journal_title：Current stem cell research & therapy

authors： Porada CD,Zanjani ED,Almeida-Porad G

更新日期：2006-09-01 00:00:00

abstract：:Telomeres are the protective end caps of eukaryotic chromosomes and they decide the proliferative lifespan of somatic cells, as the guardians of the cell replication. Telomere length in leucocytes reflects telomere length in other somatic cells. Leucocyte telomere length can be a biomarker of human ageing. The risk of...

journal_title：Current stem cell research & therapy

authors： Celtikci B,Erkmen GK,Dikmen ZG

更新日期：2020-04-21 00:00:00

abstract：:Applications of regenerative medicine technology may offer new therapies for patients with injuries, end-stage organ failure, or other clinical problems. Currently, patients suffering from diseased and injured organs can be treated with transplanted organs. However, there is a shortage of donor organs that is worsenin...

journal_title：Current stem cell research & therapy

authors： Atala A

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Today, coronary artery disease is still one of the most important causes of mortality despite advanced surgical methods, pharmacotherapies and organ transplantation. These treatment modalities are intended to prevent further progression of myocardial infarction and do not involve the repair of the damaged pa...

journal_title：Current stem cell research & therapy

authors： Aslan A,Allahverdiyev AM,Bagirova M,Abamor ES

更新日期：2018-01-01 00:00:00

abstract：:Postnatal skeletogenesis is a highly regulated process that subpopulations of bone marrow stem cells differentiate into mature skeletal tissues to maintain and repair the postnatal skeletons. Based on their skeletogenic capacity, purified bone marrow stem cells have been used to repair and replace damaged skeletal tis...

journal_title：Current stem cell research & therapy

authors： Deng P,Xu X,Chen Q

更新日期：2015-01-01 00:00:00

abstract：:Notch signaling mediates the fates of numerous cells in both invertebrates and vertebrates. In the immune system, Notch signalling contributes to the generation of hematopoietic stem cells (HSCs), the promotion of HSC self-renewal, T lineage commitment, intrathymic T cell development, and peripheral lymphocyte differe...

journal_title：Current stem cell research & therapy

authors： Nagase H,Koh CS,Nakayama K

更新日期：2011-06-01 00:00:00

abstract：:The intestine serves mainly as a place for digestion and absorption and functions as an immune and endocrine organ. Intestinal stem cells (ISCs) play critical roles in the maintenance of intestinal homeostasis and regeneration, and a complex of signaling pathways is involved in these processes. The Notch signaling pat...

journal_title：Current stem cell research & therapy

authors： Liang SJ,Li XG,Wang XQ

更新日期：2019-01-01 00:00:00

abstract：:Stem cells have been long looked at as possible therapeutic vehicles for different health related problems. Among the different existing stem cell populations, Adipose- derived Stem Cells (ASCs) have been gathering attention in the last 10 years. When compared to other stem cells populations and sources, ASCs can be e...

journal_title：Current stem cell research & therapy

authors： Salgado AJ,Reis RL,Sousa NJ,Gimble JM

更新日期：2010-06-01 00:00:00

abstract：:The discovery of neural stem cells (NSC) which ensure continuous neurogenesis in the adult mammalian brain, has led to a conceptual revolution in basic neuroscience and to high hopes for clinical nervous tissue repair. However, several research issues remain to address before neural stem cells can be harnessed for reg...

journal_title：Current stem cell research & therapy

authors： Moyse E,Segura S,Liard O,Mahaut S,Mechawar N

更新日期：2008-09-01 00:00:00