Abstract:
:The pressing demand to elucidate the biology of human embryonic stem (ES) cells and to realize their therapeutic potential has greatly promoted the progresses in the optimization of the culture systems used for this highly promising cell type. These progresses include the characterization of exogenous regulators of pluripotency and differentiation, the development of animal-free, defined, and scalable culture systems, and some pioneering efforts to establish good manufactory practice facilities to derive and expand clinical-grade human ES cells and their derivatives. All of these advancements appear to be also applicable to the derivation and culture of human induced pluripotent stem cells, an ES cell-like cell type derived from somatic cells via reprogramming. This review attempts to summarize these progresses and discuss some of the remaining challenges.
journal_name
Curr Stem Cell Res Therjournal_title
Current stem cell research & therapyauthors
Lin G,Xu RHdoi
10.2174/157488810791824548subject
Has Abstractpub_date
2010-09-01 00:00:00pages
207-14issue
3eissn
1574-888Xissn
2212-3946pii
ABSTRACT # 47journal_volume
5pub_type
杂志文章,评审abstract::Pyrroloquinoline Quinone (PQQ) is the third coenzyme found after niacinamide and flavone nucleotides and is widely present in microorganisms, plants, animals, and humans. PQQ can stimulate the growth of organisms and is very important for the growth, development and reproduction of animals. Owing to the inherent prope...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X14666181210165539
更新日期:2020-01-01 00:00:00
abstract::The intestine serves mainly as a place for digestion and absorption and functions as an immune and endocrine organ. Intestinal stem cells (ISCs) play critical roles in the maintenance of intestinal homeostasis and regeneration, and a complex of signaling pathways is involved in these processes. The Notch signaling pat...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X14666190429143734
更新日期:2019-01-01 00:00:00
abstract::The intestinal mucosa has an amazing regenerative capacity, enabling rapid restoration of its physiological functions following injury. The ability to do this resides with the epithelial stem cells located within glandular invaginations in the mucosal surface. Recent advances toward the isolation and characterization ...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488806775269124
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Cellular differentiation occurs in a complicated microenvironment containing multiple components including soluble factors and physical cues. In addition to biochemical composition, physical cues are also crucial in determining cellular behaviors. OBJECTIVE:To better understand the interaction between physi...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X13666180102121455
更新日期:2018-01-01 00:00:00
abstract::Postnatal skeletogenesis is a highly regulated process that subpopulations of bone marrow stem cells differentiate into mature skeletal tissues to maintain and repair the postnatal skeletons. Based on their skeletogenic capacity, purified bone marrow stem cells have been used to repair and replace damaged skeletal tis...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666150519093626
更新日期:2015-01-01 00:00:00
abstract::The liver is a vital organ for life and the only internal organ that is capable of natural regeneration. Although the liver has high regeneration capacity, excessive hepatocyte death can lead to liver failure. Various factors can lead to liver damage including drug abuse, some natural products, alcohol, hepatitis, and...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1568026620666200220122536
更新日期:2020-01-01 00:00:00
abstract::Liver is a major metabolic organ of the body and is known to comprise of two epithelial cell lineages, namely, hepatocytes and cholangiocytes which are known to originate from hepatoblasts during fetal developing stages. Upon acute injury, the hepatocytes and cholangiocytes undergo cellular division to compensate the ...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888x113086660066
更新日期:2014-01-01 00:00:00
abstract::Cell repair/replacing strategies for neurodegenerative diseases such as Parkinson's disease depend on well-characterized dopaminergic neuronal candidates that are healthy and show promising effect on the rejuvenation of degenerated area of the brain. Therefore, it is imperative to develop innovative therapeutic strate...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X12666161114122059
更新日期:2017-01-01 00:00:00
abstract::Despite the numerous recent advances made in conventional anticancer therapies, metastasis and recurrence still remain the major problems in cancer management. The current treatment modalities kill the bulk of the tumor, leaving cancer stem cells behind and therefore, the agents specifically targeting this cancer init...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666141126122316
更新日期:2015-01-01 00:00:00
abstract::Angiogenesis is a complex process in which capillaries are produced from blood vessels that already exists. Endothelial cells (ECs) and endothelial progenitor cells (EPCs) are pivotal for this process and for the maintenance/restorage of the endothelium. Decreased numbers and dysfunction of these cells have been relat...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x1103160303181155
更新日期:2016-01-01 00:00:00
abstract::Osteoarthritis (OA) is the most common degenerative joint disorder worldwide. OA represents an increasing threat to the quality of life of affected persons as well as for health resources expenditure. The incapability of cartilage to heal has been long time regarded as the major cause of progressive joint degeneration...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x09666140630102202
更新日期:2015-01-01 00:00:00
abstract::Heterogeneity is a well-documented phenomenon in breast cancer; one of the explanations for this phenomenon is the presence of cancer stem cells (CSCs) with the capacity to differentiate along divergent pathways. These CSCs undergo asymmetric and symmetric division resulting in both expansion of the stem cell pool and...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488809787169110
更新日期:2009-01-01 00:00:00
abstract::Imbalance between free radicals and antioxidants causes oxidative stress by the accumulation of reactive oxygen species (ROS) in the tissues and organs. Oxidative stress occurs in many damage conditions, and the increase of ROS and reduction of antioxidants enhances inflammation, apoptosis, fibrosis and may worsen the...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888X16999201124153753
更新日期:2020-11-24 00:00:00
abstract::MicroRNAs (miRNAs) are a newly discovered, yet powerful mechanism for regulating protein expression via mRNA translational inhibition. Loss of all miRNA function within mice leads to embryonic lethality with a loss of the stem cell population in the epiblast and failure to form a primitive streak. These data suggest t...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488807782793781
更新日期:2007-12-01 00:00:00
abstract::Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality globally, and traditional pharmaceutical and surgical interventions delay the progression of CVDs. Recently, stem cell therapy has emerged as a promising candidate for treating and preventing heart failure. Increasing efforts have been dev...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888X15666200102103755
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Periodontitis is a multifactorial infectious disease that affects a large population worldwide. Oral microorganisms and susceptible host have been proposed to be the prerequisite for the development of periodontitis. Recently, the involvement of epigenetic modifications in the development of periodontitis ha...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X12666170718161740
更新日期:2018-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are stromal origin cells with multilineage differentiation capacity. The immunoregulatory properties of MSCs can be interfered effectively by cytokines. Cytokines, produced by a broad range of cells, act at the systemic level to influence biological phenomena such as inflammation, wound h...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X11666160614103404
更新日期:2017-01-01 00:00:00
abstract::Stroke is the second most common cause of death and the leading cause of disability in the world. About 30% of the people that are affected by stroke die within a year; 25% of the patients that survive stroke remain in need of care after a year. Therefore, stroke is a major burden for health care costs. The most commo...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666150728121324
更新日期:2016-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are ideal candidates for different cellular therapies due to their simple isolation, extensive expansion potential, and low immunogenicity. For various therapeutic approaches, such as bone and cartilage repair, MSCs are expected to replace the damaged tissues by direct differentiation. Ho...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666150211162933
更新日期:2015-01-01 00:00:00
abstract::During the past several years, mesenchymal stem cells (MSCs) derived from adult tissue have rapidly moved from in vitro and animal studies into clinical trials as a therapeutic modality for a diverse group of clinical applications, including head and neck reconstruction. For many diseases, cell therapy could affect th...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488810791824449
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Articular cartilage defects often result in pain, loss of function and finally osteoarthritis. Developing cell-based therapies for cartilage repair is a major goal of orthopaedic research. Autologous chondrocyte implantation is currently the gold standard cell-based surgical procedure for the treatment of la...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X12666171002111026
更新日期:2018-02-23 00:00:00
abstract::Chronic myeloproliferative disorders (cMPDs) are clonal hemopoietic malignancies arising at the multipotent stem cell level. These conditions are characterized by increased blood count, marrow hyperplasia and extramedulary hemopoiesis. Vascular events might complicate their course, and transformation to either acute l...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488809788167445
更新日期:2009-05-01 00:00:00
abstract::Due to the nature of articular cartilage of being poorly vascularized the capabilities of self repair are limited. Mesenchymal stem cells transplantation is a modern technique which has been developed after the high success rates obtained by microfracturing and drilling techniques which promote the release of growth f...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x11308030006
更新日期:2013-05-01 00:00:00
abstract:: ...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888X1401181217123655
更新日期:2019-01-01 00:00:00
abstract::Sarcomas are the mesenchymal-derived malignant tumors of connective tissues (e.g., fat, bone, and cartilage) presumed to arise from aberrant development or differentiation of mesenchymal stem cells (MSCs). Appropriate control of stem cell maintenance versus differentiation allows for normal connective tissue developme...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488810790442859
更新日期:2010-03-01 00:00:00
abstract::Recent interest in developing new regenerative medicine- and tissue engineering-based treatments has motivated researchers to develop strategies for manipulating stem cells to optimize outcomes in these potentially, game-changing treatments. Cells communicate with each other, and with their surrounding tissues and org...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888X15666200129154747
更新日期:2020-01-01 00:00:00
abstract::Telomeres are the protective end caps of eukaryotic chromosomes and they decide the proliferative lifespan of somatic cells, as the guardians of the cell replication. Telomere length in leucocytes reflects telomere length in other somatic cells. Leucocyte telomere length can be a biomarker of human ageing. The risk of...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888X15666200422104423
更新日期:2020-04-21 00:00:00
abstract::Spinal cord injury (SCI) is a traumatic disorder resulting in a functional deficit that usually leads to severe and permanent paralysis. After the initial insult to the spinal cord, additional structure and function are lost through an active and complex secondary process. Since there is not effective treatment for SC...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488811796575323
更新日期:2011-09-01 00:00:00
abstract::Adipose-derived stem cells are adult stem cells which are easy to obtain and multi-potent. Stem-cell therapy has become a promising new treatment for many diseases, and plays an increasingly important role in the field of tissue repair, regeneration and reconstruction. The physicochemical properties of the extracellul...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888X15666200502000343
更新日期:2021-01-01 00:00:00
abstract::Stem/progenitor cells for cell therapy and regenerative medicine should ideally be available in large numbers, after having been isolated using minimally invasive or non-invasive methodologies. Also, they should exhibit wide differentiation potential into multiple lineages, as well as capability to be used successfull...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1381612824666180426120459
更新日期:2018-01-01 00:00:00