Breast cancer stem cells and intrinsic subtypes: controversies rage on.

abstract：BACKGROUND:Periodontitis is a multifactorial infectious disease that affects a large population worldwide. Oral microorganisms and susceptible host have been proposed to be the prerequisite for the development of periodontitis. Recently, the involvement of epigenetic modifications in the development of periodontitis ha...

journal_title：Current stem cell research & therapy

authors： Luo Y,Peng X,Duan D,Liu C,Xu X,Zhou X

更新日期：2018-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have the self-renewal ability and the ability to produce multiple differentiation. Elucidating the genetic circuits that govern MSC self-renewal and differentiation is necessary to improve our comprehension of MSCs and their role in regenerative medicine. microRNAs (miRNAs) play important...

journal_title：Current stem cell research & therapy

authors： Huang C,Gou S,Wang L,Huang K,Liu L,Zhao W,Zheng L,Xiao J

更新日期：2016-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by the selective loss of both spinal and upper motor neurons. One strategy in treating ALS is to use stem cells to replace lost spinal motor neurons. However, transplanted stem cell-derived motor neurons may not survive when exposed to the harsh...

journal_title：Current stem cell research & therapy

authors： Thonhoff JR,Ojeda L,Wu P

更新日期：2009-09-01 00:00:00

abstract：:Stem and progenitor cell research is a complex and exciting field which promises curative discoveries in numerous areas including cancer, diabetes, and regenerative medicine. Use of biotic factors or growth factors has played an essential role in the development of stem cell research. These biologically active compone...

journal_title：Current stem cell research & therapy

authors： Baadhe RR,Mekala NK,Potumarthi R

更新日期：2014-01-01 00:00:00

abstract：:Recent studies have shown that treatments involving injection of stem cells into animals with damaged cardiac tissue result in improved cardiac functionality. Clinical trials have reported conflicting results concerning the recellularization of post-infarct collagen scars. No clear mechanism has so far emerged to full...

journal_title：Current stem cell research & therapy

authors： Li SC,Acevedo J,Wang L,Jiang H,Luo J,Pestell RG,Loudon WG,Chang AC

更新日期：2012-01-01 00:00:00

abstract：:Tendon and ligament injuries are common, and repair slowly with reduced biomechanical properties. With increasing financial demands on the health service and patients to recover from tendon and ligament injuries faster, and with less morbidity, health professionals are exploring new treatment options. Tissue engineeri...

journal_title：Current stem cell research & therapy

authors： Dhinsa BS,Mahapatra AN,Khan WS

更新日期：2015-01-01 00:00:00

abstract：:Haematopoietic stem cell transplantation (HSCT) is a curative treatment of many hematological disorders. However, although significant advances have been made in donor-recipient matching or conditioning regimens, HSCT is associated with a risk of post transplant complications. Those include generation of toxic lesions...

journal_title：Current stem cell research & therapy

authors： Bogunia-Kubik K,Wysoczanska B,Lange A

更新日期：2006-05-01 00:00:00

abstract：:Combination antiretroviral therapy (cART) has significantly reduced the mortality rate and morbidity, and has increased the life expectancy of the human immunodeficiency virus (HIV) infected patients. However, the current cART is incapable of eradicating viruses from the human body, and HIV remains one of the most not...

journal_title：Current stem cell research & therapy

authors： Hu J,Feng Y,Ma P,Lai Y

更新日期：2019-01-01 00:00:00

abstract：:Intervertebral disc (IVD) degeneration is one of the leading causes of low back pain, which affects a large proportion of the global population at a huge socioeconomic burden. Current treatments focus primarily on symptomatic pain relief or surgery, but offer relatively poor long-term efficacy as they fail to address ...

journal_title：Current stem cell research & therapy

authors： Clarke LE,Richardson SM,Hoyland JA

更新日期：2015-01-01 00:00:00

abstract：:Although the existence of cancer stem cells (CSCs) has been demonstrated in colorectal cancer, further investigation is hindered by controversies over their surface markers. The sphere formation assay is widely used as in vitro method for derivation and characterization of CSCs based on the intrinsic self-renewal prop...

journal_title：Current stem cell research & therapy

authors： Wu H,Zhang H,Hu Y,Xia Q,Liu C,Li Y,Yu B,Gu T,Zhang X,Yu X,Kong W

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:The exposure of lung to noxious agents or gasses leads to injury, which further enhances repair mechanisms by promoting the proliferation and differentiation of lung stem cells. These cells could help preserve the anatomical structure and the function of the organ. Unfortunately in many lung diseases, 'this ...

journal_title：Current stem cell research & therapy

authors： Esendagli D,Gunel-Ozcan A

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Cellular differentiation occurs in a complicated microenvironment containing multiple components including soluble factors and physical cues. In addition to biochemical composition, physical cues are also crucial in determining cellular behaviors. OBJECTIVE:To better understand the interaction between physi...

journal_title：Current stem cell research & therapy

authors： Zhang Q,Lin S,Liao J,Cai X

更新日期：2018-01-01 00:00:00

abstract：: ...

journal_title：Current stem cell research & therapy

authors： Yoo JJ

更新日期：2019-01-01 00:00:00

abstract：:Umbilical cord blood (UCB) is an alternative source of hematopoietic progenitors for transplantation in the treatment of haematological malignancies, marrow failure, immunodeficiencies, hemoglobinopathies and inherited metabolic diseases. It has greatly contributed to increase the feasibility to transplantation for ma...

journal_title：Current stem cell research & therapy

authors： Solves P,Mirabet V,Roig R

更新日期：2010-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a newly discovered, yet powerful mechanism for regulating protein expression via mRNA translational inhibition. Loss of all miRNA function within mice leads to embryonic lethality with a loss of the stem cell population in the epiblast and failure to form a primitive streak. These data suggest t...

journal_title：Current stem cell research & therapy

authors： Foshay KM,Gallicano GI

更新日期：2007-12-01 00:00:00

abstract：:Liver is a major metabolic organ of the body and is known to comprise of two epithelial cell lineages, namely, hepatocytes and cholangiocytes which are known to originate from hepatoblasts during fetal developing stages. Upon acute injury, the hepatocytes and cholangiocytes undergo cellular division to compensate the ...

journal_title：Current stem cell research & therapy

authors： Rehman K,Iqbal MJ,Zahra N,Akash MS

更新日期：2014-01-01 00:00:00

abstract：:Adipose-derived stem cells are adult stem cells which are easy to obtain and multi-potent. Stem-cell therapy has become a promising new treatment for many diseases, and plays an increasingly important role in the field of tissue repair, regeneration and reconstruction. The physicochemical properties of the extracellul...

journal_title：Current stem cell research & therapy

authors： Wang L,Li Y,Zhang M,Huang K,Peng S,Xiao J

更新日期：2021-01-01 00:00:00

abstract：:Exosomes and microvesicles, which are released by most of the cells, play important roles in intracellular correspondence by transferring DNA, messenger RNA, micro RNA, and other types of RNA and proteins. Exosomes and microvesicles may contribute to the distribution of cancers and diseases through delivering the path...

journal_title：Current stem cell research & therapy

authors： Bakhshandeh B,Kamaleddin MA,Aalishah K

更新日期：2017-01-01 00:00:00

abstract：:Defects in articular cartilage injury and chronic osteoarthritis are very widespread and common, and the ability of injured cartilage to repair itself is limited. Stem cell-based cartilage tissue engineering provides a promising therapeutic option for articular cartilage damage. However, the application of the techniq...

journal_title：Current stem cell research & therapy

authors： Chen Y,Ouyang X,Wu Y,Guo S,Xie Y,Wang G

更新日期：2020-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are stromal origin cells with multilineage differentiation capacity. The immunoregulatory properties of MSCs can be interfered effectively by cytokines. Cytokines, produced by a broad range of cells, act at the systemic level to influence biological phenomena such as inflammation, wound h...

journal_title：Current stem cell research & therapy

authors： Zahari W,Hashim SN,Yusof MF,Osman ZF,Kannan TP,Mokhtar KI,Ahmad A,Noordin KB

更新日期：2017-01-01 00:00:00

abstract：:About 30 years ago circulating endothelial cells (CEC) were first observed in peripheral blood. Since then CEC have been established as a reliable indicator of vascular injury and damage and more sophisticated detection techniques, such as immunomagnetic isolation and fluorescence-activated cell sorting (FACS), have b...

journal_title：Current stem cell research & therapy

authors： Erdbruegger U,Dhaygude A,Haubitz M,Woywodt A

更新日期：2010-12-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by loss of dopaminergic neurons, oxidative stress and neuroinflammation. The classical therapeutic approach with L-DOPA is not able to control motor symptoms in the long term, thus new disease-modifying or neuroprotective treatments are urgently required in order to match such...

journal_title：Current stem cell research & therapy

authors： Conese M,Cassano R,Gavini E,Trapani G,Rassu G,Sanna E,Di Gioia S,Trapani A

更新日期：2019-01-01 00:00:00

abstract：:Most conventional treatments for neurodegenerative diseases fail due to their focus on neuroprotection rather than neurorestoration. Stem cell-based therapies are becoming a potential treatment option for neurodegenerative diseases as they can home in, engraft, differentiate and produce factors for CNS recovery. Stem ...

journal_title：Current stem cell research & therapy

authors： Anoop M,Datta I

更新日期：2020-12-21 00:00:00

abstract：:Angiogenesis is a complex process in which capillaries are produced from blood vessels that already exists. Endothelial cells (ECs) and endothelial progenitor cells (EPCs) are pivotal for this process and for the maintenance/restorage of the endothelium. Decreased numbers and dysfunction of these cells have been relat...

journal_title：Current stem cell research & therapy

authors： Sun K,Huang R,Wu S,Chen Z,Deng S,Zhou J,Xie J

更新日期：2016-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been isolated not only from bone marrow, but also from many other tissues such as adipose tissue, skeletal muscle, liver, brain and pancreas. Because MSC were found to have the ability to differentiate into cells of multiple organs and systems such as bone, fat, cartilage, muscle, ne...

journal_title：Current stem cell research & therapy

authors： Porada CD,Zanjani ED,Almeida-Porad G

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Multiple studies have focused on stem cell-based treatments for rotator cuff disorders; however, the outcomes are not consistent. OBJECTIVES:This systematic review and meta-analysis were performed to evaluate the effects of stem cells on rotator cuff healing. METHODS:A detailed search of relevant studies w...

journal_title：Current stem cell research & therapy

authors： Liu F,Meng Q,Yin H,Yan Z

更新日期：2019-01-01 00:00:00

abstract：:The intestinal mucosa has an amazing regenerative capacity, enabling rapid restoration of its physiological functions following injury. The ability to do this resides with the epithelial stem cells located within glandular invaginations in the mucosal surface. Recent advances toward the isolation and characterization ...

journal_title：Current stem cell research & therapy

authors： Day RM

更新日期：2006-01-01 00:00:00

abstract：:Reduced-intensity stem cell transplantation (RIST) has opened a new era for hematopoietic stem cell transplantation (HSCT). It was developed based on the knowledge that graft-versus-tumor (GVT) effect is the main anti-tumor effect in allogeneic HSCT. Because RIST is associated with less morbidity and mortality, it can...

journal_title：Current stem cell research & therapy

authors： Kato K,Khaled Y,Mineishi S

更新日期：2007-05-01 00:00:00

abstract：:Notch signaling mediates the fates of numerous cells in both invertebrates and vertebrates. In the immune system, Notch signalling contributes to the generation of hematopoietic stem cells (HSCs), the promotion of HSC self-renewal, T lineage commitment, intrathymic T cell development, and peripheral lymphocyte differe...

journal_title：Current stem cell research & therapy

authors： Nagase H,Koh CS,Nakayama K

更新日期：2011-06-01 00:00:00

abstract：:Chronic myeloproliferative disorders (cMPDs) are clonal hemopoietic malignancies arising at the multipotent stem cell level. These conditions are characterized by increased blood count, marrow hyperplasia and extramedulary hemopoiesis. Vascular events might complicate their course, and transformation to either acute l...

journal_title：Current stem cell research & therapy

authors： Spanoudakis E,Tsatalas C

更新日期：2009-05-01 00:00:00