Abstract:
:Mesenchymal stem cells (MSCs) are stromal origin cells with multilineage differentiation capacity. The immunoregulatory properties of MSCs can be interfered effectively by cytokines. Cytokines, produced by a broad range of cells, act at the systemic level to influence biological phenomena such as inflammation, wound healing, organogenesis and oncogenesis. Cytokines also play vital roles in the differentiation of MSCs into several cell lineages. This review summarizes on how cytokines can affect MSCs differentiation and their relative signaling pathways, which may serve to understand the possible underlying mechanisms. Also, this review reveals the potential clinical use of MSCs as promising therapeutic agents due to their special characteristics such as multipotent differentiation, immunomodulatory properties, and selfrestoration.
journal_name
Curr Stem Cell Res Therjournal_title
Current stem cell research & therapyauthors
Zahari W,Hashim SN,Yusof MF,Osman ZF,Kannan TP,Mokhtar KI,Ahmad A,Noordin KBdoi
10.2174/1574888X11666160614103404subject
Has Abstractpub_date
2017-01-01 00:00:00pages
197-206issue
3eissn
1574-888Xissn
2212-3946pii
CSCRT-EPUB-76551journal_volume
12pub_type
杂志文章,评审abstract::Intervertebral disc (IVD) degeneration is one of the leading causes of low back pain, which affects a large proportion of the global population at a huge socioeconomic burden. Current treatments focus primarily on symptomatic pain relief or surgery, but offer relatively poor long-term efficacy as they fail to address ...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666141202112638
更新日期:2015-01-01 00:00:00
abstract::Treatment of metastatic melanoma is a challenge for clinicians as most agents have failed to demonstrate improved survival in phase III trials. Despite the immunogenicity of this tumor entity, different immunological interventions including cytokine therapy, vaccination, biochemotherapy or allogeneic hematopoietic cel...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488812799859883
更新日期:2012-05-01 00:00:00
abstract::Reduced-intensity stem cell transplantation (RIST) has opened a new era for hematopoietic stem cell transplantation (HSCT). It was developed based on the knowledge that graft-versus-tumor (GVT) effect is the main anti-tumor effect in allogeneic HSCT. Because RIST is associated with less morbidity and mortality, it can...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488807780599248
更新日期:2007-05-01 00:00:00
abstract::Liver is a major metabolic organ of the body and is known to comprise of two epithelial cell lineages, namely, hepatocytes and cholangiocytes which are known to originate from hepatoblasts during fetal developing stages. Upon acute injury, the hepatocytes and cholangiocytes undergo cellular division to compensate the ...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888x113086660066
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Periodontitis is a multifactorial infectious disease that affects a large population worldwide. Oral microorganisms and susceptible host have been proposed to be the prerequisite for the development of periodontitis. Recently, the involvement of epigenetic modifications in the development of periodontitis ha...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X12666170718161740
更新日期:2018-01-01 00:00:00
abstract::Tendon and ligament injuries are common, and repair slowly with reduced biomechanical properties. With increasing financial demands on the health service and patients to recover from tendon and ligament injuries faster, and with less morbidity, health professionals are exploring new treatment options. Tissue engineeri...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x09666140710102808
更新日期:2015-01-01 00:00:00
abstract::Acute renal failure (ARF) is a syndrome of abrupt decline in renal function induced by a number of different insults. In clinic, the common etiology for ARF is ischemia-reperfusion injury (IRI). The pathophysiological process of renal IRI is complex, there is no good treatment. Stem cell therapy is a new and promising...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X11666161024143640
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Today, coronary artery disease is still one of the most important causes of mortality despite advanced surgical methods, pharmacotherapies and organ transplantation. These treatment modalities are intended to prevent further progression of myocardial infarction and do not involve the repair of the damaged pa...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X13666180510110055
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Multiple studies have focused on stem cell-based treatments for rotator cuff disorders; however, the outcomes are not consistent. OBJECTIVES:This systematic review and meta-analysis were performed to evaluate the effects of stem cells on rotator cuff healing. METHODS:A detailed search of relevant studies w...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,meta分析
doi:10.2174/1574888X14666190617143952
更新日期:2019-01-01 00:00:00
abstract::Intervertebral disc (IVD) disorders, especially degenerative disc disease, reduce the quality of life, and are short of effective therapy. A new direction for treatment of chronic tissue and organ diseases is to promote regeneration by harnessing endogenous repair mechanisms. In this review, we discuss the potential o...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666150305105114
更新日期:2015-01-01 00:00:00
abstract::Spinal surgery presents a challenge for both neurosurgery and orthopaedic surgery. Due to the heterogeneous differentiation potential of mesenchymal stem cells, there is much interest in the treatment of spine surgery. Animal and human trials focussing on the efficacy of mesenchymal stem cells in spinal cord injury, s...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X11666170907120030
更新日期:2018-01-01 00:00:00
abstract::The liver has a remarkable capability to restore its functional capacity following liver injury. According to the current paradigm, differentiated and usually quiescent hepatocytes are the primary cell type responsible for liver repair. As reserve compartment, bipotent hepatic progenitor cells are activated, especiall...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488807779317062
更新日期:2007-01-01 00:00:00
abstract::Cell repair/replacing strategies for neurodegenerative diseases such as Parkinson's disease depend on well-characterized dopaminergic neuronal candidates that are healthy and show promising effect on the rejuvenation of degenerated area of the brain. Therefore, it is imperative to develop innovative therapeutic strate...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X12666161114122059
更新日期:2017-01-01 00:00:00
abstract::The liver is a vital organ for life and the only internal organ that is capable of natural regeneration. Although the liver has high regeneration capacity, excessive hepatocyte death can lead to liver failure. Various factors can lead to liver damage including drug abuse, some natural products, alcohol, hepatitis, and...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1568026620666200220122536
更新日期:2020-01-01 00:00:00
abstract::Regenerative medicine (RM) is an interdisciplinary field that uses different approaches to accelerate the repair and regeneration or replace damaged or diseased human cells or tissues to achieve normal tissue function. These approaches include the stimulation of the body's own repair processes, transplantation of prog...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888X16999210112205826
更新日期:2021-01-12 00:00:00
abstract::Due to the nature of articular cartilage of being poorly vascularized the capabilities of self repair are limited. Mesenchymal stem cells transplantation is a modern technique which has been developed after the high success rates obtained by microfracturing and drilling techniques which promote the release of growth f...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x11308030006
更新日期:2013-05-01 00:00:00
abstract::Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality globally, and traditional pharmaceutical and surgical interventions delay the progression of CVDs. Recently, stem cell therapy has emerged as a promising candidate for treating and preventing heart failure. Increasing efforts have been dev...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888X15666200102103755
更新日期:2020-01-01 00:00:00
abstract::Neural stem cells (NSCs) are a small subset of primitive precursors that generate and maintain the main phenotypes of the nervous system. Their ability to undergo long-term proliferation and neural differentiation endows them with great potential in regenerative medicine. Therefore, the mechanisms by which NSCs are re...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x09666140213201846
更新日期:2014-05-01 00:00:00
abstract::Postnatal skeletogenesis is a highly regulated process that subpopulations of bone marrow stem cells differentiate into mature skeletal tissues to maintain and repair the postnatal skeletons. Based on their skeletogenic capacity, purified bone marrow stem cells have been used to repair and replace damaged skeletal tis...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666150519093626
更新日期:2015-01-01 00:00:00
abstract::Defects in articular cartilage injury and chronic osteoarthritis are very widespread and common, and the ability of injured cartilage to repair itself is limited. Stem cell-based cartilage tissue engineering provides a promising therapeutic option for articular cartilage damage. However, the application of the techniq...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X14666191029104249
更新日期:2020-01-01 00:00:00
abstract::Telomeres are the protective end caps of eukaryotic chromosomes and they decide the proliferative lifespan of somatic cells, as the guardians of the cell replication. Telomere length in leucocytes reflects telomere length in other somatic cells. Leucocyte telomere length can be a biomarker of human ageing. The risk of...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888X15666200422104423
更新日期:2020-04-21 00:00:00
abstract::Pyrroloquinoline Quinone (PQQ) is the third coenzyme found after niacinamide and flavone nucleotides and is widely present in microorganisms, plants, animals, and humans. PQQ can stimulate the growth of organisms and is very important for the growth, development and reproduction of animals. Owing to the inherent prope...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X14666181210165539
更新日期:2020-01-01 00:00:00
abstract::Type 1 diabetes mellitus is an autoimmune disease against pancreatic β cells. The autoimmune response begins months or years before the clinical presentation. At the time of hyperglycemic symptoms a small amount of β cell mass still remains. The main therapeutic option to type 1 diabetes mellitus is daily insulin inje...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488811794480690
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Diabetes mellitus (DM) is a widespread chronic metabolic disease which has high mortality due to its complications. In addition to traditional medication, stem cell transplantation therapeutics has become a brand-new and prospective remedy for DM. With strong self-renewal and multi-potential ability, mesench...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X10666151001114527
更新日期:2017-01-01 00:00:00
abstract::COVID-19 pandemic is a global health crisis in the 21st Century. There are currently no approved vaccine and no particular antiviral treatment for coronavirus disease. As COVID-19 has had a broad range of illnesses, it is necessary to find a safe and effective therapeutic method for COVID-19. An attractive approach fo...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888X15666201012165700
更新日期:2020-10-12 00:00:00
abstract:BACKGROUND:The urinary bladder and urethra comprise the lower urinary tracts. Pathological conditions that affect both structures necessitate reconstructive urological intervention with autologous tissue sources that cause neuromechanical and metabolic complications. Stem-cell therapies may offer an attractive alternat...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X13666180426113907
更新日期:2018-01-01 00:00:00
abstract::Despite the numerous recent advances made in conventional anticancer therapies, metastasis and recurrence still remain the major problems in cancer management. The current treatment modalities kill the bulk of the tumor, leaving cancer stem cells behind and therefore, the agents specifically targeting this cancer init...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666141126122316
更新日期:2015-01-01 00:00:00
abstract::Haematopoietic stem cell transplantation (HSCT) is a curative treatment of many hematological disorders. However, although significant advances have been made in donor-recipient matching or conditioning regimens, HSCT is associated with a risk of post transplant complications. Those include generation of toxic lesions...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488806776956850
更新日期:2006-05-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by the selective loss of both spinal and upper motor neurons. One strategy in treating ALS is to use stem cells to replace lost spinal motor neurons. However, transplanted stem cell-derived motor neurons may not survive when exposed to the harsh...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488809789057392
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Revascularisation therapy is the current gold standard of care for critical limb ischemia (CLI), although a significant proportion of patients with CLI either are not fit for or do not respond well to this procedure. Recently, novel angiogenic therapies such as the use of autologous cellbased therapy (CBT) h...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,meta分析,评审
doi:10.2174/1574888X13666180313141416
更新日期:2018-01-01 00:00:00