A Systematic Review of Mesenchymal Stem Cells in Spinal Cord Injury, Intervertebral Disc Repair and Spinal Fusion.

abstract：:Although the existence of cancer stem cells (CSCs) has been demonstrated in colorectal cancer, further investigation is hindered by controversies over their surface markers. The sphere formation assay is widely used as in vitro method for derivation and characterization of CSCs based on the intrinsic self-renewal prop...

journal_title：Current stem cell research & therapy

authors： Wu H,Zhang H,Hu Y,Xia Q,Liu C,Li Y,Yu B,Gu T,Zhang X,Yu X,Kong W

更新日期：2014-03-01 00:00:00

abstract：:Osteoarthritis (OA) is the most common degenerative joint disorder worldwide. OA represents an increasing threat to the quality of life of affected persons as well as for health resources expenditure. The incapability of cartilage to heal has been long time regarded as the major cause of progressive joint degeneration...

journal_title：Current stem cell research & therapy

authors： Labusca L,Mashayekhi K

更新日期：2015-01-01 00:00:00

abstract：:Sharing the same precursor cell lineage located in the bone marrow, mesenchymal stroma/stem cells (MSCs), osteoblasts and adipocytes have a reciprocal relationship in differentiation and function. The nuclear transcription factor peroxisome-proliferator- activated receptor-gamma (PPAR-γ) has been found expressed in bo...

journal_title：Current stem cell research & therapy

authors： Zhuang H,Zhang X,Zhu C,Tang X,Yu F,Shang GW,Cai X

更新日期：2016-01-01 00:00:00

abstract：:Due to the advent of less-toxic reduced intensity conditioning regimens (RIT), allogeneic hematopoietic cell transplantation (allo-HCT) is currently widely used to treat chemotherapy-resistant hematological diseases, particularly in older patients,which are the fastest growing group of patients receiving allo-HCT. How...

journal_title：Current stem cell research & therapy

authors： Toubai T,Tanaka J,Paczesny S,Shono Y,Reddy P,Imamura M

更新日期：2012-05-01 00:00:00

abstract：:Combination antiretroviral therapy (cART) has significantly reduced the mortality rate and morbidity, and has increased the life expectancy of the human immunodeficiency virus (HIV) infected patients. However, the current cART is incapable of eradicating viruses from the human body, and HIV remains one of the most not...

journal_title：Current stem cell research & therapy

authors： Hu J,Feng Y,Ma P,Lai Y

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Acute renal failure (ARF) resulting from ischemic or toxic insults remains a major health care problem because of its grave prognosis and the limited effectiveness of available treatment modalities. Current treatment options for ARF are limited to supportive measures and preventive strategies, none of which ...

journal_title：Current stem cell research & therapy

authors： Mohamed MI,Attia FM,Atwa KA

更新日期：2011-12-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been isolated not only from bone marrow, but also from many other tissues such as adipose tissue, skeletal muscle, liver, brain and pancreas. Because MSC were found to have the ability to differentiate into cells of multiple organs and systems such as bone, fat, cartilage, muscle, ne...

journal_title：Current stem cell research & therapy

authors： Porada CD,Zanjani ED,Almeida-Porad G

更新日期：2006-09-01 00:00:00

abstract：:The liver is a vital organ for life and the only internal organ that is capable of natural regeneration. Although the liver has high regeneration capacity, excessive hepatocyte death can lead to liver failure. Various factors can lead to liver damage including drug abuse, some natural products, alcohol, hepatitis, and...

journal_title：Current stem cell research & therapy

authors： Anwar I,Ashfaq UA,Shokat Z

更新日期：2020-01-01 00:00:00

abstract：:Defects in articular cartilage injury and chronic osteoarthritis are very widespread and common, and the ability of injured cartilage to repair itself is limited. Stem cell-based cartilage tissue engineering provides a promising therapeutic option for articular cartilage damage. However, the application of the techniq...

journal_title：Current stem cell research & therapy

authors： Chen Y,Ouyang X,Wu Y,Guo S,Xie Y,Wang G

更新日期：2020-01-01 00:00:00

abstract：: ...

journal_title：Current stem cell research & therapy

authors： Yoo JJ

更新日期：2019-01-01 00:00:00

abstract：:Stem cells have been long looked at as possible therapeutic vehicles for different health related problems. Among the different existing stem cell populations, Adipose- derived Stem Cells (ASCs) have been gathering attention in the last 10 years. When compared to other stem cells populations and sources, ASCs can be e...

journal_title：Current stem cell research & therapy

authors： Salgado AJ,Reis RL,Sousa NJ,Gimble JM

更新日期：2010-06-01 00:00:00

abstract：:Pyrroloquinoline Quinone (PQQ) is the third coenzyme found after niacinamide and flavone nucleotides and is widely present in microorganisms, plants, animals, and humans. PQQ can stimulate the growth of organisms and is very important for the growth, development and reproduction of animals. Owing to the inherent prope...

journal_title：Current stem cell research & therapy

authors： Wen H,He Y,Zhang K,Yang X,Hao D,Jiang Y,He B

更新日期：2020-01-01 00:00:00

abstract：:In contrast to their almost unlimited potential for expansion in vivo and despite years of dedicated research and optimization of expansion protocols, the expansion of Hematopoietic Stem Cells (HSCs) in vitro remains remarkably limited. Increased understanding of the mechanisms that are involved in maintenance, expans...

journal_title：Current stem cell research & therapy

authors： Aerts-Kaya F

更新日期：2020-02-24 00:00:00

abstract：:Chronic myeloproliferative disorders (cMPDs) are clonal hemopoietic malignancies arising at the multipotent stem cell level. These conditions are characterized by increased blood count, marrow hyperplasia and extramedulary hemopoiesis. Vascular events might complicate their course, and transformation to either acute l...

journal_title：Current stem cell research & therapy

authors： Spanoudakis E,Tsatalas C

更新日期：2009-05-01 00:00:00

abstract：:In this review we focus on epidermal stem cells in the normal regeneration of the skin as well as in wounded and psoriatic skin. Furthermore, we discuss current data supporting the idea of cancer stem cells in the pathogenesis of skin carcinoma and malignant melanoma. Epidermal stem cells present in the basal layer of...

journal_title：Current stem cell research & therapy

authors： Kamstrup M,Faurschou A,Gniadecki R,Wulf HC

更新日期：2008-05-01 00:00:00

abstract：:Heterogeneity is a well-documented phenomenon in breast cancer; one of the explanations for this phenomenon is the presence of cancer stem cells (CSCs) with the capacity to differentiate along divergent pathways. These CSCs undergo asymmetric and symmetric division resulting in both expansion of the stem cell pool and...

journal_title：Current stem cell research & therapy

authors： Nakshatri H,Srour EF,Badve S

更新日期：2009-01-01 00:00:00

abstract：:Notch signaling mediates the fates of numerous cells in both invertebrates and vertebrates. In the immune system, Notch signalling contributes to the generation of hematopoietic stem cells (HSCs), the promotion of HSC self-renewal, T lineage commitment, intrathymic T cell development, and peripheral lymphocyte differe...

journal_title：Current stem cell research & therapy

authors： Nagase H,Koh CS,Nakayama K

更新日期：2011-06-01 00:00:00

abstract：:The pressing demand to elucidate the biology of human embryonic stem (ES) cells and to realize their therapeutic potential has greatly promoted the progresses in the optimization of the culture systems used for this highly promising cell type. These progresses include the characterization of exogenous regulators of pl...

journal_title：Current stem cell research & therapy

authors： Lin G,Xu RH

更新日期：2010-09-01 00:00:00

abstract：:Exosomes and microvesicles, which are released by most of the cells, play important roles in intracellular correspondence by transferring DNA, messenger RNA, micro RNA, and other types of RNA and proteins. Exosomes and microvesicles may contribute to the distribution of cancers and diseases through delivering the path...

journal_title：Current stem cell research & therapy

authors： Bakhshandeh B,Kamaleddin MA,Aalishah K

更新日期：2017-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by the selective loss of both spinal and upper motor neurons. One strategy in treating ALS is to use stem cells to replace lost spinal motor neurons. However, transplanted stem cell-derived motor neurons may not survive when exposed to the harsh...

journal_title：Current stem cell research & therapy

authors： Thonhoff JR,Ojeda L,Wu P

更新日期：2009-09-01 00:00:00

abstract：:Angiogenesis is a complex process in which capillaries are produced from blood vessels that already exists. Endothelial cells (ECs) and endothelial progenitor cells (EPCs) are pivotal for this process and for the maintenance/restorage of the endothelium. Decreased numbers and dysfunction of these cells have been relat...

journal_title：Current stem cell research & therapy

authors： Sun K,Huang R,Wu S,Chen Z,Deng S,Zhou J,Xie J

更新日期：2016-01-01 00:00:00

abstract：:Acute renal failure (ARF) is a syndrome of abrupt decline in renal function induced by a number of different insults. In clinic, the common etiology for ARF is ischemia-reperfusion injury (IRI). The pathophysiological process of renal IRI is complex, there is no good treatment. Stem cell therapy is a new and promising...

journal_title：Current stem cell research & therapy

authors： Hu H,Zou C

更新日期：2017-01-01 00:00:00

abstract：:Human mesenchymal stem cells (hMSCs) are multipotent non-hematopoietic precursor cells with the ability to differentiate into several tissue types. The use of hMSCs has gained significant importance in cancer therapies as well as a large number of degenerative disease therapies due to their homing abilities. However, ...

journal_title：Current stem cell research & therapy

authors： Serakinci N,Kalkan R,Tulay P

更新日期：2016-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSC) can be obtained from human bone marrow aspirates and, thanks to their differentiation potential and excellent in vitro culture properties, represent an attractive cell line for the regeneration of mesenchymal tissue. Both in vitro and in vivo, they can differentiate into cartilage, bone, t...

journal_title：Current stem cell research & therapy

authors： Niemeyer P,Krause U,Kasten P,Kreuz PC,Henle P,Südkam NP,Mehlhorn A

更新日期：2006-01-01 00:00:00

abstract：:Intervertebral disc (IVD) degeneration is one of the leading causes of low back pain, which affects a large proportion of the global population at a huge socioeconomic burden. Current treatments focus primarily on symptomatic pain relief or surgery, but offer relatively poor long-term efficacy as they fail to address ...

journal_title：Current stem cell research & therapy

authors： Clarke LE,Richardson SM,Hoyland JA

更新日期：2015-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor γ (PPARγ) is a versatile member of the ligand-activated nuclear hormone receptor superfamily of transcription factors, with expression in several different cell lines, especially in the digestive system. After being activated by its ligand, PPARγ can suppress the growth of or...

journal_title：Current stem cell research & therapy

authors： Shu L,Huang R,Wu S,Chen Z,Sun K,Jiang Y,Cai X

更新日期：2016-01-01 00:00:00

abstract：:Rotator cuff tear causes a high rate of morbidity. After surgical repair, the presence of a scar tissue reduces tendon biomechanical properties. Emerging strategies for enhancing tendon healing are growth factors, cytokines, gene therapy and tissue engineering. However their efficacy has to be proved. Growth factors h...

journal_title：Current stem cell research & therapy

authors： Longo UG,Rizzello G,Berton A,Maltese L,Fumo C,Khan WS,Denaro V

更新日期：2013-11-01 00:00:00

abstract：:Breast cancer stem cells (BCSCs) are a small population of tumor-initiating cells that express stem cell-associated markers. In recent years, their properties and mechanisms of regulation have become the focus of intense research due to their intrinsic resistance to conventional cancer therapies. This review describes...

journal_title：Current stem cell research & therapy

authors： Flores-Ramírez I,Baranda-Avila N,Langley E

更新日期：2019-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are stromal origin cells with multilineage differentiation capacity. The immunoregulatory properties of MSCs can be interfered effectively by cytokines. Cytokines, produced by a broad range of cells, act at the systemic level to influence biological phenomena such as inflammation, wound h...

journal_title：Current stem cell research & therapy

authors： Zahari W,Hashim SN,Yusof MF,Osman ZF,Kannan TP,Mokhtar KI,Ahmad A,Noordin KB

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Multiple studies have focused on stem cell-based treatments for rotator cuff disorders; however, the outcomes are not consistent. OBJECTIVES:This systematic review and meta-analysis were performed to evaluate the effects of stem cells on rotator cuff healing. METHODS:A detailed search of relevant studies w...

journal_title：Current stem cell research & therapy

authors： Liu F,Meng Q,Yin H,Yan Z

更新日期：2019-01-01 00:00:00