Potential and limitations of intervertebral disc endogenous repair.

Abstract:

:Intervertebral disc (IVD) disorders, especially degenerative disc disease, reduce the quality of life, and are short of effective therapy. A new direction for treatment of chronic tissue and organ diseases is to promote regeneration by harnessing endogenous repair mechanisms. In this review, we discuss the potential of endogenous repair in the IVD, the recent findings on endogenous IVD progenitor cells, and stem cell niches involved in IVD endogenous repair. We also highlight the factors which may restrict IVD self-healing. Ultimately, advanced therapeutic attempts to boost endogenous repair in the IVD are discussed, including bioactive factor delivery, gene therapy, activation of endogenous IVD progenitor cells and chemokine mediated stem cell homing.

authors

Li Z,Peroglio M,Alini M,Grad S

doi

10.2174/1574888x10666150305105114

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

329-38

issue

4

eissn

1574-888X

issn

2212-3946

pii

CSCRT-EPUB-65670

journal_volume

10

pub_type

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