Clinical applications of mesenchymal stem cells in laryngotracheal reconstruction.

abstract：:Mesenchymal stem cells (MSCs) have the self-renewal ability and the ability to produce multiple differentiation. Elucidating the genetic circuits that govern MSC self-renewal and differentiation is necessary to improve our comprehension of MSCs and their role in regenerative medicine. microRNAs (miRNAs) play important...

journal_title：Current stem cell research & therapy

authors： Huang C,Gou S,Wang L,Huang K,Liu L,Zhao W,Zheng L,Xiao J

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The urinary bladder and urethra comprise the lower urinary tracts. Pathological conditions that affect both structures necessitate reconstructive urological intervention with autologous tissue sources that cause neuromechanical and metabolic complications. Stem-cell therapies may offer an attractive alternat...

journal_title：Current stem cell research & therapy

authors： Davis NF,Cunnane EM,Mulvihill JJ,Quinlan MR,Bolton DM,Walsh MT,Jack GS

更新日期：2018-01-01 00:00:00

abstract：:Heterogeneity is a well-documented phenomenon in breast cancer; one of the explanations for this phenomenon is the presence of cancer stem cells (CSCs) with the capacity to differentiate along divergent pathways. These CSCs undergo asymmetric and symmetric division resulting in both expansion of the stem cell pool and...

journal_title：Current stem cell research & therapy

authors： Nakshatri H,Srour EF,Badve S

更新日期：2009-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by the selective loss of both spinal and upper motor neurons. One strategy in treating ALS is to use stem cells to replace lost spinal motor neurons. However, transplanted stem cell-derived motor neurons may not survive when exposed to the harsh...

journal_title：Current stem cell research & therapy

authors： Thonhoff JR,Ojeda L,Wu P

更新日期：2009-09-01 00:00:00

abstract：:Liver is a major metabolic organ of the body and is known to comprise of two epithelial cell lineages, namely, hepatocytes and cholangiocytes which are known to originate from hepatoblasts during fetal developing stages. Upon acute injury, the hepatocytes and cholangiocytes undergo cellular division to compensate the ...

journal_title：Current stem cell research & therapy

authors： Rehman K,Iqbal MJ,Zahra N,Akash MS

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Cellular differentiation occurs in a complicated microenvironment containing multiple components including soluble factors and physical cues. In addition to biochemical composition, physical cues are also crucial in determining cellular behaviors. OBJECTIVE:To better understand the interaction between physi...

journal_title：Current stem cell research & therapy

authors： Zhang Q,Lin S,Liao J,Cai X

更新日期：2018-01-01 00:00:00

abstract：:Stem/progenitor cells for cell therapy and regenerative medicine should ideally be available in large numbers, after having been isolated using minimally invasive or non-invasive methodologies. Also, they should exhibit wide differentiation potential into multiple lineages, as well as capability to be used successfull...

journal_title：Current stem cell research & therapy

authors： Eiro N,Fraile M,Schneider J,Vizoso FJ

更新日期：2018-01-01 00:00:00

abstract：:Haematopoietic stem cell transplantation (HSCT) is a curative treatment of many hematological disorders. However, although significant advances have been made in donor-recipient matching or conditioning regimens, HSCT is associated with a risk of post transplant complications. Those include generation of toxic lesions...

journal_title：Current stem cell research & therapy

authors： Bogunia-Kubik K,Wysoczanska B,Lange A

更新日期：2006-05-01 00:00:00

abstract：:Neural stem cells (NSCs) are a small subset of primitive precursors that generate and maintain the main phenotypes of the nervous system. Their ability to undergo long-term proliferation and neural differentiation endows them with great potential in regenerative medicine. Therefore, the mechanisms by which NSCs are re...

journal_title：Current stem cell research & therapy

authors： Wang S,Xu J,Ye R,Wang J,Chen Z,Huang R,Peng Q,Xu Y,Cai X

更新日期：2014-05-01 00:00:00

abstract：:Differentiation of stem cells, a crucial step in the process of tissue development, repair and regeneration, can be regulated by a variety of mechanical factors such as the stiffness of extracellular matrix. In this review article, the effects of stiffness on the differentiation of stem cells, including bone marrow-de...

journal_title：Current stem cell research & therapy

authors： Zhang W,Chu G,Wang H,Chen S,Li B,Han F

更新日期：2020-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are ideal candidates for different cellular therapies due to their simple isolation, extensive expansion potential, and low immunogenicity. For various therapeutic approaches, such as bone and cartilage repair, MSCs are expected to replace the damaged tissues by direct differentiation. Ho...

journal_title：Current stem cell research & therapy

authors： Kuang W,Xu X,Lin J,Cao Y,Xu Y,Chen L,Jin L,Tan J

更新日期：2015-01-01 00:00:00

abstract：AIMS:A systematic review and meta-analysis were performed to explore the clinical outcome of the transplantation of stem cells from various human tissue sources in cirrhotic patients. METHODS:The relevant papers were searched via PubMed, EMBASE, and Cochrane Library databases. Changes in liver function before and afte...

journal_title：Current stem cell research & therapy

authors： Qi X,Guo X,Su C

更新日期：2015-01-01 00:00:00

abstract：:Most conventional treatments for neurodegenerative diseases fail due to their focus on neuroprotection rather than neurorestoration. Stem cell-based therapies are becoming a potential treatment option for neurodegenerative diseases as they can home in, engraft, differentiate and produce factors for CNS recovery. Stem ...

journal_title：Current stem cell research & therapy

authors： Anoop M,Datta I

更新日期：2020-12-21 00:00:00

abstract：:Acute renal failure (ARF) is a syndrome of abrupt decline in renal function induced by a number of different insults. In clinic, the common etiology for ARF is ischemia-reperfusion injury (IRI). The pathophysiological process of renal IRI is complex, there is no good treatment. Stem cell therapy is a new and promising...

journal_title：Current stem cell research & therapy

authors： Hu H,Zou C

更新日期：2017-01-01 00:00:00

abstract：:Recent studies have shown that treatments involving injection of stem cells into animals with damaged cardiac tissue result in improved cardiac functionality. Clinical trials have reported conflicting results concerning the recellularization of post-infarct collagen scars. No clear mechanism has so far emerged to full...

journal_title：Current stem cell research & therapy

authors： Li SC,Acevedo J,Wang L,Jiang H,Luo J,Pestell RG,Loudon WG,Chang AC

更新日期：2012-01-01 00:00:00

abstract：:Stem cells are undifferentiated cells with the ability to proliferate and convert to different types of differentiated cells that make up the various tissues and organs in the body. They exist both in embryos as pluripotent stem cells that can differentiate into the three germ layers and as multipotent or unipotent st...

journal_title：Current stem cell research & therapy

authors： Bahmad HF,Elajami MK,Daouk R,Jalloul H,Darwish B,Chalhoub RM,Assi S,Chamaa F,Abou-Kheir W

更新日期：2020-08-31 00:00:00

abstract：:Sarcomas are the mesenchymal-derived malignant tumors of connective tissues (e.g., fat, bone, and cartilage) presumed to arise from aberrant development or differentiation of mesenchymal stem cells (MSCs). Appropriate control of stem cell maintenance versus differentiation allows for normal connective tissue developme...

journal_title：Current stem cell research & therapy

authors： Siddiqi S,Mills J,Matushansky I

更新日期：2010-03-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been isolated not only from bone marrow, but also from many other tissues such as adipose tissue, skeletal muscle, liver, brain and pancreas. Because MSC were found to have the ability to differentiate into cells of multiple organs and systems such as bone, fat, cartilage, muscle, ne...

journal_title：Current stem cell research & therapy

authors： Porada CD,Zanjani ED,Almeida-Porad G

更新日期：2006-09-01 00:00:00

abstract：:Despite the numerous recent advances made in conventional anticancer therapies, metastasis and recurrence still remain the major problems in cancer management. The current treatment modalities kill the bulk of the tumor, leaving cancer stem cells behind and therefore, the agents specifically targeting this cancer init...

journal_title：Current stem cell research & therapy

authors： Sak K,Everaus H

更新日期：2015-01-01 00:00:00

abstract：:Due to the advent of less-toxic reduced intensity conditioning regimens (RIT), allogeneic hematopoietic cell transplantation (allo-HCT) is currently widely used to treat chemotherapy-resistant hematological diseases, particularly in older patients,which are the fastest growing group of patients receiving allo-HCT. How...

journal_title：Current stem cell research & therapy

authors： Toubai T,Tanaka J,Paczesny S,Shono Y,Reddy P,Imamura M

更新日期：2012-05-01 00:00:00

abstract：:In this review we focus on epidermal stem cells in the normal regeneration of the skin as well as in wounded and psoriatic skin. Furthermore, we discuss current data supporting the idea of cancer stem cells in the pathogenesis of skin carcinoma and malignant melanoma. Epidermal stem cells present in the basal layer of...

journal_title：Current stem cell research & therapy

authors： Kamstrup M,Faurschou A,Gniadecki R,Wulf HC

更新日期：2008-05-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are stromal origin cells with multilineage differentiation capacity. The immunoregulatory properties of MSCs can be interfered effectively by cytokines. Cytokines, produced by a broad range of cells, act at the systemic level to influence biological phenomena such as inflammation, wound h...

journal_title：Current stem cell research & therapy

authors： Zahari W,Hashim SN,Yusof MF,Osman ZF,Kannan TP,Mokhtar KI,Ahmad A,Noordin KB

更新日期：2017-01-01 00:00:00

abstract：:In contrast to their almost unlimited potential for expansion in vivo and despite years of dedicated research and optimization of expansion protocols, the expansion of Hematopoietic Stem Cells (HSCs) in vitro remains remarkably limited. Increased understanding of the mechanisms that are involved in maintenance, expans...

journal_title：Current stem cell research & therapy

authors： Aerts-Kaya F

更新日期：2020-02-24 00:00:00

abstract：:The pressing demand to elucidate the biology of human embryonic stem (ES) cells and to realize their therapeutic potential has greatly promoted the progresses in the optimization of the culture systems used for this highly promising cell type. These progresses include the characterization of exogenous regulators of pl...

journal_title：Current stem cell research & therapy

authors： Lin G,Xu RH

更新日期：2010-09-01 00:00:00

abstract：:Regenerative medicine (RM) is an interdisciplinary field that uses different approaches to accelerate the repair and regeneration or replace damaged or diseased human cells or tissues to achieve normal tissue function. These approaches include the stimulation of the body's own repair processes, transplantation of prog...

journal_title：Current stem cell research & therapy

authors： Asgharzad S,Alizadeh A,Arab S

更新日期：2021-01-12 00:00:00

abstract：:Due to the nature of articular cartilage of being poorly vascularized the capabilities of self repair are limited. Mesenchymal stem cells transplantation is a modern technique which has been developed after the high success rates obtained by microfracturing and drilling techniques which promote the release of growth f...

journal_title：Current stem cell research & therapy

authors： Martinelli N,Bonifacini C,Longo UG,Marinozzi A,Florio P,Khan WS,Denaro V

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Multiple studies have focused on stem cell-based treatments for rotator cuff disorders; however, the outcomes are not consistent. OBJECTIVES:This systematic review and meta-analysis were performed to evaluate the effects of stem cells on rotator cuff healing. METHODS:A detailed search of relevant studies w...

journal_title：Current stem cell research & therapy

authors： Liu F,Meng Q,Yin H,Yan Z

更新日期：2019-01-01 00:00:00

abstract：:The discovery of neural stem cells (NSC) which ensure continuous neurogenesis in the adult mammalian brain, has led to a conceptual revolution in basic neuroscience and to high hopes for clinical nervous tissue repair. However, several research issues remain to address before neural stem cells can be harnessed for reg...

journal_title：Current stem cell research & therapy

authors： Moyse E,Segura S,Liard O,Mahaut S,Mechawar N

更新日期：2008-09-01 00:00:00

abstract：:Combination antiretroviral therapy (cART) has significantly reduced the mortality rate and morbidity, and has increased the life expectancy of the human immunodeficiency virus (HIV) infected patients. However, the current cART is incapable of eradicating viruses from the human body, and HIV remains one of the most not...

journal_title：Current stem cell research & therapy

authors： Hu J,Feng Y,Ma P,Lai Y

更新日期：2019-01-01 00:00:00

abstract：:Protein kinases (PKs) mediate the reversible conversion of substrate proteins to phosphorylated forms, a key process in controlling intracellular signaling transduction cascades. Pluripotency is, among others, characterized by specifically expressed PKs forming a highly interconnected regulatory network that culminate...

journal_title：Current stem cell research & therapy

authors： Shoni M,Lui KO,Vavvas DG,Muto MG,Berkowitz RS,Vlahos N,Ng SW

更新日期：2014-01-01 00:00:00