Role of cytokines in the pathophysiology of acute graft-versus-host disease (GVHD): are serum/plasma cytokines potential biomarkers for diagnosis of acute GVHD following allogeneic hematopoietic cell transplantation (Allo-HCT)?

abstract：:Due to the nature of articular cartilage of being poorly vascularized the capabilities of self repair are limited. Mesenchymal stem cells transplantation is a modern technique which has been developed after the high success rates obtained by microfracturing and drilling techniques which promote the release of growth f...

journal_title：Current stem cell research & therapy

authors： Martinelli N,Bonifacini C,Longo UG,Marinozzi A,Florio P,Khan WS,Denaro V

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Articular cartilage defects often result in pain, loss of function and finally osteoarthritis. Developing cell-based therapies for cartilage repair is a major goal of orthopaedic research. Autologous chondrocyte implantation is currently the gold standard cell-based surgical procedure for the treatment of la...

journal_title：Current stem cell research & therapy

authors： Kubosch EJ,Lang G,Furst D,Kubosch D,Izadpanah K,Rolauffs B,Sudkamp NP,Schmal H

更新日期：2018-02-23 00:00:00

abstract：:During the past several years, mesenchymal stem cells (MSCs) derived from adult tissue have rapidly moved from in vitro and animal studies into clinical trials as a therapeutic modality for a diverse group of clinical applications, including head and neck reconstruction. For many diseases, cell therapy could affect th...

journal_title：Current stem cell research & therapy

authors： Hanson S,Thibeault SL,Hematti P

更新日期：2010-09-01 00:00:00

abstract：:Defects in articular cartilage injury and chronic osteoarthritis are very widespread and common, and the ability of injured cartilage to repair itself is limited. Stem cell-based cartilage tissue engineering provides a promising therapeutic option for articular cartilage damage. However, the application of the techniq...

journal_title：Current stem cell research & therapy

authors： Chen Y,Ouyang X,Wu Y,Guo S,Xie Y,Wang G

更新日期：2020-01-01 00:00:00

abstract：:Spinal surgery presents a challenge for both neurosurgery and orthopaedic surgery. Due to the heterogeneous differentiation potential of mesenchymal stem cells, there is much interest in the treatment of spine surgery. Animal and human trials focussing on the efficacy of mesenchymal stem cells in spinal cord injury, s...

journal_title：Current stem cell research & therapy

authors： Khan S,Mafi P,Mafi R,Khan W

更新日期：2018-01-01 00:00:00

abstract：:Pluripotent stem cells (PSCs) derived from somatic cells represent a powerful experimental tool for investigating the molecular mechanisms underlying the disease phenotype; with prospects to advance medical therapies. They also have significant potential as a renewable source of autologous cells for cellular therapy. ...

journal_title：Current stem cell research & therapy

authors： Alateeq S,Fortuna PR,Wolvetang E

更新日期：2015-01-01 00:00:00

abstract：:Pyrroloquinoline Quinone (PQQ) is the third coenzyme found after niacinamide and flavone nucleotides and is widely present in microorganisms, plants, animals, and humans. PQQ can stimulate the growth of organisms and is very important for the growth, development and reproduction of animals. Owing to the inherent prope...

journal_title：Current stem cell research & therapy

authors： Wen H,He Y,Zhang K,Yang X,Hao D,Jiang Y,He B

更新日期：2020-01-01 00:00:00

abstract：:Angiogenesis is a complex process in which capillaries are produced from blood vessels that already exists. Endothelial cells (ECs) and endothelial progenitor cells (EPCs) are pivotal for this process and for the maintenance/restorage of the endothelium. Decreased numbers and dysfunction of these cells have been relat...

journal_title：Current stem cell research & therapy

authors： Sun K,Huang R,Wu S,Chen Z,Deng S,Zhou J,Xie J

更新日期：2016-01-01 00:00:00

abstract：:Liver is a major metabolic organ of the body and is known to comprise of two epithelial cell lineages, namely, hepatocytes and cholangiocytes which are known to originate from hepatoblasts during fetal developing stages. Upon acute injury, the hepatocytes and cholangiocytes undergo cellular division to compensate the ...

journal_title：Current stem cell research & therapy

authors： Rehman K,Iqbal MJ,Zahra N,Akash MS

更新日期：2014-01-01 00:00:00

abstract：:Since the improvement of chemotherapy and innovation of rituximab, about 60% of patients with diffuse large B cell lymphoma (DLBCL) could receive long-term survival after firstline therapy. Around 30% fail to respond or experience relapse considered as the relapsed/refractory DLBCL, the highdose chemotherapy followed ...

journal_title：Current stem cell research & therapy

authors： Xiao Z,Li J,Miao K

更新日期：2017-01-01 00:00:00

abstract：:Stem cells are undifferentiated cells with the ability to proliferate and convert to different types of differentiated cells that make up the various tissues and organs in the body. They exist both in embryos as pluripotent stem cells that can differentiate into the three germ layers and as multipotent or unipotent st...

journal_title：Current stem cell research & therapy

authors： Bahmad HF,Elajami MK,Daouk R,Jalloul H,Darwish B,Chalhoub RM,Assi S,Chamaa F,Abou-Kheir W

更新日期：2020-08-31 00:00:00

abstract：BACKGROUND:Periodontitis is a multifactorial infectious disease that affects a large population worldwide. Oral microorganisms and susceptible host have been proposed to be the prerequisite for the development of periodontitis. Recently, the involvement of epigenetic modifications in the development of periodontitis ha...

journal_title：Current stem cell research & therapy

authors： Luo Y,Peng X,Duan D,Liu C,Xu X,Zhou X

更新日期：2018-01-01 00:00:00

abstract：AIMS:A systematic review and meta-analysis were performed to explore the clinical outcome of the transplantation of stem cells from various human tissue sources in cirrhotic patients. METHODS:The relevant papers were searched via PubMed, EMBASE, and Cochrane Library databases. Changes in liver function before and afte...

journal_title：Current stem cell research & therapy

authors： Qi X,Guo X,Su C

更新日期：2015-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a newly discovered, yet powerful mechanism for regulating protein expression via mRNA translational inhibition. Loss of all miRNA function within mice leads to embryonic lethality with a loss of the stem cell population in the epiblast and failure to form a primitive streak. These data suggest t...

journal_title：Current stem cell research & therapy

authors： Foshay KM,Gallicano GI

更新日期：2007-12-01 00:00:00

abstract：:Cell repair/replacing strategies for neurodegenerative diseases such as Parkinson's disease depend on well-characterized dopaminergic neuronal candidates that are healthy and show promising effect on the rejuvenation of degenerated area of the brain. Therefore, it is imperative to develop innovative therapeutic strate...

journal_title：Current stem cell research & therapy

authors： Venkatesh K,Sen D

更新日期：2017-01-01 00:00:00

abstract：:The pressing demand to elucidate the biology of human embryonic stem (ES) cells and to realize their therapeutic potential has greatly promoted the progresses in the optimization of the culture systems used for this highly promising cell type. These progresses include the characterization of exogenous regulators of pl...

journal_title：Current stem cell research & therapy

authors： Lin G,Xu RH

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Stem cell culture for regenerative medicine needs platelet rich plasma (PRP) as fetal bovine/calf serum (FBS/FCS) substitute. However, the various studies used various protocols in preparing and processing the PRP. This study aimed to compare and conclude the most effective and efficient protocol. METHODS:w...

journal_title：Current stem cell research & therapy

authors： Pawitan JA

更新日期：2012-09-01 00:00:00

abstract：:Sharing the same precursor cell lineage located in the bone marrow, mesenchymal stroma/stem cells (MSCs), osteoblasts and adipocytes have a reciprocal relationship in differentiation and function. The nuclear transcription factor peroxisome-proliferator- activated receptor-gamma (PPAR-γ) has been found expressed in bo...

journal_title：Current stem cell research & therapy

authors： Zhuang H,Zhang X,Zhu C,Tang X,Yu F,Shang GW,Cai X

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Today, coronary artery disease is still one of the most important causes of mortality despite advanced surgical methods, pharmacotherapies and organ transplantation. These treatment modalities are intended to prevent further progression of myocardial infarction and do not involve the repair of the damaged pa...

journal_title：Current stem cell research & therapy

authors： Aslan A,Allahverdiyev AM,Bagirova M,Abamor ES

更新日期：2018-01-01 00:00:00

abstract：:Umbilical cord blood (UCB) is an alternative source of hematopoietic progenitors for transplantation in the treatment of haematological malignancies, marrow failure, immunodeficiencies, hemoglobinopathies and inherited metabolic diseases. It has greatly contributed to increase the feasibility to transplantation for ma...

journal_title：Current stem cell research & therapy

authors： Solves P,Mirabet V,Roig R

更新日期：2010-12-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by the selective loss of both spinal and upper motor neurons. One strategy in treating ALS is to use stem cells to replace lost spinal motor neurons. However, transplanted stem cell-derived motor neurons may not survive when exposed to the harsh...

journal_title：Current stem cell research & therapy

authors： Thonhoff JR,Ojeda L,Wu P

更新日期：2009-09-01 00:00:00

abstract：:Intervertebral disc (IVD) degeneration is one of the leading causes of low back pain, which affects a large proportion of the global population at a huge socioeconomic burden. Current treatments focus primarily on symptomatic pain relief or surgery, but offer relatively poor long-term efficacy as they fail to address ...

journal_title：Current stem cell research & therapy

authors： Clarke LE,Richardson SM,Hoyland JA

更新日期：2015-01-01 00:00:00

abstract：:Human hepatocyte transplantation is being trialled in lieu of orthotopic liver transplants for patients with acute and chronic liver diseases. Stem cells that can be differentiated into hepatocyte-like cells may replace human hepatocytes that are difficult to source, culture and in critically short supply. Hepatocyte-...

journal_title：Current stem cell research & therapy

authors： Vaghjiani V,Vaithilingam V,Tuch B,Sievert W,Manuelpillai U

更新日期：2013-01-01 00:00:00

abstract：:Conditions affecting cartilage through damage or age-related degeneration pose significant challenges to individual patients and their healthcare systems. The disease burden will rise in the future as life expectancy increases. This has resulted in vigorous efforts to develop novel therapies to meet current and future...

journal_title：Current stem cell research & therapy

authors： Mabvuure N,Hindocha S,Jordan D,Khan WS

更新日期：2012-07-01 00:00:00

abstract：:Postnatal skeletogenesis is a highly regulated process that subpopulations of bone marrow stem cells differentiate into mature skeletal tissues to maintain and repair the postnatal skeletons. Based on their skeletogenic capacity, purified bone marrow stem cells have been used to repair and replace damaged skeletal tis...

journal_title：Current stem cell research & therapy

authors： Deng P,Xu X,Chen Q

更新日期：2015-01-01 00:00:00

abstract：:Rotator cuff tear causes a high rate of morbidity. After surgical repair, the presence of a scar tissue reduces tendon biomechanical properties. Emerging strategies for enhancing tendon healing are growth factors, cytokines, gene therapy and tissue engineering. However their efficacy has to be proved. Growth factors h...

journal_title：Current stem cell research & therapy

authors： Longo UG,Rizzello G,Berton A,Maltese L,Fumo C,Khan WS,Denaro V

更新日期：2013-11-01 00:00:00

abstract：:The intestine serves mainly as a place for digestion and absorption and functions as an immune and endocrine organ. Intestinal stem cells (ISCs) play critical roles in the maintenance of intestinal homeostasis and regeneration, and a complex of signaling pathways is involved in these processes. The Notch signaling pat...

journal_title：Current stem cell research & therapy

authors： Liang SJ,Li XG,Wang XQ

更新日期：2019-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are ideal candidates for different cellular therapies due to their simple isolation, extensive expansion potential, and low immunogenicity. For various therapeutic approaches, such as bone and cartilage repair, MSCs are expected to replace the damaged tissues by direct differentiation. Ho...

journal_title：Current stem cell research & therapy

authors： Kuang W,Xu X,Lin J,Cao Y,Xu Y,Chen L,Jin L,Tan J

更新日期：2015-01-01 00:00:00

abstract：:Tendon and ligament injuries are common, and repair slowly with reduced biomechanical properties. With increasing financial demands on the health service and patients to recover from tendon and ligament injuries faster, and with less morbidity, health professionals are exploring new treatment options. Tissue engineeri...

journal_title：Current stem cell research & therapy

authors： Dhinsa BS,Mahapatra AN,Khan WS

更新日期：2015-01-01 00:00:00

abstract：:Chronic myeloproliferative disorders (cMPDs) are clonal hemopoietic malignancies arising at the multipotent stem cell level. These conditions are characterized by increased blood count, marrow hyperplasia and extramedulary hemopoiesis. Vascular events might complicate their course, and transformation to either acute l...

journal_title：Current stem cell research & therapy

authors： Spanoudakis E,Tsatalas C

更新日期：2009-05-01 00:00:00