Coreceptor-Based Hematopoietic Stem Cell Gene Therapy for HIV Disease.

abstract：:Cell repair/replacing strategies for neurodegenerative diseases such as Parkinson's disease depend on well-characterized dopaminergic neuronal candidates that are healthy and show promising effect on the rejuvenation of degenerated area of the brain. Therefore, it is imperative to develop innovative therapeutic strate...

journal_title：Current stem cell research & therapy

authors： Venkatesh K,Sen D

更新日期：2017-01-01 00:00:00

abstract：:Heterogeneity is a well-documented phenomenon in breast cancer; one of the explanations for this phenomenon is the presence of cancer stem cells (CSCs) with the capacity to differentiate along divergent pathways. These CSCs undergo asymmetric and symmetric division resulting in both expansion of the stem cell pool and...

journal_title：Current stem cell research & therapy

authors： Nakshatri H,Srour EF,Badve S

更新日期：2009-01-01 00:00:00

abstract：:Protein kinases (PKs) mediate the reversible conversion of substrate proteins to phosphorylated forms, a key process in controlling intracellular signaling transduction cascades. Pluripotency is, among others, characterized by specifically expressed PKs forming a highly interconnected regulatory network that culminate...

journal_title：Current stem cell research & therapy

authors： Shoni M,Lui KO,Vavvas DG,Muto MG,Berkowitz RS,Vlahos N,Ng SW

更新日期：2014-01-01 00:00:00

abstract：:Liver is a major metabolic organ of the body and is known to comprise of two epithelial cell lineages, namely, hepatocytes and cholangiocytes which are known to originate from hepatoblasts during fetal developing stages. Upon acute injury, the hepatocytes and cholangiocytes undergo cellular division to compensate the ...

journal_title：Current stem cell research & therapy

authors： Rehman K,Iqbal MJ,Zahra N,Akash MS

更新日期：2014-01-01 00:00:00

abstract：: ...

journal_title：Current stem cell research & therapy

authors： Yoo JJ

更新日期：2019-01-01 00:00:00

abstract：:Human hepatocyte transplantation is being trialled in lieu of orthotopic liver transplants for patients with acute and chronic liver diseases. Stem cells that can be differentiated into hepatocyte-like cells may replace human hepatocytes that are difficult to source, culture and in critically short supply. Hepatocyte-...

journal_title：Current stem cell research & therapy

authors： Vaghjiani V,Vaithilingam V,Tuch B,Sievert W,Manuelpillai U

更新日期：2013-01-01 00:00:00

abstract：:During the past several years, mesenchymal stem cells (MSCs) derived from adult tissue have rapidly moved from in vitro and animal studies into clinical trials as a therapeutic modality for a diverse group of clinical applications, including head and neck reconstruction. For many diseases, cell therapy could affect th...

journal_title：Current stem cell research & therapy

authors： Hanson S,Thibeault SL,Hematti P

更新日期：2010-09-01 00:00:00

abstract：:Human mesenchymal stem cells (hMSCs) are multipotent non-hematopoietic precursor cells with the ability to differentiate into several tissue types. The use of hMSCs has gained significant importance in cancer therapies as well as a large number of degenerative disease therapies due to their homing abilities. However, ...

journal_title：Current stem cell research & therapy

authors： Serakinci N,Kalkan R,Tulay P

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Revascularisation therapy is the current gold standard of care for critical limb ischemia (CLI), although a significant proportion of patients with CLI either are not fit for or do not respond well to this procedure. Recently, novel angiogenic therapies such as the use of autologous cellbased therapy (CBT) h...

journal_title：Current stem cell research & therapy

authors： Wahid FSA,Ismail NA,Wan Jamaludin WF,Muhamad NA,Mohamad Idris MA,Lai NM

更新日期：2018-01-01 00:00:00

abstract：:Type 1 diabetes mellitus is an autoimmune disease against pancreatic β cells. The autoimmune response begins months or years before the clinical presentation. At the time of hyperglycemic symptoms a small amount of β cell mass still remains. The main therapeutic option to type 1 diabetes mellitus is daily insulin inje...

journal_title：Current stem cell research & therapy

authors： Couri CE,Voltarelli JC

更新日期：2011-03-01 00:00:00

abstract：:Differentiation of stem cells, a crucial step in the process of tissue development, repair and regeneration, can be regulated by a variety of mechanical factors such as the stiffness of extracellular matrix. In this review article, the effects of stiffness on the differentiation of stem cells, including bone marrow-de...

journal_title：Current stem cell research & therapy

authors： Zhang W,Chu G,Wang H,Chen S,Li B,Han F

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Cellular differentiation occurs in a complicated microenvironment containing multiple components including soluble factors and physical cues. In addition to biochemical composition, physical cues are also crucial in determining cellular behaviors. OBJECTIVE:To better understand the interaction between physi...

journal_title：Current stem cell research & therapy

authors： Zhang Q,Lin S,Liao J,Cai X

更新日期：2018-01-01 00:00:00

abstract：:Defects in articular cartilage injury and chronic osteoarthritis are very widespread and common, and the ability of injured cartilage to repair itself is limited. Stem cell-based cartilage tissue engineering provides a promising therapeutic option for articular cartilage damage. However, the application of the techniq...

journal_title：Current stem cell research & therapy

authors： Chen Y,Ouyang X,Wu Y,Guo S,Xie Y,Wang G

更新日期：2020-01-01 00:00:00

abstract：:Despite the numerous recent advances made in conventional anticancer therapies, metastasis and recurrence still remain the major problems in cancer management. The current treatment modalities kill the bulk of the tumor, leaving cancer stem cells behind and therefore, the agents specifically targeting this cancer init...

journal_title：Current stem cell research & therapy

authors： Sak K,Everaus H

更新日期：2015-01-01 00:00:00

abstract：:About 30 years ago circulating endothelial cells (CEC) were first observed in peripheral blood. Since then CEC have been established as a reliable indicator of vascular injury and damage and more sophisticated detection techniques, such as immunomagnetic isolation and fluorescence-activated cell sorting (FACS), have b...

journal_title：Current stem cell research & therapy

authors： Erdbruegger U,Dhaygude A,Haubitz M,Woywodt A

更新日期：2010-12-01 00:00:00

abstract：:The discovery of neural stem cells (NSC) which ensure continuous neurogenesis in the adult mammalian brain, has led to a conceptual revolution in basic neuroscience and to high hopes for clinical nervous tissue repair. However, several research issues remain to address before neural stem cells can be harnessed for reg...

journal_title：Current stem cell research & therapy

authors： Moyse E,Segura S,Liard O,Mahaut S,Mechawar N

更新日期：2008-09-01 00:00:00

abstract：:Stem cells have been long looked at as possible therapeutic vehicles for different health related problems. Among the different existing stem cell populations, Adipose- derived Stem Cells (ASCs) have been gathering attention in the last 10 years. When compared to other stem cells populations and sources, ASCs can be e...

journal_title：Current stem cell research & therapy

authors： Salgado AJ,Reis RL,Sousa NJ,Gimble JM

更新日期：2010-06-01 00:00:00

abstract：INTRODUCTION:Retinitis pigmentosa (RP), an inherited disease characterized by progressive loss of photoreceptors and retinal pigment epithelium, is a leading genetic cause of blindness. Cell transplantation to replace lost photoreceptors is a potential therapeutic strategy, but technical limitations have prevented clin...

journal_title：Current stem cell research & therapy

authors： Peng Y,Zhang Y,Huang B,Luo Y,Zhang M,Li K,Li W,Wen W,Tang S

更新日期：2014-03-01 00:00:00

abstract：:Angiogenesis is a complex process in which capillaries are produced from blood vessels that already exists. Endothelial cells (ECs) and endothelial progenitor cells (EPCs) are pivotal for this process and for the maintenance/restorage of the endothelium. Decreased numbers and dysfunction of these cells have been relat...

journal_title：Current stem cell research & therapy

authors： Sun K,Huang R,Wu S,Chen Z,Deng S,Zhou J,Xie J

更新日期：2016-01-01 00:00:00

abstract：:Recent interest in developing new regenerative medicine- and tissue engineering-based treatments has motivated researchers to develop strategies for manipulating stem cells to optimize outcomes in these potentially, game-changing treatments. Cells communicate with each other, and with their surrounding tissues and org...

journal_title：Current stem cell research & therapy

authors： Heng W,Bhavsar M,Han Z,Barker JH

更新日期：2020-01-01 00:00:00

abstract：:Sarcomas are the mesenchymal-derived malignant tumors of connective tissues (e.g., fat, bone, and cartilage) presumed to arise from aberrant development or differentiation of mesenchymal stem cells (MSCs). Appropriate control of stem cell maintenance versus differentiation allows for normal connective tissue developme...

journal_title：Current stem cell research & therapy

authors： Siddiqi S,Mills J,Matushansky I

更新日期：2010-03-01 00:00:00

abstract：:Postnatal skeletogenesis is a highly regulated process that subpopulations of bone marrow stem cells differentiate into mature skeletal tissues to maintain and repair the postnatal skeletons. Based on their skeletogenic capacity, purified bone marrow stem cells have been used to repair and replace damaged skeletal tis...

journal_title：Current stem cell research & therapy

authors： Deng P,Xu X,Chen Q

更新日期：2015-01-01 00:00:00

abstract：:Intervertebral disc (IVD) degeneration is one of the leading causes of low back pain, which affects a large proportion of the global population at a huge socioeconomic burden. Current treatments focus primarily on symptomatic pain relief or surgery, but offer relatively poor long-term efficacy as they fail to address ...

journal_title：Current stem cell research & therapy

authors： Clarke LE,Richardson SM,Hoyland JA

更新日期：2015-01-01 00:00:00

abstract：:Most conventional treatments for neurodegenerative diseases fail due to their focus on neuroprotection rather than neurorestoration. Stem cell-based therapies are becoming a potential treatment option for neurodegenerative diseases as they can home in, engraft, differentiate and produce factors for CNS recovery. Stem ...

journal_title：Current stem cell research & therapy

authors： Anoop M,Datta I

更新日期：2020-12-21 00:00:00

abstract：:The intestine serves mainly as a place for digestion and absorption and functions as an immune and endocrine organ. Intestinal stem cells (ISCs) play critical roles in the maintenance of intestinal homeostasis and regeneration, and a complex of signaling pathways is involved in these processes. The Notch signaling pat...

journal_title：Current stem cell research & therapy

authors： Liang SJ,Li XG,Wang XQ

更新日期：2019-01-01 00:00:00

abstract：:Since the improvement of chemotherapy and innovation of rituximab, about 60% of patients with diffuse large B cell lymphoma (DLBCL) could receive long-term survival after firstline therapy. Around 30% fail to respond or experience relapse considered as the relapsed/refractory DLBCL, the highdose chemotherapy followed ...

journal_title：Current stem cell research & therapy

authors： Xiao Z,Li J,Miao K

更新日期：2017-01-01 00:00:00

abstract：:Connections between inflammation and cancer are a rapidly developing field. Some gastrointestinal tract cancers arise from infection, chronic irritation, and ensuing inflammation. Cellular effectors and mediators are important constituents of the tumor microenvironment, including neoplastic, stromal, and migratory hem...

journal_title：Current stem cell research & therapy

authors： Zhang L,Song X,Mohri Y,Qiao L

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Stem cell culture for regenerative medicine needs platelet rich plasma (PRP) as fetal bovine/calf serum (FBS/FCS) substitute. However, the various studies used various protocols in preparing and processing the PRP. This study aimed to compare and conclude the most effective and efficient protocol. METHODS:w...

journal_title：Current stem cell research & therapy

authors： Pawitan JA

更新日期：2012-09-01 00:00:00

abstract：:Acute renal failure (ARF) is a syndrome of abrupt decline in renal function induced by a number of different insults. In clinic, the common etiology for ARF is ischemia-reperfusion injury (IRI). The pathophysiological process of renal IRI is complex, there is no good treatment. Stem cell therapy is a new and promising...

journal_title：Current stem cell research & therapy

authors： Hu H,Zou C

更新日期：2017-01-01 00:00:00

abstract：:Stroke is the second most common cause of death and the leading cause of disability in the world. About 30% of the people that are affected by stroke die within a year; 25% of the patients that survive stroke remain in need of care after a year. Therefore, stroke is a major burden for health care costs. The most commo...

journal_title：Current stem cell research & therapy

authors： Zents K,Copray S

更新日期：2016-01-01 00:00:00