Abstract:
BACKGROUND:The exposure of lung to noxious agents or gasses leads to injury, which further enhances repair mechanisms by promoting the proliferation and differentiation of lung stem cells. These cells could help preserve the anatomical structure and the function of the organ. Unfortunately in many lung diseases, 'this scenario' is changed and injury progresses despite repair mechanisms or conventional treatment. OBJECTIVE:This review summarizes the research on lung stem cells by giving an overview of the biology, function, niches and signaling that play role in lung stem cells and further of the regeneration of the lung. It also highlights the most common lung pathologies thought to be a result of a defective remodeling and overviews the clinical trials having results or publications, which are performed on the field. CONCLUSION:Though not yet approved for clinical usage, the application of stem cell therapies shown to be safe and with minimal adverse effects could be an alternative treatment to many lung diseases giving a hope for the future of severely ill patients refractory to the current therapies.
journal_name
Curr Stem Cell Res Therjournal_title
Current stem cell research & therapyauthors
Esendagli D,Gunel-Ozcan Adoi
10.2174/1574888X12666170523155846subject
Has Abstractpub_date
2017-01-01 00:00:00pages
493-505issue
6eissn
1574-888Xissn
2212-3946pii
CSCR-EPUB-83641journal_volume
12pub_type
杂志文章,评审abstract::Intervertebral disc (IVD) disorders, especially degenerative disc disease, reduce the quality of life, and are short of effective therapy. A new direction for treatment of chronic tissue and organ diseases is to promote regeneration by harnessing endogenous repair mechanisms. In this review, we discuss the potential o...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666150305105114
更新日期:2015-01-01 00:00:00
abstract::Stem cells are undifferentiated cells with the ability to proliferate and convert to different types of differentiated cells that make up the various tissues and organs in the body. They exist both in embryos as pluripotent stem cells that can differentiate into the three germ layers and as multipotent or unipotent st...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888X15999200831160710
更新日期:2020-08-31 00:00:00
abstract::The intestine serves mainly as a place for digestion and absorption and functions as an immune and endocrine organ. Intestinal stem cells (ISCs) play critical roles in the maintenance of intestinal homeostasis and regeneration, and a complex of signaling pathways is involved in these processes. The Notch signaling pat...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X14666190429143734
更新日期:2019-01-01 00:00:00
abstract::Human hepatocyte transplantation is being trialled in lieu of orthotopic liver transplants for patients with acute and chronic liver diseases. Stem cells that can be differentiated into hepatocyte-like cells may replace human hepatocytes that are difficult to source, culture and in critically short supply. Hepatocyte-...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x11308010004
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Stem cell culture for regenerative medicine needs platelet rich plasma (PRP) as fetal bovine/calf serum (FBS/FCS) substitute. However, the various studies used various protocols in preparing and processing the PRP. This study aimed to compare and conclude the most effective and efficient protocol. METHODS:w...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/157488812802481508
更新日期:2012-09-01 00:00:00
abstract::Haematopoietic stem cell transplantation (HSCT) is a curative treatment of many hematological disorders. However, although significant advances have been made in donor-recipient matching or conditioning regimens, HSCT is associated with a risk of post transplant complications. Those include generation of toxic lesions...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488806776956850
更新日期:2006-05-01 00:00:00
abstract::Due to the nature of articular cartilage of being poorly vascularized the capabilities of self repair are limited. Mesenchymal stem cells transplantation is a modern technique which has been developed after the high success rates obtained by microfracturing and drilling techniques which promote the release of growth f...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x11308030006
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Acute renal failure (ARF) resulting from ischemic or toxic insults remains a major health care problem because of its grave prognosis and the limited effectiveness of available treatment modalities. Current treatment options for ARF are limited to supportive measures and preventive strategies, none of which ...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/157488811797904344
更新日期:2011-12-01 00:00:00
abstract::Most conventional treatments for neurodegenerative diseases fail due to their focus on neuroprotection rather than neurorestoration. Stem cell-based therapies are becoming a potential treatment option for neurodegenerative diseases as they can home in, engraft, differentiate and produce factors for CNS recovery. Stem ...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888X16666201221151512
更新日期:2020-12-21 00:00:00
abstract:BACKGROUND:Articular cartilage defects often result in pain, loss of function and finally osteoarthritis. Developing cell-based therapies for cartilage repair is a major goal of orthopaedic research. Autologous chondrocyte implantation is currently the gold standard cell-based surgical procedure for the treatment of la...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X12666171002111026
更新日期:2018-02-23 00:00:00
abstract::Since the improvement of chemotherapy and innovation of rituximab, about 60% of patients with diffuse large B cell lymphoma (DLBCL) could receive long-term survival after firstline therapy. Around 30% fail to respond or experience relapse considered as the relapsed/refractory DLBCL, the highdose chemotherapy followed ...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x11666160630172414
更新日期:2017-01-01 00:00:00
abstract:AIMS:A systematic review and meta-analysis were performed to explore the clinical outcome of the transplantation of stem cells from various human tissue sources in cirrhotic patients. METHODS:The relevant papers were searched via PubMed, EMBASE, and Cochrane Library databases. Changes in liver function before and afte...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,meta分析,评审
doi:10.2174/1574888x09666141112114011
更新日期:2015-01-01 00:00:00
abstract::Stem and progenitor cell research is a complex and exciting field which promises curative discoveries in numerous areas including cancer, diabetes, and regenerative medicine. Use of biotic factors or growth factors has played an essential role in the development of stem cell research. These biologically active compone...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x09666140507124727
更新日期:2014-01-01 00:00:00
abstract::Despite the numerous recent advances made in conventional anticancer therapies, metastasis and recurrence still remain the major problems in cancer management. The current treatment modalities kill the bulk of the tumor, leaving cancer stem cells behind and therefore, the agents specifically targeting this cancer init...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666141126122316
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Revascularisation therapy is the current gold standard of care for critical limb ischemia (CLI), although a significant proportion of patients with CLI either are not fit for or do not respond well to this procedure. Recently, novel angiogenic therapies such as the use of autologous cellbased therapy (CBT) h...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,meta分析,评审
doi:10.2174/1574888X13666180313141416
更新日期:2018-01-01 00:00:00
abstract::Imbalance between free radicals and antioxidants causes oxidative stress by the accumulation of reactive oxygen species (ROS) in the tissues and organs. Oxidative stress occurs in many damage conditions, and the increase of ROS and reduction of antioxidants enhances inflammation, apoptosis, fibrosis and may worsen the...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888X16999201124153753
更新日期:2020-11-24 00:00:00
abstract::Human mesenchymal stem cells (hMSCs) are multipotent non-hematopoietic precursor cells with the ability to differentiate into several tissue types. The use of hMSCs has gained significant importance in cancer therapies as well as a large number of degenerative disease therapies due to their homing abilities. However, ...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x11666160201115733
更新日期:2016-01-01 00:00:00
abstract::Conditions affecting cartilage through damage or age-related degeneration pose significant challenges to individual patients and their healthcare systems. The disease burden will rise in the future as life expectancy increases. This has resulted in vigorous efforts to develop novel therapies to meet current and future...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488812800793090
更新日期:2012-07-01 00:00:00
abstract::Pluripotent stem cells (PSCs) derived from somatic cells represent a powerful experimental tool for investigating the molecular mechanisms underlying the disease phenotype; with prospects to advance medical therapies. They also have significant potential as a renewable source of autologous cells for cellular therapy. ...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666150220154820
更新日期:2015-01-01 00:00:00
abstract::Chronic myeloproliferative disorders (cMPDs) are clonal hemopoietic malignancies arising at the multipotent stem cell level. These conditions are characterized by increased blood count, marrow hyperplasia and extramedulary hemopoiesis. Vascular events might complicate their course, and transformation to either acute l...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488809788167445
更新日期:2009-05-01 00:00:00
abstract::Intervertebral disc (IVD) degeneration is one of the leading causes of low back pain, which affects a large proportion of the global population at a huge socioeconomic burden. Current treatments focus primarily on symptomatic pain relief or surgery, but offer relatively poor long-term efficacy as they fail to address ...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666141202112638
更新日期:2015-01-01 00:00:00
abstract::Notch signaling mediates the fates of numerous cells in both invertebrates and vertebrates. In the immune system, Notch signalling contributes to the generation of hematopoietic stem cells (HSCs), the promotion of HSC self-renewal, T lineage commitment, intrathymic T cell development, and peripheral lymphocyte differe...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488811795495459
更新日期:2011-06-01 00:00:00
abstract::Connections between inflammation and cancer are a rapidly developing field. Some gastrointestinal tract cancers arise from infection, chronic irritation, and ensuing inflammation. Cellular effectors and mediators are important constituents of the tumor microenvironment, including neoplastic, stromal, and migratory hem...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x09666140812112305
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Retinitis pigmentosa (RP), an inherited disease characterized by progressive loss of photoreceptors and retinal pigment epithelium, is a leading genetic cause of blindness. Cell transplantation to replace lost photoreceptors is a potential therapeutic strategy, but technical limitations have prevented clin...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888x09666131219115125
更新日期:2014-03-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) have the self-renewal ability and the ability to produce multiple differentiation. Elucidating the genetic circuits that govern MSC self-renewal and differentiation is necessary to improve our comprehension of MSCs and their role in regenerative medicine. microRNAs (miRNAs) play important...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666150528144517
更新日期:2016-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are stromal origin cells with multilineage differentiation capacity. The immunoregulatory properties of MSCs can be interfered effectively by cytokines. Cytokines, produced by a broad range of cells, act at the systemic level to influence biological phenomena such as inflammation, wound h...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X11666160614103404
更新日期:2017-01-01 00:00:00
abstract::Peroxisome proliferator-activated receptor γ (PPARγ) is a versatile member of the ligand-activated nuclear hormone receptor superfamily of transcription factors, with expression in several different cell lines, especially in the digestive system. After being activated by its ligand, PPARγ can suppress the growth of or...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666150630111618
更新日期:2016-01-01 00:00:00
abstract::Liver is a major metabolic organ of the body and is known to comprise of two epithelial cell lineages, namely, hepatocytes and cholangiocytes which are known to originate from hepatoblasts during fetal developing stages. Upon acute injury, the hepatocytes and cholangiocytes undergo cellular division to compensate the ...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888x113086660066
更新日期:2014-01-01 00:00:00
abstract::Acute renal failure (ARF) is a syndrome of abrupt decline in renal function induced by a number of different insults. In clinic, the common etiology for ARF is ischemia-reperfusion injury (IRI). The pathophysiological process of renal IRI is complex, there is no good treatment. Stem cell therapy is a new and promising...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X11666161024143640
更新日期:2017-01-01 00:00:00
abstract::Stroke is the second most common cause of death and the leading cause of disability in the world. About 30% of the people that are affected by stroke die within a year; 25% of the patients that survive stroke remain in need of care after a year. Therefore, stroke is a major burden for health care costs. The most commo...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666150728121324
更新日期:2016-01-01 00:00:00