Abstract:
:Exosomes and biomimetic nanoparticles have great potential to develop into a wide-scale therapeutic platform within the regenerative medicine industry. Exosomes, a subgroup of EVs with diameter ranging from 30-100 nm, have recently gained attention as an innovative approach for the treatment of various diseases, including heart disease. Their beneficial factors and regenerative properties can be contrasted with various cell types. Various biomimetic nanoparticles have also emerged as a unique platform in regenerative medicine. Biomimetic nanoparticles are a drug delivery platform, which have the ability to contain both biological and fabricated components to improve therapeutic efficiency and targeting. The novelty of these platforms holds promise for future clinical translation upon further investigation. In order for both exosome therapeutics and biomimetic nanoparticles to translate into large-scale clinical treatment, numerous factors must first be considered and improved. Standardization of different protocols, from exosome isolation to storage conditions, must be optimized to ensure batches are pure. Standardization is also important to ensure no variability in this process across studies, thus making it easier to interpret data across different disease models and treatments. Expansion of clinical trials incorporating both biomimetic nanoparticles and exosomes will require a standardization of fabrication and isolation techniques, as well as stricter regulations to ensure reproducibility across various studies and disease models. This review will summarize current research on exosome therapeutics and the application of biomimetic nanoparticles in cardiac regenerative medicine, as well as applications for exosome expansion and delivery on a large clinical scale.
journal_name
Curr Stem Cell Res Therjournal_title
Current stem cell research & therapyauthors
Stine SJ,Popowski KD,Su T,Cheng Kdoi
10.2174/1574888X15666200309143924subject
Has Abstractpub_date
2020-01-01 00:00:00pages
674-684issue
8eissn
1574-888Xissn
2212-3946pii
CSCR-EPUB-105092journal_volume
15pub_type
杂志文章abstract::Mesenchymal stem cells (MSCs) are ideal candidates for different cellular therapies due to their simple isolation, extensive expansion potential, and low immunogenicity. For various therapeutic approaches, such as bone and cartilage repair, MSCs are expected to replace the damaged tissues by direct differentiation. Ho...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666150211162933
更新日期:2015-01-01 00:00:00
abstract::Breast cancer stem cells (BCSCs) are a small population of tumor-initiating cells that express stem cell-associated markers. In recent years, their properties and mechanisms of regulation have become the focus of intense research due to their intrinsic resistance to conventional cancer therapies. This review describes...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X13666180810121415
更新日期:2019-01-01 00:00:00
abstract::Rotator cuff tear causes a high rate of morbidity. After surgical repair, the presence of a scar tissue reduces tendon biomechanical properties. Emerging strategies for enhancing tendon healing are growth factors, cytokines, gene therapy and tissue engineering. However their efficacy has to be proved. Growth factors h...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x113086660065
更新日期:2013-11-01 00:00:00
abstract::Throughout life, different types of stem cells participate in tissue generation, maintenance, plasticity, and repair. Their abilities to secrete growth factors, to proliferate and differentiate into several cell lineages, and to migrate and home into the damaged tissues have made them attractive candidates for cell th...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666150904113625
更新日期:2016-01-01 00:00:00
abstract::Since the improvement of chemotherapy and innovation of rituximab, about 60% of patients with diffuse large B cell lymphoma (DLBCL) could receive long-term survival after firstline therapy. Around 30% fail to respond or experience relapse considered as the relapsed/refractory DLBCL, the highdose chemotherapy followed ...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x11666160630172414
更新日期:2017-01-01 00:00:00
abstract::During the past several years, mesenchymal stem cells (MSCs) derived from adult tissue have rapidly moved from in vitro and animal studies into clinical trials as a therapeutic modality for a diverse group of clinical applications, including head and neck reconstruction. For many diseases, cell therapy could affect th...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488810791824449
更新日期:2010-09-01 00:00:00
abstract::Reduced-intensity stem cell transplantation (RIST) has opened a new era for hematopoietic stem cell transplantation (HSCT). It was developed based on the knowledge that graft-versus-tumor (GVT) effect is the main anti-tumor effect in allogeneic HSCT. Because RIST is associated with less morbidity and mortality, it can...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488807780599248
更新日期:2007-05-01 00:00:00
abstract::Applications of regenerative medicine technology may offer new therapies for patients with injuries, end-stage organ failure, or other clinical problems. Currently, patients suffering from diseased and injured organs can be treated with transplanted organs. However, there is a shortage of donor organs that is worsenin...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488808783489435
更新日期:2008-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are stromal origin cells with multilineage differentiation capacity. The immunoregulatory properties of MSCs can be interfered effectively by cytokines. Cytokines, produced by a broad range of cells, act at the systemic level to influence biological phenomena such as inflammation, wound h...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X11666160614103404
更新日期:2017-01-01 00:00:00
abstract::Tendon, the crucial element of the musculoskeletal system, when damaged, never restores the biological and biomechanical properties completely. Recently, tissue engineering and regenerative medicine have enabled the differentiation of postnatal somatic stem cells or mesenchymal stem cells (MSCs) to different cell line...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488810791268609
更新日期:2010-06-01 00:00:00
abstract::Umbilical cord blood (UCB) is an alternative source of hematopoietic progenitors for transplantation in the treatment of haematological malignancies, marrow failure, immunodeficiencies, hemoglobinopathies and inherited metabolic diseases. It has greatly contributed to increase the feasibility to transplantation for ma...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488810793351703
更新日期:2010-12-01 00:00:00
abstract::In contrast to their almost unlimited potential for expansion in vivo and despite years of dedicated research and optimization of expansion protocols, the expansion of Hematopoietic Stem Cells (HSCs) in vitro remains remarkably limited. Increased understanding of the mechanisms that are involved in maintenance, expans...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888X15666200225091339
更新日期:2020-02-24 00:00:00
abstract::Pluripotent stem cells (PSCs) derived from somatic cells represent a powerful experimental tool for investigating the molecular mechanisms underlying the disease phenotype; with prospects to advance medical therapies. They also have significant potential as a renewable source of autologous cells for cellular therapy. ...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666150220154820
更新日期:2015-01-01 00:00:00
abstract::Sarcomas are the mesenchymal-derived malignant tumors of connective tissues (e.g., fat, bone, and cartilage) presumed to arise from aberrant development or differentiation of mesenchymal stem cells (MSCs). Appropriate control of stem cell maintenance versus differentiation allows for normal connective tissue developme...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488810790442859
更新日期:2010-03-01 00:00:00
abstract::COVID-19 pandemic is a global health crisis in the 21st Century. There are currently no approved vaccine and no particular antiviral treatment for coronavirus disease. As COVID-19 has had a broad range of illnesses, it is necessary to find a safe and effective therapeutic method for COVID-19. An attractive approach fo...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888X15666201012165700
更新日期:2020-10-12 00:00:00
abstract:BACKGROUND:Revascularisation therapy is the current gold standard of care for critical limb ischemia (CLI), although a significant proportion of patients with CLI either are not fit for or do not respond well to this procedure. Recently, novel angiogenic therapies such as the use of autologous cellbased therapy (CBT) h...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,meta分析,评审
doi:10.2174/1574888X13666180313141416
更新日期:2018-01-01 00:00:00
abstract::Adipose-derived stem cells are adult stem cells which are easy to obtain and multi-potent. Stem-cell therapy has become a promising new treatment for many diseases, and plays an increasingly important role in the field of tissue repair, regeneration and reconstruction. The physicochemical properties of the extracellul...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888X15666200502000343
更新日期:2021-01-01 00:00:00
abstract::Tendon and ligament injuries are common, and repair slowly with reduced biomechanical properties. With increasing financial demands on the health service and patients to recover from tendon and ligament injuries faster, and with less morbidity, health professionals are exploring new treatment options. Tissue engineeri...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x09666140710102808
更新日期:2015-01-01 00:00:00
abstract::Spinal surgery presents a challenge for both neurosurgery and orthopaedic surgery. Due to the heterogeneous differentiation potential of mesenchymal stem cells, there is much interest in the treatment of spine surgery. Animal and human trials focussing on the efficacy of mesenchymal stem cells in spinal cord injury, s...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X11666170907120030
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Multiple studies have focused on stem cell-based treatments for rotator cuff disorders; however, the outcomes are not consistent. OBJECTIVES:This systematic review and meta-analysis were performed to evaluate the effects of stem cells on rotator cuff healing. METHODS:A detailed search of relevant studies w...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,meta分析
doi:10.2174/1574888X14666190617143952
更新日期:2019-01-01 00:00:00
abstract::Defects in articular cartilage injury and chronic osteoarthritis are very widespread and common, and the ability of injured cartilage to repair itself is limited. Stem cell-based cartilage tissue engineering provides a promising therapeutic option for articular cartilage damage. However, the application of the techniq...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X14666191029104249
更新日期:2020-01-01 00:00:00
abstract::About 30 years ago circulating endothelial cells (CEC) were first observed in peripheral blood. Since then CEC have been established as a reliable indicator of vascular injury and damage and more sophisticated detection techniques, such as immunomagnetic isolation and fluorescence-activated cell sorting (FACS), have b...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488810793351721
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:The exposure of lung to noxious agents or gasses leads to injury, which further enhances repair mechanisms by promoting the proliferation and differentiation of lung stem cells. These cells could help preserve the anatomical structure and the function of the organ. Unfortunately in many lung diseases, 'this ...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X12666170523155846
更新日期:2017-01-01 00:00:00
abstract::Sharing the same precursor cell lineage located in the bone marrow, mesenchymal stroma/stem cells (MSCs), osteoblasts and adipocytes have a reciprocal relationship in differentiation and function. The nuclear transcription factor peroxisome-proliferator- activated receptor-gamma (PPAR-γ) has been found expressed in bo...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666150531173309
更新日期:2016-01-01 00:00:00
abstract::Differentiation of stem cells, a crucial step in the process of tissue development, repair and regeneration, can be regulated by a variety of mechanical factors such as the stiffness of extracellular matrix. In this review article, the effects of stiffness on the differentiation of stem cells, including bone marrow-de...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888X15666200408114632
更新日期:2020-01-01 00:00:00
abstract::Human mesenchymal stem cells (hMSCs) are multipotent non-hematopoietic precursor cells with the ability to differentiate into several tissue types. The use of hMSCs has gained significant importance in cancer therapies as well as a large number of degenerative disease therapies due to their homing abilities. However, ...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x11666160201115733
更新日期:2016-01-01 00:00:00
abstract::The intestine serves mainly as a place for digestion and absorption and functions as an immune and endocrine organ. Intestinal stem cells (ISCs) play critical roles in the maintenance of intestinal homeostasis and regeneration, and a complex of signaling pathways is involved in these processes. The Notch signaling pat...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X14666190429143734
更新日期:2019-01-01 00:00:00
abstract::Angiogenesis is a complex process in which capillaries are produced from blood vessels that already exists. Endothelial cells (ECs) and endothelial progenitor cells (EPCs) are pivotal for this process and for the maintenance/restorage of the endothelium. Decreased numbers and dysfunction of these cells have been relat...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x1103160303181155
更新日期:2016-01-01 00:00:00
abstract::Acute renal failure (ARF) is a syndrome of abrupt decline in renal function induced by a number of different insults. In clinic, the common etiology for ARF is ischemia-reperfusion injury (IRI). The pathophysiological process of renal IRI is complex, there is no good treatment. Stem cell therapy is a new and promising...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X11666161024143640
更新日期:2017-01-01 00:00:00
abstract::Conditions affecting cartilage through damage or age-related degeneration pose significant challenges to individual patients and their healthcare systems. The disease burden will rise in the future as life expectancy increases. This has resulted in vigorous efforts to develop novel therapies to meet current and future...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488812800793090
更新日期:2012-07-01 00:00:00