Updates on GMSCs Treatment for Autoimmune Diseases.

Abstract:

BACKGROUND:Autoimmune disease is a refractory disease. Accumulating Evidence has revealed that the manipulation of mesenchymal stem cells may have the potential to control or even treat autoimmune diseases. Human gingiva-derived mesenchymal stem cells (GMSCs) are emerging as a new line of mesenchymal stem cells that have displayed some potential advantages in controlling and treating autoimmune diseases. OBJECTIVE:In this review, we briefly update the current understanding on the biology of GMSCs and their effects on preventing and treating autoimmune diseases. CONCLUSION:The availability of gingival mesenchymal stem cells (GMSCs), together with their potent capacity of multi-directional differentiation and inflammatory modulation, making GMSCs an ideal subtype of MSCs in treating autoimmune disease. Our and other studies have launched the earliest appraisal on GMSCs and carried out a lot of biological researches. The clinical trial of GMSCs on patients with autoimmune diseases will further approve their therapeutic effects, as well as its cellular and molecular mechanisms.

authors

Huang F,Liu ZM,Zheng SG

doi

10.2174/1574888X13666180220141114

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

345-349

issue

5

eissn

1574-888X

issn

2212-3946

pii

CSCR-EPUB-88678

journal_volume

13

pub_type

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