Towards standard protocols and guidelines for urine proteomics: a report on the Human Kidney and Urine Proteome Project (HKUPP) symposium and workshop, 6 October 2007, Seoul, Korea and 1 November 2007, San Francisco, CA, USA.

abstract：:The metacestode larval stage of Taenia solium is the causal agent of a zoonotic disease called cysticercosis. The disease has an important impact on pork trade (due to porcine cysticercosis) and public health (due to human neurocysticercosis). In order to improve the current diagnostic tools and to get a better unders...

journal_title：Proteomics

authors： Victor B,Kanobana K,Gabriël S,Polman K,Deckers N,Dorny P,Deelder AM,Palmblad M

更新日期：2012-06-01 00:00:00

abstract：:We have developed a proteome database (DB), BiomarkerDigger (http://biomarkerdigger.org) that automates data analysis, searching, and metadata-gathering function. The metadata-gathering function searches proteome DBs for protein-protein interaction, Gene Ontology, protein domain, Online Mendelian Inheritance in Man, a...

journal_title：Proteomics

authors： Jeong SK,Kwon MS,Lee EY,Lee HJ,Cho SY,Kim H,Yoo JS,Omenn GS,Aebersold R,Hanash S,Paik YK

更新日期：2009-07-01 00:00:00

abstract：:Protein expression changes induced in thioglycolate-elicited peritoneal murine macrophages (M Phi) by infection with type III Group B Streptococcus (GBS) are described. Proteins from control M Phi and M Phi incubated 2 h with live or heat-inactivated GBS were separated by 2-DE. Proteins whose expression was significan...

journal_title：Proteomics

authors： Susta F,Chiasserini D,Fettucciari K,Orvietani PL,Quotadamo F,Noce R,Bartoli A,Marconi P,Corazzi L,Binaglia L

更新日期：2010-06-01 00:00:00

abstract：:The basic problem of complexity poses a significant challenge for proteomic studies. To date two-dimensional gel electrophoresis (2-DE) followed by enzymatic in-gel digestion of the peptides, and subsequent identification by mass spectrometry (MS) is the most commonly used method to analyze complex protein mixtures. H...

journal_title：Proteomics

authors： Ihling C,Sinz A

更新日期：2005-05-01 00:00:00

abstract：:Sepsis is an extreme host response to infection that leads to loss of organ function and cardiovascular integrity. Mortality from sepsis is on the rise. Despite more than three decades of research and clinical trials, specific diagnostic and therapeutic strategies for sepsis are still absent. The use of LFQ- and TMT-b...

journal_title：Proteomics

authors： Pimienta G,Heithoff DM,Rosa-Campos A,Tran M,Esko JD,Mahan MJ,Marth JD,Smith JW

更新日期：2019-03-01 00:00:00

abstract：:This review is a meta-analysis of data describing proteins regulated by morphine influence studied worldwide across last years administration. Up to date (July 2010), 15 studies concerning this subject have been published. Animal models, examined brain structures, the route of morphine administration and proteomic pla...

journal_title：Proteomics

authors： Bodzon-Kułakowska A,Kułakowski K,Drabik A,Moszczynski A,Silberring J,Suder P

更新日期：2011-01-01 00:00:00

abstract：:Identification of differential proteomic responses to cadmium (Cd) would provide a means for better understanding the survival mechanisms of the earthworm, Eisenia fetida, living in a Cd-polluted environment, and the stress responses can be assessed by ecotoxiptoromics approaches. Extracts of whole earthworm collected...

journal_title：Proteomics

authors： Wang X,Chang L,Sun Z,Zhang Y,Yao L

更新日期：2010-12-01 00:00:00

abstract：:Sea star coelomic fluid is in contact with all internal organs, carrying signaling molecules and a large population of circulating cells, the coelomocytes. These cells, also known as echinoderm blood cells, are responsible for the innate immune responses and are also known to have an important role in the first stage ...

journal_title：Proteomics

authors： Franco CF,Santos R,Coelho AV

更新日期：2011-09-01 00:00:00

abstract：:Proteases are critical in many physiological processes and the human genome encodes for 566 predicted proteolytic enzymes. Therefore, there is great interest in identifying and characterizing physiologic protease-substrate relationships. The coagulation cascade is a well-described network of serine proteases. However,...

journal_title：Proteomics

authors： Niessen S,Hoover H,Gale AJ

更新日期：2011-06-01 00:00:00

abstract：:Staphylococcus aureus, a bacterial, food-borne pathogen of humans, can contaminate raw fruits and vegetables. While physical and chemical methods are available to control S. aureus, scientists are searching for inhibitory phytochemicals from plants. One promising compound from pomegranate is punicalagin, a natural ant...

journal_title：Proteomics

authors： Cooper B,Islam N,Xu Y,Beard HS,Garrett WM,Gu G,Nou X

更新日期：2018-05-01 00:00:00

abstract：:Plasma membrane proteins serve essential functions for cells, interacting with both cellular and extracellular components, structures and signaling molecules. Additionally, plasma membrane proteins comprise more than two-thirds of the known protein targets for existing drugs. Consequently, defining membrane proteomes ...

journal_title：Proteomics

authors： Josic D,Clifton JG

更新日期：2007-08-01 00:00:00

abstract：:Protein quantification at proteome-wide scale is an important aim, enabling insights into fundamental cellular biology and serving to constrain experiments and theoretical models. While proteome-wide quantification is not yet fully routine, many datasets approaching proteome-wide coverage are becoming available throug...

journal_title：Proteomics

authors： Wang M,Herrmann CJ,Simonovic M,Szklarczyk D,von Mering C

更新日期：2015-09-01 00:00:00

abstract：:To gain a better understanding of salt stress responses in plants, we used a proteomic approach to investigate changes in rice (Oryza sativa) root plasma-membrane-associated proteins following treatment with 150 mmol/L NaCl. With or without a 48 h salt treatment, plasma membrane fractions from root tip cells of a salt...

journal_title：Proteomics

authors： Cheng Y,Qi Y,Zhu Q,Chen X,Wang N,Zhao X,Chen H,Cui X,Xu L,Zhang W

更新日期：2009-06-01 00:00:00

abstract：:Panax ginseng is an important herb that has clear effects on the treatment of diverse diseases. Until now, the natural peptide constitution of this herb remains unclear. Here, we conduct an extensive characterization of Ginseng peptidome using MS-based data mining and sequencing. The screen on the charge states of pre...

journal_title：Proteomics

authors： Ye X,Zhao N,Yu X,Han X,Gao H,Zhang X

更新日期：2016-11-01 00:00:00

abstract：:Trophoblastic cell lines are widely used in in vitro studies of placental function as a surrogate for primary trophoblasts. To date, no reference proteomics dataset exists to directly compare the shared and unique characteristics of these cells. Here, we performed comparative proteomic profiling of the BeWo and HTR8/S...

journal_title：Proteomics

authors： Szklanna PB,Wynne K,Nolan M,Egan K,Áinle FN,Maguire PB

更新日期：2017-05-01 00:00:00

abstract：:Shewanella inhabit a wide variety of niches in nature and can utilize a broad spectrum of electron acceptors under anaerobic conditions. How they modulate their gene expression to adapt is poorly understood. ArcA, homologue of a global regulator controlling hundreds of genes involved in aerobic and anaerobic respirati...

journal_title：Proteomics

authors： Yuan J,Wei B,Lipton MS,Gao H

更新日期：2012-06-01 00:00:00

abstract：:The present review deals with the use of combinatorial ligand libraries, composed by hexapeptides, in the capture and concentration of the low-abundance proteome. This method, first reported in 2005, is compared with other current methodologies aimed at exploring the "deep proteome", such as: depletion of high-abundan...

journal_title：Proteomics

authors： Boschetti E,Righetti PG

更新日期：2009-03-01 00:00:00

abstract：:With the human Plasma Proteome Project (PPP) pilot phase completed, the largest and most ambitious proteomics experiment to date has reached its first milestone. The correspondingly impressive amount of data that came from this pilot project emphasized the need for a centralized dissemination mechanism and led to the ...

journal_title：Proteomics

authors： Martens L,Nesvizhskii AI,Hermjakob H,Adamski M,Omenn GS,Vandekerckhove J,Gevaert K

更新日期：2005-08-01 00:00:00

abstract：:Warm ischemia reperfusion (IR) injury of the liver is associated with changes in the expression and/or post-translational modification of numerous proteins. Only a few of these have been identified. We used 2-D DIGE to identify cytosolic proteins altered in the early stage of IR in an established rat model of segmenta...

journal_title：Proteomics

authors： Wilson CH,Zeile S,Chataway T,Nieuwenhuijs VB,Padbury RT,Barritt GJ

更新日期：2011-11-01 00:00:00

abstract：:We introduce a new methodology named ligand profiling and identification for effective discovery of bioactive ligands such as peptide hormones. This technology was developed from a new concept of parallel column chromatography and active fraction profiling by nano-LC MS. Traditional methods use sequential column chrom...

journal_title：Proteomics

authors： Baek MC,Kim SJ,Yea K,Kim Y,Lee BD,Kim J,Lee HJ,Kang MH,Choi SK,Kim JI,Lee TG,Suh PG,Ryu SH

更新日期：2006-03-01 00:00:00

abstract：:The skin provides protection against environmental stress. However, intrinsic and extrinsic aging causes significant alteration to skin structure and components, which subsequently impairs molecular characteristics and biochemical processes. Here, we have conducted an immunohistological investigation and established t...

journal_title：Proteomics

authors： Fang JY,Wang PW,Huang CH,Chen MH,Wu YR,Pan TL

更新日期：2016-10-01 00:00:00

abstract：:The allergen content of standardized pollen material is crucial for an effective diagnosis and treatment. However, variations in IgE reactivities of allergic patients to different preparations of Phleum pratense pollen have been reported. In order to define and directly compare the allergen composition of pollen prepa...

journal_title：Proteomics

authors： Schmidt H,Gelhaus C,Nebendahl M,Janssen O,Petersen A

更新日期：2010-12-01 00:00:00

abstract：:To develop a standard method for separating highly basic proteins in mammalian cells, we established a 2-D LC separation system coupled with chromatofocusing/nonporous RP column chromatography (CF/NPRPC) in a ProteomeLab PF2D system. After standardizing conditions for 2-D LC, a 2-D liquid protein map of uninfected mac...

journal_title：Proteomics

authors： Shin YK,Lee HJ,Lee JS,Paik YK

更新日期：2006-02-01 00:00:00

abstract：:By means of a degradomic approach applying proteomic techniques, we previously suggested that apolipoprotein E (apoE) is a substrate of matrix metalloproteinase-14 (MMP-14). Here we confirm that apoE is, in fact, a substrate of MMP-14 and also of MMP-7 and MMP-2 to a lesser extent. The 34 kDa apoE protein was initiall...

journal_title：Proteomics

authors： Park JH,Park SM,Park SH,Cho KH,Lee ST

更新日期：2008-07-01 00:00:00

abstract：:Colorectal cancer risk is increased when dietary folate intake is low, with or without a deficiency in methylenetetrahydrofolate reductase (MTHFR). We have observed that intestinal tumors are induced in mice fed low-folate diets, and that tumor incidence is increased when these mice also have MTHFR deficiency. This st...

journal_title：Proteomics

authors： Leclerc D,Dejgaard K,Mazur A,Deng L,Wu Q,Nilsson T,Rozen R

更新日期：2014-11-01 00:00:00

abstract：:Cardiac conduction defects were found in transgenic mice deficient in urea transporter UT-B. To investigate the molecular mechanisms of the conduction defects caused by UT-B deletion, we studied the protein expression profiles of heart tissue (comprising most conduction system) in wild-type versus UT-B null mice at di...

journal_title：Proteomics

authors： Yu H,Meng Y,Wang LS,Jin X,Gao LF,Zhou L,Ji K,Li Y,Zhao LJ,Chen GQ,Zhao XJ,Yang B

更新日期：2009-02-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent cells, which have the capability to differentiate into various mesenchymal tissues such as bone, cartilage, fat, tendon, muscle, and marrow stroma. However, they lose the capability of multi-lineage differentiation after several passages. It is known that basic fibroblast ...

journal_title：Proteomics

authors： Lee SK,Kim Y,Kim SS,Lee JH,Cho K,Lee SS,Lee ZW,Kwon KH,Kim YH,Suh-Kim H,Yoo JS,Park YM

更新日期：2009-09-01 00:00:00

abstract：:Two-dimensional remains one of the main experimental approaches in proteome analysis. However, comigration of protein leads to several limitations: lack of accuracy in protein identification, impaired comparative quantification, and PTM detection. We have optimized a third additional step of in-gel separation to allev...

journal_title：Proteomics

authors： Colignon B,Raes M,Dieu M,Delaive E,Mauro S

更新日期：2013-07-01 00:00:00

abstract：:MALDI-MS Imaging is a novel label-free technique that can be used to visualize the changes in multiple mass responses following treatment. Following treatment with proinflammatory cytokine interleukin-22 (IL-22), the epidermal differentiation of Labskin, a living skin equivalent (LSE), successfully modeled psoriasis i...

journal_title：Proteomics

authors： Harvey A,Cole LM,Day R,Bartlett M,Warwick J,Bojar R,Smith D,Cross N,Clench MR

更新日期：2016-06-01 00:00:00

abstract：:PROTICdb is a web-based application, mainly designed to store and analyze plant proteome data obtained by two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) and mass spectrometry (MS). The purposes of PROTICdb are (i) to store, track, and query information related to proteomic experiments, i.e., from tissue...

journal_title：Proteomics

authors： Ferry-Dumazet H,Houel G,Montalent P,Moreau L,Langella O,Negroni L,Vincent D,Lalanne C,de Daruvar A,Plomion C,Zivy M,Joets J

更新日期：2005-05-01 00:00:00