Abstract:
:Colorectal cancer risk is increased when dietary folate intake is low, with or without a deficiency in methylenetetrahydrofolate reductase (MTHFR). We have observed that intestinal tumors are induced in mice fed low-folate diets, and that tumor incidence is increased when these mice also have MTHFR deficiency. This study was undertaken to identify differentially expressed proteins in conditions favoring initial steps of murine carcinogenesis in normal preneoplastic intestine. We compared the proteome of BALB/c normal intestine in Mthfr(+/+) mice fed control diets for 1 year (low susceptibility to tumorigenesis) with the proteome of Mthfr(+/-) animals fed low folate diets (higher tumor susceptibility). Our data suggest that the NuRD complex, KRAS-related proteins, the protein synthetic machinery, and fatty acid-related metabolic proteins are upregulated in the early stages of tumorigenesis. These proteins may serve as biomarkers or targets for colorectal cancer diagnosis or therapy.
journal_name
Proteomicsjournal_title
Proteomicsauthors
Leclerc D,Dejgaard K,Mazur A,Deng L,Wu Q,Nilsson T,Rozen Rdoi
10.1002/pmic.201400280subject
Has Abstractpub_date
2014-11-01 00:00:00pages
2558-65issue
21-22eissn
1615-9853issn
1615-9861journal_volume
14pub_type
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