Abstract:
:An excess of thyroid hormone is known to produce cardiac dysfunction and failure, i.e., thyrotoxic heart. We studied the protective effect of coenzyme Q10 (CoQ10) on the thyrotoxic heart in 29 rabbits. A group treated with 1-thyroxine sodium salt (T4; 167 micrograms/kg) for 3 weeks showed marked decreases in the myocardial content of norepinephrine (NE) and ATP (0.5 +/- 0.2 microgram/g wet weight, P less than 0.05 and 31.1 +/- 2.6 nmol/mg protein, P less than 0.05, respectively) as compared with a group treated with CoQ10 solvent (2 ml/kg) for 3 weeks (1.1 +/- 0.1 microgram/g wet weight and 45.7 +/- 4.7 nmol/mg protein). The mitochondrial Ca2+ content of the T4 group showed significant increases (21.3 +/- 0.6 nmol/mg protein, P less than 0.05) compared with the solvent group (18.2 +/- 0.8 nmol/mg protein), while the total tissue Ca2+ content of the T4 group was unchanged compared with the solvent group. These biochemical derangements suggest that T4-treated rabbits were in a state of cardiac dysfunction. In contrast, a group which was assigned to concomitant treatment of T4 and CoQ10 (5 mg/kg) for 3 weeks showed no reductions in NE and ATP (0.9 +/- 0.2 micrograms/g wet weight and 44.6 +/- 1.9 nmol/mg protein, respectively) and protected an increase in the mitochondrial Ca2+ content (18.2 +/- 1.2 nmol/mg protein). A group treated with CoQ10 (5 mg/kg) for 3 weeks showed no changes in myocardial NE, ATP, and Ca2+ content in the mitochondria. These results suggest that exogenously administered CoQ10 may protect against biochemical derangements in the thyrotoxic heart.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Kotake C,Ito Y,Yokoyama M,Fukuzaki Hdoi
10.1007/BF02058524subject
Has Abstractpub_date
1987-01-01 00:00:00pages
84-90issue
2eissn
0910-8327issn
1615-2573journal_volume
3pub_type
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journal_title:Heart and vessels
pub_type: 杂志文章
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journal_title:Heart and vessels
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doi:10.1007/s00380-017-1110-4
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0912-0
更新日期:2017-05-01 00:00:00
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journal_title:Heart and vessels
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abstract::The association between periprocedural hypotension and conscious sedation (CS) during defibrillator implantation remains to be elucidated. The aim of the present study was to compare the occurrence of periprocedural hypotension after CS or local anesthesia (LA) during defibrillator implantation in a retrospective coho...
journal_title:Heart and vessels
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更新日期:2020-01-01 00:00:00
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journal_title:Heart and vessels
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更新日期:2014-07-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01747827
更新日期:1998-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-01334-5
更新日期:2019-07-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01759-x
更新日期:2021-01-23 00:00:00
abstract::Elastase (ELA) is an enzyme catalyzing the digestion of elastin, an essential constituent of elastic fibers. Using isolated guinea pig papillary muscles, we examined the effect of ELA (3 x 10(-7) -3 x 10(-4) g/ml) on resting tension (RT) and twitch tension (TT). The effects of ELA on elastic fibers located in the sube...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01744386
更新日期:1993-01-01 00:00:00
abstract::The coronary flow velocity reserve (CFR) is decreased in patients with aortic valve stenosis (AS). The aim of the present prospective study was to examine the CFR in AS patients with normal epicardial coronary arteries during a 3-year follow-up of aortic valve replacement (AVR). A total of 30 AS patients (17 women and...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-005-0883-z
更新日期:2006-05-01 00:00:00
abstract::Aortic valve stenosis (AS) is a frequent complication contributing to poor prognosis in chronic hemodialysis (CHD) patients. High blood pressure (BP) is known to be associated with AS progression in the general population. In CHD patients, however, BP varies during and between hemodialysis sessions with ultrafiltratio...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0756-z
更新日期:2016-09-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0655-3
更新日期:2016-05-01 00:00:00
abstract::Females have increase in-hospital mortality and poorer outcomes following coronary artery bypass grafting (CABG). Biological differences in the reactivity of the graft conduits to circulating catecholamine may contribute to this sex difference. This study examined sex differences in the vasoconstrictor responses of in...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01508-9
更新日期:2020-03-01 00:00:00
abstract::The efficacy of second-generation drug-eluting stent (DES) for the treatment of left main disease (LM) and/or three vessel disease (3VD) remains unclear. We compared 2-year outcomes of second- versus first -generation DES implantation among patients with LM and/or 3VD and to assess the differential of risk by complexi...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0824-z
更新日期:2016-12-01 00:00:00
abstract::Six patients with coronary arterial lesions due to Kawasaki disease underwent aortocoronary by-pass grafting at our institute. Before surgery, all of them had been closely monitored for some years by means of selective coronary arteriography, thallium myocardial imaging, electrocardiography (treadmill and/or Holter), ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02066356
更新日期:1985-05-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-013-0395-1
更新日期:2014-07-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02559993
更新日期:1996-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02482303
更新日期:1999-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02125099
更新日期:1991-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章,多中心研究
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更新日期:2020-08-01 00:00:00
abstract::The aim of this study was to evaluate the relation between aortic artery distensibility, expressed by pulse pressure (PP) and autonomic nervous system function expressed by heart rate variability (HRV), among elders. During 2009, 469 individuals (50 % males, mean age 75 ± 6 years old), permanent inhabitants of Ikaria ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-012-0267-0
更新日期:2013-07-01 00:00:00
abstract::A 53-year-old woman with end-stage renal disease and hypertension, who had received regular artificial hemodialysis for 10 years, has been treated with candesartan in a dose of 8 mg/day against her hypertension, but premature ventricular contractions were often observed during the hemodialysis. QT interval was 445 ms ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0865-3
更新日期:2017-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:2020-02-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-015-0627-7
更新日期:2016-03-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章,多中心研究
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-010-0029-9
更新日期:2011-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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