当前位置： SCI文献检索 > HEART AND VESSELS期刊下所有文献 > Sex differences in vascular reactivity of coronary artery bypass graft conduits.

Sex differences in vascular reactivity of coronary artery bypass graft conduits.

Abstract：

:Females have increase in-hospital mortality and poorer outcomes following coronary artery bypass grafting (CABG). Biological differences in the reactivity of the graft conduits to circulating catecholamine may contribute to this sex difference. This study examined sex differences in the vasoconstrictor responses of internal mammary artery (IMA) and saphenous vein (SV) conduits to phenylephrine (PE) and endothelin-1 (ET-1). Functional IMA and SV were obtained from 78 male and 50 female patients undergoing CABG (67.7 ± 11 and 69 ± 10 years, respectively) and subjected to the following experimental conditions. (1) Concentration response curves for PE and ET-1 were generated in an intact IMA and SV and endothelium denuded IMA segments, (2) in the presence of the nitric oxide synthase inhibitor (L-NAME) or the cyclooxygenase inhibitor (indomethacin) in an endothelium-intact IMA and (3) the activity state (abundance and phosphorylation) of the α1-adrenergic receptor was investigated using Phos-tag™ western blot analysis. (1) Compared to male, female IMA and SV were hypersensitive to PE but not ET-1 (p < 0.05). The female IMA hypersensitivity response to PE was abolished following endothelial denudation, (2) persisted in the presence of L-NAME but was abolished in the presence of indomethacin and (3) there was no sex differences in the abundance and phosphorylation of the α1-adrenergic receptor in IMA. Female IMA and SV graft conduits are hypersensitive to α1-adrenergic stimuli. This endothelial cyclooxygenase pathway-mediated hypersensitivity may produce excessive IMA and SV graft constriction in females administered catecholamines and could contribute to their poorer CABG outcomes.

journal_name

Heart Vessels

journal_title

Heart and vessels

authors

Jaghoori A,Lamin V,Jacobczak R,Worthington M,Edwards J,Viana F,Stuklis R,Wilson DP,Beltrame JF

doi

10.1007/s00380-019-01508-9

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

422-431

issue

3

eissn

0910-8327

issn

1615-2573

pii

10.1007/s00380-019-01508-9

journal_volume

35

pub_type

杂志文章

相关文献

HEART AND VESSELS文献大全
  • Plasma xanthine oxidoreductase (XOR) activity in patients who require cardiovascular intensive care.

    abstract：:Hyperuricemia is known to be associated with adverse outcomes in cardiovascular intensive care patients, but its mechanisms are unknown. A total of 569 emergency department patients were prospectively analyzed and assigned to intensive care (ICU group, n = 431) or other departments (n = 138). Uric acid (UA) levels wer...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/s00380-020-01608-x

    authors： Shibata Y,Shirakabe A,Okazaki H,Matsushita M,Goda H,Shigihara S,Asano K,Kiuchi K,Tani K,Murase T,Nakamura T,Kobayashi N,Hata N,Asai K,Shimizu W

    更新日期：2020-10-01 00:00:00

  • Soluble urokinase-type plasminogen activator receptor represents exercise tolerance and predicts adverse cardiac events in patients with heart failure.

    abstract：:Soluble urokinase-type plasminogen activator receptor (suPAR) is a membrane-binding protein that is released into the blood stream by immune activation. Recent reports suggest that circulating suPAR levels are associated with adverse cardiovascular outcomes. Exercise tolerance is an independent predictor of prognosis ...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/s00380-019-01538-3

    authors： Ishikawa H,Izumiya Y,Shibata A,Ichikawa Y,Yamaguchi T,Yamaguchi Y,Kitada R,Iwata S,Ehara S,Tomita S,Hanatani A,Yoshiyama M

    更新日期：2020-05-01 00:00:00

  • Clinical effectiveness of pulmonary vein isolation for arrhythmic events in a patient with catecholaminergic polymorphic ventricular tachycardia.

    abstract：:An 18-year-old woman with catecholaminergic polymorphic ventricular tachycardia (CPVT) underwent pulmonary vein isolation (PVI) because of frequent and inappropriate shocks from an implantable cardioverter defibrillator (ICD) associated with atrial fibrillation (AF) with a rapid ventricular response. While the PVI did...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/s00380-009-1214-6

    authors： Sumitomo N,Nakamura T,Fukuhara J,Nakai T,Watanabe I,Mugishima H,Hiraoka M

    更新日期：2010-09-01 00:00:00

  • Earliest pulmonary vein potential-guided cryoballoon ablation for atrial fibrillation.

    abstract：:No studies have evaluated both the time-to-isolation (TTI) and the sequence of pulmonary vein (PV) potentials in cryoballoon ablation (CBA) for atrial fibrillation (AF). This study aimed to prospectively evaluate the acute results of pulmonary vein isolation (PVI) using a novel CBA technique-the earliest potential (EP...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/s00380-019-01471-5

    authors： Mizutani Y,Kanashiro M,Makino Y,Satake A,Suzuki W,Kurobe M,Mizutani K,Ichimiya H,Uchida Y,Watanabe J,Ichimiya S,Inden Y,Murohara T

    更新日期：2020-02-01 00:00:00

  • Cardiac tamponade as an independent condition affecting the relationship between the plasma B-type natriuretic peptide levels and cardiac function.

    abstract：:Plasma B-type natriuretic peptide (BNP) is finely regulated by the cardiac function and several extracardiac factors. Therefore, the relationship between the plasma BNP levels and the severity of heart failure sometimes seems inconsistent. The purpose of the present study was to investigate the plasma BNP levels in pa...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/s00380-012-0278-x

    authors： Minai K,Komukai K,Arase S,Nagoshi T,Matsuo S,Ogawa K,Kayama Y,Inada K,Tanigawa S,Takemoto T,Sekiyama H,Date T,Ogawa T,Taniguchi I,Yoshimura M

    更新日期：2013-07-01 00:00:00

  • The clinical characteristics of sudden cardiac arrest in asymptomatic patients with congenital heart disease.

    abstract：:Sudden cardiac arrest (SCA) is a major cause of death in patients with congenital heart disease (CHD). Systemic ventricular dysfunction is a reported risk factor for SCA. We retrospectively analyzed the medical records of 46 patients (age >6 years) who experienced SCA. The following underlying cardiac defects were obs...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/s00380-013-0444-9

    authors： Miyazaki A,Sakaguchi H,Ohuchi H,Yasuda K,Tsujii N,Matsuoka M,Yamamoto T,Yazaki S,Tsuda E,Yamada O

    更新日期：2015-01-01 00:00:00

  • Endomyocardial biopsy findings in patients with atrioventricular block in the absence of apparent heart disease.

    abstract：:The purpose of this study was to examine the histopathological findings of right ventricular endomyocardial biopsies from ten patients less than 60 years of age (47 +/- 9.8 (mean +/- SD) years) with documented atrioventricular block but without apparent heart disease. They underwent electrophysiological testing, echoc...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/BF02482303

    authors： Teragaki M,Toda I,Sakamoto K,Shimada K,Yamagishi H,Yoshiyama M,Akioka K,Kawase Y,Nishimoto M,Takeuchi K,Yoshikawa J

    更新日期：1999-01-01 00:00:00

  • Cardiovascular medicine heart failure (CVM-HF) index as prognostic model for candidates to MitraClip therapy.

    abstract：:Transcatheter MitraClip repair is a new tool for the management of severe mitral regurgitation in patients at very high risk for conventional surgery. Aim of our study was reporting one-year clinical outcomes in candidates to MitraClip procedures, divided into three groups according to the cardiovascular medicine hear...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/s00380-015-0772-z

    authors： Ussia GP,Cammalleri V,Mazzotta E,Pascuzzo G,Muscoli S,Marchei M,Macrini M,Anceschi A,Romeo F

    更新日期：2016-10-01 00:00:00

  • Association between long-term prescription of febuxostat and the progression of heart failure with preserved ejection fraction in patients with hypertension and asymptomatic hyperuricemia.

    abstract：:Both hypertension and hyperuricemia are closely associated with the morbidity and mortality of heart failure. This study was designed to evaluate the influences of long-term xanthine oxidase inhibitor (febuxostat) prescription on left ventricular hypertrophy (LVH), left ventricular (LV) diastolic function, and new-ons...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/s00380-020-01619-8

    authors： Pan JA,Lin H,Wang CQ,Zhang JF,Gu J

    更新日期：2020-10-01 00:00:00

  • Forearm vasoconstriction during dynamic leg exercise in patients with chronic heart failure.

    abstract：:Previous studies assessing vascular responses in nonexercising beds during exercise in patients with chronic heart failure (CHF) have yielded varying results. We proposed that the clinical and hemodynamic severity of heart failure may explain some of the variation. We reasoned that diastolic ventricular interaction (D...

    journal_title：Heart and vessels

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF03257232

    authors： Atherton JJ,Dryburgh LG,Thomson HL,Moore TD,Wright KN,Muehle GW,Fitzpatrick LE,Frenneaux MP

    更新日期：1998-01-01 00:00:00

  • Urinary KIM-1, NGAL and L-FABP for the diagnosis of AKI in patients with acute coronary syndrome or heart failure undergoing coronary angiography.

    abstract：:Acute kidney injury (AKI) is a common complication after coronary angiography. Early biomarkers of this disease are needed since increase in serum creatinine levels is a late marker. To assess the usefulness of urinary kidney injury molecule-1 (uKIM-1), neutrophil gelatinase-associated lipocalin (uNGAL) and liver-type...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/s00380-014-0538-z

    authors： Torregrosa I,Montoliu C,Urios A,Andrés-Costa MJ,Giménez-Garzó C,Juan I,Puchades MJ,Blasco ML,Carratalá A,Sanjuán R,Miguel A

    更新日期：2015-11-01 00:00:00

  • Collateral vessels assessed by myocardial contrast echocardiography in patients with coronary artery lesions after Kawasaki disease.

    abstract：:Using myocardial contrast echocardiography (MCE), coronary arteriography, and thallium-201 myocardial imaging (TMI), we examined the characteristics and the role of collateral vessels in 35 patients with coronary artery lesions after Kawasaki disease. The male/female ratio was 25:10. The patients' ages are examination...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/BF02559993

    authors： Kinoshita Y,Suzuki A,Nakajima T,Ono Y,Arakaki Y,Kamiya T

    更新日期：1996-01-01 00:00:00

  • Correlation of anatomic and hemodynamic features with aortic valve leaflet deformity in doubly committed subarterial ventricular septal defect.

    abstract：:The records of 153 patients with doubly committed subarterial ventricular septal defect (DCVSD) who underwent intracardiac repair were analyzed to evaluate factors responsible for aortic valve leaflet deformity. The patients were divided into two groups according to their echocardiographic and angiographic features as...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/BF01747853

    authors： Kobayashi J,Koike K,Senzaki H,Kobayashi T,Tsunemoto M,Ishizawa A,Ohta Y,Shimada M,Omoto R

    更新日期：1999-01-01 00:00:00

  • Aberrant right coronary artery occlusion during the percutaneous pulmonary trunk stenting in a patient with tetralogy of Fallot.

    abstract：:Aberrant coronary arteries are frequently observed in patients presenting with Fallot's tetralogy (TOF). Before the complete surgical repair of the TOF, the percutaneously performed pulmonary trunk (PT) angioplasty is often performed in order to temporarily increase the pulmonary circulation, thus increasing the pulmo...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/s00380-007-1023-8

    authors： Perret X,Bonvini RF,Aggoun Y,Verin V

    更新日期：2008-03-01 00:00:00

  • Impaired carotid artery elastic function in patients with tetralogy of Fallot.

    abstract：:Complex congenital heart diseases with abnormal formation of the aorticopulmonary septum are also associated with defective large artery elastogenesis. In the current study, we tested the hypothesis that carotid artery elastic function was impaired in patients with tetralogy of Fallot (ToF). The study included 45 Fall...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/s00380-010-0095-z

    authors： László A,Pintér A,Horváth T,Kádár K,Temesvári A,Kollai M,Studinger P

    更新日期：2011-09-01 00:00:00

  • Changes in morphology of elastin fibers during development of the tunica intima of monkey aorta.

    abstract：:The normal development of elastin fibers in the thoracic aorta was studied in fetal, young, and adult monkeys. Tissue was examined by scanning electron microscopy (SEM) after NaOH treatment and by transmission electron microscopy (TEM). The NaOH treatment of fixed tissues effectively removed collagen fibers and enable...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/BF01745239

    authors： Sato F,Shimada T,Kitamura H,Campbell GR,Ogata J

    更新日期：1994-01-01 00:00:00

  • Longer coronary anastomosis provides lower energy loss in coronary artery bypass grafting.

    abstract：:Distal anastomosis technique affects graft patency and long-term outcomes in coronary artery bypass grafting, however, there is no standard for the appropriate length of distal anastomosis. The purpose of this study is to evaluate whether longer distal anastomosis provides higher quality of distal anastomosis and bett...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/s00380-016-0880-4

    authors： Tsukui H,Shinke M,Park YK,Yamazaki K

    更新日期：2017-01-01 00:00:00

  • Pharmacological intervention for renal protection during cardiopulmonary bypass.

    abstract：:The possibility of minimizing organ damage following cardiopulmonary bypass (CPB) was examined. In the control group, n = 21, upon completion of CPB, elevation of the lysosomal enzyme beta-glucuronidase, which is a sensitive indicator of cellular damage, was affected by the concentration of granulocyte elastase (r = 0...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/BF01744743

    authors： Hashimoto K,Nomura K,Nakano M,Sasaki T,Kurosawa H

    更新日期：1993-01-01 00:00:00

  • Reverse translational analysis of clinically reported, lamotrigine-induced cardiovascular adverse events using the halothane-anesthetized dogs.

    abstract：:Lamotrigine has been used for patients with epilepsy and/or bipolar disorder, overdose of which induced the hypotension, elevation of the atrial pacing threshold, cardiac conduction delay, wide complex tachycardia, cardiac arrest and Brugada-like electrocardiographic pattern. To clarify how lamotrigine induces those c...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/s00380-020-01716-8

    authors： Goto A,Hagiwara-Nagasawa M,Kambayashi R,Nunoi Y,Izumi-Nakaseko H,Kawai S,Takei Y,Matsumoto A,Sugiyama A

    更新日期：2020-11-02 00:00:00

  • Interrelationship in the prognostic efficacy of regional coronary flow reserve, fractional flow reserve, high-sensitivity cardiac troponin-I and NT-proBNP in patients with stable coronary artery disease.

    abstract：:This study aimed to investigate the combined efficacy in prediction of major adverse cardiac events (MACE) by coronary regional physiological indices including coronary flow reserve (CFR) or fractional flow reserve (FFR) and high-sensitivity cardiac troponin-I (hs-cTnI) or N-terminal pro brain natriuretic peptide (NT-...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/s00380-018-1260-z

    authors： Hamaya R,Yonetsu T,Kanaji Y,Usui E,Hoshino M,Hada M,Kanno Y,Murai T,Lee T,Kakuta T

    更新日期：2019-03-01 00:00:00

  • Increased C-reactive protein is associated with future development of diabetes mellitus in essential hypertensive patients.

    abstract：:Coexistence of hypertension and diabetes mellitus (DM) increases the risk of cardiovascular disease. However, factors associated with future development of DM have not been well elucidated in patients already having essential hypertension. This study prospectively included 168 patients (mean age 41 +/- 7 years, 112 me...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/s00380-009-1218-2

    authors： Weng CM,Chou CH,Huang YY,Lin CC,Liu YW,Tsai WC

    更新日期：2010-09-01 00:00:00

  • Association of uncoupling protein-2 expression with increased reactive oxygen species in residual myocardium of the enlarged left ventricle after myocardial infarction.

    abstract：:Left ventricular (LV) dilatation following myocardial infarction (MI) is a major determinant of the patient's prognosis, and myocardial energy metabolism may play a key role in LV remodeling. We aimed to investigate the relative timing of LV dilatation to LV function, myocardial energy regulation by uncoupling protein...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/s00380-004-0805-5

    authors： Guo P,Mizushige K,Noma T,Murakami K,Namba T,Ishizawa M,Tsuji T,Kimura S,Kohno M

    更新日期：2005-03-01 00:00:00

  • An adult case of Bland-White-Garland syndrome with collaterals from the bronchial artery.

    abstract：:We report herein an adult case of anomalous origin of the left coronary artery from the pulmonary artery (Bland-White-Garland syndrome; BWG syndrome). The patient had chest discomfort during exercise and signs of mitral regurgitation. We diagnosed him as having BWG syndrome by angiography, and performed surgical treat...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/BF01746067

    authors： Ishihata T,Takeda H,Katohno E,Techigawara M,Owada K,Murata N,Ohta H,Maruyama Y

    更新日期：1994-01-01 00:00:00

  • Hypocellularity and insufficient expression of angiogenic factors in implanted autologous bone marrow in patients with chronic critical limb ischemia.

    abstract：:The aim of this study was to identify the clinical parameters of absolutely poor-prognosis patients with chronic critical limb ischemia (AP-CLI). Sixteen no-option CLI patients with arteriosclerosis obliterans: ASO (nine) and non-ASO patients (seven) treated with bone marrow-mononuclear cell implantation (BMI) were an...

    journal_title：Heart and vessels

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00380-011-0125-5

    authors： Oda M,Toba K,Kato K,Ozawa T,Yanagawa T,Ikarashi N,Takayama T,Suzuki T,Hanawa H,Masuko M,Kobayashi H,Aizawa Y

    更新日期：2012-01-01 00:00:00

  • The distribution of calcified nodule and plaque rupture in patients with peripheral artery disease: an intravascular ultrasound analysis.

    abstract：:In addition to plaque rupture (PR), calcified nodule (CN) may also have the potential to develop into arterial thrombus in the peripheral arteries. This study evaluated the distribution of plaque ruptures and calcified nodules in the peripheral arteries and their impact on the outcome of endovascular therapy (EVT). Co...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/s00380-017-0984-5

    authors： Horimatsu T,Fujii K,Fukunaga M,Miki K,Nishimura M,Naito Y,Shibuya M,Imanaka T,Kawai K,Tamaru H,Sumiyoshi A,Saita T,Masuyama T,Ishihara M

    更新日期：2017-10-01 00:00:00

  • Resting qualitative and quantitative myocardial contrast echocardiography to predict cardiac events in patients with acute myocardial infarction and percutaneous revascularization.

    abstract：:Successful restoration of patency of the infarct-related artery is important in management of acute ST-segment elevation myocardial infarction (STEMI); however, it does not necessarily translate into the restoration of perfusion at the tissue level. In this study, we evaluate the prognostic role of qualitative and qua...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/s00380-013-0460-9

    authors： Abdelmoneim SS,Martinez MW,Mankad SV,Bernier M,Dhoble A,Pellikka PA,Chandrasekaran K,Oh JK,Mulvagh SL

    更新日期：2015-01-01 00:00:00

  • Aortic dissection is associated with intermittent hypoxia and re-oxygenation.

    abstract：:Aortic dissection is a life-threatening cardiovascular disease with high in-hospital mortality. However, the risk factors of aortic dissection have not been fully elucidated. Obstructive sleep apnea (OSA) has been increasingly recognized as an independent cardiovascular risk factor. Among the underlying mechanisms to ...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/s00380-011-0149-x

    authors： Naito R,Sakakura K,Kasai T,Dohi T,Wada H,Sugawara Y,Kubo N,Yamashita S,Narui K,Ishiwata S,Ohno M,Ako J,Momomura S

    更新日期：2012-05-01 00:00:00

  • Noninvasive assessment of acute cardiopulmonary effects of an oral single dose of sildenafil in patients with idiopathic pulmonary hypertension.

    abstract：:We aimed to assess the acute cardiopulmonary effects of a 100-mg oral single dose of sildenafil in patients with idiopathic pulmonary hypertension (IPAH) using a well-validated but less-used noninvasive echocardiographic method for the measurement of both systolic and diastolic pulmonary artery pressure (PAP), by tric...

    journal_title：Heart and vessels

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00380-009-1208-4

    authors： Behzadnia N,Najafizadeh K,Sharif-Kashani B,Dameshghi DO,Shahabi P

    更新日期：2010-07-01 00:00:00

  • Assessment of trough rivaroxaban concentrations on markers of coagulation activation in nonvalvular atrial fibrillation population.

    abstract：:Whether trough-phase rivaroxaban concentrations provide sufficient anticoagulation needs more study. We evaluated levels of coagulation activation markers in the trough concentration phase in nonvalvular atrial fibrillation (NVAF) patients, and the correlation between these markers and rivaroxaban concentration. Fifty...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/s00380-016-0912-0

    authors： Kitagawa F,Ishii J,Hiramitsu S,Takahashi H,Okuyama R,Kawai H,Muramatsu T,Harada M,Motoyama S,Naruse H,Matsui S,Sarai M,Hayashi M,Watanabe E,Izawa H,Ozaki Y

    更新日期：2017-05-01 00:00:00

  • Effects of elastase on contractility and morphology of elastic tissue in isolated guinea pig papillary muscles.

    abstract：:Elastase (ELA) is an enzyme catalyzing the digestion of elastin, an essential constituent of elastic fibers. Using isolated guinea pig papillary muscles, we examined the effect of ELA (3 x 10(-7) -3 x 10(-4) g/ml) on resting tension (RT) and twitch tension (TT). The effects of ELA on elastic fibers located in the sube...

    journal_title：Heart and vessels

    pub_type： 杂志文章

    doi：10.1007/BF01744386

    authors： Sato T,Imanishi S,Arita M,Shimada T

    更新日期：1993-01-01 00:00:00