Abstract:
:The timing and amplitude of reflected arterial waves in the ascending aorta were studied by analysis of the aortic pressure waveform and were compared with those derived using wave intensity analysis. Wave intensity analysis considers aortic pressure changes to be the result of forward and backward wavelets carrying energy. Wave intensity (dI = dPdU) is calculated from changes in pressure (dP) and flow velocity (dU), and its sign indicates the direction of travel of propagating wavelets (positive for forward-traveling waves and vice versa). We measured aortic pressure and flow velocity in 14 patients, mean age 60+/-9 years, with three-vessel coronary artery disease at the time of surgical revascularization. The travel time of the reflected wave derived from analysis of the aortic pressure waveform (tp) was measured from the foot of the aortic pressure waveform to the inflection point of the aortic pressure (derived objectively from the zero of second derivative of aortic pressure). From wave intensity analysis, the travel time of the reflected wave was measured to the onset of the wave intensity of the backward-traveling wave dI_ (t(i)), and to the onset of the separated backward pressure wave (t(b)). All patients showed an aortic pressure waveform characterized by an inflection point on the rising limb of the aortic pressure, followed by a secondary rise in pressure, representing the return of reflected waves. Wave intensity analysis consistently showed a negative peak in mid systole, the timing of its onset corresponding closely to the inflection point of the aortic pressure. The travel time of the reflected wave derived from the analysis of the aortic pressure waveform (t(p)) was 121+/-21ms and showed close agreement with ti (118+/-28 ms) and t(b) (115+/-29ms), with mean differences of 4 and 6ms, and 95% confidence intervals of difference (-2 to 7 ms) and (1 to 12ms), respectively. The augmentation index, a measure of the secondary increase in aortic pressure due to reflected waves, was significantly correlated with the magnitude of dI_ (r = 0.63, P < 0.001). Wave intensity is a quantity that indicates the rate of energy flux due to wave travel and since its value is positive for forward-traveling waves and negative for backward-traveling waves, its calculation allows the timing of reflected waves to be accurately predicted. Furthermore, the magnitude of wave intensity in backward-traveling waves (dI_) is related to the augmentation index and may provide a measure of the amplitude of the reflected wave. This analysis of the arterial system is done in the time domain and therefore can be easily applied to assess temporal changes in arterial characteristics.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Koh TW,Pepper JR,DeSouza AC,Parker KHdoi
10.1007/BF01747827subject
Has Abstractpub_date
1998-01-01 00:00:00pages
103-13issue
3eissn
0910-8327issn
1615-2573journal_volume
13pub_type
杂志文章abstract:BACKGROUND:An increase in epicardial adipose tissue (EAT) volume is associated with the development of atrial fibrillation (AF) and coronary artery disease (CAD), but little is known about differences in its distribution. METHODS AND RESULTS:We included 50 patients with paroxysmal AF (PAF), 50 patients with CAD, and 5...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01575-3
更新日期:2020-08-01 00:00:00
abstract::Late-acquired stent malapposition (LASM) is a common finding after sirolimus-eluting stent (SES) implantation and may be the cause for late stent thrombosis. Inflammation may play a pivotal role in LASM just as it plays in stent restenosis. We have therefore investigated seven polymorphisms involved in inflammatory pr...
journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-010-0046-8
更新日期:2011-05-01 00:00:00
abstract::It has been demonstrated that S1P receptors affect heart ischaemia-reperfusion (IR) induced injury. However, whether S1P receptors affect IR-induced cardiac death has not been investigated. The aim of this paper is to demonstrate the role of S1P receptors in IR-induced cardiac death. Healthy adult male Sprague-Dawley ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-01323-8
更新日期:2019-06-01 00:00:00
abstract::The primary study aim was to determine whether ischemia-modified albumin (IMA) predicts adverse outcome in patients attending the emergency department (ED) with acute chest pain. Ischemia-modified albumin is a sensitive marker of myocardial ischemia. However, little is known about its ability to predict outcome in pat...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-007-1031-8
更新日期:2008-05-01 00:00:00
abstract::Liver cirrhosis (LC), which may result in hepatic failure or cancer, has been reported in patients after Fontan procedure. The purpose of this study was to clarify the frequency and histological characteristics of LC, and to evaluate the risk factors and serological markers of LC with Fontan circulation. Retrospective...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0743-4
更新日期:2016-09-01 00:00:00
abstract::Aortic valve stenosis (AS) is a frequent complication contributing to poor prognosis in chronic hemodialysis (CHD) patients. High blood pressure (BP) is known to be associated with AS progression in the general population. In CHD patients, however, BP varies during and between hemodialysis sessions with ultrafiltratio...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0756-z
更新日期:2016-09-01 00:00:00
abstract::We studied the effects of cobalt-60 Gamma-radiation on the gene expression and secretion of adrenomedullin (Adm) and endothelin (ET) in cultured rat vascular smooth muscle cells (VSMCs). Rat VSMCs cultured in Dulbecoo's modified Eagle's medium containing 10% FBS were radiated with cobalt-60 Gamma-radiation at doses of...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-003-0709-9
更新日期:2003-09-01 00:00:00
abstract::To define mechanisms that may influence collateral circulation and angiogenesis, we investigated vascular endothelial growth factor (VEGF) mRNA expression in human hearts. In non-ischemic human hearts, VEGF mRNA was not detected in vessels, but was found in cardiomyocytes. In hearts with myocardial infarction, the int...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01745169
更新日期:1996-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-005-0893-x
更新日期:2006-07-01 00:00:00
abstract::Myocardial fibrosis and microvascular dysfunction are key determinants of outcome in heart failure (HF); we examined their relationship in patients with HF. Our study included 61 consecutive patients with HF but without coronary stenosis. All underwent gadolinium-enhanced cardiac magnetic resonance to evaluate late ga...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0816-z
更新日期:2016-12-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::In the original publication of the article, under the results section, the following sentence. ...
journal_title:Heart and vessels
pub_type: 已发布勘误
doi:10.1007/s00380-020-01574-4
更新日期:2020-05-01 00:00:00
abstract::We examined mRNA expression of the clock genes (Per1, Per2, and Bmal1) and PAI-1 (plasminogen activator inhibitor-1) after aldosterone treatment every 4 h up to 48 h in H9c2 cardiomyoblasts by reverse transcription-polymerase chain reaction. To block the MR (mineralocorticoid receptor), the MR antagonist, spironolacto...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0968-3
更新日期:2007-07-01 00:00:00
abstract::The objectives of the study were to evaluate the impact of aortic angulation (AA) on success of transcatheter aortic valve replacement (TAVR) with a new generation self-expandable prosthesis (Medtronic Evolut R®). Specific anatomical conditions, such as for example the presence of a horizontal aorta with elevated AA, ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01436-8
更新日期:2019-12-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058588
更新日期:1988-01-01 00:00:00
abstract::Primary myocardial involvement is common in systemic sclerosis (SSc). We evaluated the atrial and ventricular electromechanical characteristics by using tissue Doppler echocardiography in SSc patients with subclinical cardiac involvement. Twenty-seven consecutive patients (24 women; mean age +/- SD 49.9 +/- 11.3 years...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-009-1197-3
更新日期:2010-05-01 00:00:00
abstract::Coronary slow flow (CSF) is characterized by delayed opacification of coronary arteries in the absence epicardial occlusive disease. QT duration and dispersion have been reported to be longer in patients with CSF. ACE inhibitors may improve CSF through positive effects on endothelial function. The study included 32 pa...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-010-0058-4
更新日期:2011-07-01 00:00:00
abstract::Six patients with coronary arterial lesions due to Kawasaki disease underwent aortocoronary by-pass grafting at our institute. Before surgery, all of them had been closely monitored for some years by means of selective coronary arteriography, thallium myocardial imaging, electrocardiography (treadmill and/or Holter), ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02066356
更新日期:1985-05-01 00:00:00
abstract::To test the therapeutic efficacy of levamisole, 5-week-old DBA/2 mice were inoculated intraperitoneally with 10 plaque-forming units of encephalo-myocarditis virus. Levamisole (2.5 mg/kg/per day) was administered intraperitoneally daily, starting simultaneously with the virus inoculation, in experiment I for 14 days, ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02820869
更新日期:1997-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2015-01-01 00:00:00
abstract::The purpose of this study was to investigate the use of hepatocyte growth factor as a biochemical marker for acute myocardial infarction. Several biochemical markers are used for noninvasive detection of acute myocardial infarction. However, hepatocyte growth factor has not been used previously for this purpose. We me...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02766790
更新日期:1997-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-013-0367-5
更新日期:2014-05-01 00:00:00
abstract::AST-120 has been used widely in Japan to slow the deterioration of renal function in patients with chronic kidney disease (CKD) by decreasing uremic toxins. The heart and the kidney are closely related, with cardiorenal interaction being very important. This retrospective study examined whether AST-120 influences the ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0785-7
更新日期:2016-10-01 00:00:00
abstract::No studies have evaluated both the time-to-isolation (TTI) and the sequence of pulmonary vein (PV) potentials in cryoballoon ablation (CBA) for atrial fibrillation (AF). This study aimed to prospectively evaluate the acute results of pulmonary vein isolation (PVI) using a novel CBA technique-the earliest potential (EP...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01471-5
更新日期:2020-02-01 00:00:00
abstract::It is known that the heart of an athlete has been physiologically adapted by prolonged training. There are a large number of echocardiographic studies which have focused on left ventricular wall thickness and dilatation, but there are few studies concerning right heart function in the athlete's heart. The aim of this ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s003800200018
更新日期:2002-07-01 00:00:00
abstract::Several coronary angiographic studies have reported that enlarged and tortuous epicardial coronary arteries are characteristic of patients with left ventricular concentric hypertrophy (LVCH). Recently, we showed that small volumes opacified by contrast medium can be accurately measured by 64-multislice computed tomogr...
journal_title:Heart and vessels
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doi:10.1007/s00380-011-0230-5
更新日期:2013-03-01 00:00:00
abstract::Coexistence of hypertension and diabetes mellitus (DM) increases the risk of cardiovascular disease. However, factors associated with future development of DM have not been well elucidated in patients already having essential hypertension. This study prospectively included 168 patients (mean age 41 +/- 7 years, 112 me...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-009-1218-2
更新日期:2010-09-01 00:00:00
abstract::A drawback of visual assessment for late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) is the subjectivity and reproducibility of the results. The aim of this study was to investigate the relationship between left ventricular (LV) reverse remodeling in response to optimal pharmacotherapies and the d...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1196-3
更新日期:2018-12-01 00:00:00
abstract::Plasma B-type natriuretic peptide (BNP) is finely regulated by the cardiac function and several extracardiac factors. Therefore, the relationship between the plasma BNP levels and the severity of heart failure sometimes seems inconsistent. The purpose of the present study was to investigate the plasma BNP levels in pa...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-012-0278-x
更新日期:2013-07-01 00:00:00
abstract::This study is a prospective evaluation of the effectiveness of cardiac rehabilitation (CR) in terms of clinical outcomes for small abdominal aortic aneurysms (AAA) that were previously reported in a retrospective cohort study. We conducted a prospective non-randomized trial on patients with small AAA (N = 40; mean age...
journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00