Abstract:
:The efficacy of second-generation drug-eluting stent (DES) for the treatment of left main disease (LM) and/or three vessel disease (3VD) remains unclear. We compared 2-year outcomes of second- versus first -generation DES implantation among patients with LM and/or 3VD and to assess the differential of risk by complexity of coronary artery disease using synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) scores. Between April 2007 and December 2012, 341 patients with LM and/or 3VD were treated by percutaneous coronary intervention; 154 with first-generation DES and 137 with second-generation DES. After propensity matching, 101 patients remained in each group. The rate of target lesion revascularization (TLR) and major adverse cardiac event (MACE) were compared. TLR and MACE at 2 years were more common in the first- compared with second-generation DES group (TLR 19.8 vs. 8.9 %; p = 0.016, MACE 24.8 vs. 10.9 %; p = 0.008). In patients with low (0-22) and intermediate (23-32) SYNTAX scores, TLR and MACE tended to occur more often with first-generation DES group. In patients with high SYNTAX scores (≧33), TLR and MACE were significantly more common with first-generation DES group (TLR 29.0 vs. 11.1 %; p = 0.035, MACE 35.5 vs. 13.9 %; p = 0.034). Compared with first-generation DES, second-generation DES proved beneficial in reducing risk of TLR and MACE in patients with LM and/or 3VD, particularly among those with high SYNTAX scores (≧33).
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Kobayashi N,Ito Y,Hirano K,Yamawaki M,Araki M,Sakai T,Takimura H,Sakamoto Y,Mori S,Tsutsumi M,Takama T,Takafuji H,Maruyama T,Honda Y,Tokuda T,Makino K,Shirai S,Muramatsu Tdoi
10.1007/s00380-016-0824-zsubject
Has Abstractpub_date
2016-12-01 00:00:00pages
1930-1942issue
12eissn
0910-8327issn
1615-2573pii
10.1007/s00380-016-0824-zjournal_volume
31pub_type
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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doi:10.1007/s00380-017-1101-5
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journal_title:Heart and vessels
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doi:10.1007/s00380-005-0830-z
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058280
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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