Abstract:
:Hyperuricemia is common in chronic kidney disease (CKD), but data regarding the relationship between serum uric acid levels and the long-term outcomes of CKD patients have been limited. The present study evaluated the associations between baseline serum uric acid levels with mortality and end-stage renal disease (ESRD). The subjects of this study were 551 stage 2-4 CKD patients. Cox proportional hazards models were used to evaluate the relationship between serum uric acid tertiles and all-cause mortality, cardiovascular disease (CVD) mortality, 50 % reduction in estimated glomerular filtration rate (eGFR), and development of ESRD, initially without adjustment, and then after adjusting for several groups of covariates. The mean age of the study subjects was 58.5 years, 59.3 % were men, and 10.0 % had diabetes. The mean eGFR was 42.02 ± 18.52 ml/min/1.73 m(2). In all subjects, the mean serum uric acid level was 6.57 ± 1.35 mg/dl, and 52.2 % of study subjects were on hypouricemic therapy (allopurinol; 48.3 %) at baseline. Thirty-one patients (6.1 %) died during a follow-up period of approximately 6 years. There was no significant association between serum uric acid level and all-cause mortality, CVD mortality, development of ESRD and 50 % reduction in eGFR in the unadjusted Cox models. In the adjusted models, hyperuricemia was found to be associated with all-cause mortality and CVD mortality after adjustment with CVD risk factors, kidney disease factors, and allopurinol, but not associated with development of ESRD and 50 % reduction in eGFR. The results of this study showed that hyperuricemia but not serum uric acid levels were associated with all-cause mortality, CVD mortality after adjustments with CVD risk factors, kidney disease factors, and allopurinol in stage 2-4 CKD patients.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Miyaoka T,Mochizuki T,Takei T,Tsuchiya K,Nitta Kdoi
10.1007/s00380-013-0396-0subject
Has Abstractpub_date
2014-07-01 00:00:00pages
504-12issue
4eissn
0910-8327issn
1615-2573journal_volume
29pub_type
杂志文章abstract::The coronary flow velocity reserve (CFVR), a measure of endothelial function in coronary circulation, can be measured semi-invasively in the left anterior descending coronary artery by using stress transesophageal echocardiography (TEE). During the same stress TEE, aortic distensibility indices (elastic modulus [E(p)]...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0939-8
更新日期:2007-03-01 00:00:00
abstract::To test the therapeutic efficacy of levamisole, 5-week-old DBA/2 mice were inoculated intraperitoneally with 10 plaque-forming units of encephalo-myocarditis virus. Levamisole (2.5 mg/kg/per day) was administered intraperitoneally daily, starting simultaneously with the virus inoculation, in experiment I for 14 days, ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02820869
更新日期:1997-01-01 00:00:00
abstract::Acromegaly, when left untreated, is associated with premature mortality which is chiefly related to cardiovascular complications. We report on a 50-year-old acromegalic woman, resistant to therapy, who died suddenly because of thoracic aortic rupture and massive bleeding into the left pleural space. The postmortem exa...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-007-1012-y
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Predictors of left ventricular ejection fraction (LVEF) improvement after transcatheter aortic valve replacement (TAVR) in patients with a preoperative reduced LVEF are limited. OBJECTIVES:This study aimed to investigate the relationship between preprocedural valuvuloarterial impedance (ZVa), which represen...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01591-3
更新日期:2020-09-01 00:00:00
abstract::Activation of mineralocorticoid receptor antagonists (MRAs) is cardioprotective; however, this property is lost upon blockade or inactivation of adenosine (ADO) receptor A2b. In this study, we investigated whether the effects of MRAs are mediated by an interaction between cardioprotective ADO receptors A1 and A3. Spir...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01542-7
更新日期:2020-05-01 00:00:00
abstract::Compared to conscious sedation (CS), the use of general anesthesia (GA) in pulmonary vein isolation (PVI) is associated with a lower recurrence rate of atrial fibrillation (AF). GA may improve catheter stability and mapping system accuracy compared to CS, but its influence on contact force (CF) parameters during ipsil...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0961-z
更新日期:2017-08-01 00:00:00
abstract::The aim of our study was to assess the atherosclerotic burden in patients with the first symptoms of coronary artery disease (CAD). The study population consisted of 100 consecutive patients (new-onset severe angina or myocardial infarction) and 70 age- and sex-matched volunteers without symptoms of CAD. Functional an...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s003800200028
更新日期:2002-09-01 00:00:00
abstract::During left nephrectomy in a 35-year-old woman with a left renal cell carcinoma extending into the inferior vena cava (IVC) and right atrium, cardiac arrest occurred. Immediate transesophageal echocardiography demonstrated that the event was caused by a pulmonary tumor embolism. Emergent cardiopulmonary bypass (CPB) w...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02767048
更新日期:1997-01-01 00:00:00
abstract::MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression. It seems that microRNA-21 (miR-21) and Visfatin, a novel adipocytokine, play roles in inflammation and atherosclerosis. The aim of this study was to investigate the association of miR-21 with Visfatin, inflammation, atherosclerosis and acute c...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0913-z
更新日期:2017-05-01 00:00:00
abstract::Very late stent thrombosis (VLST) is a serious complication after percutaneous coronary intervention. However, the best therapy for VLST with late-acquired incomplete stent apposition and incomplete neointimal coverage remains unknown. In these cases, neointimal coverage was nearly complete and no late-acquired malapp...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0720-y
更新日期:2016-07-01 00:00:00
abstract::The purpose of this study was to examine the histopathological findings of right ventricular endomyocardial biopsies from ten patients less than 60 years of age (47 +/- 9.8 (mean +/- SD) years) with documented atrioventricular block but without apparent heart disease. They underwent electrophysiological testing, echoc...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02482303
更新日期:1999-01-01 00:00:00
abstract::Myocardial perfusion and perfusion reserve are diminished in patients with atrial fibrillation (AF). Phase-contrast (PC) cine magnetic resonance imaging (MRI) of the coronary sinus serves as a non-invasive means of quantifying coronary flow reserve (CFR) without any radioactive tracer. The present study aimed to evalu...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01759-x
更新日期:2021-01-23 00:00:00
abstract::Vascular calcification is an ectopic calcification that commonly occurs in atherosclerosis. Because taurine was previously shown to protect against cardiovascular diseases, the effect of taurine on vascular calcification was evaluated in calcified vascular smooth muscle cells (VSMCs) of rat in vitro in the present stu...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-003-0744-6
更新日期:2004-05-01 00:00:00
abstract::Previous studies showed that continuous anticoagulation or single antiplatelet therapy during implantations of cardiac implantable electronic devices (CIED) was relatively safe. However, the safety of continuous multi antithrombotic therapy (AT) in patients undergoing CIED interventions has not been clearly defined. W...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0879-x
更新日期:2017-03-01 00:00:00
abstract::Since the amount of contrast media during percutaneous coronary intervention (PCI) is closely related to the exacerbation of renal function, it should be important to reduce the dose of contrast media during PCI. The purpose of this retrospective study was to evaluate the association of less-contrast media with clinic...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01473-3
更新日期:2020-02-01 00:00:00
abstract::Percutaneous transvenous mitral commissurotomy (PTMC) increases peak oxygen uptake (VO2) chronically, but not acutely, despite early symptomatic improvements. Analysis of transient VO2 responses to submaximal exercise (an exercise regimen more comparable to the patients' daily activities than that provided by maximal ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02911391
更新日期:1995-01-01 00:00:00
abstract::The distribution and structure of lymphatic and blood capillaries in the rabbit heart conduction system were investigated by transmission electron microscopy. The sinuatrial node, atrioventricular node, and atrioventricular bundle possessed a rich network of lymphatic capillaries, which were situated not only at the p...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058423
更新日期:1988-01-01 00:00:00
abstract::Coexistence of hypertension and diabetes mellitus (DM) increases the risk of cardiovascular disease. However, factors associated with future development of DM have not been well elucidated in patients already having essential hypertension. This study prospectively included 168 patients (mean age 41 +/- 7 years, 112 me...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-009-1218-2
更新日期:2010-09-01 00:00:00
abstract::Heme oxygenase (HO)-1 is a rate-limiting enzyme for degrading heme into carbon monoxide. Longer (GT)n repeat of the HO-1 gene (HMOX1) promoter has a lower transcription rate. Subjects with longer GT repeats in the HMOX1 promoter are more likely to have coronary artery disease (CAD) and cardiovascular events. We retros...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01733-7
更新日期:2021-01-03 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) increases coronary artery disease (CAD) risk. In this study, we used T2DM clinical variables to predict abnormality in thallium-201 myocardial perfusion scans (Th-201 scans). These clinical variables were summed stress score (SSS), summed rest score, and summed difference score (SDS), w...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01681-2
更新日期:2020-08-20 00:00:00
abstract::First-generation drug-eluting stents (DES) demonstrated delay in vascular healing and increase in incidence of late and very late stent thrombosis compared with bare-metal stents (BMS). Second-generation DES, however, have shown a reduction of late and very late stent thrombosis compared with first-generation DES. Thu...
journal_title:Heart and vessels
pub_type: 杂志文章,多中心研究
doi:10.1007/s00380-015-0783-9
更新日期:2016-10-01 00:00:00
abstract::Morphological and functional changes of free arterial grafts in dogs were studied for 3 weeks after implantation and the changes were compared to those in implanted free vein grafts. In the arterial grafts, endothelial cells with abundant pinocytotic vesicles and some cytoplasmic folds were observed by transmission an...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01744868
更新日期:1992-01-01 00:00:00
abstract::The role of inflammation in acute coronary syndrome (ACS) and the mechanism by which statin treats ACS is explored. Serum high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) levels were measured in 50 patients with ACS [including 30 cases with unstable angina (UA) and 20 patients with acute myocardia...
journal_title:Heart and vessels
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00380-004-0776-6
更新日期:2004-11-01 00:00:00
abstract::We sought to recognize the blood flow velocity (BFV) through the left anterior descending (LAD) coronary artery and its small intramyocardial (IM) branches by transthoracic Doppler-echocardiography in patients with aortic stenosis (AS). Sixty-two patients, aged 74.0 ± 9.6 years, 37 women, with preserved left ventricul...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01532-9
更新日期:2020-05-01 00:00:00
abstract::Mechanical hemolysis after transcatheter occlusion of the patent ductus arteriosus using the Rashkind umbrella device has been postulated as a rare, but serious complication, even necessitating surgical repair. A rare, case of an adult patient with massive hemolytic anemia, successfully controlled by the combined use ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01747502
更新日期:1997-01-01 00:00:00
abstract::Six patients with coronary arterial lesions due to Kawasaki disease underwent aortocoronary by-pass grafting at our institute. Before surgery, all of them had been closely monitored for some years by means of selective coronary arteriography, thallium myocardial imaging, electrocardiography (treadmill and/or Holter), ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02066356
更新日期:1985-05-01 00:00:00
abstract::The hemodynamic load due to physical activity leads to structural and functional cardiac adaptations known as "Athlete's heart". We aimed to compare myocardial performance in different groups of trained athletes by means of 3D echocardiography and 3D speckle tracking echocardiography (3D-STE). 66 athletes [26 strength...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0520-9
更新日期:2015-05-01 00:00:00
abstract::Regardless of a successful operation, patients with coarctation of aorta (CoAo) are exposed to the risk of hypertension and a propensity to vascular and end-organ damage. The aim of this study is to evaluate the influence of residual aorta stenosis as well as the age at the operation on the parameters of arterial func...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-010-0063-7
更新日期:2011-07-01 00:00:00
abstract::Recent evidence has shown that apoptotic cells are present in human atherosclerotic lesions. However, the molecular mechanism of the induction of apoptosis in atherosclerotic lesions is not clear. Since T cells are present in almost all stages of atherosclerosis, we examined whether T cells can modulate the expression...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::This study was designed to test the ability of adenovirus-delivered vascular endothelial growth factor (Ad-VEGF) to stimulate angiogenesis and arteriogenesis in the rabbit hindlimb following the induction of ischemia and to evaluate the functional changes in the collateral circulation. Ten days after the surgical indu...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-003-0694-z
更新日期:2003-07-01 00:00:00