Abstract:
:Elastase (ELA) is an enzyme catalyzing the digestion of elastin, an essential constituent of elastic fibers. Using isolated guinea pig papillary muscles, we examined the effect of ELA (3 x 10(-7) -3 x 10(-4) g/ml) on resting tension (RT) and twitch tension (TT). The effects of ELA on elastic fibers located in the subendocardium were examined histologically. A relatively high concentration of ELA (3 x 10(-4) g/ml) increased TT transiently, with progressive decreases in RT. In contrast, a relatively low concentration (3 x 10(-5) g/ml) decreased both TT and RT straightforwardly. Much lower concentrations (3 x 10(-6) -3 x 10(-7) g/ml) did not reveal significant effects. The ELA-induced increases in TT were unaffected in the presence of atenolol (10(-5) g/ml), ouabain (10(-7) M) or ryanodine (10(-6)M). ELA did not increase the maximum rate of rise of slow action potentials recorded using standard microelectrodes. ELA (3 x 10(-5) g/ml) decreased the maximum TT obtained at optimal RT or Lmax, and decreased the slope of the ascending and descending limbs of the TT-RT relation curve (Frank-Starling's). Electron-microscopic findings revealed that subendocardial elastin was mostly digested at ELA concentrations of 3 x 10(-5) -3 x 10(-4) g/ml. These findings suggest that the decrease of RT by ELA may be, at least in part, caused by a decomposition of the elastic fibers. On the other hand, the increase of TT by ELA could not be attributed to a release of endogenous catecholamine, an inhibition of Na+, K(+)-pump, a release of Ca2+ from sarcoplasmic reticulum, or an increase of slow inward current.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Sato T,Imanishi S,Arita M,Shimada Tdoi
10.1007/BF01744386subject
Has Abstractpub_date
1993-01-01 00:00:00pages
71-8issue
2eissn
0910-8327issn
1615-2573journal_volume
8pub_type
杂志文章abstract::Sudden cardiac arrest (SCA) is a major cause of death in patients with congenital heart disease (CHD). Systemic ventricular dysfunction is a reported risk factor for SCA. We retrospectively analyzed the medical records of 46 patients (age >6 years) who experienced SCA. The following underlying cardiac defects were obs...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-013-0444-9
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01747827
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journal_title:Heart and vessels
pub_type: 临床试验,杂志文章
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journal_title:Heart and vessels
pub_type: 杂志文章
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journal_title:Heart and vessels
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journal_title:Heart and vessels
pub_type: 杂志文章
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journal_title:Heart and vessels
pub_type: 杂志文章
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-007-0998-5
更新日期:2007-11-01 00:00:00
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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journal_title:Heart and vessels
pub_type: 杂志文章,多中心研究
doi:10.1007/s00380-011-0144-2
更新日期:2012-05-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s003800300006
更新日期:2003-03-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058524
更新日期:1987-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01747853
更新日期:1999-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02059969
更新日期:1986-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-011-0182-9
更新日期:2012-09-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0967-6
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journal_title:Heart and vessels
pub_type: 临床试验,杂志文章
doi:10.1007/BF03257232
更新日期:1998-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-011-0222-5
更新日期:2012-11-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01745239
更新日期:1994-01-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00