A pathologic analysis of the outcome following heart-lung transplantation: an autopsy study of 22 recipients.

Abstract:

:Between 1987 and 1989, twenty-two patients who received combined heart-lung transplantation were autopsied at La Pitie Salpetriere Hospital in Paris. With the exception of two recipients who survived for 2 months and 4 months, respectively, the majority of the patients died in the early postoperative period (the mean survival was 20.1 days). At autopsy, five patients showed acute cardiac rejection of a minor grade. Perivascular and peribronchiolar mononuclear cell infiltrates suggesting acute pulmonary rejection were seen in three patients. Obliterating bronchiolitis, which might be indicative of chronic rejection, was observed in four patients who had longer survival rates, and one of these four had died of obliterating bronchiolitis. Rather than allograft rejection, the major causes of death were (1) perioperative hemorrhage, (2) infections (mainly respiratory infections and occasionally mediastinitis), (3) diffuse alveolar damage (the so-called adult respiratory distress syndrome and/or pulmonary organizing edema), and (4) multiple organ failure. The present study suggested some of the reasons why the survival rate following heart-lung transplantation is much poorer than after isolated heart transplantation. Hemodynamic or respiratory problems causing perioperative multiple organ failure as well as pre-existing complications of the recipients, such as "cardiac cirrhosis," may play an important role in the prognosis of heart-lung transplantation.

journal_name

Heart Vessels

journal_title

Heart and vessels

authors

Ishibashi-Ueda H,Chomette G,Delcourt A,Auriol M,Le Charpentier Y,Cabrol C

doi

10.1007/BF02125099

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

211-7

issue

4

eissn

0910-8327

issn

1615-2573

journal_volume

6

pub_type

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