Abstract:
:Between 1987 and 1989, twenty-two patients who received combined heart-lung transplantation were autopsied at La Pitie Salpetriere Hospital in Paris. With the exception of two recipients who survived for 2 months and 4 months, respectively, the majority of the patients died in the early postoperative period (the mean survival was 20.1 days). At autopsy, five patients showed acute cardiac rejection of a minor grade. Perivascular and peribronchiolar mononuclear cell infiltrates suggesting acute pulmonary rejection were seen in three patients. Obliterating bronchiolitis, which might be indicative of chronic rejection, was observed in four patients who had longer survival rates, and one of these four had died of obliterating bronchiolitis. Rather than allograft rejection, the major causes of death were (1) perioperative hemorrhage, (2) infections (mainly respiratory infections and occasionally mediastinitis), (3) diffuse alveolar damage (the so-called adult respiratory distress syndrome and/or pulmonary organizing edema), and (4) multiple organ failure. The present study suggested some of the reasons why the survival rate following heart-lung transplantation is much poorer than after isolated heart transplantation. Hemodynamic or respiratory problems causing perioperative multiple organ failure as well as pre-existing complications of the recipients, such as "cardiac cirrhosis," may play an important role in the prognosis of heart-lung transplantation.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Ishibashi-Ueda H,Chomette G,Delcourt A,Auriol M,Le Charpentier Y,Cabrol Cdoi
10.1007/BF02125099subject
Has Abstractpub_date
1991-01-01 00:00:00pages
211-7issue
4eissn
0910-8327issn
1615-2573journal_volume
6pub_type
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journal_title:Heart and vessels
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pub_type: 杂志文章
doi:10.1007/s00380-018-1179-4
更新日期:2018-11-01 00:00:00
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journal_title:Heart and vessels
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doi:10.1007/s00380-012-0265-2
更新日期:2013-07-01 00:00:00
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journal_title:Heart and vessels
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更新日期:2019-10-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058323
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01745103
更新日期:1994-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01744868
更新日期:1992-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/pl00007270
更新日期:2000-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 临床试验,杂志文章
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更新日期:2010-07-01 00:00:00
abstract::The effect of intravenous enoximone on forearm venous circulation was studied in ten healthy volunteers (group A) and in ten patients with NYHA class III-IV congestive heart failure (group B). Distensibility of the forearm capacitance vessels was assessed from pressure-volume curves by venous occlusion plethysmography...
journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00380-014-0503-x
更新日期:2015-03-01 00:00:00
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journal_title:Heart and vessels
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abstract::There is no proven therapy for heart failure with preserved ejection fraction (HFpEF). Research has shown beneficial responses to cardiac rehabilitation (CR) among HF patients. To date, there are no reports comparing those responses between patients with HFpEF and those with reduced ejection fraction (HFrEF). The purp...
journal_title:Heart and vessels
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doi:10.1007/s00380-018-1128-2
更新日期:2018-08-01 00:00:00
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更新日期:2004-07-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01745239
更新日期:1994-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-013-0367-5
更新日期:2014-05-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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更新日期:2019-12-01 00:00:00
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更新日期:2004-03-01 00:00:00
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journal_title:Heart and vessels
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更新日期:1992-01-01 00:00:00
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更新日期:2010-01-01 00:00:00