Abstract:
:A cardiac angiotensin II-generating system is thought to be involved in cardiac fibrosis. Both angiotensin-converting enzyme (ACE) and human chymase can convert angiotensin I to angiotensin II. However, the relative contributions of these two enzymatic pathways to angiotensin II generation in vivo remain to be clarified. In 31 patients with heart diseases, we assessed the expression levels of mRNAs for collagen type I-alpha, ACE, and chymase in right atrial appendages by competitive reverse transcriptional polymerase chain reaction and Northern blot analyses. The expression level of the ACE mRNA was about 100 times higher than that of the chymase mRNA. The collagen type I-alpha mRNA concentration was significantly and positively correlated with both the mean pulmonary arterial pressure (r = 0.414; P = 0.020) and the ACE mRNA concentration (r = 0.548; P = 0.0014). However, the chymase mRNA concentration was not correlated with the collagen type I-alpha mRNA concentration. Multivariate regression analysis revealed that the collagen type I-alpha mRNA concentration was related to the ACE mRNA concentration (P = 0.0028) and to the mean pulmonary arterial pressure (P = 0.0386) [r = 0.633, P < 0.0008]. The present results suggest that ACE may affect tissue angiotensin II levels in human atria. However, we obtained no evidence that chymase is important in determining tissue angiotensin II level.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Ohmichi N,Iwai N,Shimoike H,Izumi M,Watarida S,Mori A,Nakamura Y,Kinoshita Msubject
Has Abstractpub_date
1997-01-01 00:00:00pages
116-8eissn
0910-8327issn
1615-2573journal_volume
Suppl 12pub_type
杂志文章abstract::Compared to conscious sedation (CS), the use of general anesthesia (GA) in pulmonary vein isolation (PVI) is associated with a lower recurrence rate of atrial fibrillation (AF). GA may improve catheter stability and mapping system accuracy compared to CS, but its influence on contact force (CF) parameters during ipsil...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0961-z
更新日期:2017-08-01 00:00:00
abstract::A 65-year-old man was referred to our hospital following repetitive chest pain. Invasive coronary angiography showed an intermediate stenosis of the proximal left anterior descending artery (LAD), and a coronary fistula originating distal to the stenosis draining into the main pulmonary artery. To evaluate the functio...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0641-9
更新日期:2016-05-01 00:00:00
abstract::Although heparin allergy is a rare but well-documented entity, anticoagulation management for cardiac surgery in patients with the heparin allergy has not been established due to its rarity. Here we report a case that shows our anticoagulation strategy during a coronary bypass operation. A 67-year-old man with unstabl...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s003800300006
更新日期:2003-03-01 00:00:00
abstract::Aortic dissection is a life-threatening cardiovascular disease with high in-hospital mortality. However, the risk factors of aortic dissection have not been fully elucidated. Obstructive sleep apnea (OSA) has been increasingly recognized as an independent cardiovascular risk factor. Among the underlying mechanisms to ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-011-0149-x
更新日期:2012-05-01 00:00:00
abstract::Coexistence of hypertension and diabetes mellitus (DM) increases the risk of cardiovascular disease. However, factors associated with future development of DM have not been well elucidated in patients already having essential hypertension. This study prospectively included 168 patients (mean age 41 +/- 7 years, 112 me...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-009-1218-2
更新日期:2010-09-01 00:00:00
abstract::Although a previous randomized study showed that the use of atrial natriuretic peptide (carperitide) improved the long-term prognosis of patients with heart failure, its effect on short-term prognosis remains unclear. We retrospectively identified patients who were admitted to our tertiary-care center with acute decom...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0952-0
更新日期:2017-08-01 00:00:00
abstract::Renin-angiotensin system (RAS) inhibitors may be useful in preventing the occurrence of paroxysmal atrial fibrillation (PAF). However, evaluation of such effect is difficult because many PAF episodes are asymptomatic and not all episodes are detected by intermittent electrocardiographic monitoring. A pacemaker has bee...
journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-015-0627-7
更新日期:2016-03-01 00:00:00
abstract::The modulation of L-type Ca2+ currents (I(Ca,L)) by the basal activities of G proteins was studied in adult guinea pig ventricular myocytes by whole-cell patch-clamp techniques. With intrapipette guanosine triphosphate (GTP) (100 microM), a specific inhibition of G1 proteins by pertussis toxin (PTX) produced an increa...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s003800070013
更新日期:2000-01-01 00:00:00
abstract::Pulmonary arterial hypertension (PAH) is characterized by a progressive increase in pulmonary arterial pressure and vascular resistance. Despite advances in therapy for PAH, its treatment and prognosis remain poor. We aimed to investigate whether the transplantation of bone marrow mesenchymal stem cells (MSCs) overexp...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-013-0395-1
更新日期:2014-07-01 00:00:00
abstract::Wave intensity (WI) is a new hemodynamic index, which is defined as (dP/dt)(dU/dt) at any site of the circulation, where dP/dt and dU/dt are the time derivatives of blood pressure and velocity, respectively. Arterial WI in normal subjects has two positive sharp peaks. The first peak occurs during early systole when a ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF03257237
更新日期:1999-01-01 00:00:00
abstract::Although cisplatin is indispensable for the chemotherapy treatment of many malignancies, cisplatin-associated thrombosis is attracting increasing attention. However, experience of primary percutaneous coronary intervention (PCI) and intravascular ultrasound imaging (IVUS) for coronary thrombosis, possibly due to cispl...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-011-0222-5
更新日期:2012-11-01 00:00:00
abstract::We sought to recognize the blood flow velocity (BFV) through the left anterior descending (LAD) coronary artery and its small intramyocardial (IM) branches by transthoracic Doppler-echocardiography in patients with aortic stenosis (AS). Sixty-two patients, aged 74.0 ± 9.6 years, 37 women, with preserved left ventricul...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01532-9
更新日期:2020-05-01 00:00:00
abstract::Clinicians often have a difficulty in determining the presence of mitral regurgitation (MR)-related symptoms because of subjectivity. However, there are few actual measurement data for echocardiographic left ventricular (LV) and left atrial (LA) size related to the severity of MR and the relationship between MR-relate...
journal_title:Heart and vessels
pub_type: 杂志文章,多中心研究
doi:10.1007/s00380-019-01514-x
更新日期:2020-04-01 00:00:00
abstract::No studies have evaluated both the time-to-isolation (TTI) and the sequence of pulmonary vein (PV) potentials in cryoballoon ablation (CBA) for atrial fibrillation (AF). This study aimed to prospectively evaluate the acute results of pulmonary vein isolation (PVI) using a novel CBA technique-the earliest potential (EP...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01471-5
更新日期:2020-02-01 00:00:00
abstract::In the present study, we investigated whether gallic acid (GA) can induce death in cultured vascular smooth muscle cells (VSMCs), and whether production of the hydroxyl radical (.OH) is involved in the process of GA action. GA killed cultured VSMCs from rat aorta, in a dosc- and time-dependent manner. Cytoplasmic shri...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s003800070038
更新日期:2000-01-01 00:00:00
abstract::Insulin resistance (IR) is now considered to be a risk factor for coronary arterial atherosclerosis and is likely to be involved in a limited endothelium-dependent vasodilatory function in peripheral circulation. We investigated whether IR impairs endothelial vasodilator function in the noninfarcted coronary artery. I...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-007-1002-0
更新日期:2008-01-01 00:00:00
abstract::The inotropic effects of 5-hydroxytryptamine (5-HT) on mammalian heart muscles were investigated. 5-HT (10(-8)-10(-3)M) produced increases in the contractile tension of atrial and ventricular muscles isolated from guinea pigs, Japanese monkeys, and humans, but not in rat heart preparations. The maximum percent increas...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01744594
更新日期:1996-01-01 00:00:00
abstract::Myocardial fibrosis and microvascular dysfunction are key determinants of outcome in heart failure (HF); we examined their relationship in patients with HF. Our study included 61 consecutive patients with HF but without coronary stenosis. All underwent gadolinium-enhanced cardiac magnetic resonance to evaluate late ga...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0816-z
更新日期:2016-12-01 00:00:00
abstract::Several reports demonstrated positive effects of processing residual cardiopulmonary bypass volume using a cell salvage device in conventional open heart surgery via sternotomy on hemostasis. The present study aimed to investigate whether cell salvage processing has the same effects on postoperative blood loss and tra...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01365-6
更新日期:2019-08-01 00:00:00
abstract::Cardiac systolic (left ventricular ejection fraction) and diastolic (mitral inflow velocity pattern and/or mitral deceleration time) function were reported as predictors of clinical outcome or left ventricular remodeling in patients with acute myocardial infarction (AMI). Recently, a new index (Doppler-derived index c...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-003-0735-7
更新日期:2004-03-01 00:00:00
abstract::We developed a new individually customized contrast-injection protocol for coronary computed tomography (CT) angiography based on the time-attenuation response in a test bolus, and investigated its clinical applicability. We scanned 60 patients with suspected coronary diseases using a 64-detector CT scanner, who were ...
journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-013-0338-x
更新日期:2014-03-01 00:00:00
abstract::Both hypertension and hyperuricemia are closely associated with the morbidity and mortality of heart failure. This study was designed to evaluate the influences of long-term xanthine oxidase inhibitor (febuxostat) prescription on left ventricular hypertrophy (LVH), left ventricular (LV) diastolic function, and new-ons...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01619-8
更新日期:2020-10-01 00:00:00
abstract::The purpose of this study was to evaluate the surgical results of papillary muscle approximation (PMA) and papillary muscle relocation (PMR) for functional mitral regurgitation (FMR) and to compare the effects of both procedures on the change in mitral regurgitation (MR) and echocardiogram parameters associated with t...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-1038-8
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:An increase in epicardial adipose tissue (EAT) volume is associated with the development of atrial fibrillation (AF) and coronary artery disease (CAD), but little is known about differences in its distribution. METHODS AND RESULTS:We included 50 patients with paroxysmal AF (PAF), 50 patients with CAD, and 5...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01575-3
更新日期:2020-08-01 00:00:00
abstract::Successful restoration of patency of the infarct-related artery is important in management of acute ST-segment elevation myocardial infarction (STEMI); however, it does not necessarily translate into the restoration of perfusion at the tissue level. In this study, we evaluate the prognostic role of qualitative and qua...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-013-0460-9
更新日期:2015-01-01 00:00:00
abstract::Low levels of Soluble TNF-related apoptosis induced ligand (sTRAIL) seem to be related to worse prognosis after an acute coronary syndrome. PostConditioning (PostCond) may protect the heart from reperfusion injury. We sought to evaluate the impact of PostCond on sTRAIL in relationship to infarct size (area under the c...
journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-016-0851-9
更新日期:2017-02-01 00:00:00
abstract::We have theoretically proposed "systolic pressure-volume area" (PVA) as a measure of total mechanical energy generated by ventricular contraction. We then experimentally showed that PVA closely correlates with left ventricular oxygen consumption (Vo2) regardless of ventricular loading conditions in a stable contractil...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058751
更新日期:1991-01-01 00:00:00
abstract::It is well known that patients with gastroesophageal reflux disease (GERD) experience GERD-related chest pain, but little is known about the relationship between GERD and coronary artery disease (CAD). We evaluated medical history of GERD in patients with suspected CAD and its association with types of CAD. We enrolle...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01413-1
更新日期:2019-10-01 00:00:00
abstract::Distal anastomosis technique affects graft patency and long-term outcomes in coronary artery bypass grafting, however, there is no standard for the appropriate length of distal anastomosis. The purpose of this study is to evaluate whether longer distal anastomosis provides higher quality of distal anastomosis and bett...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0880-4
更新日期:2017-01-01 00:00:00
abstract::Recent evidence has shown that apoptotic cells are present in human atherosclerotic lesions. However, the molecular mechanism of the induction of apoptosis in atherosclerotic lesions is not clear. Since T cells are present in almost all stages of atherosclerosis, we examined whether T cells can modulate the expression...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00