Abstract:
:We have theoretically proposed "systolic pressure-volume area" (PVA) as a measure of total mechanical energy generated by ventricular contraction. We then experimentally showed that PVA closely correlates with left ventricular oxygen consumption (Vo2) regardless of ventricular loading conditions in a stable contractile state. Although Starling's law of the heart has been generally considered to describe the relation between ventricular preload as the input and the "energy of contraction" as the output, the energy of cardiac contraction has been variously identified with cardiac output, external work, contractile element work, tension-time index, etc., by different investigators. However, none of these variables has been unanimously accepted as the total mechanical energy of contraction because they do not consistently correlate with Vo2 which represents the total energy utilization for contraction. Considering the nature of PVA which has been revealed over the last decade, we now confidently propose that PVA is the most likely expression of the total mechanical energy of contraction that has been pursued for many years as the energy of contraction in Starling's law of the heart.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Suga H,Goto Y,Futaki S,Kawaguchi O,Yaku H,Hata K,Takasago Tdoi
10.1007/BF02058751subject
Has Abstractpub_date
1991-01-01 00:00:00pages
65-70issue
2eissn
0910-8327issn
1615-2573journal_volume
6pub_type
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journal_title:Heart and vessels
pub_type: 临床试验,杂志文章
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