Abstract:
:Successful restoration of patency of the infarct-related artery is important in management of acute ST-segment elevation myocardial infarction (STEMI); however, it does not necessarily translate into the restoration of perfusion at the tissue level. In this study, we evaluate the prognostic role of qualitative and quantitative myocardial contrast echocardiography (MCE) in predicting cardiac events (after adjustment for cardiovascular risk factors) in STEMI patients undergoing reperfusion. Bedside resting real-time MCE using continuous infusion of diluted contrast agent (Definity) was performed within a median of 21.4 h from revascularization in STEMI. Myocardial perfusion on qualitative MCE was graded 1 = homogenous; 2 = partial/patchy; and 3 = absent. Perfusion score index (PSI) was calculated by adding the perfusion score in all segments divided by the total number of evaluable segments. Quantitative perfusion parameters [A, dB; β, sec(-1); and Aβ] were analyzed using a 17-segment model. Patients were followed for cardiac events including death; nonfatal myocardial infarction (MI); hospitalization for cardiac symptoms; coronary revascularization; or heart failure. Thirty-seven reperfused STEMI patients with a mean age of 64 years (range, 40-86 years) were enrolled and followed for a median of 1.4 years. Cardiac events occurred in 22 patients. Patients with cardiac events had a higher perfusion score index (PSI), and lower A, β and Aβ parameters compared to patients without events [1.84 ± 0.36 vs 1.39 ± 0.17 for PSI, P < 0.001; 0.57 ± 0.24 vs 0.85 ± 0.30 for A, P = 0.03; 0.34 ± 0.15 vs. 0.53 ± 0.17 for β, P = 0.002; and 0.21 ± 0.12 vs. 0.49 ± 0.32, for Aβ, P = 0.003; respectively]. A PSI value of 1.58 provided an area under the curve (AUC) of 0.873, while β of 0.423 and Aβ of 0.323 provided an AUC of 0.858 and 0.842, respectively. PSI and Aβ were independent predictors of cardiac events with an adjusted hazard ratio of 3.41 (1.19-12.27); and 4.19 (1.3-19.09), respectively. No contrast-related side effects were reported. Evaluation of perfusion in reperfused STEMI patients by qualitative and quantitative MCE (myocardial blood flow, Aβ) provides independent prediction of cardiac events.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Abdelmoneim SS,Martinez MW,Mankad SV,Bernier M,Dhoble A,Pellikka PA,Chandrasekaran K,Oh JK,Mulvagh SLdoi
10.1007/s00380-013-0460-9subject
Has Abstractpub_date
2015-01-01 00:00:00pages
45-55issue
1eissn
0910-8327issn
1615-2573journal_volume
30pub_type
杂志文章abstract::The role of inflammation in acute coronary syndrome (ACS) and the mechanism by which statin treats ACS is explored. Serum high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) levels were measured in 50 patients with ACS [including 30 cases with unstable angina (UA) and 20 patients with acute myocardia...
journal_title:Heart and vessels
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00380-004-0776-6
更新日期:2004-11-01 00:00:00
abstract::Dilated cardiomyopathy (DCM) is a common primary myocardial disease leading to congestive heart failure, arrhythmia and sudden cardiac death. Increasing studies demonstrate substantial genetic determinants for DCM. Nevertheless, DCM is of substantial genetic heterogeneity, and the genetic basis for DCM in most patient...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-1110-4
更新日期:2018-07-01 00:00:00
abstract::A cardiac angiotensin II-generating system is thought to be involved in cardiac fibrosis. Both angiotensin-converting enzyme (ACE) and human chymase can convert angiotensin I to angiotensin II. However, the relative contributions of these two enzymatic pathways to angiotensin II generation in vivo remain to be clarifi...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Using myocardial contrast echocardiography (MCE), coronary arteriography, and thallium-201 myocardial imaging (TMI), we examined the characteristics and the role of collateral vessels in 35 patients with coronary artery lesions after Kawasaki disease. The male/female ratio was 25:10. The patients' ages are examination...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02559993
更新日期:1996-01-01 00:00:00
abstract::Eicosapentaenoic acid (EPA) has antiarrhythmic effects. The J-wave on an electrocardiogram is associated with a high incidence of ventricular tachycardia/fibrillation (VT/VF). We evaluated relationships between EPA and J-waves, and their involvement in the occurrence of VT/VF in acute myocardial infarction (AMI). Two ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-013-0435-x
更新日期:2014-11-01 00:00:00
abstract::Although drug-eluting stents have improved clinical outcomes, percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) remains a challenging procedure in terms of thrombus management. A new-generation P2Y12 receptor inhibitor, prasugrel, provides more rapid and potent antiplatelet action compared wit...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01686-x
更新日期:2020-09-09 00:00:00
abstract::Sex-related factors play an important role in the pathophysiology of heart failure (HF). However, trends in sex-related differences in hospital management for HF are not clear. We identified patients hospitalized for HF through a nationwide database (National Health Insurance in Taiwan), containing 722,272 subjects fr...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-012-0299-5
更新日期:2013-11-01 00:00:00
abstract::A growing body of evidence suggests that mitral regurgitation (MR) is associated with higher mortality in heart failure patients with reduced ejection fraction. However, prognostic impact of MR on heart failure patients with preserved ejection fraction (HFpEF) has not been fully examined. The Japanese Heart Failure Sy...
journal_title:Heart and vessels
pub_type: 杂志文章,多中心研究
doi:10.1007/s00380-020-01581-5
更新日期:2020-08-01 00:00:00
abstract::Chronic kidney disease (CKD) is well known to be associated with an increased incidence of coronary artery disease (CAD). Diabetes mellitus (DM) and hypertension (HTN), both of which are traditional risk factors for CAD, are the two most common causes of CKD. However, the influence of CKD on coronary atherosclerosis i...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-01334-5
更新日期:2019-07-01 00:00:00
abstract::Several coronary angiographic studies have reported that enlarged and tortuous epicardial coronary arteries are characteristic of patients with left ventricular concentric hypertrophy (LVCH). Recently, we showed that small volumes opacified by contrast medium can be accurately measured by 64-multislice computed tomogr...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-011-0230-5
更新日期:2013-03-01 00:00:00
abstract::Peripartum cardiomyopathy (PPCM) is a rare but life-threatening cardiac disorder characterized by maternal systolic heart failure. Although PPCM is a major cause of maternal mortality, little is known about the acute-phase management of PPCM in real-world clinical settings. We retrospectively identified patients hospi...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0958-7
更新日期:2017-08-01 00:00:00
abstract::The efficacy of second-generation drug-eluting stent (DES) for the treatment of left main disease (LM) and/or three vessel disease (3VD) remains unclear. We compared 2-year outcomes of second- versus first -generation DES implantation among patients with LM and/or 3VD and to assess the differential of risk by complexi...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0824-z
更新日期:2016-12-01 00:00:00
abstract::Pre-procedural valvuloarterial impedance (Zva) is considered as a useful predictor of mortality in patients diagnosed as having severe aortic stenosis (AS) who undergo transcatheter aortic valve implantation (TAVI). However, the prognostic significance of post-procedural Zva remains unclear. We aimed to evaluate the p...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-01329-2
更新日期:2019-06-01 00:00:00
abstract::Contrast echocardiography with sonicated radiographic contrast agents has been used for the qualitative and quantitative determination of myocardial blood flow. One major problem has been the size of the microbubbles since only bubbles smaller than 8 microns are expected to pass the capillary bed and larger bubbles ma...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01744500
更新日期:1995-01-01 00:00:00
abstract::Intracoronary acetylcholine (ACh) provocation test is useful to diagnose vasospastic angina. Although outpatient coronary angiography has been widely performed in current clinical settings, the feasibility and safety of ACh provocation test in outpatient services are unclear. A total of 323 patients, who electively un...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1139-z
更新日期:2018-08-01 00:00:00
abstract::Although cisplatin is indispensable for the chemotherapy treatment of many malignancies, cisplatin-associated thrombosis is attracting increasing attention. However, experience of primary percutaneous coronary intervention (PCI) and intravascular ultrasound imaging (IVUS) for coronary thrombosis, possibly due to cispl...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-011-0222-5
更新日期:2012-11-01 00:00:00
abstract::A 65-year-old man was referred to our hospital following repetitive chest pain. Invasive coronary angiography showed an intermediate stenosis of the proximal left anterior descending artery (LAD), and a coronary fistula originating distal to the stenosis draining into the main pulmonary artery. To evaluate the functio...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0641-9
更新日期:2016-05-01 00:00:00
abstract::Heme oxygenase (HO)-1 is a rate-limiting enzyme for degrading heme into carbon monoxide. Longer (GT)n repeat of the HO-1 gene (HMOX1) promoter has a lower transcription rate. Subjects with longer GT repeats in the HMOX1 promoter are more likely to have coronary artery disease (CAD) and cardiovascular events. We retros...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01733-7
更新日期:2021-01-03 00:00:00
abstract::Scanning electron microscopy was used to compare the shape, size, and connection of left ventricular (LV) myocytes between spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY) at 3, 8, 15, 35, and 63 weeks of age. For either strain at each age, five rats were studied, in which LV myocytes consisted of a c...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02481739
更新日期:1999-01-01 00:00:00
abstract::We assessed the plaque disruption in 245 consecutive patients with acute coronary syndrome undergoing percutaneous coronary intervention. The plaque fissure was diagnosed with optical coherence tomography, and intravascular ultrasound was used to determine arterial remodeling. Of them, 26 fissures were found in this s...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1271-9
更新日期:2019-03-01 00:00:00
abstract::The hemodynamic load due to physical activity leads to structural and functional cardiac adaptations known as "Athlete's heart". We aimed to compare myocardial performance in different groups of trained athletes by means of 3D echocardiography and 3D speckle tracking echocardiography (3D-STE). 66 athletes [26 strength...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0520-9
更新日期:2015-05-01 00:00:00
abstract::A 65-year-old man was admitted with chest pain. A diagnosis of spastic angina was made because of symptoms of recurrent anginal attacks associated with ST-segment elevations in the electrocardiogram. A selective coronary arteriogram revealed a 90% diameter narrowing of the proximal left anterior descending coronary ar...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058361
更新日期:1989-01-01 00:00:00
abstract::During cardiopulmonary bypass (CPB) mechanical stress and the contact of blood with artificial surfaces lead to the activation of pro- and anticoagulant systems and the complement cascade, and to changes in cellular components. This phenomenon causes the "postperfusion-syndrome", with leukocytosis, increased capillary...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01747190
更新日期:1996-01-01 00:00:00
abstract::The distribution and structure of lymphatic and blood capillaries in the rabbit heart conduction system were investigated by transmission electron microscopy. The sinuatrial node, atrioventricular node, and atrioventricular bundle possessed a rich network of lymphatic capillaries, which were situated not only at the p...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058423
更新日期:1988-01-01 00:00:00
abstract::Left ventricular non-compaction (LVNC) is genetically heterogeneous. It has been previously shown that LVNC is associated with defects in TAZ, DNTA, LDB3, YWHAE, MIB1, PRDM16, and sarcomeric genes. This study was aimed to investigate sarcomeric gene mutations in a Chinese population with LVNC. From 2004 to 2010, 57 un...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0503-x
更新日期:2015-03-01 00:00:00
abstract::Controlling blood pressure is essential for prevention of events after acute aortic dissection (AAD). However, in some instances a cardiac event occurs despite controlled blood pressure, and its prediction is difficult. We continuously monitored C-reactive protein (CRP) in patients receiving medical treatment for AAD ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-012-0257-2
更新日期:2013-05-01 00:00:00
abstract::Acute myocardial infarction (AMI) is a highly dynamic event, which is associated with increasing production of reactive oxygen species (ROS). The imbalance between ROS production and antioxidant defenses leads to the condition known as oxidative stress. The most widely recognized effect of increasing oxidative stress ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-010-0029-9
更新日期:2011-01-01 00:00:00
abstract::It is unclear whether the electrocardiogram amplitude in the inferior leads (Amp-I) can always predict the height of the origin of right ventricular outflow tract arrhythmias (RVOT-VAs). We analyzed patients who received catheter ablation of multiple RVOT-VAs in the same session in our hospital from 2011 to 2016. Two ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1235-0
更新日期:2019-02-01 00:00:00
abstract::Very late stent thrombosis (VLST) is a serious complication after percutaneous coronary intervention. However, the best therapy for VLST with late-acquired incomplete stent apposition and incomplete neointimal coverage remains unknown. In these cases, neointimal coverage was nearly complete and no late-acquired malapp...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0720-y
更新日期:2016-07-01 00:00:00
abstract::Increases in regional myocardial blood flow (Qm) developing soon after myocardial infarction may minimize myocardial necrosis. To test this hypothesis, Qm in the area surrounding an acutely occluded coronary artery was determined successively over 4 weeks in 11 dogs. Non-radioactive colored microspheres were injected ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01744982
更新日期:1995-01-01 00:00:00