Abstract:
:High levels of serum phosphate are associated with calcification of human smooth muscle cells (HSMCs). We investigated whether inhibition of protein kinase A (PKA) and mitogen-activated protein kinase (MAPK) signals [p38, extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK)] can reduce inorganic phosphate (Pi)-induced HSMC calcification. Inhibition of PKA or p38 MAPK by inhibitors or small interfering RNAs (siRNAs) reduced Ca levels and alkaline phosphatase activities in HSMCs treated with high Pi, but inhibition of ERK1/2 and JNK showed no significant changes. Moreover, there were no significant changes in cell viability on adding siRNAs and three inhibitors (PKA, p38, and MEK1/2), but JNK inhibitor slightly reduced cell viability. These results show that PKA and p38 MAPK are involved in the Pi-induced calcification of HSMCs, and may be good targets for reducing vascular calcification.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Kang JH,Toita R,Asai D,Yamaoka T,Murata Mdoi
10.1007/s00380-013-0427-xsubject
Has Abstractpub_date
2014-09-01 00:00:00pages
718-22issue
5eissn
0910-8327issn
1615-2573journal_volume
29pub_type
杂志文章abstract::A growing body of evidence suggests that mitral regurgitation (MR) is associated with higher mortality in heart failure patients with reduced ejection fraction. However, prognostic impact of MR on heart failure patients with preserved ejection fraction (HFpEF) has not been fully examined. The Japanese Heart Failure Sy...
journal_title:Heart and vessels
pub_type: 杂志文章,多中心研究
doi:10.1007/s00380-020-01581-5
更新日期:2020-08-01 00:00:00
abstract::Balneotherapy has been shown to reduce systemic blood pressure in healthy volunteers. Hyperthermia might ameliorate the inflammatory status in heart failure through improving cardiac function. The purpose of this study was to examine the beneficial effects of balneotherapy in patients with chronic heart failure (CHF)....
journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-011-0220-7
更新日期:2013-03-01 00:00:00
abstract::Although the suction force that moves blood into the left ventricle during early diastole is thought to play an important role in diastolic function, there have been a few studies of this phenomenon in normal children. Suction force is measured as the intraventricular pressure difference (IVPD) and intraventricular pr...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1239-9
更新日期:2019-02-01 00:00:00
abstract::Little evidence exists regarding the need for a reduction in postoperative heart rate after repair of type A acute aortic dissection. This single-center retrospective study was conducted to determine if lower heart rate during the early postoperative phase is associated with improved long-term outcomes after surgery f...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0486-7
更新日期:2015-05-01 00:00:00
abstract::In addition to plaque rupture (PR), calcified nodule (CN) may also have the potential to develop into arterial thrombus in the peripheral arteries. This study evaluated the distribution of plaque ruptures and calcified nodules in the peripheral arteries and their impact on the outcome of endovascular therapy (EVT). Co...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0984-5
更新日期:2017-10-01 00:00:00
abstract::Vector flow mapping (VFM) is a novel echocardiographic technology that shows blood flow vectors and vortexes, enabled the hydrokinetic evaluation of hemodynamics within the left ventricle. VFM provides several unique parameters: circulation, vorticity, vortex area, and energy loss. The present study aims to reveal a r...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-1093-1
更新日期:2018-05-01 00:00:00
abstract::Several reports demonstrated positive effects of processing residual cardiopulmonary bypass volume using a cell salvage device in conventional open heart surgery via sternotomy on hemostasis. The present study aimed to investigate whether cell salvage processing has the same effects on postoperative blood loss and tra...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01365-6
更新日期:2019-08-01 00:00:00
abstract::The timing and amplitude of reflected arterial waves in the ascending aorta were studied by analysis of the aortic pressure waveform and were compared with those derived using wave intensity analysis. Wave intensity analysis considers aortic pressure changes to be the result of forward and backward wavelets carrying e...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01747827
更新日期:1998-01-01 00:00:00
abstract::Left ventricular (LV) dilatation following myocardial infarction (MI) is a major determinant of the patient's prognosis, and myocardial energy metabolism may play a key role in LV remodeling. We aimed to investigate the relative timing of LV dilatation to LV function, myocardial energy regulation by uncoupling protein...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-004-0805-5
更新日期:2005-03-01 00:00:00
abstract::The purpose of this study was to examine factors influencing readmission to hospital in patients with heart failure. This multicenter, retrospective cohort study analyzed 197 heart failure patients admitted to the research cooperation facilities between January 2017 and November 2017. We defined the readmission group ...
journal_title:Heart and vessels
pub_type: 杂志文章,多中心研究
doi:10.1007/s00380-019-01500-3
更新日期:2020-03-01 00:00:00
abstract::The objective of this study is to determine whether pentraxin-3 (PTX-3) is clinically a biomarker of inflammation, a player in anti-inflammation, or both with regard to coronary atherosclerosis, we compared levels of PTX-3 with levels of adiponectin in addition to high-sensitivity C-reactive protein (hs-CRP). We enrol...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0553-0
更新日期:2015-11-01 00:00:00
abstract::Vascular smooth muscle cell (VSMC) differentiation and phenotypic modulation are characterized by changes in gene expression for smooth muscle (SM) marker contractile proteins such as SM alpha-actin and SM22alpha. Hyperplasia suppressor gene (HSG) is a potent VSMC proliferation-inhibiting factor; however, it is not kn...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0914-4
更新日期:2006-09-01 00:00:00
abstract::The progression of cardiac hypertrophy and failure is associated with marked changes in cardiac autonomic innervation, and there are sympathetic-parasympathetic interactions in the regulation of cardiac function. Although the indexes of sympathetic innervation have been found to be depressed with the development of he...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058280
更新日期:1991-01-01 00:00:00
abstract::While oxidized lipoprotein(a) (oxLp(a)) has been indicated to be involved in atherogenesis more than native lipoprotein(a) (Lp(a)), there is still a need to elucidate the associations among oxLp(a), hypertension, and atherosclerosis. The cardio-ankle vascular index (CAVI) is a recently developed index used to assess a...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-012-0265-2
更新日期:2013-07-01 00:00:00
abstract::The aim of the study was to evaluate systemic right ventricular (RV) dyssynchrony in patients with congenitally corrected transposition of the great arteries (CCTGA) and transposition of the great arteries (TGA) with New York Heart Association functional class (NYHA FC) < III. We used cardiac magnetic resonance (CMR) ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1144-2
更新日期:2018-09-01 00:00:00
abstract::No studies have evaluated both the time-to-isolation (TTI) and the sequence of pulmonary vein (PV) potentials in cryoballoon ablation (CBA) for atrial fibrillation (AF). This study aimed to prospectively evaluate the acute results of pulmonary vein isolation (PVI) using a novel CBA technique-the earliest potential (EP...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01471-5
更新日期:2020-02-01 00:00:00
abstract::Acromegaly, when left untreated, is associated with premature mortality which is chiefly related to cardiovascular complications. We report on a 50-year-old acromegalic woman, resistant to therapy, who died suddenly because of thoracic aortic rupture and massive bleeding into the left pleural space. The postmortem exa...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-007-1012-y
更新日期:2008-01-01 00:00:00
abstract::The possibility of minimizing organ damage following cardiopulmonary bypass (CPB) was examined. In the control group, n = 21, upon completion of CPB, elevation of the lysosomal enzyme beta-glucuronidase, which is a sensitive indicator of cellular damage, was affected by the concentration of granulocyte elastase (r = 0...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01744743
更新日期:1993-01-01 00:00:00
abstract::Wire crossing of a chronic total coronary occlusion (CTO) is time consuming and limited by the amount of contrast agent and time of radiation exposure. Magnetic wire navigation (MWN) might accelerate wire crossing by maintaining a coaxial vessel orientation. This study compares MWN with the conventional approach for r...
journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-015-0739-0
更新日期:2016-08-01 00:00:00
abstract::We investigated the incidence of post-intubation hypotension (PIH) in hemodynamically stable patients with STEMI requiring rapid sequences intubation (RSI) and medicated with ketamine or midazolam as induction agent. STEMI patients admitted between 1st January 2009 and 1st January 2017 who did not receive any type of ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-1049-5
更新日期:2018-03-01 00:00:00
abstract::Gradient-echo T2-star (T2*)-weighted magnetic resonance imaging (MRI) is a sensitive method to detect cerebral microbleeds (CMBs). The presence of CMBs was reported to be a marker of future cardiovascular mortality and is associated with various cardiovascular risk factors, use of antithrombotic drugs, and cognitive d...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01503-0
更新日期:2020-03-01 00:00:00
abstract::Cerebral artery stenosis (CAS) has the same pathogenesis as coronary artery disease (CAD), but the coexistence of these two diseases has been rarely reported. To detect coexistent CAS in CAD patients, we conducted a study of simultaneous coronary and cerebral angiography. Of the 663 consecutive newly diagnosed CAD pat...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0971-8
更新日期:2007-09-01 00:00:00
abstract::Blood traces tortuous paths of flow through the heart. We postulate that momentum changes associated with direction changes optimize dynamic coupling between ventricular and atrial function, particularly on exercise. Traces of pulsed Doppler mitral flow and M-mode long-axis mitral ring movement were recorded before an...
journal_title:Heart and vessels
pub_type: 临床试验,杂志文章
doi:10.1007/BF02767127
更新日期:1997-01-01 00:00:00
abstract::Sleep-disordered breathing (SDB) has a critical association with mortality and morbidity of patients with chronic heart failure (CHF). Troponin T is a marker of ongoing myocardial damage and predicts adverse clinical outcomes in patients with CHF. Carnitine plays an important role in the utilization of fatty acids in ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0479-6
更新日期:2015-05-01 00:00:00
abstract::Inflammatory markers are elevated in acute coronary syndromes, and are also known to play a crucial role in the pathogenesis of neointimal proliferation and stent restenosis. Drug-eluting stents (DESs) have been shown to decrease stent restenosis in different studies. In this study, we aimed to investigate the effect ...
journal_title:Heart and vessels
pub_type: 临床试验,杂志文章
doi:10.1007/s00380-007-1020-y
更新日期:2008-03-01 00:00:00
abstract::Distal anastomosis technique affects graft patency and long-term outcomes in coronary artery bypass grafting, however, there is no standard for the appropriate length of distal anastomosis. The purpose of this study is to evaluate whether longer distal anastomosis provides higher quality of distal anastomosis and bett...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0880-4
更新日期:2017-01-01 00:00:00
abstract::The purpose of this study was to examine the histopathological findings of right ventricular endomyocardial biopsies from ten patients less than 60 years of age (47 +/- 9.8 (mean +/- SD) years) with documented atrioventricular block but without apparent heart disease. They underwent electrophysiological testing, echoc...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02482303
更新日期:1999-01-01 00:00:00
abstract::There is no proven therapy for heart failure with preserved ejection fraction (HFpEF). Research has shown beneficial responses to cardiac rehabilitation (CR) among HF patients. To date, there are no reports comparing those responses between patients with HFpEF and those with reduced ejection fraction (HFrEF). The purp...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1128-2
更新日期:2018-08-01 00:00:00
abstract::Peripheral artery disease (PAD) is a risk factor for the development of heart failure and mortality. The serum levels of carboxy-terminal telopeptide of type I collagen (I-CTP), a marker for collagen degradation derived from the extracellular matrix of vascular and myocardial tissue, is reportedly a useful marker for ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0858-2
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:An increase in epicardial adipose tissue (EAT) volume is associated with the development of atrial fibrillation (AF) and coronary artery disease (CAD), but little is known about differences in its distribution. METHODS AND RESULTS:We included 50 patients with paroxysmal AF (PAF), 50 patients with CAD, and 5...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01575-3
更新日期:2020-08-01 00:00:00