Hyperplasia suppressor gene associates with smooth muscle alpha-actin and is involved in the redifferentiation of vascular smooth muscle cells.


:Vascular smooth muscle cell (VSMC) differentiation and phenotypic modulation are characterized by changes in gene expression for smooth muscle (SM) marker contractile proteins such as SM alpha-actin and SM22alpha. Hyperplasia suppressor gene (HSG) is a potent VSMC proliferation-inhibiting factor; however, it is not known if HSG is involved in the redifferentiation of VSMCs. Here, the redifferentiation of the dedifferentiated VSMCs was induced by serum withdrawal or all-trans retinoic acid (atRA), HSG gene expression and its role in VSMC phenotypic modulation were studied by reverse transcription - polymerase chain reaction, Western blotting, and cell migration assay. The results indicated that HSG gene expression increased significantly during VSMC redifferentiation induced by serum deprivation or atRA and peaked at 24 h, then was maintained at higher levels. Meanwhile, SM marker contractile proteins SM alpha-actin and SM22alpha were increased by more than 2-fold. Coimmunoprecipitation and immunofluorescent experiments revealed that anti-HSG antibody could precipitate SM alpha-actin, and HSG and SM alpha-actin colocalized within the cytoplasm of differentiated VSMCs. Migration activity of VSMCs was dramatically suppressed after cells were transfected with HSG expression plasmids. These findings suggested that HSG is associated with SM alpha-actin in VSMC cytoplasm, and is involved in VSMC differentiation and migration.


Heart Vessels


Heart and vessels


Jiang GJ,Han M,Zheng B,Wen JK




Has Abstract


2006-09-01 00:00:00












  • ZBTB17 loss-of-function mutation contributes to familial dilated cardiomyopathy.

    abstract::Dilated cardiomyopathy (DCM) is a common primary myocardial disease leading to congestive heart failure, arrhythmia and sudden cardiac death. Increasing studies demonstrate substantial genetic determinants for DCM. Nevertheless, DCM is of substantial genetic heterogeneity, and the genetic basis for DCM in most patient...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Sun YM,Wang J,Xu YJ,Wang XH,Yuan F,Liu H,Li RG,Zhang M,Li YJ,Shi HY,Zhao L,Qiu XB,Qu XK,Yang YQ

    更新日期:2018-07-01 00:00:00

  • Comparison of magnetic wire navigation with the conventional wire technique for percutaneous coronary intervention of chronic total occlusions: a randomised, controlled study.

    abstract::Wire crossing of a chronic total coronary occlusion (CTO) is time consuming and limited by the amount of contrast agent and time of radiation exposure. Magnetic wire navigation (MWN) might accelerate wire crossing by maintaining a coaxial vessel orientation. This study compares MWN with the conventional approach for r...

    journal_title:Heart and vessels

    pub_type: 杂志文章,随机对照试验


    authors: Roth C,Berger R,Scherzer S,Krenn L,Gangl C,Dalos D,Delle-Karth G,Neunteufl T

    更新日期:2016-08-01 00:00:00

  • Cardioprotective effect of thyroid hormone is mediated by AT2 receptor and involves nitric oxide production via Akt activation in mice.

    abstract::Studies have demonstrated that thyroid hormone (T3) can precondition the heart against ischaemic injury and improve post-ischaemic recovery. This study investigated whether the AT2 receptor (AT2R) is involved in cardioprotection and the potential molecular mechanism responsible for this effect. Hyperthyroidism was ind...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: da Silva IB,Gomes DA,Alenina N,Bader M,Dos Santos RA,Barreto-Chaves MLM

    更新日期:2018-06-01 00:00:00

  • Earliest pulmonary vein potential-guided cryoballoon ablation for atrial fibrillation.

    abstract::No studies have evaluated both the time-to-isolation (TTI) and the sequence of pulmonary vein (PV) potentials in cryoballoon ablation (CBA) for atrial fibrillation (AF). This study aimed to prospectively evaluate the acute results of pulmonary vein isolation (PVI) using a novel CBA technique-the earliest potential (EP...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Mizutani Y,Kanashiro M,Makino Y,Satake A,Suzuki W,Kurobe M,Mizutani K,Ichimiya H,Uchida Y,Watanabe J,Ichimiya S,Inden Y,Murohara T

    更新日期:2020-02-01 00:00:00

  • Re-elevation of T-wave from day 2 to day 4 after successful percutaneous coronary intervention predicts chronic cardiac systolic dysfunction in patients with first anterior acute myocardial infarction.

    abstract::This study evaluates the clinical significance of re-elevation of T-wave in patients with ST segment elevation acute myocardial infarction (STEMI) undergoing successful percutaneous coronary intervention (PCI). Resolution of ST elevation within 24 h after reperfusion is associated with better outcome. However, little ...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Nishizaki F,Tomita H,Yokoyama H,Higuma T,Abe N,Suzuki A,Endo T,Tateyama S,Ishida Y,Osanai T,Okumura K

    更新日期:2013-11-01 00:00:00

  • Intraoperative behavior of arterial grafts in the elderly and the young: a flowmetric systematic analysis.

    abstract::Extensive arterial grafting (Art-CABG) in the elderly is still questioned due to the reduced life expectancy and the supposed higher periprocedural risk. Reports further demonstrated accelerated atherosclerosis of arterial grafts in the elderly, with hampered short-term and long-term results. We reviewed our experienc...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Onorati F,Santarpino G,Lerose MA,Impiombato B,Mastroroberto P,Renzulli A

    更新日期:2008-09-01 00:00:00

  • Subjects with coronary artery disease and reduced ejection fraction have longer (GT)n repeats in the heme-oxygenase 1 gene promoter.

    abstract::Heme oxygenase (HO)-1 is a rate-limiting enzyme for degrading heme into carbon monoxide. Longer (GT)n repeat of the HO-1 gene (HMOX1) promoter has a lower transcription rate. Subjects with longer GT repeats in the HMOX1 promoter are more likely to have coronary artery disease (CAD) and cardiovascular events. We retros...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Liang KW,Lee WJ,Lee WL,Wu JP,Lee IT,Wang JS,Sheu WH

    更新日期:2021-01-03 00:00:00

  • Myocardial deformational adaptations to different forms of training: a real-time three-dimensional speckle tracking echocardiographic study.

    abstract::The hemodynamic load due to physical activity leads to structural and functional cardiac adaptations known as "Athlete's heart". We aimed to compare myocardial performance in different groups of trained athletes by means of 3D echocardiography and 3D speckle tracking echocardiography (3D-STE). 66 athletes [26 strength...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Monte IP,Mangiafico S,Buccheri S,Bottari VE,Lavanco V,Arcidiacono AA,Leggio S,Deste W,Tamburino C

    更新日期:2015-05-01 00:00:00

  • Association between sarcopenia and atherosclerosis in elderly patients with ischemic heart disease.

    abstract::Compared to the general population, elderly patients with cardiovascular disease have a higher prevalence of sarcopenia, and it shows an association with increased mortality risk. Although several studies have indicated that atherosclerosis may cause sarcopenia in community dwelling elderly subjects, the association b...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Uchida S,Kamiya K,Hamazaki N,Matsuzawa R,Nozaki K,Ichikawa T,Suzuki Y,Nakamura T,Yamashita M,Kariya H,Maekawa E,Yamaoka-Tojo M,Matsunaga A,Ako J

    更新日期:2020-06-01 00:00:00

  • The distribution of calcified nodule and plaque rupture in patients with peripheral artery disease: an intravascular ultrasound analysis.

    abstract::In addition to plaque rupture (PR), calcified nodule (CN) may also have the potential to develop into arterial thrombus in the peripheral arteries. This study evaluated the distribution of plaque ruptures and calcified nodules in the peripheral arteries and their impact on the outcome of endovascular therapy (EVT). Co...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Horimatsu T,Fujii K,Fukunaga M,Miki K,Nishimura M,Naito Y,Shibuya M,Imanaka T,Kawai K,Tamaru H,Sumiyoshi A,Saita T,Masuyama T,Ishihara M

    更新日期:2017-10-01 00:00:00

  • Expression of vascular endothelial growth factor in human myocardial infarction.

    abstract::To define mechanisms that may influence collateral circulation and angiogenesis, we investigated vascular endothelial growth factor (VEGF) mRNA expression in human hearts. In non-ischemic human hearts, VEGF mRNA was not detected in vessels, but was found in cardiomyocytes. In hearts with myocardial infarction, the int...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Shinohara K,Shinohara T,Mochizuki N,Mochizuki Y,Sawa H,Kohya T,Fujita M,Fujioka Y,Kitabatake A,Nagashima K

    更新日期:1996-01-01 00:00:00

  • Factors affecting hospital readmission heart failure patients in Japan: a multicenter retrospective cohort study.

    abstract::The purpose of this study was to examine factors influencing readmission to hospital in patients with heart failure. This multicenter, retrospective cohort study analyzed 197 heart failure patients admitted to the research cooperation facilities between January 2017 and November 2017. We defined the readmission group ...

    journal_title:Heart and vessels

    pub_type: 杂志文章,多中心研究


    authors: Umehara T,Katayama N,Tsunematsu M,Kakehashi M

    更新日期:2020-03-01 00:00:00

  • Points to note from indications for heart transplantation to post-heart transplant care: from the care of patients with refractory heart failure and overseas heart transplantation.

    abstract::To examine important points surrounding the indications for heart transplantation (HTX) to care after HTX, we reviewed 22 patients with refractory heart failure aged less than 60 years who had been observed for the past 6 years. Sixteen patients had dilated cardiomyopathy; 1, dilated hypertrophic cardiomyopathy; 3, re...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Nunoda S,Kurosawa R,Kogashi K,Yamagishi S,Mitsui F,Funabashi W

    更新日期:1997-01-01 00:00:00

  • Effects of a new thromboxane A2-antagonist (ONO-3708) and a new leukotriene-antagonist (ONO-1078) on thromboxane A2 analogue-, leukotriene C4-, and D4-induced regional myocardial blood flow reduction.

    abstract::Effects of the administration of a thromboxane A2 (TXA2) analogue (STA2), a leukotriene C4 (LTC4), and a leukotriene D4 (LTD4) on regional myocardial blood flow (RMBF) and hemodynamics were studied in anesthetized, open-chest dogs. The blocking ability of a recently synthesized TXA2 selective antagonist, ONO-3708, and...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Torii T,Toki Y,Hieda N,Ito Y,Okumura K,Hashimoto H,Ito T,Ogawa K,Satake T

    更新日期:1988-01-01 00:00:00

  • Hypocellularity and insufficient expression of angiogenic factors in implanted autologous bone marrow in patients with chronic critical limb ischemia.

    abstract::The aim of this study was to identify the clinical parameters of absolutely poor-prognosis patients with chronic critical limb ischemia (AP-CLI). Sixteen no-option CLI patients with arteriosclerosis obliterans: ASO (nine) and non-ASO patients (seven) treated with bone marrow-mononuclear cell implantation (BMI) were an...

    journal_title:Heart and vessels

    pub_type: 临床试验,杂志文章


    authors: Oda M,Toba K,Kato K,Ozawa T,Yanagawa T,Ikarashi N,Takayama T,Suzuki T,Hanawa H,Masuko M,Kobayashi H,Aizawa Y

    更新日期:2012-01-01 00:00:00

  • Is the coronary flow velocity reserve improvement after aortic valve replacement for aortic stenosis transient? Results of a 3-year follow-up.

    abstract::The coronary flow velocity reserve (CFR) is decreased in patients with aortic valve stenosis (AS). The aim of the present prospective study was to examine the CFR in AS patients with normal epicardial coronary arteries during a 3-year follow-up of aortic valve replacement (AVR). A total of 30 AS patients (17 women and...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Nemes A,Forster T,Kovács Z,Csanády M

    更新日期:2006-05-01 00:00:00

  • Higher visit-to-visit intra-dialytic blood pressure is associated with the progression of aortic valve stenosis in chronic hemodialysis patients.

    abstract::Aortic valve stenosis (AS) is a frequent complication contributing to poor prognosis in chronic hemodialysis (CHD) patients. High blood pressure (BP) is known to be associated with AS progression in the general population. In CHD patients, however, BP varies during and between hemodialysis sessions with ultrafiltratio...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Norioka N,Iwata S,Yanagi S,Ishii H,Sugioka K,Kamimori K,Ota T,Di Tullio MR,Homma S,Yoshiyama M

    更新日期:2016-09-01 00:00:00

  • The potential of cardiac rehabilitation as a method of suppressing abdominal aortic aneurysm expansion: a pilot study.

    abstract::This study is a prospective evaluation of the effectiveness of cardiac rehabilitation (CR) in terms of clinical outcomes for small abdominal aortic aneurysms (AAA) that were previously reported in a retrospective cohort study. We conducted a prospective non-randomized trial on patients with small AAA (N = 40; mean age...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Nakayama A,Amiya E,Morita H,Hyodo K,Takayama N,Konishi Y,Taya M,Fujiwara T,Hosoya Y,Hoshina K,Komuro I

    更新日期:2019-12-01 00:00:00

  • Ibutilide protects against cardiomyocytes injury via inhibiting endoplasmic reticulum and mitochondrial stress pathways.

    abstract::Atrial fibrillation (AF) is a complex disease with multiple inter-relating causes culminating in rapid atrial activation and atrial structural remodeling. The contribution of endoplasmic reticulum and mitochondria stress to AF has been highlighted. As the class III antiarrhythmic agent, ibutilide are widely used to AF...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Wang Y,Wang YL,Huang X,Yang Y,Zhao YJ,Wei CX,Zhao M

    更新日期:2017-02-01 00:00:00

  • Aldosterone induces circadian gene expression of clock genes in H9c2 cardiomyoblasts.

    abstract::We examined mRNA expression of the clock genes (Per1, Per2, and Bmal1) and PAI-1 (plasminogen activator inhibitor-1) after aldosterone treatment every 4 h up to 48 h in H9c2 cardiomyoblasts by reverse transcription-polymerase chain reaction. To block the MR (mineralocorticoid receptor), the MR antagonist, spironolacto...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Tanaka K,Ashizawa N,Kawano H,Sato O,Seto S,Nishihara E,Terazono H,Isomoto S,Shinohara K,Yano K

    更新日期:2007-07-01 00:00:00

  • Aortic annulus angulation does not attenuate procedural success of transcatheter aortic valve replacement using a novel self-expanding bioprosthesis.

    abstract::The objectives of the study were to evaluate the impact of aortic angulation (AA) on success of transcatheter aortic valve replacement (TAVR) with a new generation self-expandable prosthesis (Medtronic Evolut R®). Specific anatomical conditions, such as for example the presence of a horizontal aorta with elevated AA, ...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: D'Ancona G,Kische S,El-Mawardy M,Dißmann M,Heinze H,Zohlnhöfer-Momm D,Gürer H,Ince H

    更新日期:2019-12-01 00:00:00

  • Reverse translational analysis of clinically reported, lamotrigine-induced cardiovascular adverse events using the halothane-anesthetized dogs.

    abstract::Lamotrigine has been used for patients with epilepsy and/or bipolar disorder, overdose of which induced the hypotension, elevation of the atrial pacing threshold, cardiac conduction delay, wide complex tachycardia, cardiac arrest and Brugada-like electrocardiographic pattern. To clarify how lamotrigine induces those c...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Goto A,Hagiwara-Nagasawa M,Kambayashi R,Nunoi Y,Izumi-Nakaseko H,Kawai S,Takei Y,Matsumoto A,Sugiyama A

    更新日期:2020-11-02 00:00:00

  • Long-term effects of AST-120 on the progression and prognosis of pre-dialysis chronic kidney disease: a 5-year retrospective study.

    abstract::AST-120 has been used widely in Japan to slow the deterioration of renal function in patients with chronic kidney disease (CKD) by decreasing uremic toxins. The heart and the kidney are closely related, with cardiorenal interaction being very important. This retrospective study examined whether AST-120 influences the ...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Sato E,Tanaka A,Oyama J,Yamasaki A,Shimomura M,Hiwatashi A,Ueda Y,Amaha M,Nomura M,Matsumura D,Nakamura T,Node K

    更新日期:2016-10-01 00:00:00

  • Diagnostic value of electrocardiographic P-wave characteristics in atrial fibrillation recurrence and tachycardia-induced cardiomyopathy after catheter ablation.

    abstract::Abnormal P-wave characteristics were reportedly associated with left ventricular interstitial fibrosis as defined by cardiac magnetic resonance images. The objective of this study is to investigate the utility of P-wave characteristics to predict atrial fibrillation (AF) recurrence and the recovery of left ventricular...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Doi A,Takagi M,Katayama H,Yoshiyama T,Hayashi Y,Tatsumi H,Yoshiyama M

    更新日期:2018-11-01 00:00:00

  • Clinicopathological study of myocardial infarction with normal or nearly normal extracardiac coronary arteries. Quantitative analysis of contraction band necrosis, coagulation necrosis, hemorrhage, and infarct size.

    abstract::In order to clarify the pathogenesis of acute myocardial infarction (MI) in hearts with normal coronary arteries, infarct size, and the extent of contraction band necrosis (CBN), coagulation necrosis, and hemorrhage were quantitatively examined using an image analyzer in 5 autopsy cases of MI with normal or nearly nor...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Wu DJ,Fujiwara H,Matsuda M,Ishida M,Kawamura A,Takemura G,Kida M,Uegaito T,Fujiwara T,Kawai C

    更新日期:1990-01-01 00:00:00

  • Takotsubo-shaped cardiomyopathy with type I CD36 deficiency.

    abstract::A transient left ventricular apical ballooning (so-called "ampulla" or "Takotsubo-shaped" cardiomyopathy) with type I CD36 deficiency is described in a 71-year-old woman. The patient was referred because of chest pain and worsening of dyspnea. Electrocardiogram showed T-wave inversions on the precordal leads, and acut...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Kushiro T,Saito F,Kusama J,Takahashi H,Imazeki T,Tani S,Kikuchi S,Imai S,Matsudaira K,Watanabe I,Hino T,Sato Y,Nakayama T,Nagao K,Kanmatsuse K

    更新日期:2005-05-01 00:00:00

  • Aortic artery distensibility shows inverse correlation with heart rate variability in elderly non-hypertensive, cardiovascular disease-free individuals: the Ikaria Study.

    abstract::The aim of this study was to evaluate the relation between aortic artery distensibility, expressed by pulse pressure (PP) and autonomic nervous system function expressed by heart rate variability (HRV), among elders. During 2009, 469 individuals (50 % males, mean age 75 ± 6 years old), permanent inhabitants of Ikaria ...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Chrysohoou C,Skoumas J,Oikonomou E,Tsiachris D,Metaxa V,Lagoudakou S,Felekos J,Masoura C,Athanassopoulou S,Kosyfa H,Pitsavos C,Stefanadis C

    更新日期:2013-07-01 00:00:00

  • Body mass index is associated with prognosis in Japanese elderly patients with atrial fibrillation: an observational study from the outpatient clinic.

    abstract::The relationship between body mass index (BMI) and the prognosis of elderly patients with atrial fibrillation (AF) is unknown. We aimed to examine the association of body weight with the clinical outcomes among Japanese elderly patients with a history of documented AF. This observational study of AF patients from an o...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Yanagisawa S,Inden Y,Yoshida N,Kato H,Miyoshi-Fujii A,Mizutani Y,Ito T,Kamikubo Y,Kanzaki Y,Hirai M,Murohara T

    更新日期:2016-09-01 00:00:00

  • Effect of serum uric acid on the positive predictive value of dobutamine stress echocardiography.

    abstract::There is controversial data regarding the relationship between uric acid (UA) and coronary artery disease and cardiovascular events. Despite the deleterious effects of hyperuricemia on endothelial function, the effect of UA on myocardial ischemia has not been previously studied. We aimed to investigate the relationshi...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Aribas A,Akilli H,Kayrak M,Alibasic H,Yildirim O,Sertdemir AL,Karanfil M,Ozdemir K

    更新日期:2016-03-01 00:00:00

  • Preprocedural valvuloarterial impedance as a predictor of left ventricular ejection fraction improvement after transcatheter aortic valve replacement in patients with reduced left ventricular ejection fraction.

    abstract:BACKGROUND:Predictors of left ventricular ejection fraction (LVEF) improvement after transcatheter aortic valve replacement (TAVR) in patients with a preoperative reduced LVEF are limited. OBJECTIVES:This study aimed to investigate the relationship between preprocedural valuvuloarterial impedance (ZVa), which represen...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Komatsu I,Hart C,Lau J,Spies C

    更新日期:2020-09-01 00:00:00