Abstract:
:Left ventricular (LV) dilatation following myocardial infarction (MI) is a major determinant of the patient's prognosis, and myocardial energy metabolism may play a key role in LV remodeling. We aimed to investigate the relative timing of LV dilatation to LV function, myocardial energy regulation by uncoupling protein (UCP)-2, and cellular damage in the noninfarct zone. Myocardial infarction was produced in Sprague-Dawley rats by ligation of the coronary artery. The LV end-diastolic dimension (mm) increased (8.9+/-0.3 vs 6.8+/-0.8 in sham-operated rats, P<0.01) in association with elevation of the LV end-diastolic pressure (mmHg) (18+/-5 vs 6+/-2 in sham-operated rats) at 1 week following the ligation. At 4 weeks, the UCP-2 expression (180% of that in sham-operated rats) and LV end-diastolic dimension increased further (11.1+/-0.5, P<0.01) but there was no change in the LV end-diastolic pressure. The mechanisms for LV dilatation were quite different between the early and late stages after MI. In the late stage, augmentation of UCP-2 expression in the noninfarct zone may be related to the LV dilatation. Further examinations regarding the possibility of the protective role of UCP-2 are needed.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Guo P,Mizushige K,Noma T,Murakami K,Namba T,Ishizawa M,Tsuji T,Kimura S,Kohno Mdoi
10.1007/s00380-004-0805-5subject
Has Abstractpub_date
2005-03-01 00:00:00pages
61-5issue
2eissn
0910-8327issn
1615-2573journal_volume
20pub_type
杂志文章abstract::Amiodarone is a highly effective antiarrhythmic agent. Unfortunately amiodarone-induced pulmonary toxicity is described for medium-long term therapy. We describe a case of a 65-year-old man admitted to our department for breathlessness and with a history of recurrent episodes of atrial fibrillation for which he had be...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0487-6
更新日期:2015-05-01 00:00:00
abstract::This study is a prospective evaluation of the effectiveness of cardiac rehabilitation (CR) in terms of clinical outcomes for small abdominal aortic aneurysms (AAA) that were previously reported in a retrospective cohort study. We conducted a prospective non-randomized trial on patients with small AAA (N = 40; mean age...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01441-x
更新日期:2019-12-01 00:00:00
abstract::Normoxic isolated rat hearts were perfused for 30 or 60 min with Krebs-Henseleit bicarbonate buffer (KHB) (in which the Pi concentration was adjusted to 0, 1.2, 2.4, or 10 mM) in both the presence and the absence of glucose as exogenous substrate. Functional performance and coronary flow were monitored throughout the ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058588
更新日期:1988-01-01 00:00:00
abstract::Extensive arterial grafting (Art-CABG) in the elderly is still questioned due to the reduced life expectancy and the supposed higher periprocedural risk. Reports further demonstrated accelerated atherosclerosis of arterial grafts in the elderly, with hampered short-term and long-term results. We reviewed our experienc...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-008-1055-8
更新日期:2008-09-01 00:00:00
abstract::Mechanical alternans (MA) is frequently observed in patients with heart failure, and is a predictor of cardiac events. However, there have been controversies regarding the conditions and mechanisms of MA. To clarify heart rate-dependent contractile properties related to MA, we performed incremental right atrial pacing...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-012-0251-8
更新日期:2013-05-01 00:00:00
abstract::In the present study, we investigated whether gallic acid (GA) can induce death in cultured vascular smooth muscle cells (VSMCs), and whether production of the hydroxyl radical (.OH) is involved in the process of GA action. GA killed cultured VSMCs from rat aorta, in a dosc- and time-dependent manner. Cytoplasmic shri...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s003800070038
更新日期:2000-01-01 00:00:00
abstract::An unusual case of total occlusion of aorta just distal to the left subclavian artery, bicuspid aortic valve, and occluded left external iliac artery in a 21-year-old man who was admitted with headache and severe hypertension is presented. We wish to report this case because so far there have been none reported with s...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0947-8
更新日期:2007-03-01 00:00:00
abstract::The purpose of this study was to evaluate the surgical results of papillary muscle approximation (PMA) and papillary muscle relocation (PMR) for functional mitral regurgitation (FMR) and to compare the effects of both procedures on the change in mitral regurgitation (MR) and echocardiogram parameters associated with t...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-1038-8
更新日期:2018-01-01 00:00:00
abstract::While recent guidelines for the treatment of acute heart failure syndromes (AHFS) recommend pharmacotherapy with vasodilators in patients without excessively low blood pressure (BP), few reports have compared the relative efficiency of vasodilators on hemodynamics in AHFS patients. The present study aimed to assess th...
journal_title:Heart and vessels
pub_type: 临床试验,杂志文章
doi:10.1007/s00380-012-0252-7
更新日期:2013-05-01 00:00:00
abstract::We have theoretically proposed "systolic pressure-volume area" (PVA) as a measure of total mechanical energy generated by ventricular contraction. We then experimentally showed that PVA closely correlates with left ventricular oxygen consumption (Vo2) regardless of ventricular loading conditions in a stable contractil...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058751
更新日期:1991-01-01 00:00:00
abstract::Levels of testosterone and estradiol influence the incidence of cardiovascular diseases: generally, estrogens in females are protective before menopause; coronaropathies, hypertension, and dyslipidemias in normal men are more frequent at comparable ages. We investigated the modulation by castration of in vitro vasorea...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-008-1098-x
更新日期:2009-03-01 00:00:00
abstract::Resting bradycardia is an important symptom for early diagnosis of anorexia nervosa (AN) during weight loss, and it improves with body-weight recovery. However, chronotropic incompetence (CI) in exercise is observed in some patients with AN despite amelioration of resting bradycardia in the recovery phase. We examined...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1282-6
更新日期:2019-04-01 00:00:00
abstract::Cerebral artery stenosis (CAS) has the same pathogenesis as coronary artery disease (CAD), but the coexistence of these two diseases has been rarely reported. To detect coexistent CAS in CAD patients, we conducted a study of simultaneous coronary and cerebral angiography. Of the 663 consecutive newly diagnosed CAD pat...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0971-8
更新日期:2007-09-01 00:00:00
abstract::Radiofrequency catheter ablation of an atrial tachycardia (AT) and atrial fibrillation (AF) was performed in a patient with a history of pulmonary vein isolation for paroxysmal AF. The AT exhibited a centrifugal pattern with the posterolateral LA as the earliest activation site. The AT was not terminated by ablation a...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0498-3
更新日期:2015-05-01 00:00:00
abstract::Subclavian artery stenosis can cause a flow reversal-so-called steal-not only in the ipsilateral vertebral artery, but also in the internal mammary artery in patients with a history of coronary-artery bypass grafting. Subclavian artery stenosis is also associated with peripheral artery disease elsewhere. We report a n...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0821-2
更新日期:2016-11-01 00:00:00
abstract::Myocardial ischemia leads to the activation of neutrophils as well as endothelial cells. The interaction between these cells is dependent on certain adhesion glycoproteins which are expressed on their surface. Adhesion of neutrophils to endothelium, mediated by adhesion molecules, has been shown to result in coronary ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01745043
更新日期:1998-01-01 00:00:00
abstract::A 53-year-old woman with end-stage renal disease and hypertension, who had received regular artificial hemodialysis for 10 years, has been treated with candesartan in a dose of 8 mg/day against her hypertension, but premature ventricular contractions were often observed during the hemodialysis. QT interval was 445 ms ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0865-3
更新日期:2017-01-01 00:00:00
abstract::Inflammatory markers are elevated in acute coronary syndromes, and are also known to play a crucial role in the pathogenesis of neointimal proliferation and stent restenosis. Drug-eluting stents (DESs) have been shown to decrease stent restenosis in different studies. In this study, we aimed to investigate the effect ...
journal_title:Heart and vessels
pub_type: 临床试验,杂志文章
doi:10.1007/s00380-007-1020-y
更新日期:2008-03-01 00:00:00
abstract::The effect of intravenous enoximone on forearm venous circulation was studied in ten healthy volunteers (group A) and in ten patients with NYHA class III-IV congestive heart failure (group B). Distensibility of the forearm capacitance vessels was assessed from pressure-volume curves by venous occlusion plethysmography...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058791
更新日期:1987-01-01 00:00:00
abstract::It is well known the relationship between oxidative stress and vascular function. However, association between total antioxidative capacity and arterial stiffness was not studied in patients with hypertension (HT). This study investigated whether total antioxidative capacity is associated with arterial stiffness and w...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-008-1129-7
更新日期:2009-09-01 00:00:00
abstract::Several coronary angiographic studies have reported that enlarged and tortuous epicardial coronary arteries are characteristic of patients with left ventricular concentric hypertrophy (LVCH). Recently, we showed that small volumes opacified by contrast medium can be accurately measured by 64-multislice computed tomogr...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-011-0230-5
更新日期:2013-03-01 00:00:00
abstract::Drug-eluting stents reduce restenosis due to neointimal growth suppression. Considering long-term outcomes, it is both difficult and important to predict drug-eluting stent restenosis. Thus, this study was designed to examine the utility of myocardial fractional flow reserve (FFR) as a predictor of sirolimus-eluting s...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-010-0105-1
更新日期:2011-11-01 00:00:00
abstract::The effects of nifedipine on regional dysfunction during pacing-induced ischemia were studied in eight patients with coronary artery disease. Single-plane left ventriculograms were obtained using a high-fidelity micromanometer-tipped catheter in the control and post-pacing periods both before and after pretreatment wi...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02073655
更新日期:1985-11-01 00:00:00
abstract::Raising high-density lipoprotein cholesterol (HDL-C) is an important strategy for reducing residual cardiovascular risk. In the present study, we sought to assess the effect of extended-release niacin/laropiprant on endothelial function in patients after a myocardial infarction with target low-density lipoprotein chol...
journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-013-0367-5
更新日期:2014-05-01 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) increases coronary artery disease (CAD) risk. In this study, we used T2DM clinical variables to predict abnormality in thallium-201 myocardial perfusion scans (Th-201 scans). These clinical variables were summed stress score (SSS), summed rest score, and summed difference score (SDS), w...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01681-2
更新日期:2020-08-20 00:00:00
abstract::Soluble urokinase-type plasminogen activator receptor (suPAR) is a membrane-binding protein that is released into the blood stream by immune activation. Recent reports suggest that circulating suPAR levels are associated with adverse cardiovascular outcomes. Exercise tolerance is an independent predictor of prognosis ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01538-3
更新日期:2020-05-01 00:00:00
abstract::Contrast echocardiography with sonicated radiographic contrast agents has been used for the qualitative and quantitative determination of myocardial blood flow. One major problem has been the size of the microbubbles since only bubbles smaller than 8 microns are expected to pass the capillary bed and larger bubbles ma...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01744500
更新日期:1995-01-01 00:00:00
abstract::This study aimed to examine whether alpha-human atrial natriuretic peptide (alpha-hANP) alters cardiac dimensions in humans. Left atrial (LA) and left ventricular diastolic (LV) diameters were measured by echocardiography at control and with lower body negative pressure (LBNP) at -10 and -20 mmHg during intravenous (I...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058323
更新日期:1990-01-01 00:00:00
abstract::Based on the unique property of fluorine-18 fluorodeoxyglucose, localization and follow-up of hypermetabolic processes is possible with positron emission tomography (PET). The dual-modality PET/computed tomography (CT) systems provide intrinsically fused morphologic and functional data in a single examination. We repo...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-004-0808-2
更新日期:2005-07-01 00:00:00
abstract::Although drug-eluting stents (DES) for percutaneous coronary intervention (PCI) have dramatically reduced the incidence of in-stent restenosis, their deployment for large-size coronary lesions is still controversial because of problems such as late in-stent thrombosis and late catch-up in DES. We aimed to evaluate the...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0655-3
更新日期:2016-05-01 00:00:00