Gallic acid induces vascular smooth muscle cell death via hydroxyl radical production.

Abstract:

:In the present study, we investigated whether gallic acid (GA) can induce death in cultured vascular smooth muscle cells (VSMCs), and whether production of the hydroxyl radical (.OH) is involved in the process of GA action. GA killed cultured VSMCs from rat aorta, in a dosc- and time-dependent manner. Cytoplasmic shrinkage and nuclear condensation were observed light microscopically in GA-treated VSMCs, which appeared apoptotic. However, the ultrastructure of the VSMC was not typical of apoptosis: nuclear condensation was not glossy, and the plasma membrane and subccellular organelles were disrupted. Although the VSMC were positive for in situ nick end-labeling (TUNEL). they did not show a DNA ladder pattern on gel electrophoresis and were negative for T aq polymerase-based in situ ligation, which is more specific for apoptosis than TUNEL. Moreover. GA-induced cell death was not prevented by Boc-Asp-fmk (a pan-caspase inhibitor). Production of OH was detected in GA-treated VSMCs using high-performance liquid chromatography with salicylic acid as a trapping agent. Lipid peroxidation was also observed. The production of .OH was inhibited by catalase (CAT) and deferoxamine (DFX), and these treatments completely rescued VSMCs from cell death. In a cell-free system, GA produced .OH in the presence of Fe2+-EDTA, which was quenched by CAT and DFX, suggesting involvement of the Haber-Weiss reaction. Oxidative stress by reactive oxygen species, .OH in particular, is one of the mechanisms of GA-induced death of VSMCs, the mode of which was different from typical apoptosis.

journal_name

Heart Vessels

journal_title

Heart and vessels

authors

Qiu X,Takemura G,Koshiji M,Hayakawa Y,Kanoh M,Maruyama R,Ohno Y,Minatoguchi S,Akao S,Fukuda K,Fujiwara T,Fujiwara H

doi

10.1007/s003800070038

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

90-9

issue

2

eissn

0910-8327

issn

1615-2573

journal_volume

15

pub_type

杂志文章
  • Comparison of first- and second-generation drug-eluting stent efficacies for treating left main and/or three-vessel disease: a propensity matched study.

    abstract::The efficacy of second-generation drug-eluting stent (DES) for the treatment of left main disease (LM) and/or three vessel disease (3VD) remains unclear. We compared 2-year outcomes of second- versus first -generation DES implantation among patients with LM and/or 3VD and to assess the differential of risk by complexi...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-016-0824-z

    authors: Kobayashi N,Ito Y,Hirano K,Yamawaki M,Araki M,Sakai T,Takimura H,Sakamoto Y,Mori S,Tsutsumi M,Takama T,Takafuji H,Maruyama T,Honda Y,Tokuda T,Makino K,Shirai S,Muramatsu T

    更新日期:2016-12-01 00:00:00

  • Aberrant right coronary artery occlusion during the percutaneous pulmonary trunk stenting in a patient with tetralogy of Fallot.

    abstract::Aberrant coronary arteries are frequently observed in patients presenting with Fallot's tetralogy (TOF). Before the complete surgical repair of the TOF, the percutaneously performed pulmonary trunk (PT) angioplasty is often performed in order to temporarily increase the pulmonary circulation, thus increasing the pulmo...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-007-1023-8

    authors: Perret X,Bonvini RF,Aggoun Y,Verin V

    更新日期:2008-03-01 00:00:00

  • Altered myocardial acetylcholine and norepinephrine concentrations in right ventricular hypertrophy and failure.

    abstract::The progression of cardiac hypertrophy and failure is associated with marked changes in cardiac autonomic innervation, and there are sympathetic-parasympathetic interactions in the regulation of cardiac function. Although the indexes of sympathetic innervation have been found to be depressed with the development of he...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02058280

    authors: Yamada Y,Okumura K,Hashimoto H,Ito T,Satake T

    更新日期:1991-01-01 00:00:00

  • Ketamine and midazolam differently impact post-intubation hemodynamic profile when used as induction agents during emergency airway management in hemodynamically stable patients with ST elevation myocardial infarction.

    abstract::We investigated the incidence of post-intubation hypotension (PIH) in hemodynamically stable patients with STEMI requiring rapid sequences intubation (RSI) and medicated with ketamine or midazolam as induction agent. STEMI patients admitted between 1st January 2009 and 1st January 2017 who did not receive any type of ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-017-1049-5

    authors: Zuin M,Rigatelli G,Dell'Avvocata F,Faggian G,Conte L,Giatti S,Michielan F,Roncon L

    更新日期:2018-03-01 00:00:00

  • Increased release of the soluble form of the adhesion molecules L-selectin and ICAM-1 but not E-selectin during attacks of angina pectoris.

    abstract::Myocardial ischemia leads to the activation of neutrophils as well as endothelial cells. The interaction between these cells is dependent on certain adhesion glycoproteins which are expressed on their surface. Adhesion of neutrophils to endothelium, mediated by adhesion molecules, has been shown to result in coronary ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF01745043

    authors: Siminiak T,Smielecki J,Dye JF,Baliñski M,El-Gendi H,Wysocki H,Sheridan DJ

    更新日期:1998-01-01 00:00:00

  • Feasibility and safety of outpatient cardiac catheterization with intracoronary acetylcholine provocation test.

    abstract::Intracoronary acetylcholine (ACh) provocation test is useful to diagnose vasospastic angina. Although outpatient coronary angiography has been widely performed in current clinical settings, the feasibility and safety of ACh provocation test in outpatient services are unclear. A total of 323 patients, who electively un...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-018-1139-z

    authors: Saito Y,Kitahara H,Shoji T,Tokimasa S,Nakayama T,Sugimoto K,Fujimoto Y,Kobayashi Y

    更新日期:2018-08-01 00:00:00

  • Diverse inotropic effects of 5-hydroxytryptamine in heart muscles of various mammalian species.

    abstract::The inotropic effects of 5-hydroxytryptamine (5-HT) on mammalian heart muscles were investigated. 5-HT (10(-8)-10(-3)M) produced increases in the contractile tension of atrial and ventricular muscles isolated from guinea pigs, Japanese monkeys, and humans, but not in rat heart preparations. The maximum percent increas...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF01744594

    authors: Zaizen H,Imanishi S,Nasu M,Arita M

    更新日期:1996-01-01 00:00:00

  • Changes of echocardiographic parameters in primary mitral regurgitation and determinants of symptom: an assessment from the Asian Valve Registry data.

    abstract::Clinicians often have a difficulty in determining the presence of mitral regurgitation (MR)-related symptoms because of subjectivity. However, there are few actual measurement data for echocardiographic left ventricular (LV) and left atrial (LA) size related to the severity of MR and the relationship between MR-relate...

    journal_title:Heart and vessels

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00380-019-01514-x

    authors: Amano M,Izumi C,Kim YJ,Park SJ,Park SW,Tanaka H,Hozumi T,Ling LH,Yu CM,Fukuda S,Otsuji Y,Song JK,Sohn DW

    更新日期:2020-04-01 00:00:00

  • Association between sarcopenia and atherosclerosis in elderly patients with ischemic heart disease.

    abstract::Compared to the general population, elderly patients with cardiovascular disease have a higher prevalence of sarcopenia, and it shows an association with increased mortality risk. Although several studies have indicated that atherosclerosis may cause sarcopenia in community dwelling elderly subjects, the association b...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-020-01554-8

    authors: Uchida S,Kamiya K,Hamazaki N,Matsuzawa R,Nozaki K,Ichikawa T,Suzuki Y,Nakamura T,Yamashita M,Kariya H,Maekawa E,Yamaoka-Tojo M,Matsunaga A,Ako J

    更新日期:2020-06-01 00:00:00

  • Downregulation of miR-34a promotes endothelial cell growth and suppresses apoptosis in atherosclerosis by regulating Bcl-2.

    abstract::Several miRNAs have been demonstrated to be involved in endothelial dysfunction during atherosclerosis (AS). However, the detailed roles and underlying mechanisms of miR-34a in AS-associated endothelial cell apoptosis are far from being addressed. Apolipoprotein E-deficient (ApoE-/-) mice fed with high-fat diet (HFD) ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-018-1169-6

    authors: Su G,Sun G,Liu H,Shu L,Liang Z

    更新日期:2018-10-01 00:00:00

  • Short- and long-term benefits of drug-eluting stents compared to bare metal stents even in treatment for large coronary arteries.

    abstract::Although drug-eluting stents (DES) for percutaneous coronary intervention (PCI) have dramatically reduced the incidence of in-stent restenosis, their deployment for large-size coronary lesions is still controversial because of problems such as late in-stent thrombosis and late catch-up in DES. We aimed to evaluate the...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-015-0655-3

    authors: Yoshida T,Sakata K,Nitta Y,Taguchi T,Kaku B,Katsuda S,Shimojima M,Gamou T,Nakahashi T,Konno T,Kawashiri MA,Yamagishi M,Hayashi K

    更新日期:2016-05-01 00:00:00

  • Analysis of 10-year nationwide population-based data on sex differences in hospitalization for heart failure.

    abstract::Sex-related factors play an important role in the pathophysiology of heart failure (HF). However, trends in sex-related differences in hospital management for HF are not clear. We identified patients hospitalized for HF through a nationwide database (National Health Insurance in Taiwan), containing 722,272 subjects fr...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-012-0299-5

    authors: Yang HY,Chiu WC,Huang JH,Hsu CY,Lin YK,Chen YJ

    更新日期:2013-11-01 00:00:00

  • Immunological features in a case of hypereosinophilic syndrome and myocarditis.

    abstract::The clinical and immunological follow-up of a 38-year-old female patient with hypereosinophilic syndrome and classical cardiac involvement, but without demonstrable degranulation of eosinophils and lacking binding of a specific antibody for activated eosinophils, is presented. Instead, the patient demonstrated all the...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02058696

    authors: Maisch B,Drude L,Kochsiek K

    更新日期:1990-01-01 00:00:00

  • Side-by-side false and true lumen stenting for recanalization of the chronically occluded right coronary artery.

    abstract::Subintimal or false lumen stent deployment is a rare complication of percutaneous coronary interventions. The most balloon-induced small non-flow limiting dissections heal spontaneously and can be treated medically with close observation if distal coronary flow is not compromised. However, the complex and severe flow-...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-008-1052-y

    authors: Omurlu K,Ozeke O

    更新日期:2008-07-01 00:00:00

  • Prosthetic valve visualization by cine-computed tomography: a case report.

    abstract::The use of cine-computed tomography scanning is described in evaluating cardiac function in a patient with a bileaflet mitral valve prosthesis (St. Jude medical valve) and in a second patient with both mitral and aortic bileaflet prostheses. Both biventricular and prosthesis function were assessed successfully. ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02058316

    authors: Wachspress JD,Untereker WJ,Kraushaar BT

    更新日期:1987-01-01 00:00:00

  • Successful repair of a large aortic abscess causing apical displacement of the anterior mitral valve.

    abstract::Anatomic continuity between the anterior mitral leaflet and the aortic root may predispose those patients with aortic root pathology to functional changes of the mitral valve without any involvement of this valve. A 34-year-old man presented with aortic valve endocarditis. Transthoracic echocardiograpy showed severe a...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-004-0761-0

    authors: Gunay I,Mert M,Kucukoglu S,Ozkan AA,Okcun B

    更新日期:2005-02-01 00:00:00

  • Measurement of aortic diameters and detection of asymptomatic aortic aneurysms in a mass screening program using a mobile helical computed tomography unit.

    abstract::In a mass chest computed tomography (CT) screening using a mobile helical CT unit, we measured the aortic diameter at three segments to confirm standard values and also attempted to detect any asymptomatic aortic aneurysms. The population screened in the present study consisted of 6971 subjects (3847 men and 3124 wome...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s380-002-8315-1

    authors: Itani Y,Watanabe S,Masuda Y,Hanamura K,Asakura K,Sone S,Sunami Y,Miyamoto T

    更新日期:2002-01-01 00:00:00

  • Taurine prevents myocardial ischemia/reperfusion-induced oxidative stress and apoptosis in prolonged hypothermic rat heart preservation.

    abstract::Taurine (2-aminoethanesulfonic acid) is a potent antioxidant and inhibits cell apoptosis in ischemic reperfusion injury. In this study we evaluated whether addition of taurine to St. Thomas' cardioplegic solution enhances its myocardial protective effects in prolonged hypothermic heart preservation in rats. Hearts iso...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-005-0841-9

    authors: Oriyanhan W,Yamazaki K,Miwa S,Takaba K,Ikeda T,Komeda M

    更新日期:2005-11-01 00:00:00

  • Echocardiographic surrogates of right atrial pressure in pulmonary hypertension.

    abstract::Right atrial pressure (RAP), a representative parameter of right heart failure, is very important for prognostic evaluation and risk assessment in pulmonary hypertension. However, its measurement requires invasive cardiac catheterization. In this study, we determined the most accurate echocardiographic surrogate of ca...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-018-1264-8

    authors: Watanabe R,Amano H,Saito F,Toyoda S,Sakuma M,Abe S,Nakajima T,Inoue T

    更新日期:2019-03-01 00:00:00

  • Factors related to in-hospital heart failure are very different for unstable angina and non-ST elevation myocardial infarction.

    abstract::Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) resulted in different degrees of damage to the heart muscle, and yet, when factors related to in-hospital outcomes were examined, these two subsets were often lumped together as non-STelevation acute coronary syndrome. Therefore, we investigated ...

    journal_title:Heart and vessels

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00380-008-1141-y

    authors: Saejueng B,Yipintsoi T,Chaisuksuwan R,Kehasukcharoen W,Boonsom W,Kanjanavanit R,Thai ACS-Registry group.

    更新日期:2009-11-01 00:00:00

  • Low-dose nesiritide improves renal function in heart failure patients following acute myocardial infarction.

    abstract::This study was designed to investigate the effect of low-dose nesiritide on renal function and major cardiac events in patients with acute decompensated heart failure following acute myocardial infarction. Sixty patients were randomized into nesiritide (loading dose 0.5 microg/kg, maintenance dose 0.0075 microg/kg/min...

    journal_title:Heart and vessels

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00380-009-1171-0

    authors: Zhao Q,Wu TG,Lin Y,Li B,Luo JY,Wang LX

    更新日期:2010-03-01 00:00:00

  • Castration modifies aortic vasoreactivity and serum fatty acids in a sucrose-fed rat model of metabolic syndrome.

    abstract::Levels of testosterone and estradiol influence the incidence of cardiovascular diseases: generally, estrogens in females are protective before menopause; coronaropathies, hypertension, and dyslipidemias in normal men are more frequent at comparable ages. We investigated the modulation by castration of in vitro vasorea...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-008-1098-x

    authors: Perez I,El Hafidi M,Carvajal K,Baños G

    更新日期:2009-03-01 00:00:00

  • Hydrodynamics in the heart modulates work.

    abstract::The hydrostatic pressure (perfusion pressure) of the isovolumic isolated perfused rat heart regulated the hydrodynamics (water movement) of the myocardium. An abrupt (10 s) decrease in hydrostatic pressure caused an immediate decrease in oxygen consumption, left ventricular developed pressure, and wall thickness. Wall...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02058424

    authors: Watters TA,Bouchard A,Wu ST,Parmley WW,Wikman-Coffelt J

    更新日期:1988-01-01 00:00:00

  • Age-related decline of PCr/ATP-ratio in progressively hypertrophied hearts of spontaneously hypertensive rats.

    abstract::Although the ultimate cause for the myocardial dysfunction of hypertensive heart disease is still unclear, a crucial role of the myocardial energy metabolism has been suggested. Therefore, the aim of the present study was to investigate whether age-related myocardial dysfunction in hearts of spontaneously hypertensive...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/pl00007270

    authors: Perings SM,Schulze K,Decking U,Kelm M,Strauer BE

    更新日期:2000-01-01 00:00:00

  • An adult case of Bland-White-Garland syndrome with collaterals from the bronchial artery.

    abstract::We report herein an adult case of anomalous origin of the left coronary artery from the pulmonary artery (Bland-White-Garland syndrome; BWG syndrome). The patient had chest discomfort during exercise and signs of mitral regurgitation. We diagnosed him as having BWG syndrome by angiography, and performed surgical treat...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF01746067

    authors: Ishihata T,Takeda H,Katohno E,Techigawara M,Owada K,Murata N,Ohta H,Maruyama Y

    更新日期:1994-01-01 00:00:00

  • Increased C-reactive protein is associated with future development of diabetes mellitus in essential hypertensive patients.

    abstract::Coexistence of hypertension and diabetes mellitus (DM) increases the risk of cardiovascular disease. However, factors associated with future development of DM have not been well elucidated in patients already having essential hypertension. This study prospectively included 168 patients (mean age 41 +/- 7 years, 112 me...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-009-1218-2

    authors: Weng CM,Chou CH,Huang YY,Lin CC,Liu YW,Tsai WC

    更新日期:2010-09-01 00:00:00

  • Utility of measuring C-reactive protein for prediction of in-hospital events in patients with acute aortic dissection.

    abstract::Controlling blood pressure is essential for prevention of events after acute aortic dissection (AAD). However, in some instances a cardiac event occurs despite controlled blood pressure, and its prediction is difficult. We continuously monitored C-reactive protein (CRP) in patients receiving medical treatment for AAD ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-012-0257-2

    authors: Okina N,Ohuchida M,Takeuchi T,Fujiyama T,Satoh A,Sakamoto T,Adachi H,Imaizumi T

    更新日期:2013-05-01 00:00:00

  • Effect of myocardial contractility on hemodynamic end points under concomitant microvascular disease in a porcine model.

    abstract::In this study, coronary diagnostic parameters, pressure drop coefficient (CDP: ratio of trans-stenotic pressure drop to distal dynamic pressure), and lesion flow coefficient (LFC: ratio of % area stenosis (%AS) to the CDP at throat region), were evaluated to distinguish levels of %AS under varying contractility condit...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-013-0355-9

    authors: Peelukhana SV,Kolli KK,Leesar MA,Effat MA,Helmy TA,Arif I,Schneeberger EW,Succop P,Banerjee RK

    更新日期:2014-01-01 00:00:00

  • Protective effect of coenzyme Q10 on thyrotoxic heart in rabbits.

    abstract::An excess of thyroid hormone is known to produce cardiac dysfunction and failure, i.e., thyrotoxic heart. We studied the protective effect of coenzyme Q10 (CoQ10) on the thyrotoxic heart in 29 rabbits. A group treated with 1-thyroxine sodium salt (T4; 167 micrograms/kg) for 3 weeks showed marked decreases in the myoca...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02058524

    authors: Kotake C,Ito Y,Yokoyama M,Fukuzaki H

    更新日期:1987-01-01 00:00:00

  • Association of less-contrast media with clinical factors in elective percutaneous coronary intervention.

    abstract::Since the amount of contrast media during percutaneous coronary intervention (PCI) is closely related to the exacerbation of renal function, it should be important to reduce the dose of contrast media during PCI. The purpose of this retrospective study was to evaluate the association of less-contrast media with clinic...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-019-01473-3

    authors: Mukai Y,Sakakura K,Yamamoto K,Taniguchi Y,Tsukui T,Seguchi M,Wada H,Momomura SI,Fujita H

    更新日期:2020-02-01 00:00:00