Short- and long-term benefits of drug-eluting stents compared to bare metal stents even in treatment for large coronary arteries.


:Although drug-eluting stents (DES) for percutaneous coronary intervention (PCI) have dramatically reduced the incidence of in-stent restenosis, their deployment for large-size coronary lesions is still controversial because of problems such as late in-stent thrombosis and late catch-up in DES. We aimed to evaluate the long-term outcome beyond 2 years of bare metal stents (BMS) as compared with DES in large vessels. Consecutive 228 patients who underwent PCI with large-size stents (>3.5 mm in diameter) in our hospital were enrolled in this study. The end points of this study are target lesion revascularization (TLR) and occurrence of major adverse cardiac events (MACE) for subject patients. We analyzed 183 patients (152 men, mean age 65.8 ± 10.5 years) whose outcome could be followed up for at least 2 years. At the first 8-month follow-up, clinically driven TLR rate was significantly higher in patients who received BMS than those who received DES (17.2 vs. 2.2 %, p < 0.05), although the rate of TLR was not different between the 2 groups beyond 8 months. Thus, overall rate of TLR was higher in BMS than in DES (22.7 vs. 5.4 %, p < 0.05). Under these conditions, the higher rate of TLR for BMS was observed in simple as well as complex lesions with or without diabetes, although there were no significant differences in MACE between BMS and DES. Multivariate analysis showed that BMS was an only independent factor of TLR at the 8 month follow-up period [p = 0.004, odds ratio 9.58, 95 % confidence interval (2.10-43.8)]. These results demonstrate that the rate of in-stent restenosis in large-size coronary lesions was transiently higher in the first 8 months for patients implanted with BMS compared with DES in which no in-stent thrombosis and TLR beyond 2 years were observed. We suggest using the DES even in large-size coronary lesions in terms of short- and long-term outcomes.


Heart Vessels


Heart and vessels


Yoshida T,Sakata K,Nitta Y,Taguchi T,Kaku B,Katsuda S,Shimojima M,Gamou T,Nakahashi T,Konno T,Kawashiri MA,Yamagishi M,Hayashi K




Has Abstract


2016-05-01 00:00:00














  • Impact of sleep-disordered breathing on myocardial damage and metabolism in patients with chronic heart failure.

    abstract::Sleep-disordered breathing (SDB) has a critical association with mortality and morbidity of patients with chronic heart failure (CHF). Troponin T is a marker of ongoing myocardial damage and predicts adverse clinical outcomes in patients with CHF. Carnitine plays an important role in the utilization of fatty acids in ...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Miyata M,Yoshihisa A,Yamauchi H,Owada T,Sato T,Suzuki S,Sugimoto K,Yamaki T,Kunii H,Nakazato K,Suzuki H,Saitoh S,Takeishi Y

    更新日期:2015-05-01 00:00:00

  • Longer coronary anastomosis provides lower energy loss in coronary artery bypass grafting.

    abstract::Distal anastomosis technique affects graft patency and long-term outcomes in coronary artery bypass grafting, however, there is no standard for the appropriate length of distal anastomosis. The purpose of this study is to evaluate whether longer distal anastomosis provides higher quality of distal anastomosis and bett...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Tsukui H,Shinke M,Park YK,Yamazaki K

    更新日期:2017-01-01 00:00:00

  • Stroke prevention following modified endoscopic ablation and appendectomy for atrial fibrillation.

    abstract::We reported the results of stroke prevention following modified endoscopic procedure for atrial fibrillation. 82 patients underwent modified endoscopic procedure for atrial fibrillation (AF), in whom 47 had paroxysmal, 28 had persistent, and 7 had long-standing atrial fibrillation. CHA2DS2VASC median score was 3 (rang...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Ma N,Jiang Z,Chen F,Yin H,Ding F,Mei J

    更新日期:2016-09-01 00:00:00

  • Late gadolinium enhancement on cardiac magnetic resonance predicts coronary vasomotor abnormality and myocardial lactate production in patients with chronic heart failure.

    abstract::Myocardial fibrosis and microvascular dysfunction are key determinants of outcome in heart failure (HF); we examined their relationship in patients with HF. Our study included 61 consecutive patients with HF but without coronary stenosis. All underwent gadolinium-enhanced cardiac magnetic resonance to evaluate late ga...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Uemura T,Yamamuro M,Kaikita K,Takashio S,Utsunomiya D,Hirakawa K,Nakayama M,Sakamoto K,Yamamoto E,Tsujita K,Kojima S,Hokimoto S,Yamashita Y,Ogawa H

    更新日期:2016-12-01 00:00:00

  • More coronary artery stenosis, more cerebral artery stenosis? A simultaneous angiographic study discloses their strong correlation.

    abstract::Cerebral artery stenosis (CAS) has the same pathogenesis as coronary artery disease (CAD), but the coexistence of these two diseases has been rarely reported. To detect coexistent CAS in CAD patients, we conducted a study of simultaneous coronary and cerebral angiography. Of the 663 consecutive newly diagnosed CAD pat...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Li AH,Chu YT,Yang LH,Chen KC,Chu SH

    更新日期:2007-09-01 00:00:00

  • Analysis of wave reflections in the arterial system using wave intensity: a novel method for predicting the timing and amplitude of reflected waves.

    abstract::The timing and amplitude of reflected arterial waves in the ascending aorta were studied by analysis of the aortic pressure waveform and were compared with those derived using wave intensity analysis. Wave intensity analysis considers aortic pressure changes to be the result of forward and backward wavelets carrying e...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Koh TW,Pepper JR,DeSouza AC,Parker KH

    更新日期:1998-01-01 00:00:00

  • Primary cardiac osteosarcoma in a pregnant woman.

    abstract::Primary cardiac osteosarcomas are uncommon tumors. Their growth pattern is aggressive and the prognosis is poor. A 34-year-old, 7-month pregnant woman with a primary cardiac osteosarcoma associated with the anterior mitral leaflet and connected to the interatrial septum, causing nearly subtotal obstruction of the mitr...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Koçak H,Karapolat S,Gündogdu C,Bozkurt E,Unlü Y

    更新日期:2006-01-01 00:00:00

  • Low serum eicosapentaenoic acid level is a risk for ventricular arrhythmia in patients with acute myocardial infarction: a possible link to J-waves.

    abstract::Eicosapentaenoic acid (EPA) has antiarrhythmic effects. The J-wave on an electrocardiogram is associated with a high incidence of ventricular tachycardia/fibrillation (VT/VF). We evaluated relationships between EPA and J-waves, and their involvement in the occurrence of VT/VF in acute myocardial infarction (AMI). Two ...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Endo T,Tomita H,Higuma T,Abe N,Kushibiki M,Saitoh S,Yamada M,Yokota T,Echizen T,Yokoyama H,Tateyama S,Suzuki A,Ishida Y,Murakami K,Osanai T,Okumura K

    更新日期:2014-11-01 00:00:00

  • Sonicated X-ray contrast agents for quantitative myocardial contrast echocardiography--a critical approach.

    abstract::Contrast echocardiography with sonicated radiographic contrast agents has been used for the qualitative and quantitative determination of myocardial blood flow. One major problem has been the size of the microbubbles since only bubbles smaller than 8 microns are expected to pass the capillary bed and larger bubbles ma...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Mayer IV,Lazarov MP,Utzinger U,Freiburghaus AU,Hess OM

    更新日期:1995-01-01 00:00:00

  • Effect of myocardial contractility on hemodynamic end points under concomitant microvascular disease in a porcine model.

    abstract::In this study, coronary diagnostic parameters, pressure drop coefficient (CDP: ratio of trans-stenotic pressure drop to distal dynamic pressure), and lesion flow coefficient (LFC: ratio of % area stenosis (%AS) to the CDP at throat region), were evaluated to distinguish levels of %AS under varying contractility condit...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Peelukhana SV,Kolli KK,Leesar MA,Effat MA,Helmy TA,Arif I,Schneeberger EW,Succop P,Banerjee RK

    更新日期:2014-01-01 00:00:00

  • Low-dose nesiritide improves renal function in heart failure patients following acute myocardial infarction.

    abstract::This study was designed to investigate the effect of low-dose nesiritide on renal function and major cardiac events in patients with acute decompensated heart failure following acute myocardial infarction. Sixty patients were randomized into nesiritide (loading dose 0.5 microg/kg, maintenance dose 0.0075 microg/kg/min...

    journal_title:Heart and vessels

    pub_type: 杂志文章,随机对照试验


    authors: Zhao Q,Wu TG,Lin Y,Li B,Luo JY,Wang LX

    更新日期:2010-03-01 00:00:00

  • Utility of measuring C-reactive protein for prediction of in-hospital events in patients with acute aortic dissection.

    abstract::Controlling blood pressure is essential for prevention of events after acute aortic dissection (AAD). However, in some instances a cardiac event occurs despite controlled blood pressure, and its prediction is difficult. We continuously monitored C-reactive protein (CRP) in patients receiving medical treatment for AAD ...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Okina N,Ohuchida M,Takeuchi T,Fujiyama T,Satoh A,Sakamoto T,Adachi H,Imaizumi T

    更新日期:2013-05-01 00:00:00

  • Lower heart rate in the early postoperative period does not correlate with long-term outcomes after repair of type A acute aortic dissection.

    abstract::Little evidence exists regarding the need for a reduction in postoperative heart rate after repair of type A acute aortic dissection. This single-center retrospective study was conducted to determine if lower heart rate during the early postoperative phase is associated with improved long-term outcomes after surgery f...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Ohnuma T,Kimura N,Sasabuchi Y,Asaka K,Shiotsuka J,Komuro T,Mouri H,Lefor AT,Adachi H,Sanui M

    更新日期:2015-05-01 00:00:00

  • Coronary sinus catheter placement via left cubital vein for phrenic nerve stimulation during pulmonary vein isolation.

    abstract::Phrenic nerve (PN) stimulation is essential for the elimination of PN palsy during balloon-based pulmonary vein isolation (PVI). Although ultrasound-guided vascular access is safe, insertion of a PN stimulation catheter via central venous access carries a potential risk of the development of mechanical complications. ...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Chikata A,Kato T,Usuda K,Fujita S,Maruyama M,Otowa KI,Takashima SI,Murai H,Usui S,Furusho H,Kaneko S,Takamura M

    更新日期:2019-10-01 00:00:00

  • Percutaneous transvenous mitral commissurotomy immediately restores quick response of VO2 to mild exercise despite insignificant increases in peak VO2.

    abstract::Percutaneous transvenous mitral commissurotomy (PTMC) increases peak oxygen uptake (VO2) chronically, but not acutely, despite early symptomatic improvements. Analysis of transient VO2 responses to submaximal exercise (an exercise regimen more comparable to the patients' daily activities than that provided by maximal ...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Takaki H,Sunagawa K,Sugimachi M,Tamai J,Okano Y,Kurita T,Aihara N,Shimizu W,Suyama K,Kamakura S

    更新日期:1995-01-01 00:00:00

  • Effect of fibrillatory wave amplitude on coronary blood flow as assessed by thrombolysis in myocardial infarction frame count in patients with atrial fibrillation.

    abstract::Atrial fibrillation (AF) is the most common arrhythmia, characterized by a lack of atrial contraction and an irregular ventricular rhythm. We assessed the effect of fibrillatory wave amplitude on coronary blood flow in patients with AF using the thrombolysis in myocardial infarction (TIMI) frame count. Sixty-one patie...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Sumimoto Y,Kurisu S,Hitta K,Ikenaga H,Ishibashi K,Fukuda Y,Nakano Y,Kihara Y

    更新日期:2018-07-01 00:00:00

  • Sudden death due to aortic rupture in acromegaly.

    abstract::Acromegaly, when left untreated, is associated with premature mortality which is chiefly related to cardiovascular complications. We report on a 50-year-old acromegalic woman, resistant to therapy, who died suddenly because of thoracic aortic rupture and massive bleeding into the left pleural space. The postmortem exa...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Maffei P,Menegazzo C,Michelotto M,Salmaso R,Martini C,De Carlo E,Carli M,Barban M,Fassina A,Vettor R,Sicolo N

    更新日期:2008-01-01 00:00:00

  • Reperfusion through balloon catheter to minimize myocardial infarction during the interval between failed percutaneous transluminal coronary angioplasty and emergency coronary artery bypass grafting.

    abstract::A 65-year-old man was admitted with chest pain. A diagnosis of spastic angina was made because of symptoms of recurrent anginal attacks associated with ST-segment elevations in the electrocardiogram. A selective coronary arteriogram revealed a 90% diameter narrowing of the proximal left anterior descending coronary ar...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Kusachi S,Takata S,Iwasaki K,Nishiyama O,Kita T,Namba H,Hata T,Taniguchi G,Saito D,Haraoka S

    更新日期:1989-01-01 00:00:00

  • Cell salvage processing of residual cardiopulmonary bypass volume in minimally invasive cardiac surgery.

    abstract::Several reports demonstrated positive effects of processing residual cardiopulmonary bypass volume using a cell salvage device in conventional open heart surgery via sternotomy on hemostasis. The present study aimed to investigate whether cell salvage processing has the same effects on postoperative blood loss and tra...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Muraki R,Totsugawa T,Nagata K,Nakajima K,Oshita T,Arimichi M,Yoshitaka H,Sakaguchi T

    更新日期:2019-08-01 00:00:00

  • Re-elevation of T-wave from day 2 to day 4 after successful percutaneous coronary intervention predicts chronic cardiac systolic dysfunction in patients with first anterior acute myocardial infarction.

    abstract::This study evaluates the clinical significance of re-elevation of T-wave in patients with ST segment elevation acute myocardial infarction (STEMI) undergoing successful percutaneous coronary intervention (PCI). Resolution of ST elevation within 24 h after reperfusion is associated with better outcome. However, little ...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Nishizaki F,Tomita H,Yokoyama H,Higuma T,Abe N,Suzuki A,Endo T,Tateyama S,Ishida Y,Osanai T,Okumura K

    更新日期:2013-11-01 00:00:00

  • Vasoconstrictor effects of endogenous digitalis-like factors extracted from urine of hypertensive patients.

    abstract::The vascular effects of endogenous digitalis-like factors (EDLFs) extracted from the urine of hypertensive patients were investigated in isolated and perfused intermediate auricular and mesenteric arterial preparations of dogs. EDLFs produced a transient vasoconstriction in a dose-related manner in intermediate auricu...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Chiba S,Tsukada M,Katsuyama Y,Tada A,Zenda H

    更新日期:1987-01-01 00:00:00

  • Independent no-reflow predictors in female patients with ST-elevation acute myocardial infarction treated with primary percutaneous coronary intervention.

    abstract::Independent no-reflow predictors should be evaluated in female patients with ST-segment elevation acute myocardial infarction (STEMI) and successfully treated with primary percutaneous coronary intervention (PPCI) in the current interventional equipment and techniques, thus to be constructed a no-reflow predicting mod...

    journal_title:Heart and vessels

    pub_type: 杂志文章,多中心研究


    authors: Chen Y,Wang C,Yang X,Wang L,Sun Z,Liu H,Chen L

    更新日期:2012-05-01 00:00:00

  • Asymptomatic kindred of patients with coronary events have increased peripheral T-cell activities.

    abstract::T cells are involved in the pathogenesis of atherosclerosis. We aimed to search for any association between the peripheral T-cell activities and atherogenic risk factors in healthy subjects. Fifty male volunteers (age 22.0 +/- 2.4 years) were enrolled. No subject had any chronic disease or was under any drug treatment...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Sonmez A,Kisa U,Uckaya G,Eyileten T,Kinalp C,Yilmaz MI,Dogru T,Turan M,Kocar IH

    更新日期:2006-07-01 00:00:00

  • Inter- and intra-ventricular dyssynchrony in the systemic right ventricle is a surrogate marker of major cardiac events in mildly symptomatic patients.

    abstract::The aim of the study was to evaluate systemic right ventricular (RV) dyssynchrony in patients with congenitally corrected transposition of the great arteries (CCTGA) and transposition of the great arteries (TGA) with New York Heart Association functional class (NYHA FC) < III. We used cardiac magnetic resonance (CMR) ...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Shiina Y,Inai K,Takahashi T,Taniguchi K,Watanabe E,Fukushima K,Niwa K,Nagao M

    更新日期:2018-09-01 00:00:00

  • Hypocellularity and insufficient expression of angiogenic factors in implanted autologous bone marrow in patients with chronic critical limb ischemia.

    abstract::The aim of this study was to identify the clinical parameters of absolutely poor-prognosis patients with chronic critical limb ischemia (AP-CLI). Sixteen no-option CLI patients with arteriosclerosis obliterans: ASO (nine) and non-ASO patients (seven) treated with bone marrow-mononuclear cell implantation (BMI) were an...

    journal_title:Heart and vessels

    pub_type: 临床试验,杂志文章


    authors: Oda M,Toba K,Kato K,Ozawa T,Yanagawa T,Ikarashi N,Takayama T,Suzuki T,Hanawa H,Masuko M,Kobayashi H,Aizawa Y

    更新日期:2012-01-01 00:00:00

  • Efficacy and safety of novel epicardial circumferential left atrial ablation with pulmonary vein isolation in sustained atrial fibrillation.

    abstract::The aim of this study was to examine the efficacy and safety of this novel epicardial circumferential left atrial ablation (CLAA) with pulmonary vein isolation (PVI) in sustained atrial fibrillation (AF). Thirty domestic pigs were divided equally into 3 groups: AF without ablation (AF group), AF with PVI (PVI group), ...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Jiang Z,Yin H,He Y,Ma N,Tang M,Liu H,Ding F,Mei J

    更新日期:2015-09-01 00:00:00

  • An adult case of Bland-White-Garland syndrome with collaterals from the bronchial artery.

    abstract::We report herein an adult case of anomalous origin of the left coronary artery from the pulmonary artery (Bland-White-Garland syndrome; BWG syndrome). The patient had chest discomfort during exercise and signs of mitral regurgitation. We diagnosed him as having BWG syndrome by angiography, and performed surgical treat...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Ishihata T,Takeda H,Katohno E,Techigawara M,Owada K,Murata N,Ohta H,Maruyama Y

    更新日期:1994-01-01 00:00:00

  • Increased respiratory disturbance index measured using an advanced device algorithm is associated with heart failure development.

    abstract::Previous studies suggested that sleep-disordered breathing was associated with cardiovascular diseases such as heart failure (HF). Recently, algorithms of cardiac implantable electronic devices (CIEDs) have been developed to detect advanced sleep apnea (SA); the Apnea Scan (AP Scan) being an example. The purpose of th...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Wakabayashi Y,Koyama T,Kurihara K,Kobayashi M,Ichikawa T,Abe H

    更新日期:2020-06-01 00:00:00

  • Aldosterone induces circadian gene expression of clock genes in H9c2 cardiomyoblasts.

    abstract::We examined mRNA expression of the clock genes (Per1, Per2, and Bmal1) and PAI-1 (plasminogen activator inhibitor-1) after aldosterone treatment every 4 h up to 48 h in H9c2 cardiomyoblasts by reverse transcription-polymerase chain reaction. To block the MR (mineralocorticoid receptor), the MR antagonist, spironolacto...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Tanaka K,Ashizawa N,Kawano H,Sato O,Seto S,Nishihara E,Terazono H,Isomoto S,Shinohara K,Yano K

    更新日期:2007-07-01 00:00:00

  • Axillo-femoral bypass steal due to subclavian artery stenosis.

    abstract::Subclavian artery stenosis can cause a flow reversal-so-called steal-not only in the ipsilateral vertebral artery, but also in the internal mammary artery in patients with a history of coronary-artery bypass grafting. Subclavian artery stenosis is also associated with peripheral artery disease elsewhere. We report a n...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Shigyo H,Kawarada O,Noguchi T,Ogawa H,Yasuda S

    更新日期:2016-11-01 00:00:00