Short- and long-term benefits of drug-eluting stents compared to bare metal stents even in treatment for large coronary arteries.


:Although drug-eluting stents (DES) for percutaneous coronary intervention (PCI) have dramatically reduced the incidence of in-stent restenosis, their deployment for large-size coronary lesions is still controversial because of problems such as late in-stent thrombosis and late catch-up in DES. We aimed to evaluate the long-term outcome beyond 2 years of bare metal stents (BMS) as compared with DES in large vessels. Consecutive 228 patients who underwent PCI with large-size stents (>3.5 mm in diameter) in our hospital were enrolled in this study. The end points of this study are target lesion revascularization (TLR) and occurrence of major adverse cardiac events (MACE) for subject patients. We analyzed 183 patients (152 men, mean age 65.8 ± 10.5 years) whose outcome could be followed up for at least 2 years. At the first 8-month follow-up, clinically driven TLR rate was significantly higher in patients who received BMS than those who received DES (17.2 vs. 2.2 %, p < 0.05), although the rate of TLR was not different between the 2 groups beyond 8 months. Thus, overall rate of TLR was higher in BMS than in DES (22.7 vs. 5.4 %, p < 0.05). Under these conditions, the higher rate of TLR for BMS was observed in simple as well as complex lesions with or without diabetes, although there were no significant differences in MACE between BMS and DES. Multivariate analysis showed that BMS was an only independent factor of TLR at the 8 month follow-up period [p = 0.004, odds ratio 9.58, 95 % confidence interval (2.10-43.8)]. These results demonstrate that the rate of in-stent restenosis in large-size coronary lesions was transiently higher in the first 8 months for patients implanted with BMS compared with DES in which no in-stent thrombosis and TLR beyond 2 years were observed. We suggest using the DES even in large-size coronary lesions in terms of short- and long-term outcomes.


Heart Vessels


Heart and vessels


Yoshida T,Sakata K,Nitta Y,Taguchi T,Kaku B,Katsuda S,Shimojima M,Gamou T,Nakahashi T,Konno T,Kawashiri MA,Yamagishi M,Hayashi K




Has Abstract


2016-05-01 00:00:00














  • Cell salvage processing of residual cardiopulmonary bypass volume in minimally invasive cardiac surgery.

    abstract::Several reports demonstrated positive effects of processing residual cardiopulmonary bypass volume using a cell salvage device in conventional open heart surgery via sternotomy on hemostasis. The present study aimed to investigate whether cell salvage processing has the same effects on postoperative blood loss and tra...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Muraki R,Totsugawa T,Nagata K,Nakajima K,Oshita T,Arimichi M,Yoshitaka H,Sakaguchi T

    更新日期:2019-08-01 00:00:00

  • Body mass index is associated with prognosis in Japanese elderly patients with atrial fibrillation: an observational study from the outpatient clinic.

    abstract::The relationship between body mass index (BMI) and the prognosis of elderly patients with atrial fibrillation (AF) is unknown. We aimed to examine the association of body weight with the clinical outcomes among Japanese elderly patients with a history of documented AF. This observational study of AF patients from an o...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Yanagisawa S,Inden Y,Yoshida N,Kato H,Miyoshi-Fujii A,Mizutani Y,Ito T,Kamikubo Y,Kanzaki Y,Hirai M,Murohara T

    更新日期:2016-09-01 00:00:00

  • Warfarin-induced skin necrosis after open heart surgery due to protein S and C deficiency.

    abstract::Warfarin-induced skin necrosis is the rare but potentially devastating complication of anticoagulant therapy and commonly occurs in previously undetected C- and S-protein deficient patients. Because routine preoperative examination does not include protein C and S level measurement, detection of these patients preoper...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Oz BS,Asgun F,Oz K,Kuralay E,Tatar H

    更新日期:2007-01-01 00:00:00

  • Analysis of 10-year nationwide population-based data on sex differences in hospitalization for heart failure.

    abstract::Sex-related factors play an important role in the pathophysiology of heart failure (HF). However, trends in sex-related differences in hospital management for HF are not clear. We identified patients hospitalized for HF through a nationwide database (National Health Insurance in Taiwan), containing 722,272 subjects fr...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Yang HY,Chiu WC,Huang JH,Hsu CY,Lin YK,Chen YJ

    更新日期:2013-11-01 00:00:00

  • Late gadolinium enhancement on cardiac magnetic resonance predicts coronary vasomotor abnormality and myocardial lactate production in patients with chronic heart failure.

    abstract::Myocardial fibrosis and microvascular dysfunction are key determinants of outcome in heart failure (HF); we examined their relationship in patients with HF. Our study included 61 consecutive patients with HF but without coronary stenosis. All underwent gadolinium-enhanced cardiac magnetic resonance to evaluate late ga...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Uemura T,Yamamuro M,Kaikita K,Takashio S,Utsunomiya D,Hirakawa K,Nakayama M,Sakamoto K,Yamamoto E,Tsujita K,Kojima S,Hokimoto S,Yamashita Y,Ogawa H

    更新日期:2016-12-01 00:00:00

  • Impaired carotid artery elastic function in patients with tetralogy of Fallot.

    abstract::Complex congenital heart diseases with abnormal formation of the aorticopulmonary septum are also associated with defective large artery elastogenesis. In the current study, we tested the hypothesis that carotid artery elastic function was impaired in patients with tetralogy of Fallot (ToF). The study included 45 Fall...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: László A,Pintér A,Horváth T,Kádár K,Temesvári A,Kollai M,Studinger P

    更新日期:2011-09-01 00:00:00

  • Higher body mass index at the time of acute myocardial infarction is associated with a favorable long-term prognosis (8-year follow-up).

    abstract::Obesity is an important public health problem, especially among patients with cardiovascular disease. However, little is known about the impact of obesity on the long-term prognoses of patients with acute myocardial infarction (AMI). Major adverse cardiac and cerebrovascular events (MACCE) consist of all causes of dea...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Ikeda N,Nakajima R,Utsunomiya M,Hori M,Itaya H,Makino K,Ono T,Yamamoto M,Nemoto N,Iijima R,Hara H,Takagi T,Hara H,Nakamura M,Sugi K

    更新日期:2011-09-01 00:00:00

  • Low serum eicosapentaenoic acid level is a risk for ventricular arrhythmia in patients with acute myocardial infarction: a possible link to J-waves.

    abstract::Eicosapentaenoic acid (EPA) has antiarrhythmic effects. The J-wave on an electrocardiogram is associated with a high incidence of ventricular tachycardia/fibrillation (VT/VF). We evaluated relationships between EPA and J-waves, and their involvement in the occurrence of VT/VF in acute myocardial infarction (AMI). Two ...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Endo T,Tomita H,Higuma T,Abe N,Kushibiki M,Saitoh S,Yamada M,Yokota T,Echizen T,Yokoyama H,Tateyama S,Suzuki A,Ishida Y,Murakami K,Osanai T,Okumura K

    更新日期:2014-11-01 00:00:00

  • Endomyocardial biopsy findings in patients with atrioventricular block in the absence of apparent heart disease.

    abstract::The purpose of this study was to examine the histopathological findings of right ventricular endomyocardial biopsies from ten patients less than 60 years of age (47 +/- 9.8 (mean +/- SD) years) with documented atrioventricular block but without apparent heart disease. They underwent electrophysiological testing, echoc...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Teragaki M,Toda I,Sakamoto K,Shimada K,Yamagishi H,Yoshiyama M,Akioka K,Kawase Y,Nishimoto M,Takeuchi K,Yoshikawa J

    更新日期:1999-01-01 00:00:00

  • Impact of pharmacological spasm provocation test in patients with a history of syncope.

    abstract::Coronary artery spasm is involved in the pathogenesis of various cardiac disorders. We investigated patients with a history of syncope who underwent elective coronary angiography. We retrospectively analyzed 5781 consecutive patients who had diagnostic or follow-up angiography during a 26-year period. During this peri...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Sueda S,Kohno H

    更新日期:2018-02-01 00:00:00

  • Atherosclerotic burden in coronary and peripheral arteries in patients with first clinical manifestation of coronary artery disease.

    abstract::The aim of our study was to assess the atherosclerotic burden in patients with the first symptoms of coronary artery disease (CAD). The study population consisted of 100 consecutive patients (new-onset severe angina or myocardial infarction) and 70 age- and sex-matched volunteers without symptoms of CAD. Functional an...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Cerne A,Kranjec I

    更新日期:2002-09-01 00:00:00

  • Insulin resistance and acute coronary syndrome in the young Japanese population have a strong association.

    abstract::There are few data regarding acute coronary syndrome (ACS) in young Japanese patients. We examined the risk factors for ACS in young Japanese patients, especially impaired glucose metabolism. From a database of 789 consecutive patients admitted to our hospital with ACS between 2000 and 2005, we compared risk factors o...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Ikeda N,Nakajima R,Tsunoda T,Nakamura M,Sugi K

    更新日期:2007-05-01 00:00:00

  • Castration modifies aortic vasoreactivity and serum fatty acids in a sucrose-fed rat model of metabolic syndrome.

    abstract::Levels of testosterone and estradiol influence the incidence of cardiovascular diseases: generally, estrogens in females are protective before menopause; coronaropathies, hypertension, and dyslipidemias in normal men are more frequent at comparable ages. We investigated the modulation by castration of in vitro vasorea...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Perez I,El Hafidi M,Carvajal K,Baños G

    更新日期:2009-03-01 00:00:00

  • Chelation of copper reduces inhibition by oxidized lipoproteins of endothelium-dependent relaxation in porcine coronary arteries.

    abstract::We examined the effect of dialyzing oxidized low-density lipoprotein (oLDL) against Krebs-Ringer solution, in the absence (yielding d-oLDL) or presence (yielding EDTA-oLDL) of ethylenediamine tetraacetic acid (EDTA), to investigate the mechanism that underlies the inhibition of endothelium-dependent relaxation (EDR) b...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Hayashi T,Ishikawa T,Kuzuya M,Naito M,Yamada K,Asai K,Hidaka H,Iguchi A

    更新日期:1994-01-01 00:00:00

  • Pharmacological intervention for renal protection during cardiopulmonary bypass.

    abstract::The possibility of minimizing organ damage following cardiopulmonary bypass (CPB) was examined. In the control group, n = 21, upon completion of CPB, elevation of the lysosomal enzyme beta-glucuronidase, which is a sensitive indicator of cellular damage, was affected by the concentration of granulocyte elastase (r = 0...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Hashimoto K,Nomura K,Nakano M,Sasaki T,Kurosawa H

    更新日期:1993-01-01 00:00:00

  • Utility of measuring C-reactive protein for prediction of in-hospital events in patients with acute aortic dissection.

    abstract::Controlling blood pressure is essential for prevention of events after acute aortic dissection (AAD). However, in some instances a cardiac event occurs despite controlled blood pressure, and its prediction is difficult. We continuously monitored C-reactive protein (CRP) in patients receiving medical treatment for AAD ...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Okina N,Ohuchida M,Takeuchi T,Fujiyama T,Satoh A,Sakamoto T,Adachi H,Imaizumi T

    更新日期:2013-05-01 00:00:00

  • Utility of myocardial fractional flow reserve for prediction of restenosis following sirolimus-eluting stent implantation.

    abstract::Drug-eluting stents reduce restenosis due to neointimal growth suppression. Considering long-term outcomes, it is both difficult and important to predict drug-eluting stent restenosis. Thus, this study was designed to examine the utility of myocardial fractional flow reserve (FFR) as a predictor of sirolimus-eluting s...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Ishii H,Kataoka T,Kobayashi Y,Tsumori T,Takeshita H,Matsumoto R,Shirai N,Nishioka H,Hasegawa T,Nakata S,Shimada Y,Ehara S,Muro T,Yoshiyama M

    更新日期:2011-11-01 00:00:00

  • Prognostic value of the Tei index combining systolic and diastolic myocardial performance in patients with acute myocardial infarction treated by successful primary angioplasty.

    abstract::Cardiac systolic (left ventricular ejection fraction) and diastolic (mitral inflow velocity pattern and/or mitral deceleration time) function were reported as predictors of clinical outcome or left ventricular remodeling in patients with acute myocardial infarction (AMI). Recently, a new index (Doppler-derived index c...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Sasao H,Noda R,Hasegawa T,Endo A,Oimatsu H,Takada T

    更新日期:2004-03-01 00:00:00

  • Urinary KIM-1, NGAL and L-FABP for the diagnosis of AKI in patients with acute coronary syndrome or heart failure undergoing coronary angiography.

    abstract::Acute kidney injury (AKI) is a common complication after coronary angiography. Early biomarkers of this disease are needed since increase in serum creatinine levels is a late marker. To assess the usefulness of urinary kidney injury molecule-1 (uKIM-1), neutrophil gelatinase-associated lipocalin (uNGAL) and liver-type...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Torregrosa I,Montoliu C,Urios A,Andrés-Costa MJ,Giménez-Garzó C,Juan I,Puchades MJ,Blasco ML,Carratalá A,Sanjuán R,Miguel A

    更新日期:2015-11-01 00:00:00

  • Resting qualitative and quantitative myocardial contrast echocardiography to predict cardiac events in patients with acute myocardial infarction and percutaneous revascularization.

    abstract::Successful restoration of patency of the infarct-related artery is important in management of acute ST-segment elevation myocardial infarction (STEMI); however, it does not necessarily translate into the restoration of perfusion at the tissue level. In this study, we evaluate the prognostic role of qualitative and qua...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Abdelmoneim SS,Martinez MW,Mankad SV,Bernier M,Dhoble A,Pellikka PA,Chandrasekaran K,Oh JK,Mulvagh SL

    更新日期:2015-01-01 00:00:00

  • Oxidized lipoprotein(a) and cardio-ankle vascular index (CAVI) in hypertensive subjects.

    abstract::While oxidized lipoprotein(a) (oxLp(a)) has been indicated to be involved in atherogenesis more than native lipoprotein(a) (Lp(a)), there is still a need to elucidate the associations among oxLp(a), hypertension, and atherosclerosis. The cardio-ankle vascular index (CAVI) is a recently developed index used to assess a...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Kotani K,Yamada S,Yamada T,Kario K,Taniguchi N

    更新日期:2013-07-01 00:00:00

  • Analysis of wave reflections in the arterial system using wave intensity: a novel method for predicting the timing and amplitude of reflected waves.

    abstract::The timing and amplitude of reflected arterial waves in the ascending aorta were studied by analysis of the aortic pressure waveform and were compared with those derived using wave intensity analysis. Wave intensity analysis considers aortic pressure changes to be the result of forward and backward wavelets carrying e...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Koh TW,Pepper JR,DeSouza AC,Parker KH

    更新日期:1998-01-01 00:00:00

  • Increased C-reactive protein is associated with future development of diabetes mellitus in essential hypertensive patients.

    abstract::Coexistence of hypertension and diabetes mellitus (DM) increases the risk of cardiovascular disease. However, factors associated with future development of DM have not been well elucidated in patients already having essential hypertension. This study prospectively included 168 patients (mean age 41 +/- 7 years, 112 me...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Weng CM,Chou CH,Huang YY,Lin CC,Liu YW,Tsai WC

    更新日期:2010-09-01 00:00:00

  • Surgical management of a uterine leiomyoma extending through the inferior vena cava into the right heart.

    abstract::We present a case of a 38-year-old woman with intravenous leiomyomatosis originating from the uterus involving the right ventricle, right atrium, inferior vena cava, and iliac veins. Tumors in the heart and the inferior vena cava were removed using cardiopulmonary bypass and circulatory arrest; 10 days after the cardi...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Gaudino M,Spatuzza P,Snider F,Luciani N,Cina G,Possati G

    更新日期:2002-12-01 00:00:00

  • Optimal therapeutic range for oral anticoagulants in Japanese patients with prosthetic heart valves: a preliminary report from a single institution using conversion from thrombotest to PT-INR.

    abstract::The thrombotest (TT) technique has been widely used in Japan for monitoring oral anticoagulant therapy (OAT). The therapeutic range was originally recommended to be 10%-25%. However, the International Committee for Standardization in Hematology/International Committee on Thrombosis and Hemostasis (ICSH/ICTH) recommend...

    journal_title:Heart and vessels

    pub_type: 临床试验,杂志文章


    authors: Uetsuka Y,Hosoda S,Kasanuki H,Aosaki M,Murasaki K,Ooki K,Inoue M,Akiyama E,Kitada M

    更新日期:2000-01-01 00:00:00

  • U-shaped association of central pulse pressure with long-term prognosis after ST-segment elevation myocardial infarction.

    abstract::The relationship between central pulse pressure (CPP) measured at the time of primary percutaneous coronary intervention (PPCI) and long-term prognosis after ST-segment elevation myocardial infarction (STEMI) has not been investigated. CPP measurements were performed in 1348 patients with STEMI (327 women; mean age 62...

    journal_title:Heart and vessels

    pub_type: 杂志文章,多中心研究


    authors: Ndrepepa G,Cassese S,Kufner S,Xhepa E,Fusaro M,Laugwitz KL,Schunkert H,Kastrati A

    更新日期:2019-07-01 00:00:00

  • The synergistic therapeutic effect of hepatocyte growth factor and granulocyte colony-stimulating factor on pulmonary hypertension in rats.

    abstract::Pulmonary arterial hypertension (PAH) is characterized by a progressive increase in pulmonary arterial pressure and vascular resistance. Despite advances in therapy for PAH, its treatment and prognosis remain poor. We aimed to investigate whether the transplantation of bone marrow mesenchymal stem cells (MSCs) overexp...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Guo Y,Su L,Li Y,Guo N,Xie L,Zhang D,Zhang X,Li H,Zhang G,Wang Y,Liu C

    更新日期:2014-07-01 00:00:00

  • Increased circulating CD3+/CD31+ T cells in patients with acute coronary syndrome.

    abstract::The number of circulating endothelial progenitor cells (EPCs) is considered to be a surrogate marker for coronary artery disease (CAD). Recent studies have identified a novel T-cell subset labeled with CD3(+)/CD31(+), which is necessary for EPC colony formation and constitutes the central cluster. However, the clinica...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Kakizaki M,Nobori K,Watanabe H,Iino K,Ishida M,Ito H

    更新日期:2013-09-01 00:00:00

  • Vascular endothelial growth factor stimulates angiogenesis without improving collateral blood flow following hindlimb ischemia in rabbits.

    abstract::This study was designed to test the ability of adenovirus-delivered vascular endothelial growth factor (Ad-VEGF) to stimulate angiogenesis and arteriogenesis in the rabbit hindlimb following the induction of ischemia and to evaluate the functional changes in the collateral circulation. Ten days after the surgical indu...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Hershey JC,Baskin EP,Corcoran HA,Bett A,Dougherty NM,Gilberto DB,Mao X,Thomas KA,Cook JJ

    更新日期:2003-07-01 00:00:00

  • Adiponectin levels in coronary artery ectasia.

    abstract::Etiopathogenesis of coronary artery ectasia (CAE), which is defined as abnormal dilatation of a segment of the coronary artery to 1.5 times of an adjacent normal coronary artery segment, is unclear. However, it is speculated that CAE develops in the atherosclerosis process through degeneration of coronary artery media...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Dagli N,Ozturk U,Karaca I,Yavuzkir M,Koca S,Akbulut H,Balin M

    更新日期:2009-03-01 00:00:00