Functional and metabolic responses of the isolated rat heart to changes in circulating inorganic phosphate concentration.

Abstract:

:Normoxic isolated rat hearts were perfused for 30 or 60 min with Krebs-Henseleit bicarbonate buffer (KHB) (in which the Pi concentration was adjusted to 0, 1.2, 2.4, or 10 mM) in both the presence and the absence of glucose as exogenous substrate. Functional performance and coronary flow were monitored throughout the perfusion period, and at its conclusion tissue high-energy phosphates (HEP), glycogen, Pi, and calcium were determined. In the presence of glucose, both developed pressure and coronary flow were significantly (P less than 0.05) reduced by perfusion with 10 mM Pi, while heart rate and energy status were unchanged. Tissue Pi levels were directly related to perfusate concentrations, with an apparent loss of 34% from hearts perfused with 0 mM Pi and a gain of 27% in hearts perfused with 10 mM Pi (which also caused a highly significant [P less than 0.01] uptake of calcium). HEP (ATP and creatine phosphate [CP]) were decreased after 60 min of perfusion with 0 mM Pi. In the absence of glucose, coronary flow was again significantly reduced by perfusion with 10 mM Pi. HEP were significantly (P less than 0.05) conserved and uptake of Pi and calcium was greater than in the presence of glucose. Equivalent free-Ca2+/normal Pi controls for the 10 mM Pi showed that the observed functional effects were not due to a lowering of perfusate free-Ca2+ by the raised Pi level. The effect on coronary flow appears to involve, primarily, a vasomotor mechanism.

journal_name

Heart Vessels

journal_title

Heart and vessels

authors

Humphrey SM,Armiger LC,Holliss DG,Buckman JE

doi

10.1007/BF02058588

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

207-14

issue

4

eissn

0910-8327

issn

1615-2573

journal_volume

4

pub_type

杂志文章
  • Aortic annulus angulation does not attenuate procedural success of transcatheter aortic valve replacement using a novel self-expanding bioprosthesis.

    abstract::The objectives of the study were to evaluate the impact of aortic angulation (AA) on success of transcatheter aortic valve replacement (TAVR) with a new generation self-expandable prosthesis (Medtronic Evolut R®). Specific anatomical conditions, such as for example the presence of a horizontal aorta with elevated AA, ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-019-01436-8

    authors: D'Ancona G,Kische S,El-Mawardy M,Dißmann M,Heinze H,Zohlnhöfer-Momm D,Gürer H,Ince H

    更新日期:2019-12-01 00:00:00

  • Effect of ectasia size or the ectasia ratio on the thrombosis in myocardial infarction frame count in patients with isolated coronary artery ectasia.

    abstract::Coronary blood flow was quantified using the thrombosis in myocardial infarction (TIMI) frame-count method. This measurement has been significantly correlated with flow velocity measured invasively by use of a Doppler flow wire. Coronary artery ectasia or aneurysm (CEA) is thought to be present in patients with a slow...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-005-0831-y

    authors: Kosar F,Acikgoz N,Sahin I,Topal E,Aksoy Y,Cehreli S

    更新日期:2005-09-01 00:00:00

  • Regional work of the ventricle: wall tension--area relation.

    abstract::We clarified that the set of the isotropic component (T) of wall tension and the area (A) of a selected region of the left ventricular wall expresses the regional work with sufficient accuracy. The area surrounded by the locus of the T-A relation in the T-A plane is approximately equal to the real work done by that re...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02066408

    authors: Sugawara M,Tamiya K,Nakano K

    更新日期:1985-08-01 00:00:00

  • Effect of carperitide on in-hospital mortality of patients admitted for heart failure: propensity score analyses.

    abstract::Although a previous randomized study showed that the use of atrial natriuretic peptide (carperitide) improved the long-term prognosis of patients with heart failure, its effect on short-term prognosis remains unclear. We retrospectively identified patients who were admitted to our tertiary-care center with acute decom...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-017-0952-0

    authors: Ogiso M,Isogai T,Okabe Y,Ito K,Tsuji M,Tanaka H

    更新日期:2017-08-01 00:00:00

  • General anesthesia improves contact force and reduces gap formation in pulmonary vein isolation: a comparison with conscious sedation.

    abstract::Compared to conscious sedation (CS), the use of general anesthesia (GA) in pulmonary vein isolation (PVI) is associated with a lower recurrence rate of atrial fibrillation (AF). GA may improve catheter stability and mapping system accuracy compared to CS, but its influence on contact force (CF) parameters during ipsil...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-017-0961-z

    authors: Chikata A,Kato T,Yaegashi T,Sakagami S,Kato C,Saeki T,Kawai K,Takashima SI,Murai H,Usui S,Furusho H,Kaneko S,Takamura M

    更新日期:2017-08-01 00:00:00

  • Electrocardiographic morphology of multiple ventricular arrhythmias originating from the right ventricular outflow tract: inverse correlation of the amplitude in the inferior leads and anatomic height of the origin.

    abstract::It is unclear whether the electrocardiogram amplitude in the inferior leads (Amp-I) can always predict the height of the origin of right ventricular outflow tract arrhythmias (RVOT-VAs). We analyzed patients who received catheter ablation of multiple RVOT-VAs in the same session in our hospital from 2011 to 2016. Two ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-018-1235-0

    authors: Kajiyama T,Hachiya H,Kusa S,Watanabe T,Hamaya R,Yamao K,Miyazaki S,Igarashi M,Nakamura H,Iesaka Y

    更新日期:2019-02-01 00:00:00

  • The correlation between the cardio-ankle vascular index (CAVI) and serum amyloid A in asymptomatic Japanese subjects.

    abstract::Chronic inflammation has received a great deal of attention due to the role it plays in cardiovascular disease (CVD). The cardio-ankle vascular index (CAVI) has recently been developed to evaluate arterial stiffness. This index is independent of blood pressure at the time that it is measured, making it a better measur...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-011-0182-9

    authors: Kotani K,Yamada T,Miyamoto M,Kario K,Ishibashi S,Taniguchi N

    更新日期:2012-09-01 00:00:00

  • Effects of cobalt-60 gamma-radiation on the synthesis of adrenomedullin and endothelin in rat vascular smooth muscle cells.

    abstract::We studied the effects of cobalt-60 Gamma-radiation on the gene expression and secretion of adrenomedullin (Adm) and endothelin (ET) in cultured rat vascular smooth muscle cells (VSMCs). Rat VSMCs cultured in Dulbecoo's modified Eagle's medium containing 10% FBS were radiated with cobalt-60 Gamma-radiation at doses of...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-003-0709-9

    authors: Zhong G,Chen F,Bu D,Li J,Qi Y,Niu D,Wang S,Pang Y,Tang C

    更新日期:2003-09-01 00:00:00

  • Body mass index is associated with prognosis in Japanese elderly patients with atrial fibrillation: an observational study from the outpatient clinic.

    abstract::The relationship between body mass index (BMI) and the prognosis of elderly patients with atrial fibrillation (AF) is unknown. We aimed to examine the association of body weight with the clinical outcomes among Japanese elderly patients with a history of documented AF. This observational study of AF patients from an o...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-015-0765-y

    authors: Yanagisawa S,Inden Y,Yoshida N,Kato H,Miyoshi-Fujii A,Mizutani Y,Ito T,Kamikubo Y,Kanzaki Y,Hirai M,Murohara T

    更新日期:2016-09-01 00:00:00

  • Assessment of trough rivaroxaban concentrations on markers of coagulation activation in nonvalvular atrial fibrillation population.

    abstract::Whether trough-phase rivaroxaban concentrations provide sufficient anticoagulation needs more study. We evaluated levels of coagulation activation markers in the trough concentration phase in nonvalvular atrial fibrillation (NVAF) patients, and the correlation between these markers and rivaroxaban concentration. Fifty...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-016-0912-0

    authors: Kitagawa F,Ishii J,Hiramitsu S,Takahashi H,Okuyama R,Kawai H,Muramatsu T,Harada M,Motoyama S,Naruse H,Matsui S,Sarai M,Hayashi M,Watanabe E,Izawa H,Ozaki Y

    更新日期:2017-05-01 00:00:00

  • Aortic artery distensibility shows inverse correlation with heart rate variability in elderly non-hypertensive, cardiovascular disease-free individuals: the Ikaria Study.

    abstract::The aim of this study was to evaluate the relation between aortic artery distensibility, expressed by pulse pressure (PP) and autonomic nervous system function expressed by heart rate variability (HRV), among elders. During 2009, 469 individuals (50 % males, mean age 75 ± 6 years old), permanent inhabitants of Ikaria ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-012-0267-0

    authors: Chrysohoou C,Skoumas J,Oikonomou E,Tsiachris D,Metaxa V,Lagoudakou S,Felekos J,Masoura C,Athanassopoulou S,Kosyfa H,Pitsavos C,Stefanadis C

    更新日期:2013-07-01 00:00:00

  • Impact of antiplatelet therapy on tissue prolapse at super acute phase after stenting: serial OCT study in acute coronary syndrome patients.

    abstract::Although drug-eluting stents have improved clinical outcomes, percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) remains a challenging procedure in terms of thrombus management. A new-generation P2Y12 receptor inhibitor, prasugrel, provides more rapid and potent antiplatelet action compared wit...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-020-01686-x

    authors: Naito K,Nakano Y,Waseda K,Takashima H,Ando H,Sakurai S,Suzuki A,Saka Y,Sawada H,Nagahiro S,Suzuki M,Shimoda M,Amano T

    更新日期:2020-09-09 00:00:00

  • Systolic pressure-volume area (PVA) as the energy of contraction in Starling's law of the heart.

    abstract::We have theoretically proposed "systolic pressure-volume area" (PVA) as a measure of total mechanical energy generated by ventricular contraction. We then experimentally showed that PVA closely correlates with left ventricular oxygen consumption (Vo2) regardless of ventricular loading conditions in a stable contractil...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02058751

    authors: Suga H,Goto Y,Futaki S,Kawaguchi O,Yaku H,Hata K,Takasago T

    更新日期:1991-01-01 00:00:00

  • Feasibility and safety of outpatient cardiac catheterization with intracoronary acetylcholine provocation test.

    abstract::Intracoronary acetylcholine (ACh) provocation test is useful to diagnose vasospastic angina. Although outpatient coronary angiography has been widely performed in current clinical settings, the feasibility and safety of ACh provocation test in outpatient services are unclear. A total of 323 patients, who electively un...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-018-1139-z

    authors: Saito Y,Kitahara H,Shoji T,Tokimasa S,Nakayama T,Sugimoto K,Fujimoto Y,Kobayashi Y

    更新日期:2018-08-01 00:00:00

  • Influence of mild cognitive impairment on activities of daily living in patients with cardiovascular disease.

    abstract::Activities of daily living (ADL) are maintained in patients with mild cognitive impairment (MCI), but, in patients with cardiovascular disease, ADL may have already declined. MCI combined with cardiac disease may accentuate the decline of ADL in these patients. Because the relationship between MCI and ADL in patients ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-019-01437-7

    authors: Ishihara K,Izawa KP,Kitamura M,Shimogai T,Kanejima Y,Morisawa T,Shimizu I

    更新日期:2019-12-01 00:00:00

  • Analysis of 10-year nationwide population-based data on sex differences in hospitalization for heart failure.

    abstract::Sex-related factors play an important role in the pathophysiology of heart failure (HF). However, trends in sex-related differences in hospital management for HF are not clear. We identified patients hospitalized for HF through a nationwide database (National Health Insurance in Taiwan), containing 722,272 subjects fr...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-012-0299-5

    authors: Yang HY,Chiu WC,Huang JH,Hsu CY,Lin YK,Chen YJ

    更新日期:2013-11-01 00:00:00

  • The effects of perindopril on QT duration and dispersion in patients with coronary slow flow.

    abstract::Coronary slow flow (CSF) is characterized by delayed opacification of coronary arteries in the absence epicardial occlusive disease. QT duration and dispersion have been reported to be longer in patients with CSF. ACE inhibitors may improve CSF through positive effects on endothelial function. The study included 32 pa...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-010-0058-4

    authors: Guntekin U,Gumrukcuoglu HA,Gunes Y,Gunes A,Simsek H,Sahin M,Sezen Y,Akdağ S,Tuncer M

    更新日期:2011-07-01 00:00:00

  • Reduction of inorganic phosphate-induced human smooth muscle cells calcification by inhibition of protein kinase A and p38 mitogen-activated protein kinase.

    abstract::High levels of serum phosphate are associated with calcification of human smooth muscle cells (HSMCs). We investigated whether inhibition of protein kinase A (PKA) and mitogen-activated protein kinase (MAPK) signals [p38, extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK)] can reduce inorga...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-013-0427-x

    authors: Kang JH,Toita R,Asai D,Yamaoka T,Murata M

    更新日期:2014-09-01 00:00:00

  • Aortic dissection is associated with intermittent hypoxia and re-oxygenation.

    abstract::Aortic dissection is a life-threatening cardiovascular disease with high in-hospital mortality. However, the risk factors of aortic dissection have not been fully elucidated. Obstructive sleep apnea (OSA) has been increasingly recognized as an independent cardiovascular risk factor. Among the underlying mechanisms to ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-011-0149-x

    authors: Naito R,Sakakura K,Kasai T,Dohi T,Wada H,Sugawara Y,Kubo N,Yamashita S,Narui K,Ishiwata S,Ohno M,Ako J,Momomura S

    更新日期:2012-05-01 00:00:00

  • Adenosine constricts the isolated and perfused monkey coronary artery.

    abstract::Adenosine constricted 37 of 58 isolated and perfused monkey coronary arteries, whereas it dilated dog coronary arteries in all cases. The vasoconstriction induced by 0.1-10 micrograms (0.37-37.4 nmol) of adenosine was examined, since adenosine in large doses produced tachyphylaxis. The adenosine-induced vasoconstricti...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02058320

    authors: Nakane T,Chiba S

    更新日期:1990-01-01 00:00:00

  • The efficacy of everolimus-eluting stent implantation in patients with ST-segment elevation myocardial infarction: outcomes of 2-year clinical follow-up.

    abstract::First-generation drug-eluting stents (DES) demonstrated delay in vascular healing and increase in incidence of late and very late stent thrombosis compared with bare-metal stents (BMS). Second-generation DES, however, have shown a reduction of late and very late stent thrombosis compared with first-generation DES. Thu...

    journal_title:Heart and vessels

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00380-015-0783-9

    authors: Yano H,Horinaka S,Ishikawa M,Ishimitsu T

    更新日期:2016-10-01 00:00:00

  • Increased release of the soluble form of the adhesion molecules L-selectin and ICAM-1 but not E-selectin during attacks of angina pectoris.

    abstract::Myocardial ischemia leads to the activation of neutrophils as well as endothelial cells. The interaction between these cells is dependent on certain adhesion glycoproteins which are expressed on their surface. Adhesion of neutrophils to endothelium, mediated by adhesion molecules, has been shown to result in coronary ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF01745043

    authors: Siminiak T,Smielecki J,Dye JF,Baliñski M,El-Gendi H,Wysocki H,Sheridan DJ

    更新日期:1998-01-01 00:00:00

  • Is pentraxin 3 a biomarker, a player, or both in the context of coronary atherosclerosis and metabolic factors?

    abstract::The objective of this study is to determine whether pentraxin-3 (PTX-3) is clinically a biomarker of inflammation, a player in anti-inflammation, or both with regard to coronary atherosclerosis, we compared levels of PTX-3 with levels of adiponectin in addition to high-sensitivity C-reactive protein (hs-CRP). We enrol...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-014-0553-0

    authors: Nakamura A,Miura S,Shiga Y,Norimatsu K,Miyase Y,Suematsu Y,Mitsutake R,Saku K

    更新日期:2015-11-01 00:00:00

  • Cardiovascular medicine heart failure (CVM-HF) index as prognostic model for candidates to MitraClip therapy.

    abstract::Transcatheter MitraClip repair is a new tool for the management of severe mitral regurgitation in patients at very high risk for conventional surgery. Aim of our study was reporting one-year clinical outcomes in candidates to MitraClip procedures, divided into three groups according to the cardiovascular medicine hear...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-015-0772-z

    authors: Ussia GP,Cammalleri V,Mazzotta E,Pascuzzo G,Muscoli S,Marchei M,Macrini M,Anceschi A,Romeo F

    更新日期:2016-10-01 00:00:00

  • The quantitative aspect of photoplethysmography revised.

    abstract::The overall transfer function of a photoplethysmograph (PPG) converting changes in intravascular volume to changes in recorder pen deflection was investigated. The specifications of the apparatus working as a red cell densitometer were assessed in vitro, and it was found that PPG output is a logarithmic function of re...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02128146

    authors: Jespersen LT,Pedersen OL

    更新日期:1986-01-01 00:00:00

  • Remodeling of cardiomyocytes and their branches in juvenile, adult, and senescent spontaneously hypertensive rats and Wistar Kyoto rats: comparative morphometric analyses by scanning electron microscopy.

    abstract::Scanning electron microscopy was used to compare the shape, size, and connection of left ventricular (LV) myocytes between spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY) at 3, 8, 15, 35, and 63 weeks of age. For either strain at each age, five rats were studied, in which LV myocytes consisted of a c...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02481739

    authors: Okabe M,Kawamura K,Terasaki F,Hayashi T

    更新日期:1999-01-01 00:00:00

  • Hydrogen peroxide-induced vascular relaxation in porcine coronary arteries is mediated by Ca2+-activated K+ channels.

    abstract::Hydrogen peroxide (H2O2) elicited concentration-dependent relaxation of endothelium-denuded rings of porcine coronary arteries. The relaxation induced by the H2O2 was markedly attenuated by 10 microM 1H-[1,2,4]oxadiazolo [4,3,a]quinoxalin-1-one (ODQ), an inhibitor of soluble guanylate cyclase, or by 100 nM charybdotox...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02750638

    authors: Hayabuchi Y,Nakaya Y,Matsuoka S,Kuroda Y

    更新日期:1998-01-01 00:00:00

  • Extended-release niacin/laropiprant improves endothelial function in patients after myocardial infarction.

    abstract::Raising high-density lipoprotein cholesterol (HDL-C) is an important strategy for reducing residual cardiovascular risk. In the present study, we sought to assess the effect of extended-release niacin/laropiprant on endothelial function in patients after a myocardial infarction with target low-density lipoprotein chol...

    journal_title:Heart and vessels

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00380-013-0367-5

    authors: Bregar U,Jug B,Keber I,Cevc M,Sebestjen M

    更新日期:2014-05-01 00:00:00

  • Cardioprotective effect of thyroid hormone is mediated by AT2 receptor and involves nitric oxide production via Akt activation in mice.

    abstract::Studies have demonstrated that thyroid hormone (T3) can precondition the heart against ischaemic injury and improve post-ischaemic recovery. This study investigated whether the AT2 receptor (AT2R) is involved in cardioprotection and the potential molecular mechanism responsible for this effect. Hyperthyroidism was ind...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-017-1101-5

    authors: da Silva IB,Gomes DA,Alenina N,Bader M,Dos Santos RA,Barreto-Chaves MLM

    更新日期:2018-06-01 00:00:00

  • Persistent symptomatic pleural effusion following coronary bypass surgery: clinical and histologic features, and treatment.

    abstract::Pleural effusions following coronary artery bypass grafting (CABG) have been reported in 65%-89% of the cases. The majority of pleural effusions are left-sided, of little significance, and resolve spontaneously. However, a few pleural effusions require specific therapeutics. We report clinical and pleural histologic f...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-006-0930-4

    authors: Charniot JC,Zerhouni K,Kambouchner M,Martinod E,Vignat N,Azorin J,Gandjbakhch I,Artigou JY

    更新日期:2007-01-01 00:00:00