Abstract:
:Scanning electron microscopy was used to compare the shape, size, and connection of left ventricular (LV) myocytes between spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY) at 3, 8, 15, 35, and 63 weeks of age. For either strain at each age, five rats were studied, in which LV myocytes consisted of a cylindrical trunk with series (SB) and/ or lateral branch(es) (LB) and step formations; cell junctions had 12 common basic patterns. The length (L), width (W), and L/W ratio of the myocytes, and various indices for SB, LB, and three selected types of cell junctions were measured in 100 cells from each heart and averaged for comparison studies. In the growing period (3-8 weeks of age), the LV myocytes were similar in shape and width in the two age-matched strains and grew similarly with the same L/W ratio. In adolescent (15-week-old) WKY, LV cells grew with the same L/W ratio as in the younger rats, whereas in adolescent SHR, the cells showed a much greater increase in width than in length (disproportionate hypertrophy), the LB proliferated significantly, and the numbers of step-to-step and side-to-side junctions were diminished. In adult (15-35-week-old) WKY, LV cells continued to grow without much change in SB, LB, and the cell junctions, whereas in adult SHR, LV hypertrophy progressed with enhanced cardiomyocyte hypertrophy, increased number of SB, LB, and step-to-end junctions, and reduction in the number of step-to-step and side-to-side junctions per cell. In aged (63-week-old) WKY and SHR, the indices of LV myocytes, SB, LB, and cell junctions did not differ from those in adult WKY and SHR, except for LB thinning in the WKY and significant LB loss in the SHR. Age-related reductions in side-to-side- and step-to-step junctions, and LB loss with myocardial fibrosis in adult and aged SHR may indicate increased loss of gap junctions which couple the cells for transverse conduction, and contribute to anisotropic discontinuous propagation and potential reentrant LV arrhythmias.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Okabe M,Kawamura K,Terasaki F,Hayashi Tdoi
10.1007/BF02481739subject
Has Abstractpub_date
1999-01-01 00:00:00pages
15-28issue
1eissn
0910-8327issn
1615-2573journal_volume
14pub_type
杂志文章abstract::Radiofrequency catheter ablation of an atrial tachycardia (AT) and atrial fibrillation (AF) was performed in a patient with a history of pulmonary vein isolation for paroxysmal AF. The AT exhibited a centrifugal pattern with the posterolateral LA as the earliest activation site. The AT was not terminated by ablation a...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0498-3
更新日期:2015-05-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2020-02-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-012-0235-8
更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00380-019-01440-y
更新日期:2019-12-01 00:00:00
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journal_title:Heart and vessels
pub_type: 临床试验,杂志文章
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更新日期:2008-03-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058684
更新日期:1988-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01747502
更新日期:1997-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-010-0095-z
更新日期:2011-09-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0520-9
更新日期:2015-05-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2020-03-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/s00380-014-0515-6
更新日期:2015-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00380-008-1066-5
更新日期:2008-11-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-011-0210-9
更新日期:2013-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01746067
更新日期:1994-01-01 00:00:00
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更新日期:2014-09-01 00:00:00
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更新日期:2021-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-11-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章,多中心研究
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更新日期:2018-08-01 00:00:00
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pub_type: 杂志文章
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journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2011-05-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:2016-08-01 00:00:00