Abstract:
:Transcatheter MitraClip repair is a new tool for the management of severe mitral regurgitation in patients at very high risk for conventional surgery. Aim of our study was reporting one-year clinical outcomes in candidates to MitraClip procedures, divided into three groups according to the cardiovascular medicine heart failure (CVM-HF) index. The study population consists of 46 consecutive patients, divided, in accordance with CVM-HF index, as follows: one patient in the low-risk category (group A); 27 patients in the medium-risk (group B) and 18 patients in high-risk category (group C). The primary study endpoint was a combined of all-cause mortality and re-hospitalization rate. Secondary endpoints were all-cause mortality and cardiac mortality. Patients of group B and group C were compared. Regarding the primary endpoint, patients in group C had significantly poorer outcomes than patients in group B, with a 12-month survival freedom from events of 44.4 and 74.1 %, respectively (log-rank test, p = 0.039); survival freedom from cardiac mortality was 100 and 83.3 % in group B and C, respectively (log-rank test, p = 0.027). One-year survival free from re-hospitalization was 74.1 % in group B and 39.9 % in group C (log-rank test; p = 0.036). Survival free from all-cause of mortality was 92.6 and 77.8 %, respectively (log-rank test; p = 0.129). In our initial experience the CVM-HF index showed to be valuable for understanding if the patient with advanced heart failure and functional mitral regurgitation can really benefit by MitraClip therapy.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Ussia GP,Cammalleri V,Mazzotta E,Pascuzzo G,Muscoli S,Marchei M,Macrini M,Anceschi A,Romeo Fdoi
10.1007/s00380-015-0772-zsubject
Has Abstractpub_date
2016-10-01 00:00:00pages
1633-42issue
10eissn
0910-8327issn
1615-2573pii
10.1007/s00380-015-0772-zjournal_volume
31pub_type
杂志文章abstract::Insulin resistance (IR) is now considered to be a risk factor for coronary arterial atherosclerosis and is likely to be involved in a limited endothelium-dependent vasodilatory function in peripheral circulation. We investigated whether IR impairs endothelial vasodilator function in the noninfarcted coronary artery. I...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-007-1002-0
更新日期:2008-01-01 00:00:00
abstract::Several reports demonstrated positive effects of processing residual cardiopulmonary bypass volume using a cell salvage device in conventional open heart surgery via sternotomy on hemostasis. The present study aimed to investigate whether cell salvage processing has the same effects on postoperative blood loss and tra...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01365-6
更新日期:2019-08-01 00:00:00
abstract::Myocardial perfusion and perfusion reserve are diminished in patients with atrial fibrillation (AF). Phase-contrast (PC) cine magnetic resonance imaging (MRI) of the coronary sinus serves as a non-invasive means of quantifying coronary flow reserve (CFR) without any radioactive tracer. The present study aimed to evalu...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01759-x
更新日期:2021-01-23 00:00:00
abstract::In early systole, before the effects of reflected waves from the periphery become significant, the following equation applies: PA - PO = rho cu (1) where PA and PO are the instantaneous and end-diastolic pressures in the ascending aorta, rho the density of blood, c the velocity of the pulse wave in the aorta, and u th...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02073644
更新日期:1987-01-01 00:00:00
abstract::To test the therapeutic efficacy of levamisole, 5-week-old DBA/2 mice were inoculated intraperitoneally with 10 plaque-forming units of encephalo-myocarditis virus. Levamisole (2.5 mg/kg/per day) was administered intraperitoneally daily, starting simultaneously with the virus inoculation, in experiment I for 14 days, ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02820869
更新日期:1997-01-01 00:00:00
abstract::A drawback of visual assessment for late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) is the subjectivity and reproducibility of the results. The aim of this study was to investigate the relationship between left ventricular (LV) reverse remodeling in response to optimal pharmacotherapies and the d...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1196-3
更新日期:2018-12-01 00:00:00
abstract::There are few data regarding acute coronary syndrome (ACS) in young Japanese patients. We examined the risk factors for ACS in young Japanese patients, especially impaired glucose metabolism. From a database of 789 consecutive patients admitted to our hospital with ACS between 2000 and 2005, we compared risk factors o...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0956-7
更新日期:2007-05-01 00:00:00
abstract::We have theoretically proposed "systolic pressure-volume area" (PVA) as a measure of total mechanical energy generated by ventricular contraction. We then experimentally showed that PVA closely correlates with left ventricular oxygen consumption (Vo2) regardless of ventricular loading conditions in a stable contractil...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058751
更新日期:1991-01-01 00:00:00
abstract::We recently reported that preoperative endothelial dysfunction [i.e., reactive hyperemia index (RHI) ≤ 1.64] predicted short-term postoperative adverse events in patients undergoing cardiovascular surgery. However, the relationship between preoperative RHI and long-term cardiovascular risk in these patients is unclear...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1248-8
更新日期:2019-02-01 00:00:00
abstract::Hyperuricemia is known to be associated with adverse outcomes in cardiovascular intensive care patients, but its mechanisms are unknown. A total of 569 emergency department patients were prospectively analyzed and assigned to intensive care (ICU group, n = 431) or other departments (n = 138). Uric acid (UA) levels wer...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01608-x
更新日期:2020-10-01 00:00:00
abstract::The aim of the study was to evaluate systemic right ventricular (RV) dyssynchrony in patients with congenitally corrected transposition of the great arteries (CCTGA) and transposition of the great arteries (TGA) with New York Heart Association functional class (NYHA FC) < III. We used cardiac magnetic resonance (CMR) ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1144-2
更新日期:2018-09-01 00:00:00
abstract::T cells are involved in the pathogenesis of atherosclerosis. We aimed to search for any association between the peripheral T-cell activities and atherogenic risk factors in healthy subjects. Fifty male volunteers (age 22.0 +/- 2.4 years) were enrolled. No subject had any chronic disease or was under any drug treatment...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-005-0893-x
更新日期:2006-07-01 00:00:00
abstract::Liver cirrhosis (LC), which may result in hepatic failure or cancer, has been reported in patients after Fontan procedure. The purpose of this study was to clarify the frequency and histological characteristics of LC, and to evaluate the risk factors and serological markers of LC with Fontan circulation. Retrospective...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0743-4
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:An increase in epicardial adipose tissue (EAT) volume is associated with the development of atrial fibrillation (AF) and coronary artery disease (CAD), but little is known about differences in its distribution. METHODS AND RESULTS:We included 50 patients with paroxysmal AF (PAF), 50 patients with CAD, and 5...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01575-3
更新日期:2020-08-01 00:00:00
abstract::We investigated the signaling mechanism of stretch-induced cell remodeling in human umbilical vein endothelial cells (HUVECs). Freshly dissociated HUVECs were cultured on an elastic silicon membrane and subjected to uniaxial cyclic stretch (20% in length, 1 Hz). The cells started to change their morphology as early as...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::In addition to plaque rupture (PR), calcified nodule (CN) may also have the potential to develop into arterial thrombus in the peripheral arteries. This study evaluated the distribution of plaque ruptures and calcified nodules in the peripheral arteries and their impact on the outcome of endovascular therapy (EVT). Co...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0984-5
更新日期:2017-10-01 00:00:00
abstract::The aim of our study was to assess the atherosclerotic burden in patients with the first symptoms of coronary artery disease (CAD). The study population consisted of 100 consecutive patients (new-onset severe angina or myocardial infarction) and 70 age- and sex-matched volunteers without symptoms of CAD. Functional an...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s003800200028
更新日期:2002-09-01 00:00:00
abstract::Hypertension and high serum cholesterol level are important risk factors for atherosclerosis and coronary heart disease. In the present study we tested the hypothesis whether high sodium intake, when given in combination with Western type high-fat diet, induces endothelial dysfunction and promotes atherosclerosis. Fur...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-008-1066-5
更新日期:2008-11-01 00:00:00
abstract::It is known that the heart of an athlete has been physiologically adapted by prolonged training. There are a large number of echocardiographic studies which have focused on left ventricular wall thickness and dilatation, but there are few studies concerning right heart function in the athlete's heart. The aim of this ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s003800200018
更新日期:2002-07-01 00:00:00
abstract::Compared to conscious sedation (CS), the use of general anesthesia (GA) in pulmonary vein isolation (PVI) is associated with a lower recurrence rate of atrial fibrillation (AF). GA may improve catheter stability and mapping system accuracy compared to CS, but its influence on contact force (CF) parameters during ipsil...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0961-z
更新日期:2017-08-01 00:00:00
abstract::A 70-year-old man underwent stent implantation for right coronary artery (RCA) lesions with a bare metal stent (BMS) and two sirolimus-eluting stents (SES). However, as both the BMS and SES stented sites developed restenosis after 13 months, he underwent target lesion revascularization using directional coronary ather...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0676-y
更新日期:2016-06-01 00:00:00
abstract::Effects of the administration of a thromboxane A2 (TXA2) analogue (STA2), a leukotriene C4 (LTC4), and a leukotriene D4 (LTD4) on regional myocardial blood flow (RMBF) and hemodynamics were studied in anesthetized, open-chest dogs. The blocking ability of a recently synthesized TXA2 selective antagonist, ONO-3708, and...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058997
更新日期:1988-01-01 00:00:00
abstract::This study was designed to investigate the effect of low-dose nesiritide on renal function and major cardiac events in patients with acute decompensated heart failure following acute myocardial infarction. Sixty patients were randomized into nesiritide (loading dose 0.5 microg/kg, maintenance dose 0.0075 microg/kg/min...
journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-009-1171-0
更新日期:2010-03-01 00:00:00
abstract::Although heparin allergy is a rare but well-documented entity, anticoagulation management for cardiac surgery in patients with the heparin allergy has not been established due to its rarity. Here we report a case that shows our anticoagulation strategy during a coronary bypass operation. A 67-year-old man with unstabl...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s003800300006
更新日期:2003-03-01 00:00:00
abstract::Inflammatory markers are elevated in acute coronary syndromes, and are also known to play a crucial role in the pathogenesis of neointimal proliferation and stent restenosis. Drug-eluting stents (DESs) have been shown to decrease stent restenosis in different studies. In this study, we aimed to investigate the effect ...
journal_title:Heart and vessels
pub_type: 临床试验,杂志文章
doi:10.1007/s00380-007-1020-y
更新日期:2008-03-01 00:00:00
abstract::This study assesses the global left ventricular function and volumes using dual-source computed tomography (DSCT) with improved temporal resolution (83 ms) by use of a semi-automatic software tool in comparison to invasive angiography (IVA). One hundred patients scheduled for invasive coronary angiography because of s...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-009-1157-y
更新日期:2010-01-01 00:00:00
abstract::Dilated cardiomyopathy (DCM) is a common primary myocardial disease leading to congestive heart failure, arrhythmia and sudden cardiac death. Increasing studies demonstrate substantial genetic determinants for DCM. Nevertheless, DCM is of substantial genetic heterogeneity, and the genetic basis for DCM in most patient...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-1110-4
更新日期:2018-07-01 00:00:00
abstract::The association between periprocedural hypotension and conscious sedation (CS) during defibrillator implantation remains to be elucidated. The aim of the present study was to compare the occurrence of periprocedural hypotension after CS or local anesthesia (LA) during defibrillator implantation in a retrospective coho...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01462-6
更新日期:2020-01-01 00:00:00
abstract::We analyzed whether smoking was associated with major adverse cardiovascular events (MACE) and the progression of coronary atherosclerosis as assessed by coronary computed tomography angiography (CCTA) as screening for coronary artery disease (CAD). We enrolled 443 patients who had all undergone CCTA and either were c...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01727-5
更新日期:2020-11-27 00:00:00
abstract::Although a previous randomized study showed that the use of atrial natriuretic peptide (carperitide) improved the long-term prognosis of patients with heart failure, its effect on short-term prognosis remains unclear. We retrospectively identified patients who were admitted to our tertiary-care center with acute decom...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0952-0
更新日期:2017-08-01 00:00:00