Abstract:
:To test the therapeutic efficacy of levamisole, 5-week-old DBA/2 mice were inoculated intraperitoneally with 10 plaque-forming units of encephalo-myocarditis virus. Levamisole (2.5 mg/kg/per day) was administered intraperitoneally daily, starting simultaneously with the virus inoculation, in experiment I for 14 days, and daily on days 14 to 28 in experiment II in mice that survived to 14 days after virus inoculation. In experiment I, survival was higher, the severity of myocarditis was less, and myocardial virus titers were lower in treated than in untreated animals. In experiment II, levamisole was not effective. No significant changes in serum neutralizing antibody titers occurred in either experiment. Furthermore, levamisole prevented associated lymphoid organ atrophy induced by the virus infection. An additional in vitro study revealed the absence of anti-viral activity of the drug. Thus, levamisole may have favorable effects upon encephalomyocarditis virus myocarditis by preventing the virus-induced lymphoid organ atrophy and reducing myocardial virus replication in the acute stage.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Kishimoto C,Takada H,Hiraoka Y,Kurokawa M,Ochiai Hdoi
10.1007/BF02820869subject
Has Abstractpub_date
1997-01-01 00:00:00pages
67-73issue
2eissn
0910-8327issn
1615-2573journal_volume
12pub_type
杂志文章abstract::We explored the influence of global longitudinal strain (GLS) measured with two-dimensional speckle-tracking echocardiography on left ventricular mass regression (LVMR) in patients with pure aortic stenosis (AS) and normal left ventricular function undergoing aortic valve replacement (AVR). The study population includ...
journal_title:Heart and vessels
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abstract::Recent evidence has shown that apoptotic cells are present in human atherosclerotic lesions. However, the molecular mechanism of the induction of apoptosis in atherosclerotic lesions is not clear. Since T cells are present in almost all stages of atherosclerosis, we examined whether T cells can modulate the expression...
journal_title:Heart and vessels
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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doi:10.1007/s00380-012-0235-8
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journal_title:Heart and vessels
pub_type: 杂志文章
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journal_title:Heart and vessels
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journal_title:Heart and vessels
pub_type: 杂志文章
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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更新日期:2005-11-01 00:00:00
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journal_title:Heart and vessels
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journal_title:Heart and vessels
pub_type: 杂志文章
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journal_title:Heart and vessels
pub_type: 杂志文章
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-003-0744-6
更新日期:2004-05-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0912-0
更新日期:2017-05-01 00:00:00
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更新日期:2020-09-09 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-009-1180-z
更新日期:2010-03-01 00:00:00
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journal_title:Heart and vessels
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doi:10.1007/s00380-019-01487-x
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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