Low-density lipoproteins inhibit histamine and NaNO2 relaxations of the coronary vasculature and reduce contractile function in isolated rat hearts.

Abstract:

:In the present study we examined the action of native and oxidized low-density lipoproteins (LDL) on coronary vascular and cardiac function and ultrastructure in rat hearts perfused isovolumically in the Langendorff mode. Responses of the coronary resistance vessels to the endothelium-dependent vasodilator, histamine, and the endothelium-independent vasodilator, NaNO2, were measured together with contractile function (rate-pressure product) before and after perfusion for 20 min with native - or oxidized-LDL at a concentration of 100 mu g protein/ml. Ultrastructural damage was assessed via electron microscopy of perfusion-fixed heart specimens. When compared to findings in untreated, control hearts, both native and oxidized LDL significantly reduced the responsiveness of the coronary resistance vessels to histamine and NaNO2, by about 50%. The rate-pressure product was decreased more by oxidized-LDL (41%) than by native-LDL (26%). Electron microscopy showed no ultrastructural abnormalities in the vasculature or myocytes of control hearts. The administration of both native- and oxidized-LDL caused distortion of endothelial cells, increased levels of pinocytotic vesicles in both endothelial and smooth muscle cells, detachment of blood vessels from surrounding tissue, and some regions of myocyte injury with evidence of mitochondrial injury and fluid accumulation. Our results show that both native- and oxidized-LDL are toxic to the isolated heart preparation. They inhibit coronary vascular responsiveness to vasodilators, reduce contractile function, and produce damage to cardiac ultrastructure.

journal_name

Heart Vessels

journal_title

Heart and vessels

authors

Harrison GJ,Jordan LR,Selley ML,Willis RJ

doi

10.1007/BF01744904

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

249-57

issue

5

eissn

0910-8327

issn

1615-2573

journal_volume

10

pub_type

杂志文章
  • Clinical significance of discrepant mid-wall late gadolinium enhancement in patients with nonischemic dilated cardiomyopathy.

    abstract::A drawback of visual assessment for late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) is the subjectivity and reproducibility of the results. The aim of this study was to investigate the relationship between left ventricular (LV) reverse remodeling in response to optimal pharmacotherapies and the d...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-018-1196-3

    authors: Ehara S,Matsumoto K,Kitada R,Nishimura S,Shimada K,Yoshiyama M

    更新日期:2018-12-01 00:00:00

  • Associations between smoking habits and major adverse cardiovascular events in patients who underwent coronary computed tomography angiography as screening for coronary artery disease.

    abstract::We analyzed whether smoking was associated with major adverse cardiovascular events (MACE) and the progression of coronary atherosclerosis as assessed by coronary computed tomography angiography (CCTA) as screening for coronary artery disease (CAD). We enrolled 443 patients who had all undergone CCTA and either were c...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-020-01727-5

    authors: Higashi S,Shiga Y,Yano M,Imaizumi T,Tashiro K,Idemoto Y,Kato Y,Kuwano T,Sugihara M,Miura SI

    更新日期:2020-11-27 00:00:00

  • Factors affecting hospital readmission heart failure patients in Japan: a multicenter retrospective cohort study.

    abstract::The purpose of this study was to examine factors influencing readmission to hospital in patients with heart failure. This multicenter, retrospective cohort study analyzed 197 heart failure patients admitted to the research cooperation facilities between January 2017 and November 2017. We defined the readmission group ...

    journal_title:Heart and vessels

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00380-019-01500-3

    authors: Umehara T,Katayama N,Tsunematsu M,Kakehashi M

    更新日期:2020-03-01 00:00:00

  • The relationship between systolic vector flow mapping parameters and left ventricular cardiac function in healthy dogs.

    abstract::Vector flow mapping (VFM) is a novel echocardiographic technology that shows blood flow vectors and vortexes, enabled the hydrokinetic evaluation of hemodynamics within the left ventricle. VFM provides several unique parameters: circulation, vorticity, vortex area, and energy loss. The present study aims to reveal a r...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-017-1093-1

    authors: Goya S,Wada T,Shimada K,Hirao D,Tanaka R

    更新日期:2018-05-01 00:00:00

  • Timing of continuous veno-venous hemodialysis in the treatment of acute renal failure following cardiac surgery.

    abstract::The purpose was to study optimum timing of continuous veno-venous hemodialysis (CVVHD) for acute renal failure (ARF) after cardiac surgery. CVVHD was performed in two groups [elapsed time between urine output (UO) <0.5 ml/kg/h and dialysis of no more than 12 h in group A and >12 h in group B] with a total of 58 adult ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-010-0045-9

    authors: Ji Q,Mei Y,Wang X,Feng J,Cai J,Zhou Y,Sun Y,Xie S,Hu D

    更新日期:2011-03-01 00:00:00

  • Increased circulating CD3+/CD31+ T cells in patients with acute coronary syndrome.

    abstract::The number of circulating endothelial progenitor cells (EPCs) is considered to be a surrogate marker for coronary artery disease (CAD). Recent studies have identified a novel T-cell subset labeled with CD3(+)/CD31(+), which is necessary for EPC colony formation and constitutes the central cluster. However, the clinica...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-012-0284-z

    authors: Kakizaki M,Nobori K,Watanabe H,Iino K,Ishida M,Ito H

    更新日期:2013-09-01 00:00:00

  • Inter- and intra-ventricular dyssynchrony in the systemic right ventricle is a surrogate marker of major cardiac events in mildly symptomatic patients.

    abstract::The aim of the study was to evaluate systemic right ventricular (RV) dyssynchrony in patients with congenitally corrected transposition of the great arteries (CCTGA) and transposition of the great arteries (TGA) with New York Heart Association functional class (NYHA FC) < III. We used cardiac magnetic resonance (CMR) ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-018-1144-2

    authors: Shiina Y,Inai K,Takahashi T,Taniguchi K,Watanabe E,Fukushima K,Niwa K,Nagao M

    更新日期:2018-09-01 00:00:00

  • Impact of Killip classification on acute myocardial infarction: data from the SAIKUMA registry.

    abstract::Therapeutic devices for acute myocardial infarction (AMI) have evolved dramatically in recent years. However, the impact of the Killip classification of AMI outcomes in patients undergoing aggressive percutaneous coronary intervention remains unclear. We performed a 10-year retrospective review of 2062 patients diagno...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-017-1017-0

    authors: Taguchi E,Konami Y,Inoue M,Suzuyama H,Kodama K,Yoshida M,Miyamoto S,Nakao K,Sakamoto T

    更新日期:2017-12-01 00:00:00

  • Castration modifies aortic vasoreactivity and serum fatty acids in a sucrose-fed rat model of metabolic syndrome.

    abstract::Levels of testosterone and estradiol influence the incidence of cardiovascular diseases: generally, estrogens in females are protective before menopause; coronaropathies, hypertension, and dyslipidemias in normal men are more frequent at comparable ages. We investigated the modulation by castration of in vitro vasorea...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-008-1098-x

    authors: Perez I,El Hafidi M,Carvajal K,Baños G

    更新日期:2009-03-01 00:00:00

  • Hyperthermia by bathing in a hot spring improves cardiovascular functions and reduces the production of inflammatory cytokines in patients with chronic heart failure.

    abstract::Balneotherapy has been shown to reduce systemic blood pressure in healthy volunteers. Hyperthermia might ameliorate the inflammatory status in heart failure through improving cardiac function. The purpose of this study was to examine the beneficial effects of balneotherapy in patients with chronic heart failure (CHF)....

    journal_title:Heart and vessels

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00380-011-0220-7

    authors: Oyama J,Kudo Y,Maeda T,Node K,Makino N

    更新日期:2013-03-01 00:00:00

  • Mechanotransduction and intracellular signaling mechanisms of stretch-induced remodeling in endothelial cells.

    abstract::We investigated the signaling mechanism of stretch-induced cell remodeling in human umbilical vein endothelial cells (HUVECs). Freshly dissociated HUVECs were cultured on an elastic silicon membrane and subjected to uniaxial cyclic stretch (20% in length, 1 Hz). The cells started to change their morphology as early as...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:

    authors: Sokabe M,Naruse K,Sai S,Yamada T,Kawakami K,Inoue M,Murase K,Miyazu M

    更新日期:1997-01-01 00:00:00

  • Increased respiratory disturbance index measured using an advanced device algorithm is associated with heart failure development.

    abstract::Previous studies suggested that sleep-disordered breathing was associated with cardiovascular diseases such as heart failure (HF). Recently, algorithms of cardiac implantable electronic devices (CIEDs) have been developed to detect advanced sleep apnea (SA); the Apnea Scan (AP Scan) being an example. The purpose of th...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-019-01551-6

    authors: Wakabayashi Y,Koyama T,Kurihara K,Kobayashi M,Ichikawa T,Abe H

    更新日期:2020-06-01 00:00:00

  • Differences in prothrombotic response between the uninterrupted and interrupted apixaban therapies in patients undergoing cryoballoon ablation for paroxysmal atrial fibrillation: a randomized controlled study.

    abstract::Periprocedural bleeding and thromboembolic events are worrisome complications of catheter ablation for atrial fibrillation (AF). Periprocedural anticoagulation management could decrease the risk of these complications. However, evaluation of the complications from pulmonary vein isolation using cryoballoon related to ...

    journal_title:Heart and vessels

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00380-019-01370-9

    authors: Ando M,Inden Y,Yoshida Y,Sairaku A,Yanagisawa S,Suzuki H,Watanabe R,Takenaka M,Maeda M,Murohara T

    更新日期:2019-09-01 00:00:00

  • Analysis of wave reflections in the arterial system using wave intensity: a novel method for predicting the timing and amplitude of reflected waves.

    abstract::The timing and amplitude of reflected arterial waves in the ascending aorta were studied by analysis of the aortic pressure waveform and were compared with those derived using wave intensity analysis. Wave intensity analysis considers aortic pressure changes to be the result of forward and backward wavelets carrying e...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF01747827

    authors: Koh TW,Pepper JR,DeSouza AC,Parker KH

    更新日期:1998-01-01 00:00:00

  • Echocardiographic surrogates of right atrial pressure in pulmonary hypertension.

    abstract::Right atrial pressure (RAP), a representative parameter of right heart failure, is very important for prognostic evaluation and risk assessment in pulmonary hypertension. However, its measurement requires invasive cardiac catheterization. In this study, we determined the most accurate echocardiographic surrogate of ca...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-018-1264-8

    authors: Watanabe R,Amano H,Saito F,Toyoda S,Sakuma M,Abe S,Nakajima T,Inoue T

    更新日期:2019-03-01 00:00:00

  • Endothelial function estimated by digital reactive hyperemia in patients with atherosclerotic risk factors or coronary artery disease.

    abstract::Due to the complex profile of atherosclerotic risk factors, an integrated analysis of a specific individual is difficult. Endothelial function reflects a composite of various risk factors, and may be used as an optimal tool to estimate the overall atherosclerotic risk. In this study, we investigated the value of digit...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-018-1118-4

    authors: Kang J,Kim HL,Seo JB,Lee JY,Moon MK,Chung WY

    更新日期:2018-07-01 00:00:00

  • Impact of sleep-disordered breathing on myocardial damage and metabolism in patients with chronic heart failure.

    abstract::Sleep-disordered breathing (SDB) has a critical association with mortality and morbidity of patients with chronic heart failure (CHF). Troponin T is a marker of ongoing myocardial damage and predicts adverse clinical outcomes in patients with CHF. Carnitine plays an important role in the utilization of fatty acids in ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-014-0479-6

    authors: Miyata M,Yoshihisa A,Yamauchi H,Owada T,Sato T,Suzuki S,Sugimoto K,Yamaki T,Kunii H,Nakazato K,Suzuki H,Saitoh S,Takeishi Y

    更新日期:2015-05-01 00:00:00

  • A low prevalence of sarcomeric gene variants in a Chinese cohort with left ventricular non-compaction.

    abstract::Left ventricular non-compaction (LVNC) is genetically heterogeneous. It has been previously shown that LVNC is associated with defects in TAZ, DNTA, LDB3, YWHAE, MIB1, PRDM16, and sarcomeric genes. This study was aimed to investigate sarcomeric gene mutations in a Chinese population with LVNC. From 2004 to 2010, 57 un...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-014-0503-x

    authors: Tian T,Wang J,Wang H,Sun K,Wang Y,Jia L,Zou Y,Hui R,Zhou X,Song L

    更新日期:2015-03-01 00:00:00

  • Clinical application of wave intensity for the treatment of essential hypertension.

    abstract::Wave intensity analysis is a method of studying intravascular flow wave propagation, calculated as the product of the rate of change in pressure (d P/ t) and the rate of change in velocity (d U/d t). The typical pattern of wave intensity seen during the cardiac cycle has two dominant peaks. The larger first peak (FP) ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-003-0725-9

    authors: Fujimoto S,Mizuno R,Saito Y,Nakamura S

    更新日期:2004-01-01 00:00:00

  • Regional work of the ventricle: wall tension--area relation.

    abstract::We clarified that the set of the isotropic component (T) of wall tension and the area (A) of a selected region of the left ventricular wall expresses the regional work with sufficient accuracy. The area surrounded by the locus of the T-A relation in the T-A plane is approximately equal to the real work done by that re...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02066408

    authors: Sugawara M,Tamiya K,Nakano K

    更新日期:1985-08-01 00:00:00

  • Axillo-femoral bypass steal due to subclavian artery stenosis.

    abstract::Subclavian artery stenosis can cause a flow reversal-so-called steal-not only in the ipsilateral vertebral artery, but also in the internal mammary artery in patients with a history of coronary-artery bypass grafting. Subclavian artery stenosis is also associated with peripheral artery disease elsewhere. We report a n...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-016-0821-2

    authors: Shigyo H,Kawarada O,Noguchi T,Ogawa H,Yasuda S

    更新日期:2016-11-01 00:00:00

  • Correction to: Increased prevalence of cerebral microbleeds in patients with low left ventricular systolic function.

    abstract::In the original publication of the article, under the results section, the following sentence. ...

    journal_title:Heart and vessels

    pub_type: 已发布勘误

    doi:10.1007/s00380-020-01574-4

    authors: Watanabe T,Kanzaki Y,Yamauchi Y,Ito T,Nishida Y,Yamamura K,Komori T,Sohmiya K,Hoshiga M

    更新日期:2020-05-01 00:00:00

  • Plasma xanthine oxidoreductase (XOR) activity in patients who require cardiovascular intensive care.

    abstract::Hyperuricemia is known to be associated with adverse outcomes in cardiovascular intensive care patients, but its mechanisms are unknown. A total of 569 emergency department patients were prospectively analyzed and assigned to intensive care (ICU group, n = 431) or other departments (n = 138). Uric acid (UA) levels wer...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-020-01608-x

    authors: Shibata Y,Shirakabe A,Okazaki H,Matsushita M,Goda H,Shigihara S,Asano K,Kiuchi K,Tani K,Murase T,Nakamura T,Kobayashi N,Hata N,Asai K,Shimizu W

    更新日期:2020-10-01 00:00:00

  • Adiponectin levels in coronary artery ectasia.

    abstract::Etiopathogenesis of coronary artery ectasia (CAE), which is defined as abnormal dilatation of a segment of the coronary artery to 1.5 times of an adjacent normal coronary artery segment, is unclear. However, it is speculated that CAE develops in the atherosclerosis process through degeneration of coronary artery media...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-008-1087-0

    authors: Dagli N,Ozturk U,Karaca I,Yavuzkir M,Koca S,Akbulut H,Balin M

    更新日期:2009-03-01 00:00:00

  • In-hospital management and outcomes in patients with peripartum cardiomyopathy: a descriptive study using a national inpatient database in Japan.

    abstract::Peripartum cardiomyopathy (PPCM) is a rare but life-threatening cardiac disorder characterized by maternal systolic heart failure. Although PPCM is a major cause of maternal mortality, little is known about the acute-phase management of PPCM in real-world clinical settings. We retrospectively identified patients hospi...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-017-0958-7

    authors: Isogai T,Matsui H,Tanaka H,Fushimi K,Yasunaga H

    更新日期:2017-08-01 00:00:00

  • Interrelationship in the prognostic efficacy of regional coronary flow reserve, fractional flow reserve, high-sensitivity cardiac troponin-I and NT-proBNP in patients with stable coronary artery disease.

    abstract::This study aimed to investigate the combined efficacy in prediction of major adverse cardiac events (MACE) by coronary regional physiological indices including coronary flow reserve (CFR) or fractional flow reserve (FFR) and high-sensitivity cardiac troponin-I (hs-cTnI) or N-terminal pro brain natriuretic peptide (NT-...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-018-1260-z

    authors: Hamaya R,Yonetsu T,Kanaji Y,Usui E,Hoshino M,Hada M,Kanno Y,Murai T,Lee T,Kakuta T

    更新日期:2019-03-01 00:00:00

  • Points to note from indications for heart transplantation to post-heart transplant care: from the care of patients with refractory heart failure and overseas heart transplantation.

    abstract::To examine important points surrounding the indications for heart transplantation (HTX) to care after HTX, we reviewed 22 patients with refractory heart failure aged less than 60 years who had been observed for the past 6 years. Sixteen patients had dilated cardiomyopathy; 1, dilated hypertrophic cardiomyopathy; 3, re...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:

    authors: Nunoda S,Kurosawa R,Kogashi K,Yamagishi S,Mitsui F,Funabashi W

    更新日期:1997-01-01 00:00:00

  • Low total antioxidative capacity levels are associated with augmentation index but not pulse-wave velocity.

    abstract::It is well known the relationship between oxidative stress and vascular function. However, association between total antioxidative capacity and arterial stiffness was not studied in patients with hypertension (HT). This study investigated whether total antioxidative capacity is associated with arterial stiffness and w...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-008-1129-7

    authors: Gedikli O,Ozturk S,Yilmaz H,Baykan M,Kiris A,Durmus I,Karaman K,Karahan C,Celik S

    更新日期:2009-09-01 00:00:00

  • Comparison of magnetic wire navigation with the conventional wire technique for percutaneous coronary intervention of chronic total occlusions: a randomised, controlled study.

    abstract::Wire crossing of a chronic total coronary occlusion (CTO) is time consuming and limited by the amount of contrast agent and time of radiation exposure. Magnetic wire navigation (MWN) might accelerate wire crossing by maintaining a coaxial vessel orientation. This study compares MWN with the conventional approach for r...

    journal_title:Heart and vessels

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00380-015-0739-0

    authors: Roth C,Berger R,Scherzer S,Krenn L,Gangl C,Dalos D,Delle-Karth G,Neunteufl T

    更新日期:2016-08-01 00:00:00

  • Difference in epicardial adipose tissue distribution between paroxysmal atrial fibrillation and coronary artery disease.

    abstract:BACKGROUND:An increase in epicardial adipose tissue (EAT) volume is associated with the development of atrial fibrillation (AF) and coronary artery disease (CAD), but little is known about differences in its distribution. METHODS AND RESULTS:We included 50 patients with paroxysmal AF (PAF), 50 patients with CAD, and 5...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-020-01575-3

    authors: Hasebe H,Yoshida K,Nogami A,Ieda M

    更新日期:2020-08-01 00:00:00