Abstract:
:In the present study we examined the action of native and oxidized low-density lipoproteins (LDL) on coronary vascular and cardiac function and ultrastructure in rat hearts perfused isovolumically in the Langendorff mode. Responses of the coronary resistance vessels to the endothelium-dependent vasodilator, histamine, and the endothelium-independent vasodilator, NaNO2, were measured together with contractile function (rate-pressure product) before and after perfusion for 20 min with native - or oxidized-LDL at a concentration of 100 mu g protein/ml. Ultrastructural damage was assessed via electron microscopy of perfusion-fixed heart specimens. When compared to findings in untreated, control hearts, both native and oxidized LDL significantly reduced the responsiveness of the coronary resistance vessels to histamine and NaNO2, by about 50%. The rate-pressure product was decreased more by oxidized-LDL (41%) than by native-LDL (26%). Electron microscopy showed no ultrastructural abnormalities in the vasculature or myocytes of control hearts. The administration of both native- and oxidized-LDL caused distortion of endothelial cells, increased levels of pinocytotic vesicles in both endothelial and smooth muscle cells, detachment of blood vessels from surrounding tissue, and some regions of myocyte injury with evidence of mitochondrial injury and fluid accumulation. Our results show that both native- and oxidized-LDL are toxic to the isolated heart preparation. They inhibit coronary vascular responsiveness to vasodilators, reduce contractile function, and produce damage to cardiac ultrastructure.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Harrison GJ,Jordan LR,Selley ML,Willis RJdoi
10.1007/BF01744904subject
Has Abstractpub_date
1995-01-01 00:00:00pages
249-57issue
5eissn
0910-8327issn
1615-2573journal_volume
10pub_type
杂志文章abstract::A drawback of visual assessment for late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) is the subjectivity and reproducibility of the results. The aim of this study was to investigate the relationship between left ventricular (LV) reverse remodeling in response to optimal pharmacotherapies and the d...
journal_title:Heart and vessels
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pub_type: 杂志文章,多中心研究
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journal_title:Heart and vessels
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doi:10.1007/s00380-017-1093-1
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journal_title:Heart and vessels
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更新日期:2017-12-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:1998-01-01 00:00:00
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更新日期:2015-05-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0503-x
更新日期:2015-03-01 00:00:00
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更新日期:2004-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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journal_title:Heart and vessels
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更新日期:2017-08-01 00:00:00
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更新日期:2019-03-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
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journal_title:Heart and vessels
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更新日期:2009-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2016-08-01 00:00:00
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