Associations between smoking habits and major adverse cardiovascular events in patients who underwent coronary computed tomography angiography as screening for coronary artery disease.

Abstract:

:We analyzed whether smoking was associated with major adverse cardiovascular events (MACE) and the progression of coronary atherosclerosis as assessed by coronary computed tomography angiography (CCTA) as screening for coronary artery disease (CAD). We enrolled 443 patients who had all undergone CCTA and either were clinically suspected of having CAD or had at least one cardiovascular risk factor. We divided the patients into smoking (past and current smoker) and non-smoking groups and into males and females, and evaluated the presence of CAD, severity of coronary atherosclerosis and MACE (cardiovascular death, ischemic stroke, acute myocardial infarction and coronary revascularization) with a follow-up of up to 5 years. %CAD and the severity of coronary atherosclerosis in the smoking group were significantly higher than those in the non-smoking group. %MACE in males and smokers were significantly higher than those in females and non-smokers, respectively. Interestingly, Kaplan-Meier curves also showed that female non-smokers enjoyed significantly greater freedom from MACE than female smokers (p = 0.007), whereas there was no significant difference in freedom from MACE between male non-smokers and male smokers (p = 0.984). Although there were no significant predictors of MACE in all patients according to a multiple logistic regression analysis, smoking was useful for predicting MACE in females, but not males. In conclusion, smoking was significantly associated with MACE in females, but not males, who underwent CCTA as screening for CAD.

journal_name

Heart Vessels

journal_title

Heart and vessels

authors

Higashi S,Shiga Y,Yano M,Imaizumi T,Tashiro K,Idemoto Y,Kato Y,Kuwano T,Sugihara M,Miura SI

doi

10.1007/s00380-020-01727-5

subject

Has Abstract

pub_date

2020-11-27 00:00:00

eissn

0910-8327

issn

1615-2573

pii

10.1007/s00380-020-01727-5

pub_type

杂志文章
  • Measurement of aortic diameters and detection of asymptomatic aortic aneurysms in a mass screening program using a mobile helical computed tomography unit.

    abstract::In a mass chest computed tomography (CT) screening using a mobile helical CT unit, we measured the aortic diameter at three segments to confirm standard values and also attempted to detect any asymptomatic aortic aneurysms. The population screened in the present study consisted of 6971 subjects (3847 men and 3124 wome...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s380-002-8315-1

    authors: Itani Y,Watanabe S,Masuda Y,Hanamura K,Asakura K,Sone S,Sunami Y,Miyamoto T

    更新日期:2002-01-01 00:00:00

  • Correlation of anatomic and hemodynamic features with aortic valve leaflet deformity in doubly committed subarterial ventricular septal defect.

    abstract::The records of 153 patients with doubly committed subarterial ventricular septal defect (DCVSD) who underwent intracardiac repair were analyzed to evaluate factors responsible for aortic valve leaflet deformity. The patients were divided into two groups according to their echocardiographic and angiographic features as...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF01747853

    authors: Kobayashi J,Koike K,Senzaki H,Kobayashi T,Tsunemoto M,Ishizawa A,Ohta Y,Shimada M,Omoto R

    更新日期:1999-01-01 00:00:00

  • Does additional coronary artery bypass grafting to aortic valve replacement in elderly patients affect the early and long-term outcome?

    abstract::Early and long-term outcomes in elderly patients who underwent isolated aortic valve replacement (iAVR) are well defined. Conflicting data exist in elderly patients who underwent AVR plus coronary artery bypass grafting (CABG). We sought to evaluate the early and long-term outcomes of combined AVR + CABG in patients o...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-019-01519-6

    authors: Formica F,Mariani S,D'Alessandro S,Singh G,Di Mauro M,Cerrito MG,Messina LA,Scianna S,Papesso F,Sangalli F

    更新日期:2020-04-01 00:00:00

  • Ketamine and midazolam differently impact post-intubation hemodynamic profile when used as induction agents during emergency airway management in hemodynamically stable patients with ST elevation myocardial infarction.

    abstract::We investigated the incidence of post-intubation hypotension (PIH) in hemodynamically stable patients with STEMI requiring rapid sequences intubation (RSI) and medicated with ketamine or midazolam as induction agent. STEMI patients admitted between 1st January 2009 and 1st January 2017 who did not receive any type of ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-017-1049-5

    authors: Zuin M,Rigatelli G,Dell'Avvocata F,Faggian G,Conte L,Giatti S,Michielan F,Roncon L

    更新日期:2018-03-01 00:00:00

  • Coronary sinus catheter placement via left cubital vein for phrenic nerve stimulation during pulmonary vein isolation.

    abstract::Phrenic nerve (PN) stimulation is essential for the elimination of PN palsy during balloon-based pulmonary vein isolation (PVI). Although ultrasound-guided vascular access is safe, insertion of a PN stimulation catheter via central venous access carries a potential risk of the development of mechanical complications. ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-019-01402-4

    authors: Chikata A,Kato T,Usuda K,Fujita S,Maruyama M,Otowa KI,Takashima SI,Murai H,Usui S,Furusho H,Kaneko S,Takamura M

    更新日期:2019-10-01 00:00:00

  • Aneurysmal aorto-left ventricular tunnel causing right ventricular outflow tract obstruction, associated with bicuspid aortic valve.

    abstract::We report the case of a newborn with an aneurysmal aorto-left ventricular tunnel causing significant paravalvular aortic regurgitation and obstruction of the right ventricular outflow tract (RVOT), coexisting with a bicuspid aortic valve. The coexistence of the two malformations together with the obstruction of the RV...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-013-0445-8

    authors: Toganel R,Benedek T,Suteu C,Benedek I

    更新日期:2015-01-01 00:00:00

  • Energy dynamics of the intraventricular vortex after mitral valve surgery.

    abstract::Mitral valve morphology after mitral valve surgery affects postoperative intraventricular flow patterns and long-term cardiac performance. We visualized ventricular flow by echocardiography vector flow mapping (VFM) to reveal the impact of different mitral valve procedures. Eleven cases of mechanical mitral valve repl...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-017-0967-6

    authors: Nakashima K,Itatani K,Kitamura T,Oka N,Horai T,Miyazaki S,Nie M,Miyaji K

    更新日期:2017-09-01 00:00:00

  • Association between sarcopenia and atherosclerosis in elderly patients with ischemic heart disease.

    abstract::Compared to the general population, elderly patients with cardiovascular disease have a higher prevalence of sarcopenia, and it shows an association with increased mortality risk. Although several studies have indicated that atherosclerosis may cause sarcopenia in community dwelling elderly subjects, the association b...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-020-01554-8

    authors: Uchida S,Kamiya K,Hamazaki N,Matsuzawa R,Nozaki K,Ichikawa T,Suzuki Y,Nakamura T,Yamashita M,Kariya H,Maekawa E,Yamaoka-Tojo M,Matsunaga A,Ako J

    更新日期:2020-06-01 00:00:00

  • Points to note from indications for heart transplantation to post-heart transplant care: from the care of patients with refractory heart failure and overseas heart transplantation.

    abstract::To examine important points surrounding the indications for heart transplantation (HTX) to care after HTX, we reviewed 22 patients with refractory heart failure aged less than 60 years who had been observed for the past 6 years. Sixteen patients had dilated cardiomyopathy; 1, dilated hypertrophic cardiomyopathy; 3, re...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:

    authors: Nunoda S,Kurosawa R,Kogashi K,Yamagishi S,Mitsui F,Funabashi W

    更新日期:1997-01-01 00:00:00

  • Soluble urokinase-type plasminogen activator receptor represents exercise tolerance and predicts adverse cardiac events in patients with heart failure.

    abstract::Soluble urokinase-type plasminogen activator receptor (suPAR) is a membrane-binding protein that is released into the blood stream by immune activation. Recent reports suggest that circulating suPAR levels are associated with adverse cardiovascular outcomes. Exercise tolerance is an independent predictor of prognosis ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-019-01538-3

    authors: Ishikawa H,Izumiya Y,Shibata A,Ichikawa Y,Yamaguchi T,Yamaguchi Y,Kitada R,Iwata S,Ehara S,Tomita S,Hanatani A,Yoshiyama M

    更新日期:2020-05-01 00:00:00

  • Increased prevalence of cerebral microbleeds in patients with low left ventricular systolic function.

    abstract::Gradient-echo T2-star (T2*)-weighted magnetic resonance imaging (MRI) is a sensitive method to detect cerebral microbleeds (CMBs). The presence of CMBs was reported to be a marker of future cardiovascular mortality and is associated with various cardiovascular risk factors, use of antithrombotic drugs, and cognitive d...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-019-01503-0

    authors: Watanabe T,Kanzaki Y,Yamauchi Y,Ito T,Nishida Y,Yamamura K,Komori T,Sohmiya K,Hoshiga M

    更新日期:2020-03-01 00:00:00

  • Effects of elastase on contractility and morphology of elastic tissue in isolated guinea pig papillary muscles.

    abstract::Elastase (ELA) is an enzyme catalyzing the digestion of elastin, an essential constituent of elastic fibers. Using isolated guinea pig papillary muscles, we examined the effect of ELA (3 x 10(-7) -3 x 10(-4) g/ml) on resting tension (RT) and twitch tension (TT). The effects of ELA on elastic fibers located in the sube...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF01744386

    authors: Sato T,Imanishi S,Arita M,Shimada T

    更新日期:1993-01-01 00:00:00

  • Chelation of copper reduces inhibition by oxidized lipoproteins of endothelium-dependent relaxation in porcine coronary arteries.

    abstract::We examined the effect of dialyzing oxidized low-density lipoprotein (oLDL) against Krebs-Ringer solution, in the absence (yielding d-oLDL) or presence (yielding EDTA-oLDL) of ethylenediamine tetraacetic acid (EDTA), to investigate the mechanism that underlies the inhibition of endothelium-dependent relaxation (EDR) b...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF01745093

    authors: Hayashi T,Ishikawa T,Kuzuya M,Naito M,Yamada K,Asai K,Hidaka H,Iguchi A

    更新日期:1994-01-01 00:00:00

  • Endovascular treatment combined with stratified surgery is effective in the management of venous thoracic outlet syndrome complications: a long term ultrasound follow-up study in patients with thrombotic events due to venous thoracic outlet syndrome.

    abstract::Thoracic outlet syndrome (TOS) is caused by compression of peripheral nerves and vascular structures along their course through the upper thoracic aperture to the axilla. The aim of our study was to analyze long-term outcomes of different treatments stratified by symptom severity. We performed a retrospective analysis...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-010-0112-2

    authors: Skalicka L,Lubanda JC,Jirat S,Varejka P,Beran S,Dostal O,Prochazka P,Mrazek V,Linhart A

    更新日期:2011-11-01 00:00:00

  • Activated T cells induce up-regulation of Fas antigen in cultured endothelial cells.

    abstract::Recent evidence has shown that apoptotic cells are present in human atherosclerotic lesions. However, the molecular mechanism of the induction of apoptosis in atherosclerotic lesions is not clear. Since T cells are present in almost all stages of atherosclerosis, we examined whether T cells can modulate the expression...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:

    authors: Fukuo K,Suhara T,Nakahashi T,Hata S,Shimizu M,Niinobu T,Morimoto S,Ogihara T

    更新日期:1997-01-01 00:00:00

  • Axillo-femoral bypass steal due to subclavian artery stenosis.

    abstract::Subclavian artery stenosis can cause a flow reversal-so-called steal-not only in the ipsilateral vertebral artery, but also in the internal mammary artery in patients with a history of coronary-artery bypass grafting. Subclavian artery stenosis is also associated with peripheral artery disease elsewhere. We report a n...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-016-0821-2

    authors: Shigyo H,Kawarada O,Noguchi T,Ogawa H,Yasuda S

    更新日期:2016-11-01 00:00:00

  • Impact of pharmacological spasm provocation test in patients with a history of syncope.

    abstract::Coronary artery spasm is involved in the pathogenesis of various cardiac disorders. We investigated patients with a history of syncope who underwent elective coronary angiography. We retrospectively analyzed 5781 consecutive patients who had diagnostic or follow-up angiography during a 26-year period. During this peri...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-017-1046-8

    authors: Sueda S,Kohno H

    更新日期:2018-02-01 00:00:00

  • ECMO for pulmonary rescue in an adult with amiodarone-induced toxicity.

    abstract::Amiodarone is a highly effective antiarrhythmic agent. Unfortunately amiodarone-induced pulmonary toxicity is described for medium-long term therapy. We describe a case of a 65-year-old man admitted to our department for breathlessness and with a history of recurrent episodes of atrial fibrillation for which he had be...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-014-0487-6

    authors: Benassi F,Molardi A,Righi E,Santangelo R,Meli M

    更新日期:2015-05-01 00:00:00

  • Oxidative stress versus antioxidant defenses in patients with acute myocardial infarction.

    abstract::Acute myocardial infarction (AMI) is a highly dynamic event, which is associated with increasing production of reactive oxygen species (ROS). The imbalance between ROS production and antioxidant defenses leads to the condition known as oxidative stress. The most widely recognized effect of increasing oxidative stress ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-010-0029-9

    authors: Bagatini MD,Martins CC,Battisti V,Gasparetto D,da Rosa CS,Spanevello RM,Ahmed M,Schmatz R,Schetinger MR,Morsch VM

    更新日期:2011-01-01 00:00:00

  • Diverse inotropic effects of 5-hydroxytryptamine in heart muscles of various mammalian species.

    abstract::The inotropic effects of 5-hydroxytryptamine (5-HT) on mammalian heart muscles were investigated. 5-HT (10(-8)-10(-3)M) produced increases in the contractile tension of atrial and ventricular muscles isolated from guinea pigs, Japanese monkeys, and humans, but not in rat heart preparations. The maximum percent increas...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF01744594

    authors: Zaizen H,Imanishi S,Nasu M,Arita M

    更新日期:1996-01-01 00:00:00

  • Atherosclerotic burden in coronary and peripheral arteries in patients with first clinical manifestation of coronary artery disease.

    abstract::The aim of our study was to assess the atherosclerotic burden in patients with the first symptoms of coronary artery disease (CAD). The study population consisted of 100 consecutive patients (new-onset severe angina or myocardial infarction) and 70 age- and sex-matched volunteers without symptoms of CAD. Functional an...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s003800200028

    authors: Cerne A,Kranjec I

    更新日期:2002-09-01 00:00:00

  • Novel contrast-injection protocol for coronary computed tomographic angiography: contrast-injection protocol customized according to the patient's time-attenuation response.

    abstract::We developed a new individually customized contrast-injection protocol for coronary computed tomography (CT) angiography based on the time-attenuation response in a test bolus, and investigated its clinical applicability. We scanned 60 patients with suspected coronary diseases using a 64-detector CT scanner, who were ...

    journal_title:Heart and vessels

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00380-013-0338-x

    authors: Kidoh M,Nakaura T,Nakamura S,Awai K,Utsunomiya D,Namimoto T,Harada K,Yamashita Y

    更新日期:2014-03-01 00:00:00

  • History of gastroesophageal reflux disease in patients with suspected coronary artery disease.

    abstract::It is well known that patients with gastroesophageal reflux disease (GERD) experience GERD-related chest pain, but little is known about the relationship between GERD and coronary artery disease (CAD). We evaluated medical history of GERD in patients with suspected CAD and its association with types of CAD. We enrolle...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-019-01413-1

    authors: Teragawa H,Oshita C,Ueda T

    更新日期:2019-10-01 00:00:00

  • Assessment of trough rivaroxaban concentrations on markers of coagulation activation in nonvalvular atrial fibrillation population.

    abstract::Whether trough-phase rivaroxaban concentrations provide sufficient anticoagulation needs more study. We evaluated levels of coagulation activation markers in the trough concentration phase in nonvalvular atrial fibrillation (NVAF) patients, and the correlation between these markers and rivaroxaban concentration. Fifty...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-016-0912-0

    authors: Kitagawa F,Ishii J,Hiramitsu S,Takahashi H,Okuyama R,Kawai H,Muramatsu T,Harada M,Motoyama S,Naruse H,Matsui S,Sarai M,Hayashi M,Watanabe E,Izawa H,Ozaki Y

    更新日期:2017-05-01 00:00:00

  • Increased respiratory disturbance index measured using an advanced device algorithm is associated with heart failure development.

    abstract::Previous studies suggested that sleep-disordered breathing was associated with cardiovascular diseases such as heart failure (HF). Recently, algorithms of cardiac implantable electronic devices (CIEDs) have been developed to detect advanced sleep apnea (SA); the Apnea Scan (AP Scan) being an example. The purpose of th...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-019-01551-6

    authors: Wakabayashi Y,Koyama T,Kurihara K,Kobayashi M,Ichikawa T,Abe H

    更新日期:2020-06-01 00:00:00

  • Optimal therapeutic range for oral anticoagulants in Japanese patients with prosthetic heart valves: a preliminary report from a single institution using conversion from thrombotest to PT-INR.

    abstract::The thrombotest (TT) technique has been widely used in Japan for monitoring oral anticoagulant therapy (OAT). The therapeutic range was originally recommended to be 10%-25%. However, the International Committee for Standardization in Hematology/International Committee on Thrombosis and Hemostasis (ICSH/ICTH) recommend...

    journal_title:Heart and vessels

    pub_type: 临床试验,杂志文章

    doi:10.1007/pl00007265

    authors: Uetsuka Y,Hosoda S,Kasanuki H,Aosaki M,Murasaki K,Ooki K,Inoue M,Akiyama E,Kitada M

    更新日期:2000-01-01 00:00:00

  • Impact of Killip classification on acute myocardial infarction: data from the SAIKUMA registry.

    abstract::Therapeutic devices for acute myocardial infarction (AMI) have evolved dramatically in recent years. However, the impact of the Killip classification of AMI outcomes in patients undergoing aggressive percutaneous coronary intervention remains unclear. We performed a 10-year retrospective review of 2062 patients diagno...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-017-1017-0

    authors: Taguchi E,Konami Y,Inoue M,Suzuyama H,Kodama K,Yoshida M,Miyamoto S,Nakao K,Sakamoto T

    更新日期:2017-12-01 00:00:00

  • Prognostic impact of moderate mitral regurgitation on hospitalized heart failure patients with preserved ejection fraction: A report from the JASPER registry.

    abstract::A growing body of evidence suggests that mitral regurgitation (MR) is associated with higher mortality in heart failure patients with reduced ejection fraction. However, prognostic impact of MR on heart failure patients with preserved ejection fraction (HFpEF) has not been fully examined. The Japanese Heart Failure Sy...

    journal_title:Heart and vessels

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00380-020-01581-5

    authors: Oikawa M,Yoshihisa A,Sato Y,Nagai T,Yoshikawa T,Saito Y,Yamamoto K,Takeishi Y,Anzai T

    更新日期:2020-08-01 00:00:00

  • The P wave morphology in lead V7 on the synthesized 18-lead ECG is a useful parameter for identifying arrhythmias originating from the right inferior pulmonary vein.

    abstract::Atrial tachyarrhythmias often originate from the superior vena cava (SVC), and right superior (RSPV) and inferior pulmonary veins (RIPV). However, a precise differentiation of those origins is challenging using the standard 12-lead electrocardiogram (ECG) P-wave morphology due to the anatomical proximity. The recently...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-019-01483-1

    authors: Hisazaki K,Miyazaki S,Hasegawa K,Kaseno K,Amaya N,Shiomi Y,Tama N,Ikeda H,Fukuoka Y,Morishita T,Ishida K,Uzui H,Tada H

    更新日期:2020-02-01 00:00:00

  • Expression of vascular endothelial growth factor in human myocardial infarction.

    abstract::To define mechanisms that may influence collateral circulation and angiogenesis, we investigated vascular endothelial growth factor (VEGF) mRNA expression in human hearts. In non-ischemic human hearts, VEGF mRNA was not detected in vessels, but was found in cardiomyocytes. In hearts with myocardial infarction, the int...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF01745169

    authors: Shinohara K,Shinohara T,Mochizuki N,Mochizuki Y,Sawa H,Kohya T,Fujita M,Fujioka Y,Kitabatake A,Nagashima K

    更新日期:1996-01-01 00:00:00