Abstract:
:Recent evidence has shown that apoptotic cells are present in human atherosclerotic lesions. However, the molecular mechanism of the induction of apoptosis in atherosclerotic lesions is not clear. Since T cells are present in almost all stages of atherosclerosis, we examined whether T cells can modulate the expression of Fas, a death signal, in endothelial cells (ECs), using a coculture system. Human umbilical vein ECs were cultured alone or cocultured with human peripheral T cells activated with phorbol myristate acetate and ionomycin. Flow cytometric (FACscan) analysis showed that Fas antigen was up-regulated in ECs when ECs were cocultured for 24 h with activated T cells. However, Fas antigen was not up-regulated in ECs cocultured with non-activated T cells. The up-regulation of Fas antigen induced by coculturing ECs with activated T cells was partially, but significantly, neutralized by antibody against interferon-gamma (IFN-gamma). Actually, incubation with IFN-gamma induced a dose-dependent increase in the level of Fas antigen in ECs cultured alone. These findings indicate that activated T cells induce up-regulation of Fas antigen in ECs. Thus, the Fas system induced by activated T cells could participate in the mechanism of EC injury in atherosclerotic lesions.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Fukuo K,Suhara T,Nakahashi T,Hata S,Shimizu M,Niinobu T,Morimoto S,Ogihara Tsubject
Has Abstractpub_date
1997-01-01 00:00:00pages
81-3eissn
0910-8327issn
1615-2573journal_volume
Suppl 12pub_type
杂志文章abstract::Cross-sectional data suggest that the degree of coronary atherosclerosis is associated with aerobic fitness. However, there are limited longitudinal data addressing whether aerobic fitness is a predictor of coronary atherosclerosis progression. This study investigated whether peak oxygen consumption is related to a lo...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0745-2
更新日期:2016-09-01 00:00:00
abstract::A 65-year-old man was referred to our hospital following repetitive chest pain. Invasive coronary angiography showed an intermediate stenosis of the proximal left anterior descending artery (LAD), and a coronary fistula originating distal to the stenosis draining into the main pulmonary artery. To evaluate the functio...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0641-9
更新日期:2016-05-01 00:00:00
abstract::Levels of testosterone and estradiol influence the incidence of cardiovascular diseases: generally, estrogens in females are protective before menopause; coronaropathies, hypertension, and dyslipidemias in normal men are more frequent at comparable ages. We investigated the modulation by castration of in vitro vasorea...
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pub_type: 杂志文章
doi:10.1007/s00380-008-1098-x
更新日期:2009-03-01 00:00:00
abstract::We herein present a case (72 years, male) with total absence of pulmonary veins (PVs) potentials at the beginning of the first procedure for paroxysmal atrial fibrillation (AF), demonstrating dormant conduction between the left atrium and all PVs revealed by adenosine triphosphate provocation with relation to the inci...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0928-5
更新日期:2017-04-01 00:00:00
abstract::An expandable polytetrafluoroethylene (ePTFE) covered stent is generally employed to seal coronary artery perforation. The frequency of ePTFE covered stent use is relatively low; thus, only a handful of studies have reported neointimal coverage and endothelialization inside the deployed ePTFE and clinical time course ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0964-9
更新日期:2017-06-01 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) increases coronary artery disease (CAD) risk. In this study, we used T2DM clinical variables to predict abnormality in thallium-201 myocardial perfusion scans (Th-201 scans). These clinical variables were summed stress score (SSS), summed rest score, and summed difference score (SDS), w...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01681-2
更新日期:2020-08-20 00:00:00
abstract::Vector flow mapping (VFM) is a novel echocardiographic technology that shows blood flow vectors and vortexes, enabled the hydrokinetic evaluation of hemodynamics within the left ventricle. VFM provides several unique parameters: circulation, vorticity, vortex area, and energy loss. The present study aims to reveal a r...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-1093-1
更新日期:2018-05-01 00:00:00
abstract::Taurine (2-aminoethanesulfonic acid) is a potent antioxidant and inhibits cell apoptosis in ischemic reperfusion injury. In this study we evaluated whether addition of taurine to St. Thomas' cardioplegic solution enhances its myocardial protective effects in prolonged hypothermic heart preservation in rats. Hearts iso...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-005-0841-9
更新日期:2005-11-01 00:00:00
abstract::Drug-eluting stents reduce restenosis due to neointimal growth suppression. Considering long-term outcomes, it is both difficult and important to predict drug-eluting stent restenosis. Thus, this study was designed to examine the utility of myocardial fractional flow reserve (FFR) as a predictor of sirolimus-eluting s...
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pub_type: 杂志文章
doi:10.1007/s00380-010-0105-1
更新日期:2011-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00380-017-0961-z
更新日期:2017-08-01 00:00:00
abstract::The clinical efficacy of glucagon-like peptide-1 (GLP-1) analogs in patients with acute myocardial infarction (AMI) is uncertain. The purpose of the present study was to evaluate the effects of the GLP-1 analog liraglutide on left ventricular (LV) remodeling in patients with AMI. We retrospectively evaluated the effec...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0734-5
更新日期:2016-08-01 00:00:00
abstract::In the original publication of the article, under the results section, the following sentence. ...
journal_title:Heart and vessels
pub_type: 已发布勘误
doi:10.1007/s00380-020-01574-4
更新日期:2020-05-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1201-x
更新日期:2018-12-01 00:00:00
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doi:10.1007/s00380-019-01483-1
更新日期:2020-02-01 00:00:00
abstract::The coronary flow velocity reserve (CFVR), a measure of endothelial function in coronary circulation, can be measured semi-invasively in the left anterior descending coronary artery by using stress transesophageal echocardiography (TEE). During the same stress TEE, aortic distensibility indices (elastic modulus [E(p)]...
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pub_type: 杂志文章
doi:10.1007/s00380-017-0958-7
更新日期:2017-08-01 00:00:00
abstract::Thin-cap fibroatheroma (TCFA) is the most common type of vulnerable plaque and is the precursor of plaque rupture. However, rupture of a TCFA is not the only mechanism underlying thrombus formation or acute coronary syndrome. Although statin therapy changes the composition of coronary artery plaques, the effects of st...
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01744594
更新日期:1996-01-01 00:00:00
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journal_title:Heart and vessels
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