Abstract:
:Thin-cap fibroatheroma (TCFA) is the most common type of vulnerable plaque and is the precursor of plaque rupture. However, rupture of a TCFA is not the only mechanism underlying thrombus formation or acute coronary syndrome. Although statin therapy changes the composition of coronary artery plaques, the effects of statins, particularly different types of statins, on plaque phenotype have not been fully examined. This study compared the effects of pitavastatin versus pravastatin on coronary artery plaque phenotype assessed by virtual histology (VH) intravascular ultrasound (IVUS) in patients with angina pectoris (AP). Coronary atherosclerosis in nonculprit lesions was evaluated using VH-IVUS at baseline and 8 months after statin therapy; analyzable IVUS data were obtained from 83 patients with stable AP (39 patients treated with pitavastatin and 44 with pravastatin) and 36 patients with unstable AP (19 patients treated with pitavastatin and 17 with pravastatin). Pitavastatin had a strong effect on reducing pathologic intimal thickening (PIT), especially in patients with unstable AP, but had no impact on VH-TCFA or fibroatheroma (FA). By contrast, pravastatin had weak effects on reducing PIT, VH-TCFA, or FA. Increases in the number of calcified plaques were observed for both statins. In conclusion, pitavastatin and pravastatin changed coronary artery plaque phenotype as assessed by VH-IVUS in patients with AP. However, the effects of these statins on coronary artery plaque phenotype were different.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Nozue T,Yamamoto S,Tohyama S,Fukui K,Umezawa S,Onishi Y,Kunishima T,Sato A,Nozato T,Miyake S,Takeyama Y,Morino Y,Yamauchi T,Muramatsu T,Hibi K,Terashima M,Michishita Idoi
10.1007/s00380-013-0453-8subject
Has Abstractpub_date
2015-01-01 00:00:00pages
36-44issue
1eissn
0910-8327issn
1615-2573journal_volume
30pub_type
杂志文章,多中心研究,随机对照试验abstract::Little evidence exists regarding the need for a reduction in postoperative heart rate after repair of type A acute aortic dissection. This single-center retrospective study was conducted to determine if lower heart rate during the early postoperative phase is associated with improved long-term outcomes after surgery f...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0486-7
更新日期:2015-05-01 00:00:00
abstract::Taurine (2-aminoethanesulfonic acid) is a potent antioxidant and inhibits cell apoptosis in ischemic reperfusion injury. In this study we evaluated whether addition of taurine to St. Thomas' cardioplegic solution enhances its myocardial protective effects in prolonged hypothermic heart preservation in rats. Hearts iso...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-005-0841-9
更新日期:2005-11-01 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) increases coronary artery disease (CAD) risk. In this study, we used T2DM clinical variables to predict abnormality in thallium-201 myocardial perfusion scans (Th-201 scans). These clinical variables were summed stress score (SSS), summed rest score, and summed difference score (SDS), w...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01681-2
更新日期:2020-08-20 00:00:00
abstract::Left ventricular non-compaction (LVNC) is genetically heterogeneous. It has been previously shown that LVNC is associated with defects in TAZ, DNTA, LDB3, YWHAE, MIB1, PRDM16, and sarcomeric genes. This study was aimed to investigate sarcomeric gene mutations in a Chinese population with LVNC. From 2004 to 2010, 57 un...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0503-x
更新日期:2015-03-01 00:00:00
abstract::Mitral valve morphology after mitral valve surgery affects postoperative intraventricular flow patterns and long-term cardiac performance. We visualized ventricular flow by echocardiography vector flow mapping (VFM) to reveal the impact of different mitral valve procedures. Eleven cases of mechanical mitral valve repl...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0967-6
更新日期:2017-09-01 00:00:00
abstract::Distal anastomosis technique affects graft patency and long-term outcomes in coronary artery bypass grafting, however, there is no standard for the appropriate length of distal anastomosis. The purpose of this study is to evaluate whether longer distal anastomosis provides higher quality of distal anastomosis and bett...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0880-4
更新日期:2017-01-01 00:00:00
abstract::Thoracic outlet syndrome (TOS) is caused by compression of peripheral nerves and vascular structures along their course through the upper thoracic aperture to the axilla. The aim of our study was to analyze long-term outcomes of different treatments stratified by symptom severity. We performed a retrospective analysis...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-010-0112-2
更新日期:2011-11-01 00:00:00
abstract::The coronary flow velocity reserve (CFR) is decreased in patients with aortic valve stenosis (AS). The aim of the present prospective study was to examine the CFR in AS patients with normal epicardial coronary arteries during a 3-year follow-up of aortic valve replacement (AVR). A total of 30 AS patients (17 women and...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-005-0883-z
更新日期:2006-05-01 00:00:00
abstract::Effects of the administration of a thromboxane A2 (TXA2) analogue (STA2), a leukotriene C4 (LTC4), and a leukotriene D4 (LTD4) on regional myocardial blood flow (RMBF) and hemodynamics were studied in anesthetized, open-chest dogs. The blocking ability of a recently synthesized TXA2 selective antagonist, ONO-3708, and...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058997
更新日期:1988-01-01 00:00:00
abstract::Peripartum cardiomyopathy (PPCM) is a rare but life-threatening cardiac disorder characterized by maternal systolic heart failure. Although PPCM is a major cause of maternal mortality, little is known about the acute-phase management of PPCM in real-world clinical settings. We retrospectively identified patients hospi...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0958-7
更新日期:2017-08-01 00:00:00
abstract::Although the number of pregnancies in women with cardiac disease is increasing worldwide, there are few data concerning their clinical characteristics and peripartum outcomes. Using the Diagnosis Procedure Combination database between 2008 and 2014 in Japan, we retrospectively identified pregnant women who underwent h...
journal_title:Heart and vessels
pub_type: 杂志文章,多中心研究
doi:10.1007/s00380-018-1137-1
更新日期:2018-08-01 00:00:00
abstract::The purpose was to study optimum timing of continuous veno-venous hemodialysis (CVVHD) for acute renal failure (ARF) after cardiac surgery. CVVHD was performed in two groups [elapsed time between urine output (UO) <0.5 ml/kg/h and dialysis of no more than 12 h in group A and >12 h in group B] with a total of 58 adult ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-010-0045-9
更新日期:2011-03-01 00:00:00
abstract::Coexistence of hypertension and diabetes mellitus (DM) increases the risk of cardiovascular disease. However, factors associated with future development of DM have not been well elucidated in patients already having essential hypertension. This study prospectively included 168 patients (mean age 41 +/- 7 years, 112 me...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-009-1218-2
更新日期:2010-09-01 00:00:00
abstract::A 54-year-old man with prior inferior myocardial infarction suffered from monomorphic ventricular tachycardia (VT) with narrow QRS complex of 120 ms. During VT, a fragmented prepotential preceding QRS onset by 30 ms at the right ventricular posterior septum and a late diastolic potential preceding QRS onset by 70 ms a...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-009-1180-z
更新日期:2010-03-01 00:00:00
abstract::Primary cardiac osteosarcomas are uncommon tumors. Their growth pattern is aggressive and the prognosis is poor. A 34-year-old, 7-month pregnant woman with a primary cardiac osteosarcoma associated with the anterior mitral leaflet and connected to the interatrial septum, causing nearly subtotal obstruction of the mitr...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-005-0830-z
更新日期:2006-01-01 00:00:00
abstract::Vector flow mapping (VFM) is a novel echocardiographic technology that shows blood flow vectors and vortexes, enabled the hydrokinetic evaluation of hemodynamics within the left ventricle. VFM provides several unique parameters: circulation, vorticity, vortex area, and energy loss. The present study aims to reveal a r...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-1093-1
更新日期:2018-05-01 00:00:00
abstract::Obesity is an important public health problem, especially among patients with cardiovascular disease. However, little is known about the impact of obesity on the long-term prognoses of patients with acute myocardial infarction (AMI). Major adverse cardiac and cerebrovascular events (MACCE) consist of all causes of dea...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-010-0083-3
更新日期:2011-09-01 00:00:00
abstract::Very late stent thrombosis (VLST) is a serious complication after percutaneous coronary intervention. However, the best therapy for VLST with late-acquired incomplete stent apposition and incomplete neointimal coverage remains unknown. In these cases, neointimal coverage was nearly complete and no late-acquired malapp...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0720-y
更新日期:2016-07-01 00:00:00
abstract::It is well known that silent myocardial ischemia (SMI) often complicates patients with cerebral infarction and that stroke patients often die of ischemic heart disease. Therefore, it is considered important to treat myocardial ischemia in stroke patients. This study investigated SMI complicating Japanese patients with...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-011-0210-9
更新日期:2013-01-01 00:00:00
abstract::An excess of thyroid hormone is known to produce cardiac dysfunction and failure, i.e., thyrotoxic heart. We studied the protective effect of coenzyme Q10 (CoQ10) on the thyrotoxic heart in 29 rabbits. A group treated with 1-thyroxine sodium salt (T4; 167 micrograms/kg) for 3 weeks showed marked decreases in the myoca...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058524
更新日期:1987-01-01 00:00:00
abstract::Atrial fibrillation (AF) is the most common arrhythmia, characterized by a lack of atrial contraction and an irregular ventricular rhythm. We assessed the effect of fibrillatory wave amplitude on coronary blood flow in patients with AF using the thrombolysis in myocardial infarction (TIMI) frame count. Sixty-one patie...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1121-9
更新日期:2018-07-01 00:00:00
abstract::Several miRNAs have been demonstrated to be involved in endothelial dysfunction during atherosclerosis (AS). However, the detailed roles and underlying mechanisms of miR-34a in AS-associated endothelial cell apoptosis are far from being addressed. Apolipoprotein E-deficient (ApoE-/-) mice fed with high-fat diet (HFD) ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1169-6
更新日期:2018-10-01 00:00:00
abstract::Hyperuricemia is known to be associated with adverse outcomes in cardiovascular intensive care patients, but its mechanisms are unknown. A total of 569 emergency department patients were prospectively analyzed and assigned to intensive care (ICU group, n = 431) or other departments (n = 138). Uric acid (UA) levels wer...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01608-x
更新日期:2020-10-01 00:00:00
abstract::Extensive arterial grafting (Art-CABG) in the elderly is still questioned due to the reduced life expectancy and the supposed higher periprocedural risk. Reports further demonstrated accelerated atherosclerosis of arterial grafts in the elderly, with hampered short-term and long-term results. We reviewed our experienc...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-008-1055-8
更新日期:2008-09-01 00:00:00
abstract::The aim of our study was to assess the atherosclerotic burden in patients with the first symptoms of coronary artery disease (CAD). The study population consisted of 100 consecutive patients (new-onset severe angina or myocardial infarction) and 70 age- and sex-matched volunteers without symptoms of CAD. Functional an...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s003800200028
更新日期:2002-09-01 00:00:00
abstract::Cross-sectional data suggest that the degree of coronary atherosclerosis is associated with aerobic fitness. However, there are limited longitudinal data addressing whether aerobic fitness is a predictor of coronary atherosclerosis progression. This study investigated whether peak oxygen consumption is related to a lo...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0745-2
更新日期:2016-09-01 00:00:00
abstract::Predictors of outcomes in patients with heart failure with preserved left-ventricular ejection fraction (HFpEF) remain unclear. The ratio of early diastolic transmitral flow velocity to early diastolic myocardial velocity (E/e') has been proposed, but the predictive accuracy remains unsatisfactory. We hypothesized tha...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1211-8
更新日期:2018-12-01 00:00:00
abstract::Treatment with inhibitors of 3-hydroxyl-3-methylglutaryl coenzyme A reductase (statins) reduces the incidence of cardiovascular events, but it is unclear whether the beneficial effects are mediated solely by their lipid-lowering properties. We therefore investigated whether atorvastatin reduces inflammation and oxidat...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-005-0833-9
更新日期:2005-07-01 00:00:00
abstract::Periprocedural bleeding and thromboembolic events are worrisome complications of catheter ablation for atrial fibrillation (AF). Periprocedural anticoagulation management could decrease the risk of these complications. However, evaluation of the complications from pulmonary vein isolation using cryoballoon related to ...
journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-019-01370-9
更新日期:2019-09-01 00:00:00
abstract::Both hypertension and hyperuricemia are closely associated with the morbidity and mortality of heart failure. This study was designed to evaluate the influences of long-term xanthine oxidase inhibitor (febuxostat) prescription on left ventricular hypertrophy (LVH), left ventricular (LV) diastolic function, and new-ons...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01619-8
更新日期:2020-10-01 00:00:00