Abstract:
:Coexistence of hypertension and diabetes mellitus (DM) increases the risk of cardiovascular disease. However, factors associated with future development of DM have not been well elucidated in patients already having essential hypertension. This study prospectively included 168 patients (mean age 41 +/- 7 years, 112 men) with essential hypertension. All patients did not have DM and vascular or renal complications initially. Baseline demographic data, blood pressure, body mass index, and antihypertensive agents were carefully evaluated and serum high-sensitivity C-reactive protein (hsCRP) was measured at the beginning of the study. All of the patients were followed for at least 6 months. The study endpoint was occurrence of new DM. After a mean follow-up period of 32 +/- 10 months, 22 subjects (13.1%) developed new DM. Patients with new DM had higher baseline glucose (105.2 +/- 11.8 vs 94.2 +/- 8.0 mg/dl, P < 0.001), triglyceride level (213.7 +/- 112.4 vs 155.6 +/- 83.2 mg/dl, P = 0.04), log hsCRP (0.31 +/- 0.44 vs 0.19 +/- 0.25 mg/dl, P = 0.016), and lower high-density lipoprotein (40.2 +/- 7.8 vs 46.6 +/- 14.4 mg/dl, P = 0.045). Total cholesterol, low-density lipoprotein, homeostasis model assessment index, and adiponectin were not different in patients with or without new DM. Among antihypertensive agents, only use of beta-blocker was significantly associated with new DM (P = 0.008). Multivariate Cox regression analysis showed log hsCRP (hazard ratio [HR] 9.77, 95% confidence interval [CI] 2.97-32.10, P < 0.001), age (HR 1.21, 95% CI 1.06-1.38, P = 0.004), and baseline glucose level (HR 1.11, 95% CI 1.06-1.15, P < 0.001) to be independent predictors for occurrence of new DM. High-sensitivity CRP was an independent factor for future development of DM in essential hypertensive patients. Increased inflammation might have a key role in the pathogenesis of DM in hypertension.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Weng CM,Chou CH,Huang YY,Lin CC,Liu YW,Tsai WCdoi
10.1007/s00380-009-1218-2subject
Has Abstractpub_date
2010-09-01 00:00:00pages
386-91issue
5eissn
0910-8327issn
1615-2573journal_volume
25pub_type
杂志文章abstract::Subclavian artery stenosis can cause a flow reversal-so-called steal-not only in the ipsilateral vertebral artery, but also in the internal mammary artery in patients with a history of coronary-artery bypass grafting. Subclavian artery stenosis is also associated with peripheral artery disease elsewhere. We report a n...
journal_title:Heart and vessels
pub_type: 杂志文章
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abstract::No studies have evaluated both the time-to-isolation (TTI) and the sequence of pulmonary vein (PV) potentials in cryoballoon ablation (CBA) for atrial fibrillation (AF). This study aimed to prospectively evaluate the acute results of pulmonary vein isolation (PVI) using a novel CBA technique-the earliest potential (EP...
journal_title:Heart and vessels
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doi:10.1007/s00380-019-01471-5
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02125099
更新日期:1991-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0930-4
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058316
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abstract::Thin-cap fibroatheroma (TCFA) is the most common type of vulnerable plaque and is the precursor of plaque rupture. However, rupture of a TCFA is not the only mechanism underlying thrombus formation or acute coronary syndrome. Although statin therapy changes the composition of coronary artery plaques, the effects of st...
journal_title:Heart and vessels
pub_type: 杂志文章,多中心研究,随机对照试验
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abstract::The inotropic effects of 5-hydroxytryptamine (5-HT) on mammalian heart muscles were investigated. 5-HT (10(-8)-10(-3)M) produced increases in the contractile tension of atrial and ventricular muscles isolated from guinea pigs, Japanese monkeys, and humans, but not in rat heart preparations. The maximum percent increas...
journal_title:Heart and vessels
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更新日期:1996-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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journal_title:Heart and vessels
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journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
abstract::Renin-angiotensin system (RAS) inhibitors may be useful in preventing the occurrence of paroxysmal atrial fibrillation (PAF). However, evaluation of such effect is difficult because many PAF episodes are asymptomatic and not all episodes are detected by intermittent electrocardiographic monitoring. A pacemaker has bee...
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doi:10.1007/s00380-015-0627-7
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0720-y
更新日期:2016-07-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058423
更新日期:1988-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02301880
更新日期:1990-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-011-0220-7
更新日期:2013-03-01 00:00:00
abstract::Electrocardiographic left ventricular hypertrophy (ECG-LVH) gradually regressed after aortic valve replacement (AVR) in patients with severe aortic stenosis. Sokolow-Lyon voltage (SV1 + RV5/6) is possibly the most widely used criterion for ECG-LVH. The aim of this study was to determine whether decrease in Sokolow-Lyo...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0761-2
更新日期:2016-09-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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