Abstract:
:Existing methods to calculate pre-test probability of obstructive coronary artery disease (CAD) have been established using selected high-risk patients who were referred to conventional coronary angiography. The purpose of this study is to develop and validate our new method for pre-test probability of obstructive CAD using patients who underwent coronary CT angiography (CTA), which could be applicable to a wider range of patient population. Using consecutive 4137 patients with suspected CAD who underwent coronary CTA at our institution, a multivariate logistic regression model including clinical factors as covariates calculated the pre-test probability (K-score) of obstructive CAD determined by coronary CTA. The K-score was compared with the Duke clinical score using the area under the curve (AUC) for the receiver-operating characteristic curve. External validation was performed by an independent sample of 319 patients. The final model included eight significant predictors: age, gender, coronary risk factor (hypertension, diabetes mellitus, dyslipidemia, smoking), history of cerebral infarction, and chest symptom. The AUC of the K-score was significantly greater than that of the Duke clinical score for both derivation (0.736 vs. 0.699) and validation (0.714 vs. 0.688) data sets. Among patients who underwent coronary CTA, newly developed K-score had better pre-test prediction ability of obstructive CAD compared to Duke clinical score in Japanese population.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Fujimoto S,Kondo T,Yamamoto H,Yokoyama N,Tarutani Y,Takamura K,Urabe Y,Konno K,Nishizaki Y,Shinozaki T,Kihara Y,Daida H,Isshiki T,Takase Sdoi
10.1007/s00380-014-0515-6subject
Has Abstractpub_date
2015-09-01 00:00:00pages
563-71issue
5eissn
0910-8327issn
1615-2573pii
10.1007/s00380-014-0515-6journal_volume
30pub_type
杂志文章abstract::In a mass chest computed tomography (CT) screening using a mobile helical CT unit, we measured the aortic diameter at three segments to confirm standard values and also attempted to detect any asymptomatic aortic aneurysms. The population screened in the present study consisted of 6971 subjects (3847 men and 3124 wome...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s380-002-8315-1
更新日期:2002-01-01 00:00:00
abstract::Based on the unique property of fluorine-18 fluorodeoxyglucose, localization and follow-up of hypermetabolic processes is possible with positron emission tomography (PET). The dual-modality PET/computed tomography (CT) systems provide intrinsically fused morphologic and functional data in a single examination. We repo...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-004-0808-2
更新日期:2005-07-01 00:00:00
abstract::The purpose of this study was to investigate the use of hepatocyte growth factor as a biochemical marker for acute myocardial infarction. Several biochemical markers are used for noninvasive detection of acute myocardial infarction. However, hepatocyte growth factor has not been used previously for this purpose. We me...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02766790
更新日期:1997-01-01 00:00:00
abstract::This study investigates the interactions between cyclooxygenase (COX-2) and vascular smooth muscle cell (VSMC) phenotypic switching, the two important coupling mechanisms of the vasculature on arterial remodeling in response to high laminal shear stress. High aortic blood flow was induced by creating a fistula in the ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-011-0148-y
更新日期:2012-05-01 00:00:00
abstract::Whether trough-phase rivaroxaban concentrations provide sufficient anticoagulation needs more study. We evaluated levels of coagulation activation markers in the trough concentration phase in nonvalvular atrial fibrillation (NVAF) patients, and the correlation between these markers and rivaroxaban concentration. Fifty...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0912-0
更新日期:2017-05-01 00:00:00
abstract::Coronary artery calcification (CAC) as measured by computed tomography is a strong predictor of coronary artery disease. The brachial intima-media thickness (IMT) was recently reported to be associated with cardiovascular risk factors. This study investigated the association of brachial IMT with CAC, which is a marker...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01371-8
更新日期:2019-09-01 00:00:00
abstract::Phrenic nerve (PN) stimulation is essential for the elimination of PN palsy during balloon-based pulmonary vein isolation (PVI). Although ultrasound-guided vascular access is safe, insertion of a PN stimulation catheter via central venous access carries a potential risk of the development of mechanical complications. ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01402-4
更新日期:2019-10-01 00:00:00
abstract::The coronary flow velocity reserve (CFVR), a measure of endothelial function in coronary circulation, can be measured semi-invasively in the left anterior descending coronary artery by using stress transesophageal echocardiography (TEE). During the same stress TEE, aortic distensibility indices (elastic modulus [E(p)]...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0939-8
更新日期:2007-03-01 00:00:00
abstract::Although cisplatin is indispensable for the chemotherapy treatment of many malignancies, cisplatin-associated thrombosis is attracting increasing attention. However, experience of primary percutaneous coronary intervention (PCI) and intravascular ultrasound imaging (IVUS) for coronary thrombosis, possibly due to cispl...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-011-0222-5
更新日期:2012-11-01 00:00:00
abstract::In the present study, we investigated whether gallic acid (GA) can induce death in cultured vascular smooth muscle cells (VSMCs), and whether production of the hydroxyl radical (.OH) is involved in the process of GA action. GA killed cultured VSMCs from rat aorta, in a dosc- and time-dependent manner. Cytoplasmic shri...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s003800070038
更新日期:2000-01-01 00:00:00
abstract::Contrast echocardiography with sonicated radiographic contrast agents has been used for the qualitative and quantitative determination of myocardial blood flow. One major problem has been the size of the microbubbles since only bubbles smaller than 8 microns are expected to pass the capillary bed and larger bubbles ma...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01744500
更新日期:1995-01-01 00:00:00
abstract::Mitral valve morphology after mitral valve surgery affects postoperative intraventricular flow patterns and long-term cardiac performance. We visualized ventricular flow by echocardiography vector flow mapping (VFM) to reveal the impact of different mitral valve procedures. Eleven cases of mechanical mitral valve repl...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0967-6
更新日期:2017-09-01 00:00:00
abstract::Angiotensin II type 2 receptor (AT2R) has been proved to be involved in a cardioprotective role, but only a few studies have addressed the association of AT2R-genotype with this role. Whether the AT2R genotype is associated with hypertension is controversial. The aim of the study was to explore the information of sing...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-005-0865-1
更新日期:2006-03-01 00:00:00
abstract::Several coronary angiographic studies have reported that enlarged and tortuous epicardial coronary arteries are characteristic of patients with left ventricular concentric hypertrophy (LVCH). Recently, we showed that small volumes opacified by contrast medium can be accurately measured by 64-multislice computed tomogr...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-011-0230-5
更新日期:2013-03-01 00:00:00
abstract::We explored the influence of global longitudinal strain (GLS) measured with two-dimensional speckle-tracking echocardiography on left ventricular mass regression (LVMR) in patients with pure aortic stenosis (AS) and normal left ventricular function undergoing aortic valve replacement (AVR). The study population includ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-012-0308-8
更新日期:2013-11-01 00:00:00
abstract::There are few studies regarding the assessment of left ventricular contractile function in patients with atrial fibrillation (AF). The aim of this study was to assess the left ventricular (LV) contractile function, i.e., the end-systolic pressure-volume relation (Ees) and a recently developed LV systolic myocardial st...
journal_title:Heart and vessels
pub_type: 临床试验,杂志文章
doi:10.1007/BF01744589
更新日期:1998-01-01 00:00:00
abstract::We studied the effects of cobalt-60 Gamma-radiation on the gene expression and secretion of adrenomedullin (Adm) and endothelin (ET) in cultured rat vascular smooth muscle cells (VSMCs). Rat VSMCs cultured in Dulbecoo's modified Eagle's medium containing 10% FBS were radiated with cobalt-60 Gamma-radiation at doses of...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-003-0709-9
更新日期:2003-09-01 00:00:00
abstract::An unusual case of total occlusion of aorta just distal to the left subclavian artery, bicuspid aortic valve, and occluded left external iliac artery in a 21-year-old man who was admitted with headache and severe hypertension is presented. We wish to report this case because so far there have been none reported with s...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0947-8
更新日期:2007-03-01 00:00:00
abstract::Compared to conscious sedation (CS), the use of general anesthesia (GA) in pulmonary vein isolation (PVI) is associated with a lower recurrence rate of atrial fibrillation (AF). GA may improve catheter stability and mapping system accuracy compared to CS, but its influence on contact force (CF) parameters during ipsil...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0961-z
更新日期:2017-08-01 00:00:00
abstract::This study evaluates the clinical significance of re-elevation of T-wave in patients with ST segment elevation acute myocardial infarction (STEMI) undergoing successful percutaneous coronary intervention (PCI). Resolution of ST elevation within 24 h after reperfusion is associated with better outcome. However, little ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-012-0313-y
更新日期:2013-11-01 00:00:00
abstract::AST-120 has been used widely in Japan to slow the deterioration of renal function in patients with chronic kidney disease (CKD) by decreasing uremic toxins. The heart and the kidney are closely related, with cardiorenal interaction being very important. This retrospective study examined whether AST-120 influences the ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0785-7
更新日期:2016-10-01 00:00:00
abstract::We reported the results of stroke prevention following modified endoscopic procedure for atrial fibrillation. 82 patients underwent modified endoscopic procedure for atrial fibrillation (AF), in whom 47 had paroxysmal, 28 had persistent, and 7 had long-standing atrial fibrillation. CHA2DS2VASC median score was 3 (rang...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0749-y
更新日期:2016-09-01 00:00:00
abstract::To elucidate involvement of age-related impairments of right ventricular (RV) distensibility in the elderly congestive heart failure (CHF), we examined the prevalence of less-distensible right ventricle in patients with preserved left ventricular ejection fraction (LVEF) over a wide range of ages. In 893 patients aged...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-1092-2
更新日期:2018-06-01 00:00:00
abstract::Chronic kidney disease (CKD) is well known to be associated with an increased incidence of coronary artery disease (CAD). Diabetes mellitus (DM) and hypertension (HTN), both of which are traditional risk factors for CAD, are the two most common causes of CKD. However, the influence of CKD on coronary atherosclerosis i...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-01334-5
更新日期:2019-07-01 00:00:00
abstract::Six patients with coronary arterial lesions due to Kawasaki disease underwent aortocoronary by-pass grafting at our institute. Before surgery, all of them had been closely monitored for some years by means of selective coronary arteriography, thallium myocardial imaging, electrocardiography (treadmill and/or Holter), ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02066356
更新日期:1985-05-01 00:00:00
abstract::No studies have evaluated both the time-to-isolation (TTI) and the sequence of pulmonary vein (PV) potentials in cryoballoon ablation (CBA) for atrial fibrillation (AF). This study aimed to prospectively evaluate the acute results of pulmonary vein isolation (PVI) using a novel CBA technique-the earliest potential (EP...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01471-5
更新日期:2020-02-01 00:00:00
abstract::It is well known the relationship between oxidative stress and vascular function. However, association between total antioxidative capacity and arterial stiffness was not studied in patients with hypertension (HT). This study investigated whether total antioxidative capacity is associated with arterial stiffness and w...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-008-1129-7
更新日期:2009-09-01 00:00:00
abstract::The possibility of minimizing organ damage following cardiopulmonary bypass (CPB) was examined. In the control group, n = 21, upon completion of CPB, elevation of the lysosomal enzyme beta-glucuronidase, which is a sensitive indicator of cellular damage, was affected by the concentration of granulocyte elastase (r = 0...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01744743
更新日期:1993-01-01 00:00:00
abstract::It has been demonstrated that S1P receptors affect heart ischaemia-reperfusion (IR) induced injury. However, whether S1P receptors affect IR-induced cardiac death has not been investigated. The aim of this paper is to demonstrate the role of S1P receptors in IR-induced cardiac death. Healthy adult male Sprague-Dawley ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-01323-8
更新日期:2019-06-01 00:00:00
abstract::Vascular calcification is an ectopic calcification that commonly occurs in atherosclerosis. Because taurine was previously shown to protect against cardiovascular diseases, the effect of taurine on vascular calcification was evaluated in calcified vascular smooth muscle cells (VSMCs) of rat in vitro in the present stu...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-003-0744-6
更新日期:2004-05-01 00:00:00