Hepatocyte growth factor(HGF): a new biochemical marker for acute myocardial infarction.

Abstract:

:The purpose of this study was to investigate the use of hepatocyte growth factor as a biochemical marker for acute myocardial infarction. Several biochemical markers are used for noninvasive detection of acute myocardial infarction. However, hepatocyte growth factor has not been used previously for this purpose. We measured hepatocyte growth factor, creatine phosphokinase, and MB isoenzyme (CK-MB) levels in 6 patients with stable effort angina after diagnostic catheterization (controls) and in 12 patients with acute myocardial infarction (AMI). The measurements in the AMI patients were recorded twice a day for the first 3 days after onset of chest pain and once a day for the next 4 days. Furthermore, in each patient we evaluated the time to reach the maximum level and the time for the level to decline to less than half the maximum. Hepatocyte growth factor levels (ng/ml) were 0.3+/-0.1 for angina pectoris patients, and 15.7+/-9.1 within 6h and 12.5+/-4.6 within 12h after the onset for AMI patients, respectively. The correlation coefficients between hepatocyte growth factor and creatine phosphokinase and between hepatocyte growth factor and CK-MB were 0.68 and 0.74, respectively. The time to reach the maximum (h) and the time to decline to less than half of the maximum level (days) were 6.6+/-2.6 and 1.2 +/-0.2 for hepatocyte growth factor, 19.4+/-8.7 and 2.5+/-1.4 for creatine phosphokinase, and 16.6+/-7.7 and 1.5+/-0.4 for CK-MB, respectively. Hepatocyte growth factor is useful as a prognostic indicator and reflects the clinical course in patients with acute myocardial infarction.

journal_name

Heart Vessels

journal_title

Heart and vessels

authors

Sato T,Yoshinouchi T,Sakamoto T,Fujieda H,Murao S,Sato H,Kobayashi H,Ohe T

doi

10.1007/BF02766790

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

241-6

issue

5

eissn

0910-8327

issn

1615-2573

journal_volume

12

pub_type

杂志文章
  • Comparison between drug-coated balloon angioplasty and second-generation drug-eluting stent placement for the treatment of in-stent restenosis after drug-eluting stent implantation.

    abstract::Even though drug-coated balloon (DCB) angioplasty has emerged as a treatment option for drug-eluting stent in-stent restenosis (DES-ISR), the most effective treatment strategy for DES-ISR is still under debate. Therefore, we compared long-term clinical outcomes following DCB treatment of DES-ISR with those following 2...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-015-0741-6

    authors: Kang IS,Shehata I,Shin DH,Kim JS,Kim BK,Ko YG,Choi D,Jang Y,Hong MK

    更新日期:2016-09-01 00:00:00

  • Vascular restenosis in coronary artery bypass grafting might be associated with VEGF-C/VEGFR-3 signaling pathway.

    abstract::The vascular endothelial growth factor (VEGF) family of peptides and caveolins (CAVs) are reported to contribute, in early graft failure in patients, a coronary artery bypass grafting (CABG). To investigate the possible association of ultimate luminal occlusion to VEGFs and CAVs expression, a functional analysis (base...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-018-1158-9

    authors: Podemska-Jedrzejczak Z,Malinska A,Sujka-Kordowska P,Nowicki M,Puslecki M,Jemielity M,Perek B

    更新日期:2018-09-01 00:00:00

  • Late gadolinium enhancement on cardiac magnetic resonance predicts coronary vasomotor abnormality and myocardial lactate production in patients with chronic heart failure.

    abstract::Myocardial fibrosis and microvascular dysfunction are key determinants of outcome in heart failure (HF); we examined their relationship in patients with HF. Our study included 61 consecutive patients with HF but without coronary stenosis. All underwent gadolinium-enhanced cardiac magnetic resonance to evaluate late ga...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-016-0816-z

    authors: Uemura T,Yamamuro M,Kaikita K,Takashio S,Utsunomiya D,Hirakawa K,Nakayama M,Sakamoto K,Yamamoto E,Tsujita K,Kojima S,Hokimoto S,Yamashita Y,Ogawa H

    更新日期:2016-12-01 00:00:00

  • Measurement of aortic diameters and detection of asymptomatic aortic aneurysms in a mass screening program using a mobile helical computed tomography unit.

    abstract::In a mass chest computed tomography (CT) screening using a mobile helical CT unit, we measured the aortic diameter at three segments to confirm standard values and also attempted to detect any asymptomatic aortic aneurysms. The population screened in the present study consisted of 6971 subjects (3847 men and 3124 wome...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s380-002-8315-1

    authors: Itani Y,Watanabe S,Masuda Y,Hanamura K,Asakura K,Sone S,Sunami Y,Miyamoto T

    更新日期:2002-01-01 00:00:00

  • Novel contrast-injection protocol for coronary computed tomographic angiography: contrast-injection protocol customized according to the patient's time-attenuation response.

    abstract::We developed a new individually customized contrast-injection protocol for coronary computed tomography (CT) angiography based on the time-attenuation response in a test bolus, and investigated its clinical applicability. We scanned 60 patients with suspected coronary diseases using a 64-detector CT scanner, who were ...

    journal_title:Heart and vessels

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00380-013-0338-x

    authors: Kidoh M,Nakaura T,Nakamura S,Awai K,Utsunomiya D,Namimoto T,Harada K,Yamashita Y

    更新日期:2014-03-01 00:00:00

  • Activated T cells induce up-regulation of Fas antigen in cultured endothelial cells.

    abstract::Recent evidence has shown that apoptotic cells are present in human atherosclerotic lesions. However, the molecular mechanism of the induction of apoptosis in atherosclerotic lesions is not clear. Since T cells are present in almost all stages of atherosclerosis, we examined whether T cells can modulate the expression...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:

    authors: Fukuo K,Suhara T,Nakahashi T,Hata S,Shimizu M,Niinobu T,Morimoto S,Ogihara T

    更新日期:1997-01-01 00:00:00

  • Assessment of the angiotensin II-forming pathway in human atria.

    abstract::A cardiac angiotensin II-generating system is thought to be involved in cardiac fibrosis. Both angiotensin-converting enzyme (ACE) and human chymase can convert angiotensin I to angiotensin II. However, the relative contributions of these two enzymatic pathways to angiotensin II generation in vivo remain to be clarifi...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:

    authors: Ohmichi N,Iwai N,Shimoike H,Izumi M,Watarida S,Mori A,Nakamura Y,Kinoshita M

    更新日期:1997-01-01 00:00:00

  • Association between sarcopenia and atherosclerosis in elderly patients with ischemic heart disease.

    abstract::Compared to the general population, elderly patients with cardiovascular disease have a higher prevalence of sarcopenia, and it shows an association with increased mortality risk. Although several studies have indicated that atherosclerosis may cause sarcopenia in community dwelling elderly subjects, the association b...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-020-01554-8

    authors: Uchida S,Kamiya K,Hamazaki N,Matsuzawa R,Nozaki K,Ichikawa T,Suzuki Y,Nakamura T,Yamashita M,Kariya H,Maekawa E,Yamaoka-Tojo M,Matsunaga A,Ako J

    更新日期:2020-06-01 00:00:00

  • ZBTB17 loss-of-function mutation contributes to familial dilated cardiomyopathy.

    abstract::Dilated cardiomyopathy (DCM) is a common primary myocardial disease leading to congestive heart failure, arrhythmia and sudden cardiac death. Increasing studies demonstrate substantial genetic determinants for DCM. Nevertheless, DCM is of substantial genetic heterogeneity, and the genetic basis for DCM in most patient...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-017-1110-4

    authors: Sun YM,Wang J,Xu YJ,Wang XH,Yuan F,Liu H,Li RG,Zhang M,Li YJ,Shi HY,Zhao L,Qiu XB,Qu XK,Yang YQ

    更新日期:2018-07-01 00:00:00

  • Myocardial deformational adaptations to different forms of training: a real-time three-dimensional speckle tracking echocardiographic study.

    abstract::The hemodynamic load due to physical activity leads to structural and functional cardiac adaptations known as "Athlete's heart". We aimed to compare myocardial performance in different groups of trained athletes by means of 3D echocardiography and 3D speckle tracking echocardiography (3D-STE). 66 athletes [26 strength...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-014-0520-9

    authors: Monte IP,Mangiafico S,Buccheri S,Bottari VE,Lavanco V,Arcidiacono AA,Leggio S,Deste W,Tamburino C

    更新日期:2015-05-01 00:00:00

  • Usefulness of the subendocardial myocardial velocity gradient in low-dose dobutamine stress echocardiography.

    abstract::The subendocardial side of myocardium makes a major contribution to left ventricular (LV) contraction and is very susceptible to ischemia. In this study we sought to quantify regional wall motion during low-dose dobutamine stress echocardiography (DSE) by using the myocardial velocity gradient (MVG) derived from tissu...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s003800070042

    authors: Tsutsui H,Uematsu M,Yamagishi M,Haruta S,Shimakura T,Miyatake K

    更新日期:2000-01-01 00:00:00

  • Prosthetic valve visualization by cine-computed tomography: a case report.

    abstract::The use of cine-computed tomography scanning is described in evaluating cardiac function in a patient with a bileaflet mitral valve prosthesis (St. Jude medical valve) and in a second patient with both mitral and aortic bileaflet prostheses. Both biventricular and prosthesis function were assessed successfully. ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02058316

    authors: Wachspress JD,Untereker WJ,Kraushaar BT

    更新日期:1987-01-01 00:00:00

  • Points to note from indications for heart transplantation to post-heart transplant care: from the care of patients with refractory heart failure and overseas heart transplantation.

    abstract::To examine important points surrounding the indications for heart transplantation (HTX) to care after HTX, we reviewed 22 patients with refractory heart failure aged less than 60 years who had been observed for the past 6 years. Sixteen patients had dilated cardiomyopathy; 1, dilated hypertrophic cardiomyopathy; 3, re...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:

    authors: Nunoda S,Kurosawa R,Kogashi K,Yamagishi S,Mitsui F,Funabashi W

    更新日期:1997-01-01 00:00:00

  • Adiponectin levels in coronary artery ectasia.

    abstract::Etiopathogenesis of coronary artery ectasia (CAE), which is defined as abnormal dilatation of a segment of the coronary artery to 1.5 times of an adjacent normal coronary artery segment, is unclear. However, it is speculated that CAE develops in the atherosclerosis process through degeneration of coronary artery media...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-008-1087-0

    authors: Dagli N,Ozturk U,Karaca I,Yavuzkir M,Koca S,Akbulut H,Balin M

    更新日期:2009-03-01 00:00:00

  • Correction to: High-intensity aerobic interval training can lead to improvement in skeletal muscle power among in-hospital patients with advanced heart failure.

    abstract::In the original publication of the article, the unit of hand in Fig. 2 was wrongly given as "N/kg" instead of "kg". ...

    journal_title:Heart and vessels

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s00380-018-1132-6

    authors: Taya M,Amiya E,Hatano M,Maki H,Nitta D,Saito A,Tsuji M,Hosoya Y,Minatsuki S,Nakayama A,Fujiwara T,Konishi Y,Yokota K,Watanabe M,Morita H,Haga N,Komuro I

    更新日期:2018-07-01 00:00:00

  • Is the coronary flow velocity reserve improvement after aortic valve replacement for aortic stenosis transient? Results of a 3-year follow-up.

    abstract::The coronary flow velocity reserve (CFR) is decreased in patients with aortic valve stenosis (AS). The aim of the present prospective study was to examine the CFR in AS patients with normal epicardial coronary arteries during a 3-year follow-up of aortic valve replacement (AVR). A total of 30 AS patients (17 women and...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-005-0883-z

    authors: Nemes A,Forster T,Kovács Z,Csanády M

    更新日期:2006-05-01 00:00:00

  • Percutaneous transvenous mitral commissurotomy immediately restores quick response of VO2 to mild exercise despite insignificant increases in peak VO2.

    abstract::Percutaneous transvenous mitral commissurotomy (PTMC) increases peak oxygen uptake (VO2) chronically, but not acutely, despite early symptomatic improvements. Analysis of transient VO2 responses to submaximal exercise (an exercise regimen more comparable to the patients' daily activities than that provided by maximal ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02911391

    authors: Takaki H,Sunagawa K,Sugimachi M,Tamai J,Okano Y,Kurita T,Aihara N,Shimizu W,Suyama K,Kamakura S

    更新日期:1995-01-01 00:00:00

  • Morphological characteristics of optical coherence tomography defined plaque fissure in patients with acute coronary syndrome.

    abstract::We assessed the plaque disruption in 245 consecutive patients with acute coronary syndrome undergoing percutaneous coronary intervention. The plaque fissure was diagnosed with optical coherence tomography, and intravascular ultrasound was used to determine arterial remodeling. Of them, 26 fissures were found in this s...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-018-1271-9

    authors: Goyal M,Kim SW,Mishra S,Sharmin S,Won H,Cho I,Jung MK,Shin SY,Lee KJ,Kim TH,Kim CJ,Lee WS

    更新日期:2019-03-01 00:00:00

  • Insulin resistance and acute coronary syndrome in the young Japanese population have a strong association.

    abstract::There are few data regarding acute coronary syndrome (ACS) in young Japanese patients. We examined the risk factors for ACS in young Japanese patients, especially impaired glucose metabolism. From a database of 789 consecutive patients admitted to our hospital with ACS between 2000 and 2005, we compared risk factors o...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-006-0956-7

    authors: Ikeda N,Nakajima R,Tsunoda T,Nakamura M,Sugi K

    更新日期:2007-05-01 00:00:00

  • Hyperplasia suppressor gene associates with smooth muscle alpha-actin and is involved in the redifferentiation of vascular smooth muscle cells.

    abstract::Vascular smooth muscle cell (VSMC) differentiation and phenotypic modulation are characterized by changes in gene expression for smooth muscle (SM) marker contractile proteins such as SM alpha-actin and SM22alpha. Hyperplasia suppressor gene (HSG) is a potent VSMC proliferation-inhibiting factor; however, it is not kn...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-006-0914-4

    authors: Jiang GJ,Han M,Zheng B,Wen JK

    更新日期:2006-09-01 00:00:00

  • Effects of levamisole, an immunomodulator, upon murine encephalomyocarditis virus myocarditis.

    abstract::To test the therapeutic efficacy of levamisole, 5-week-old DBA/2 mice were inoculated intraperitoneally with 10 plaque-forming units of encephalo-myocarditis virus. Levamisole (2.5 mg/kg/per day) was administered intraperitoneally daily, starting simultaneously with the virus inoculation, in experiment I for 14 days, ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02820869

    authors: Kishimoto C,Takada H,Hiraoka Y,Kurokawa M,Ochiai H

    更新日期:1997-01-01 00:00:00

  • Difference in epicardial adipose tissue distribution between paroxysmal atrial fibrillation and coronary artery disease.

    abstract:BACKGROUND:An increase in epicardial adipose tissue (EAT) volume is associated with the development of atrial fibrillation (AF) and coronary artery disease (CAD), but little is known about differences in its distribution. METHODS AND RESULTS:We included 50 patients with paroxysmal AF (PAF), 50 patients with CAD, and 5...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-020-01575-3

    authors: Hasebe H,Yoshida K,Nogami A,Ieda M

    更新日期:2020-08-01 00:00:00

  • Higher visit-to-visit intra-dialytic blood pressure is associated with the progression of aortic valve stenosis in chronic hemodialysis patients.

    abstract::Aortic valve stenosis (AS) is a frequent complication contributing to poor prognosis in chronic hemodialysis (CHD) patients. High blood pressure (BP) is known to be associated with AS progression in the general population. In CHD patients, however, BP varies during and between hemodialysis sessions with ultrafiltratio...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-015-0756-z

    authors: Norioka N,Iwata S,Yanagi S,Ishii H,Sugioka K,Kamimori K,Ota T,Di Tullio MR,Homma S,Yoshiyama M

    更新日期:2016-09-01 00:00:00

  • Heart failure with preserved vs reduced ejection fraction following cardiac rehabilitation: impact of endothelial function.

    abstract::There is no proven therapy for heart failure with preserved ejection fraction (HFpEF). Research has shown beneficial responses to cardiac rehabilitation (CR) among HF patients. To date, there are no reports comparing those responses between patients with HFpEF and those with reduced ejection fraction (HFrEF). The purp...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-018-1128-2

    authors: Tanaka S,Sanuki Y,Ozumi K,Harada T,Tasaki H

    更新日期:2018-08-01 00:00:00

  • Effects of liraglutide, a glucagon-like peptide-1 analog, on left ventricular remodeling assessed by cardiac magnetic resonance imaging in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention.

    abstract::The clinical efficacy of glucagon-like peptide-1 (GLP-1) analogs in patients with acute myocardial infarction (AMI) is uncertain. The purpose of the present study was to evaluate the effects of the GLP-1 analog liraglutide on left ventricular (LV) remodeling in patients with AMI. We retrospectively evaluated the effec...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-015-0734-5

    authors: Nozue T,Yamada M,Tsunoda T,Katoh H,Ito S,Iwaki T,Michishita I

    更新日期:2016-08-01 00:00:00

  • Recent therapeutic strategy for sustained ventricular tachycardia in Japan.

    abstract::We investigated the therapeutic principles and strategies to treat sustained ventricular tachycardia (SVT) as five leading medical institutions in the Tokyo area and summarized the present situation of SVT treatment in Japan. Catheter ablation (ABL) has been almost established to be effective in idiopathic ventricular...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:

    authors: Ogura H,Katoh T,Kasanuki H,Iinuma H,Ozawa Y,Majima S,Hayakawa H

    更新日期:1997-01-01 00:00:00

  • Ibutilide protects against cardiomyocytes injury via inhibiting endoplasmic reticulum and mitochondrial stress pathways.

    abstract::Atrial fibrillation (AF) is a complex disease with multiple inter-relating causes culminating in rapid atrial activation and atrial structural remodeling. The contribution of endoplasmic reticulum and mitochondria stress to AF has been highlighted. As the class III antiarrhythmic agent, ibutilide are widely used to AF...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-016-0891-1

    authors: Wang Y,Wang YL,Huang X,Yang Y,Zhao YJ,Wei CX,Zhao M

    更新日期:2017-02-01 00:00:00

  • Diverse inotropic effects of 5-hydroxytryptamine in heart muscles of various mammalian species.

    abstract::The inotropic effects of 5-hydroxytryptamine (5-HT) on mammalian heart muscles were investigated. 5-HT (10(-8)-10(-3)M) produced increases in the contractile tension of atrial and ventricular muscles isolated from guinea pigs, Japanese monkeys, and humans, but not in rat heart preparations. The maximum percent increas...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF01744594

    authors: Zaizen H,Imanishi S,Nasu M,Arita M

    更新日期:1996-01-01 00:00:00

  • Fractional flow reserve-guided percutaneous coronary intervention for an intermediate stenosis complicated by a coronary-to-pulmonary artery fistula.

    abstract::A 65-year-old man was referred to our hospital following repetitive chest pain. Invasive coronary angiography showed an intermediate stenosis of the proximal left anterior descending artery (LAD), and a coronary fistula originating distal to the stenosis draining into the main pulmonary artery. To evaluate the functio...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-015-0641-9

    authors: Ito T,Murai S,Fujita H,Tani T,Ohte N

    更新日期:2016-05-01 00:00:00

  • Preprocedural valvuloarterial impedance as a predictor of left ventricular ejection fraction improvement after transcatheter aortic valve replacement in patients with reduced left ventricular ejection fraction.

    abstract:BACKGROUND:Predictors of left ventricular ejection fraction (LVEF) improvement after transcatheter aortic valve replacement (TAVR) in patients with a preoperative reduced LVEF are limited. OBJECTIVES:This study aimed to investigate the relationship between preprocedural valuvuloarterial impedance (ZVa), which represen...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-020-01591-3

    authors: Komatsu I,Hart C,Lau J,Spies C

    更新日期:2020-09-01 00:00:00