Insulin resistance and acute coronary syndrome in the young Japanese population have a strong association.

Abstract:

:There are few data regarding acute coronary syndrome (ACS) in young Japanese patients. We examined the risk factors for ACS in young Japanese patients, especially impaired glucose metabolism. From a database of 789 consecutive patients admitted to our hospital with ACS between 2000 and 2005, we compared risk factors of patients divided into two age categories: < or =45 years (group Y, n = 41) and > or =46 years (group O, n = 748). All patients in group Y were male. Overt diabetes, hypertension, and a family history of ischemic heart disease were not so important to group Y. Higher triglyceride (160.5 +/- 86.0 vs 133.9 +/- 75.2 mg/dl, P = 0.0296) and lower high-density lipoprotein cholesterol (43.9 +/- 12.1 vs 48.7 +/- 13.5 mg/dl, P = 0.027) concentrations were present in group Y. We obtained data concerning insulin resistance in 326 of 789 patients. Although the incidence of impaired glucose tolerance was similar between the groups (31% vs 31%, not significant), a higher homeostasis model assessment insulin resistance index (2.26 +/- 2.03), indicating insulin resistance, was present in group Y. Insulin resistance might be correlated with the development of ACS in the young adult Japanese population.

journal_name

Heart Vessels

journal_title

Heart and vessels

authors

Ikeda N,Nakajima R,Tsunoda T,Nakamura M,Sugi K

doi

10.1007/s00380-006-0956-7

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

165-9

issue

3

eissn

0910-8327

issn

1615-2573

journal_volume

22

pub_type

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