Abstract:
:To examine important points surrounding the indications for heart transplantation (HTX) to care after HTX, we reviewed 22 patients with refractory heart failure aged less than 60 years who had been observed for the past 6 years. Sixteen patients had dilated cardiomyopathy; 1, dilated hypertrophic cardiomyopathy; 3, restrictive cardiomyopathy; and 2, ischemic cardiomyopathy; there were 15 males and 7 females, and 6 of the 22 patients were children. The 22 patients were divided into two groups according to their response to tailored medical therapy. Group 1 (n = 6) consisted of those whose cardiac function improved to New York Heart Association (NYHA) status 2 from NYHA status 3 or 4. Group 2 (n = 16) still exhibited refractory heart failure. Seven of these 16 patients went on to have successful HTX. Survival in groups 1 and 2 combined was significantly lower than actuarial survival post-HTX cited in the registry of the International Society for Heart and Lung Transplantation, and group 2 had an even lower survival than the total groups 1 and 2 survival. Survival in children was much lower than that in adults. Seven of the 16 patients in group 2 showed a genetic link, but there was no genetic link in group 1 patients. One patient in group 2 had a panel reactive antibody (PRA) value of 46% and died while awaiting HTX. Post-HTX care in terms of immunosuppressant therapy, was modified for each patient. It is particularly necessary to consider the time a patient will wait on the list for candidates for HTX who are children, have a genetic link, or are positive for PRA. A genetic approach is helpful to determine indications for HTX. Sensitive monitoring of post-HTX immunosuppression is needed.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Nunoda S,Kurosawa R,Kogashi K,Yamagishi S,Mitsui F,Funabashi Wsubject
Has Abstractpub_date
1997-01-01 00:00:00pages
37-40eissn
0910-8327issn
1615-2573journal_volume
Suppl 12pub_type
杂志文章abstract::Anatomic continuity between the anterior mitral leaflet and the aortic root may predispose those patients with aortic root pathology to functional changes of the mitral valve without any involvement of this valve. A 34-year-old man presented with aortic valve endocarditis. Transthoracic echocardiograpy showed severe a...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-004-0761-0
更新日期:2005-02-01 00:00:00
abstract::Acromegaly, when left untreated, is associated with premature mortality which is chiefly related to cardiovascular complications. We report on a 50-year-old acromegalic woman, resistant to therapy, who died suddenly because of thoracic aortic rupture and massive bleeding into the left pleural space. The postmortem exa...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-007-1012-y
更新日期:2008-01-01 00:00:00
abstract::The presence of myocardial interstitial edema in acute myocarditis (AM) leads to thickening of the ventricular wall, and conduction disturbances, such as complete atrioventricular block (CAV), also frequently develop. This study was undertaken in order to clarify the relationship between conduction disturbances and my...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0922-4
更新日期:2006-11-01 00:00:00
abstract::To assess left ventricular diastolic properties in response to dynamic exercise, mitral inflow velocity integrals were measured by pulsed-wave Doppler echocardiography in ten patients with myocardial infarction and in ten normal subjects, and simultaneous left ventricular pressure was obtained with micromanometry in t...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::The aim of this study was to evaluate the relation between aortic artery distensibility, expressed by pulse pressure (PP) and autonomic nervous system function expressed by heart rate variability (HRV), among elders. During 2009, 469 individuals (50 % males, mean age 75 ± 6 years old), permanent inhabitants of Ikaria ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-012-0267-0
更新日期:2013-07-01 00:00:00
abstract::Controlling blood pressure is essential for prevention of events after acute aortic dissection (AAD). However, in some instances a cardiac event occurs despite controlled blood pressure, and its prediction is difficult. We continuously monitored C-reactive protein (CRP) in patients receiving medical treatment for AAD ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-012-0257-2
更新日期:2013-05-01 00:00:00
abstract::Myocardial fibrosis and microvascular dysfunction are key determinants of outcome in heart failure (HF); we examined their relationship in patients with HF. Our study included 61 consecutive patients with HF but without coronary stenosis. All underwent gadolinium-enhanced cardiac magnetic resonance to evaluate late ga...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0816-z
更新日期:2016-12-01 00:00:00
abstract::Soluble urokinase-type plasminogen activator receptor (suPAR) is a membrane-binding protein that is released into the blood stream by immune activation. Recent reports suggest that circulating suPAR levels are associated with adverse cardiovascular outcomes. Exercise tolerance is an independent predictor of prognosis ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01538-3
更新日期:2020-05-01 00:00:00
abstract::There is no proven therapy for heart failure with preserved ejection fraction (HFpEF). Research has shown beneficial responses to cardiac rehabilitation (CR) among HF patients. To date, there are no reports comparing those responses between patients with HFpEF and those with reduced ejection fraction (HFrEF). The purp...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1128-2
更新日期:2018-08-01 00:00:00
abstract::Thoracic outlet syndrome (TOS) is caused by compression of peripheral nerves and vascular structures along their course through the upper thoracic aperture to the axilla. The aim of our study was to analyze long-term outcomes of different treatments stratified by symptom severity. We performed a retrospective analysis...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-010-0112-2
更新日期:2011-11-01 00:00:00
abstract::To test the therapeutic efficacy of levamisole, 5-week-old DBA/2 mice were inoculated intraperitoneally with 10 plaque-forming units of encephalo-myocarditis virus. Levamisole (2.5 mg/kg/per day) was administered intraperitoneally daily, starting simultaneously with the virus inoculation, in experiment I for 14 days, ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02820869
更新日期:1997-01-01 00:00:00
abstract::A cardiac angiotensin II-generating system is thought to be involved in cardiac fibrosis. Both angiotensin-converting enzyme (ACE) and human chymase can convert angiotensin I to angiotensin II. However, the relative contributions of these two enzymatic pathways to angiotensin II generation in vivo remain to be clarifi...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::The objective of this study is to determine whether pentraxin-3 (PTX-3) is clinically a biomarker of inflammation, a player in anti-inflammation, or both with regard to coronary atherosclerosis, we compared levels of PTX-3 with levels of adiponectin in addition to high-sensitivity C-reactive protein (hs-CRP). We enrol...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0553-0
更新日期:2015-11-01 00:00:00
abstract::Previous studies showed that continuous anticoagulation or single antiplatelet therapy during implantations of cardiac implantable electronic devices (CIED) was relatively safe. However, the safety of continuous multi antithrombotic therapy (AT) in patients undergoing CIED interventions has not been clearly defined. W...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0879-x
更新日期:2017-03-01 00:00:00
abstract::The aim of the study was to evaluate systemic right ventricular (RV) dyssynchrony in patients with congenitally corrected transposition of the great arteries (CCTGA) and transposition of the great arteries (TGA) with New York Heart Association functional class (NYHA FC) < III. We used cardiac magnetic resonance (CMR) ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1144-2
更新日期:2018-09-01 00:00:00
abstract::A transient left ventricular apical ballooning (so-called "ampulla" or "Takotsubo-shaped" cardiomyopathy) with type I CD36 deficiency is described in a 71-year-old woman. The patient was referred because of chest pain and worsening of dyspnea. Electrocardiogram showed T-wave inversions on the precordal leads, and acut...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-004-0787-3
更新日期:2005-05-01 00:00:00
abstract::Vascular smooth muscle cell (VSMC) differentiation and phenotypic modulation are characterized by changes in gene expression for smooth muscle (SM) marker contractile proteins such as SM alpha-actin and SM22alpha. Hyperplasia suppressor gene (HSG) is a potent VSMC proliferation-inhibiting factor; however, it is not kn...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0914-4
更新日期:2006-09-01 00:00:00
abstract::Raising high-density lipoprotein cholesterol (HDL-C) is an important strategy for reducing residual cardiovascular risk. In the present study, we sought to assess the effect of extended-release niacin/laropiprant on endothelial function in patients after a myocardial infarction with target low-density lipoprotein chol...
journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-013-0367-5
更新日期:2014-05-01 00:00:00
abstract::Morphological and functional changes of free arterial grafts in dogs were studied for 3 weeks after implantation and the changes were compared to those in implanted free vein grafts. In the arterial grafts, endothelial cells with abundant pinocytotic vesicles and some cytoplasmic folds were observed by transmission an...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01744868
更新日期:1992-01-01 00:00:00
abstract::Taurine (2-aminoethanesulfonic acid) is a potent antioxidant and inhibits cell apoptosis in ischemic reperfusion injury. In this study we evaluated whether addition of taurine to St. Thomas' cardioplegic solution enhances its myocardial protective effects in prolonged hypothermic heart preservation in rats. Hearts iso...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-005-0841-9
更新日期:2005-11-01 00:00:00
abstract::Coronary artery calcification (CAC) as measured by computed tomography is a strong predictor of coronary artery disease. The brachial intima-media thickness (IMT) was recently reported to be associated with cardiovascular risk factors. This study investigated the association of brachial IMT with CAC, which is a marker...
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pub_type: 杂志文章
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abstract::Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) resulted in different degrees of damage to the heart muscle, and yet, when factors related to in-hospital outcomes were examined, these two subsets were often lumped together as non-STelevation acute coronary syndrome. Therefore, we investigated ...
journal_title:Heart and vessels
pub_type: 杂志文章,多中心研究
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更新日期:2009-11-01 00:00:00
abstract::To elucidate involvement of age-related impairments of right ventricular (RV) distensibility in the elderly congestive heart failure (CHF), we examined the prevalence of less-distensible right ventricle in patients with preserved left ventricular ejection fraction (LVEF) over a wide range of ages. In 893 patients aged...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-1092-2
更新日期:2018-06-01 00:00:00
abstract::The purpose of this study was to investigate the use of hepatocyte growth factor as a biochemical marker for acute myocardial infarction. Several biochemical markers are used for noninvasive detection of acute myocardial infarction. However, hepatocyte growth factor has not been used previously for this purpose. We me...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02766790
更新日期:1997-01-01 00:00:00
abstract::Aortic dissection is a life-threatening cardiovascular disease with high in-hospital mortality. However, the risk factors of aortic dissection have not been fully elucidated. Obstructive sleep apnea (OSA) has been increasingly recognized as an independent cardiovascular risk factor. Among the underlying mechanisms to ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-011-0149-x
更新日期:2012-05-01 00:00:00
abstract::Successful restoration of patency of the infarct-related artery is important in management of acute ST-segment elevation myocardial infarction (STEMI); however, it does not necessarily translate into the restoration of perfusion at the tissue level. In this study, we evaluate the prognostic role of qualitative and qua...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-013-0460-9
更新日期:2015-01-01 00:00:00
abstract::A drawback of visual assessment for late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) is the subjectivity and reproducibility of the results. The aim of this study was to investigate the relationship between left ventricular (LV) reverse remodeling in response to optimal pharmacotherapies and the d...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1196-3
更新日期:2018-12-01 00:00:00
abstract::Pulmonary arterial hypertension (PAH) is characterized by a progressive increase in pulmonary arterial pressure and vascular resistance. Despite advances in therapy for PAH, its treatment and prognosis remain poor. We aimed to investigate whether the transplantation of bone marrow mesenchymal stem cells (MSCs) overexp...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-013-0395-1
更新日期:2014-07-01 00:00:00
abstract::We recently reported that preoperative endothelial dysfunction [i.e., reactive hyperemia index (RHI) ≤ 1.64] predicted short-term postoperative adverse events in patients undergoing cardiovascular surgery. However, the relationship between preoperative RHI and long-term cardiovascular risk in these patients is unclear...
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journal_title:Heart and vessels
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更新日期:2019-06-01 00:00:00