Sudden death due to aortic rupture in acromegaly.

Abstract:

:Acromegaly, when left untreated, is associated with premature mortality which is chiefly related to cardiovascular complications. We report on a 50-year-old acromegalic woman, resistant to therapy, who died suddenly because of thoracic aortic rupture and massive bleeding into the left pleural space. The postmortem examination disclosed, nearby the point of rupture, a pulmonary abscess as well as extensive intrinsic alteration of arteries originating from the aortic arch and aorta itself, which featured microscopic cystic medial necrosis. We discussed how these aspects could be related to long-term exposition to growth hormone excess. In particular, this case gives further evidence of vascular system frailty in acromegaly.

journal_name

Heart Vessels

journal_title

Heart and vessels

authors

Maffei P,Menegazzo C,Michelotto M,Salmaso R,Martini C,De Carlo E,Carli M,Barban M,Fassina A,Vettor R,Sicolo N

doi

10.1007/s00380-007-1012-y

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

71-4

issue

1

eissn

0910-8327

issn

1615-2573

journal_volume

23

pub_type

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