Abstract:
:Blood traces tortuous paths of flow through the heart. We postulate that momentum changes associated with direction changes optimize dynamic coupling between ventricular and atrial function, particularly on exercise. Traces of pulsed Doppler mitral flow and M-mode long-axis mitral ring movement were recorded before and during exercise, increased in 25-W steps to strenuous levels (146 +/- 30 W), in 16 healthy volunteers, aged 38 +/- 10 years. R-R intervals fell from 821 +/- 151 to 437 +/- 51 ms, and diastole from 458 +/- 134 to 169 +/- 33 ms. Peak mitral flow velocities rose from 0.68 +/- 0.17 to 1.27 +/- 0.16 m/s, and mitral valve ring displacements from 13.8 +/- 3.3 to 19.3 +/- 3.4 mm. Biphasic diastolic curves of flow and movement became monophasic as R-R fell below 500 ms, with atrial systole apparently coming to coincide with elastic ventricular recoil to give a single elevated peak of mitral flow. The increased slope and amplitude of Doppler curves indicate increased rates of change of momentum, which imply enhanced inertial forces. The illustrated patterns of flow and movement on exercise accord with the postulated "dynamic" mode of function, in which forces between atria, ventricles, and passing blood masses become tightly coupled to achieve a sling-like redirection of momentum through tortuous paths of flow, but more extensive data are needed to adequately model and quantify inertial force exchanges of the exercising heart.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Kilner PJ,Henein MY,Gibson DGdoi
10.1007/BF02767127subject
Has Abstractpub_date
1997-01-01 00:00:00pages
103-10issue
3eissn
0910-8327issn
1615-2573journal_volume
12pub_type
临床试验,杂志文章abstract::We clarified that the set of the isotropic component (T) of wall tension and the area (A) of a selected region of the left ventricular wall expresses the regional work with sufficient accuracy. The area surrounded by the locus of the T-A relation in the T-A plane is approximately equal to the real work done by that re...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02066408
更新日期:1985-08-01 00:00:00
abstract::There is no proven therapy for heart failure with preserved ejection fraction (HFpEF). Research has shown beneficial responses to cardiac rehabilitation (CR) among HF patients. To date, there are no reports comparing those responses between patients with HFpEF and those with reduced ejection fraction (HFrEF). The purp...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1128-2
更新日期:2018-08-01 00:00:00
abstract::In a mass chest computed tomography (CT) screening using a mobile helical CT unit, we measured the aortic diameter at three segments to confirm standard values and also attempted to detect any asymptomatic aortic aneurysms. The population screened in the present study consisted of 6971 subjects (3847 men and 3124 wome...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s380-002-8315-1
更新日期:2002-01-01 00:00:00
abstract::We assessed the plaque disruption in 245 consecutive patients with acute coronary syndrome undergoing percutaneous coronary intervention. The plaque fissure was diagnosed with optical coherence tomography, and intravascular ultrasound was used to determine arterial remodeling. Of them, 26 fissures were found in this s...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1271-9
更新日期:2019-03-01 00:00:00
abstract::Whether trough-phase rivaroxaban concentrations provide sufficient anticoagulation needs more study. We evaluated levels of coagulation activation markers in the trough concentration phase in nonvalvular atrial fibrillation (NVAF) patients, and the correlation between these markers and rivaroxaban concentration. Fifty...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0912-0
更新日期:2017-05-01 00:00:00
abstract::Intracellular Na(+) ([Na(+)](i)) regulation plays a crucial role in the structural, mechanical, and electrical properties of myocardium. It is assumed that the [Na(+)](i) handling system may differ not only between normal and diseased hearts but also regionally within a heart. To gain new insight concerning disease- a...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-008-1071-8
更新日期:2009-01-01 00:00:00
abstract::Incretin hormones have been reported to have cytoprotective actions in addition to their glucose-lowering effects. We evaluated whether teneligliptin, a novel dipeptidyl peptidase-4 (DPP-4) inhibitor, affects left ventricular (LV) function in patients with type 2 diabetes mellitus (T2DM). Twenty-nine T2DM patients not...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0724-7
更新日期:2016-08-01 00:00:00
abstract::The aim of this study was to evaluate the relation between aortic artery distensibility, expressed by pulse pressure (PP) and autonomic nervous system function expressed by heart rate variability (HRV), among elders. During 2009, 469 individuals (50 % males, mean age 75 ± 6 years old), permanent inhabitants of Ikaria ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-012-0267-0
更新日期:2013-07-01 00:00:00
abstract::The resting full-cycle ratio (RFR), a novel resting index, is well correlated with and shows good diagnostic accuracy to the fractional flow reserve (FFR). However, discordance results between the RFR and FFR have been observed to occur in about 20% of cases. This study aimed to clarify the prevalence and factors of d...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01763-1
更新日期:2021-01-05 00:00:00
abstract::Eicosapentaenoic acid (EPA) has antiarrhythmic effects. The J-wave on an electrocardiogram is associated with a high incidence of ventricular tachycardia/fibrillation (VT/VF). We evaluated relationships between EPA and J-waves, and their involvement in the occurrence of VT/VF in acute myocardial infarction (AMI). Two ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-013-0435-x
更新日期:2014-11-01 00:00:00
abstract::It is well known the relationship between oxidative stress and vascular function. However, association between total antioxidative capacity and arterial stiffness was not studied in patients with hypertension (HT). This study investigated whether total antioxidative capacity is associated with arterial stiffness and w...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-008-1129-7
更新日期:2009-09-01 00:00:00
abstract::We developed a new individually customized contrast-injection protocol for coronary computed tomography (CT) angiography based on the time-attenuation response in a test bolus, and investigated its clinical applicability. We scanned 60 patients with suspected coronary diseases using a 64-detector CT scanner, who were ...
journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-013-0338-x
更新日期:2014-03-01 00:00:00
abstract::The coronary flow velocity reserve (CFR) is decreased in patients with aortic valve stenosis (AS). The aim of the present prospective study was to examine the CFR in AS patients with normal epicardial coronary arteries during a 3-year follow-up of aortic valve replacement (AVR). A total of 30 AS patients (17 women and...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-005-0883-z
更新日期:2006-05-01 00:00:00
abstract::Although the suction force that moves blood into the left ventricle during early diastole is thought to play an important role in diastolic function, there have been a few studies of this phenomenon in normal children. Suction force is measured as the intraventricular pressure difference (IVPD) and intraventricular pr...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1239-9
更新日期:2019-02-01 00:00:00
abstract::Several coronary angiographic studies have reported that enlarged and tortuous epicardial coronary arteries are characteristic of patients with left ventricular concentric hypertrophy (LVCH). Recently, we showed that small volumes opacified by contrast medium can be accurately measured by 64-multislice computed tomogr...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-011-0230-5
更新日期:2013-03-01 00:00:00
abstract::Cerebral artery stenosis (CAS) has the same pathogenesis as coronary artery disease (CAD), but the coexistence of these two diseases has been rarely reported. To detect coexistent CAS in CAD patients, we conducted a study of simultaneous coronary and cerebral angiography. Of the 663 consecutive newly diagnosed CAD pat...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0971-8
更新日期:2007-09-01 00:00:00
abstract::First-generation drug-eluting stents (DES) demonstrated delay in vascular healing and increase in incidence of late and very late stent thrombosis compared with bare-metal stents (BMS). Second-generation DES, however, have shown a reduction of late and very late stent thrombosis compared with first-generation DES. Thu...
journal_title:Heart and vessels
pub_type: 杂志文章,多中心研究
doi:10.1007/s00380-015-0783-9
更新日期:2016-10-01 00:00:00
abstract::Previous studies showed that continuous anticoagulation or single antiplatelet therapy during implantations of cardiac implantable electronic devices (CIED) was relatively safe. However, the safety of continuous multi antithrombotic therapy (AT) in patients undergoing CIED interventions has not been clearly defined. W...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0879-x
更新日期:2017-03-01 00:00:00
abstract::The essential role of the renin-angiotensin system (RAS) in controlling blood pressure has been well established. Genes encoding components of the RAS have been proposed as candidate genes that determine genetic predisposition to hypertension and the risk of developing cardiovascular complications. The purpose of this...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-008-1101-6
更新日期:2009-05-01 00:00:00
abstract::Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) resulted in different degrees of damage to the heart muscle, and yet, when factors related to in-hospital outcomes were examined, these two subsets were often lumped together as non-STelevation acute coronary syndrome. Therefore, we investigated ...
journal_title:Heart and vessels
pub_type: 杂志文章,多中心研究
doi:10.1007/s00380-008-1141-y
更新日期:2009-11-01 00:00:00
abstract::The distribution and structure of lymphatic and blood capillaries in the rabbit heart conduction system were investigated by transmission electron microscopy. The sinuatrial node, atrioventricular node, and atrioventricular bundle possessed a rich network of lymphatic capillaries, which were situated not only at the p...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058423
更新日期:1988-01-01 00:00:00
abstract::Peripartum cardiomyopathy (PPCM) is a rare but life-threatening cardiac disorder characterized by maternal systolic heart failure. Although PPCM is a major cause of maternal mortality, little is known about the acute-phase management of PPCM in real-world clinical settings. We retrospectively identified patients hospi...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0958-7
更新日期:2017-08-01 00:00:00
abstract::We report herein an adult case of anomalous origin of the left coronary artery from the pulmonary artery (Bland-White-Garland syndrome; BWG syndrome). The patient had chest discomfort during exercise and signs of mitral regurgitation. We diagnosed him as having BWG syndrome by angiography, and performed surgical treat...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01746067
更新日期:1994-01-01 00:00:00
abstract::The use of cine-computed tomography scanning is described in evaluating cardiac function in a patient with a bileaflet mitral valve prosthesis (St. Jude medical valve) and in a second patient with both mitral and aortic bileaflet prostheses. Both biventricular and prosthesis function were assessed successfully. ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058316
更新日期:1987-01-01 00:00:00
abstract::The clinical and immunological follow-up of a 38-year-old female patient with hypereosinophilic syndrome and classical cardiac involvement, but without demonstrable degranulation of eosinophils and lacking binding of a specific antibody for activated eosinophils, is presented. Instead, the patient demonstrated all the...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058696
更新日期:1990-01-01 00:00:00
abstract::Lamotrigine has been used for patients with epilepsy and/or bipolar disorder, overdose of which induced the hypotension, elevation of the atrial pacing threshold, cardiac conduction delay, wide complex tachycardia, cardiac arrest and Brugada-like electrocardiographic pattern. To clarify how lamotrigine induces those c...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01716-8
更新日期:2020-11-02 00:00:00
abstract::Although heparin allergy is a rare but well-documented entity, anticoagulation management for cardiac surgery in patients with the heparin allergy has not been established due to its rarity. Here we report a case that shows our anticoagulation strategy during a coronary bypass operation. A 67-year-old man with unstabl...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s003800300006
更新日期:2003-03-01 00:00:00
abstract::Atrial fibrillation (AF) is a complex disease with multiple inter-relating causes culminating in rapid atrial activation and atrial structural remodeling. The contribution of endoplasmic reticulum and mitochondria stress to AF has been highlighted. As the class III antiarrhythmic agent, ibutilide are widely used to AF...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0891-1
更新日期:2017-02-01 00:00:00
abstract::Atrial fibrillation (AF) is the most common arrhythmia, characterized by a lack of atrial contraction and an irregular ventricular rhythm. We assessed the effect of fibrillatory wave amplitude on coronary blood flow in patients with AF using the thrombolysis in myocardial infarction (TIMI) frame count. Sixty-one patie...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1121-9
更新日期:2018-07-01 00:00:00
abstract::We investigated the signaling mechanism of stretch-induced cell remodeling in human umbilical vein endothelial cells (HUVECs). Freshly dissociated HUVECs were cultured on an elastic silicon membrane and subjected to uniaxial cyclic stretch (20% in length, 1 Hz). The cells started to change their morphology as early as...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00