Is the coronary flow velocity reserve improvement after aortic valve replacement for aortic stenosis transient? Results of a 3-year follow-up.


:The coronary flow velocity reserve (CFR) is decreased in patients with aortic valve stenosis (AS). The aim of the present prospective study was to examine the CFR in AS patients with normal epicardial coronary arteries during a 3-year follow-up of aortic valve replacement (AVR). A total of 30 AS patients (17 women and 13 men) were enrolled in this prospective follow-up study; they all had a normal coronary angiogram and underwent dipyridamole stress transesophageal echocardiography (STEE) for CFR measurement before AVR. Nine of them participated in this 3-year follow-up study, and all patients were examined 16 months and 3 years after AVR by STEE. The CFR of AS patients was decreased before AVR. Different extents of diastolic coronary flow velocity reduction (resting and posthyperaemic) were observed resulting in a significant CFR improvement, despite the low number of patients during the 16-month follow-up. A further posthyperaemic flow velocity reduction was demonstrated after the 3-year follow-up, resulting in a significant CFR impairment. The CFR decreased in 5 cases, but remained practically unchanged in 3 after the first CFR measurement; only the CFR of 1 patient improved minimally. The main finding of the current study is that the CFR improvement 16 months after AVR, which paralleled the regression of the left ventricular hypertrophy, was found to be transient. Coronary flow velocity reserve impairment was demonstrated after the long-term (3-year) follow-up in most of the patients, which could not be explained by extravascular compressive forces.


Heart Vessels


Heart and vessels


Nemes A,Forster T,Kovács Z,Csanády M




Has Abstract


2006-05-01 00:00:00












  • Effects of a new thromboxane A2-antagonist (ONO-3708) and a new leukotriene-antagonist (ONO-1078) on thromboxane A2 analogue-, leukotriene C4-, and D4-induced regional myocardial blood flow reduction.

    abstract::Effects of the administration of a thromboxane A2 (TXA2) analogue (STA2), a leukotriene C4 (LTC4), and a leukotriene D4 (LTD4) on regional myocardial blood flow (RMBF) and hemodynamics were studied in anesthetized, open-chest dogs. The blocking ability of a recently synthesized TXA2 selective antagonist, ONO-3708, and...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Torii T,Toki Y,Hieda N,Ito Y,Okumura K,Hashimoto H,Ito T,Ogawa K,Satake T

    更新日期:1988-01-01 00:00:00

  • Long-term treatment with angiotensin II type 1 receptor antagonist, CV-11974, restores beta-catenin mRNA expression in volume-overloaded rabbit hearts.

    abstract::This study aimed to search genes altered in expression after long-term treatment with the angiotensin II type 1 receptor (AT1) antagonist, CV-11974, in volume-overloaded hearts. Arteriovenous shunt was made between the common carotid artery and jugular vein in Japanese White rabbits. Shunt-operated rabbits were random...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Itoh M,Takeishi Y,Nakada S,Miyamoto T,Tsunoda Y,Takahashi H,Kubota I,Tomoike H

    更新日期:2002-11-01 00:00:00

  • Impact of pharmacological spasm provocation test in patients with a history of syncope.

    abstract::Coronary artery spasm is involved in the pathogenesis of various cardiac disorders. We investigated patients with a history of syncope who underwent elective coronary angiography. We retrospectively analyzed 5781 consecutive patients who had diagnostic or follow-up angiography during a 26-year period. During this peri...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Sueda S,Kohno H

    更新日期:2018-02-01 00:00:00

  • Adenosine constricts the isolated and perfused monkey coronary artery.

    abstract::Adenosine constricted 37 of 58 isolated and perfused monkey coronary arteries, whereas it dilated dog coronary arteries in all cases. The vasoconstriction induced by 0.1-10 micrograms (0.37-37.4 nmol) of adenosine was examined, since adenosine in large doses produced tachyphylaxis. The adenosine-induced vasoconstricti...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Nakane T,Chiba S

    更新日期:1990-01-01 00:00:00

  • Serum carboxy-terminal telopeptide of type I collagen (I-CTP) is predictive of clinical outcome in peripheral artery disease patients following endovascular therapy.

    abstract::Peripheral artery disease (PAD) is a risk factor for the development of heart failure and mortality. The serum levels of carboxy-terminal telopeptide of type I collagen (I-CTP), a marker for collagen degradation derived from the extracellular matrix of vascular and myocardial tissue, is reportedly a useful marker for ...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Otaki Y,Watanabe T,Takahashi H,Yamaura G,Nishiyama S,Arimoto T,Shishido T,Miyamoto T,Kubota I

    更新日期:2017-02-01 00:00:00

  • Sonicated X-ray contrast agents for quantitative myocardial contrast echocardiography--a critical approach.

    abstract::Contrast echocardiography with sonicated radiographic contrast agents has been used for the qualitative and quantitative determination of myocardial blood flow. One major problem has been the size of the microbubbles since only bubbles smaller than 8 microns are expected to pass the capillary bed and larger bubbles ma...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Mayer IV,Lazarov MP,Utzinger U,Freiburghaus AU,Hess OM

    更新日期:1995-01-01 00:00:00

  • The clinical characteristics of sudden cardiac arrest in asymptomatic patients with congenital heart disease.

    abstract::Sudden cardiac arrest (SCA) is a major cause of death in patients with congenital heart disease (CHD). Systemic ventricular dysfunction is a reported risk factor for SCA. We retrospectively analyzed the medical records of 46 patients (age >6 years) who experienced SCA. The following underlying cardiac defects were obs...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Miyazaki A,Sakaguchi H,Ohuchi H,Yasuda K,Tsujii N,Matsuoka M,Yamamoto T,Yazaki S,Tsuda E,Yamada O

    更新日期:2015-01-01 00:00:00

  • General anesthesia improves contact force and reduces gap formation in pulmonary vein isolation: a comparison with conscious sedation.

    abstract::Compared to conscious sedation (CS), the use of general anesthesia (GA) in pulmonary vein isolation (PVI) is associated with a lower recurrence rate of atrial fibrillation (AF). GA may improve catheter stability and mapping system accuracy compared to CS, but its influence on contact force (CF) parameters during ipsil...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Chikata A,Kato T,Yaegashi T,Sakagami S,Kato C,Saeki T,Kawai K,Takashima SI,Murai H,Usui S,Furusho H,Kaneko S,Takamura M

    更新日期:2017-08-01 00:00:00

  • Hydrodynamics in the heart modulates work.

    abstract::The hydrostatic pressure (perfusion pressure) of the isovolumic isolated perfused rat heart regulated the hydrodynamics (water movement) of the myocardium. An abrupt (10 s) decrease in hydrostatic pressure caused an immediate decrease in oxygen consumption, left ventricular developed pressure, and wall thickness. Wall...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Watters TA,Bouchard A,Wu ST,Parmley WW,Wikman-Coffelt J

    更新日期:1988-01-01 00:00:00

  • Assessment of vascular autonomic function using peripheral arterial tonometry.

    abstract::Peripheral autonomic function is impaired in diabetic polyneuropathy. However, it is difficult to evaluate it due to the lack of non-invasive quantitative assessment. We aimed to establish a novel index to evaluate vascular autonomic function using reactive hyperemia peripheral arterial tonometry (RH-PAT), a widely pe...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Hamada S,Oono A,Ishihara Y,Hasegawa Y,Akaza M,Sumi Y,Inoue Y,Izumiyama H,Hirao K,Isobe M,Sasano T

    更新日期:2017-03-01 00:00:00

  • A pathologic analysis of the outcome following heart-lung transplantation: an autopsy study of 22 recipients.

    abstract::Between 1987 and 1989, twenty-two patients who received combined heart-lung transplantation were autopsied at La Pitie Salpetriere Hospital in Paris. With the exception of two recipients who survived for 2 months and 4 months, respectively, the majority of the patients died in the early postoperative period (the mean ...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Ishibashi-Ueda H,Chomette G,Delcourt A,Auriol M,Le Charpentier Y,Cabrol C

    更新日期:1991-01-01 00:00:00

  • Layer-specific dyssynchrony and its relationship to the change of left ventricular function in hypertensive patients.

    abstract::Left ventricular (LV) remodeling in systemic arterial hypertension causes electrical conduction delay and impairs synchronous contraction, which may contribute to the development of heart failure. This study aimed to assess the change of LV mechanics in hypertension by layer-specific dyssynchrony. One hundred and twen...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Kim SA,Kim MN,Shim WJ,Park SM

    更新日期:2016-04-01 00:00:00

  • Changes in morphology of elastin fibers during development of the tunica intima of monkey aorta.

    abstract::The normal development of elastin fibers in the thoracic aorta was studied in fetal, young, and adult monkeys. Tissue was examined by scanning electron microscopy (SEM) after NaOH treatment and by transmission electron microscopy (TEM). The NaOH treatment of fixed tissues effectively removed collagen fibers and enable...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Sato F,Shimada T,Kitamura H,Campbell GR,Ogata J

    更新日期:1994-01-01 00:00:00

  • Changes in lung to finger circulation time measured via cardiopulmonary polygraphy in patients with varying types of heart disease.

    abstract::Cardiopulmonary polygraphy (PG) demonstrates not only parameters for sleep disordered breathing (SDB) but also hemodynamics. We previously developed a software that detects lung to fingertip circulation time (LFCT) derived from PG dataset and reported that those LFCT reflected the cardiac output. The purpose of this s...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Tobushi T,Hosokawa K,Abe K,Kon-No S,Kadokami T,Nakamura R,Tsutsui H,Ando SI

    更新日期:2021-01-01 00:00:00

  • Associations of sensitive cardiac troponin-I with left ventricular morphology, function and prognosis in end-stage renal disease patients with preserved ejection fraction.

    abstract::Sensitive cardiac troponin I (cTnI) predicts all-cause and cardiovascular mortality in various clinical settings. However, its clinical significance in hemodialysis (HD) patients with preserved left ventricular ejection fraction (LVEF) has not been fully elucidated. This study investigated the association of cTnI with...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Otsuka K,Nakanishi K,Shimada K,Nakamura H,Inanami H,Nishioka H,Fujimoto K,Kasayuki N,Yoshiyama M

    更新日期:2018-11-01 00:00:00

  • Oxidized lipoprotein(a) and cardio-ankle vascular index (CAVI) in hypertensive subjects.

    abstract::While oxidized lipoprotein(a) (oxLp(a)) has been indicated to be involved in atherogenesis more than native lipoprotein(a) (Lp(a)), there is still a need to elucidate the associations among oxLp(a), hypertension, and atherosclerosis. The cardio-ankle vascular index (CAVI) is a recently developed index used to assess a...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Kotani K,Yamada S,Yamada T,Kario K,Taniguchi N

    更新日期:2013-07-01 00:00:00

  • Effects of dietary sodium on reactive oxygen species formation and endothelial dysfunction in low-density lipoprotein receptor-deficient mice on high-fat diet.

    abstract::Hypertension and high serum cholesterol level are important risk factors for atherosclerosis and coronary heart disease. In the present study we tested the hypothesis whether high sodium intake, when given in combination with Western type high-fat diet, induces endothelial dysfunction and promotes atherosclerosis. Fur...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Ketonen J,Mervaala E

    更新日期:2008-11-01 00:00:00

  • Role of QT interval prolongation in the creation of spiral wave type reentry.

    abstract::The inducibility of reentry was compared for four QT patterns in a heart conduction simulation model. Local (L) and gradual (G) QT prolongation models are more susceptible to reentry induction than the no (N) QT prolongation model (reentry induced episodes for N, L, and G numbered 90, 120, and 122, respectively). This...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Shibata N,Watanabe H,Sakuma I,Kodama I,Niwa R,Fukui Y,Toyama J,Hosoda S

    更新日期:1997-01-01 00:00:00

  • Semi-automatic assessment of global left ventricular function and left ventricular parameters with dual-source computed tomography: comparison with invasive angiography.

    abstract::This study assesses the global left ventricular function and volumes using dual-source computed tomography (DSCT) with improved temporal resolution (83 ms) by use of a semi-automatic software tool in comparison to invasive angiography (IVA). One hundred patients scheduled for invasive coronary angiography because of s...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Drosch T,Tsiflikas I,Brodoefel H,Heuschmid M,Reimann A,Thomas C,Ketelsen D,Wurster D,Schroeder S,Burgstahler C

    更新日期:2010-01-01 00:00:00

  • Hepatocyte growth factor(HGF): a new biochemical marker for acute myocardial infarction.

    abstract::The purpose of this study was to investigate the use of hepatocyte growth factor as a biochemical marker for acute myocardial infarction. Several biochemical markers are used for noninvasive detection of acute myocardial infarction. However, hepatocyte growth factor has not been used previously for this purpose. We me...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Sato T,Yoshinouchi T,Sakamoto T,Fujieda H,Murao S,Sato H,Kobayashi H,Ohe T

    更新日期:1997-01-01 00:00:00

  • Short- and long-term benefits of drug-eluting stents compared to bare metal stents even in treatment for large coronary arteries.

    abstract::Although drug-eluting stents (DES) for percutaneous coronary intervention (PCI) have dramatically reduced the incidence of in-stent restenosis, their deployment for large-size coronary lesions is still controversial because of problems such as late in-stent thrombosis and late catch-up in DES. We aimed to evaluate the...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Yoshida T,Sakata K,Nitta Y,Taguchi T,Kaku B,Katsuda S,Shimojima M,Gamou T,Nakahashi T,Konno T,Kawashiri MA,Yamagishi M,Hayashi K

    更新日期:2016-05-01 00:00:00

  • Ketamine and midazolam differently impact post-intubation hemodynamic profile when used as induction agents during emergency airway management in hemodynamically stable patients with ST elevation myocardial infarction.

    abstract::We investigated the incidence of post-intubation hypotension (PIH) in hemodynamically stable patients with STEMI requiring rapid sequences intubation (RSI) and medicated with ketamine or midazolam as induction agent. STEMI patients admitted between 1st January 2009 and 1st January 2017 who did not receive any type of ...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Zuin M,Rigatelli G,Dell'Avvocata F,Faggian G,Conte L,Giatti S,Michielan F,Roncon L

    更新日期:2018-03-01 00:00:00

  • ECMO for pulmonary rescue in an adult with amiodarone-induced toxicity.

    abstract::Amiodarone is a highly effective antiarrhythmic agent. Unfortunately amiodarone-induced pulmonary toxicity is described for medium-long term therapy. We describe a case of a 65-year-old man admitted to our department for breathlessness and with a history of recurrent episodes of atrial fibrillation for which he had be...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Benassi F,Molardi A,Righi E,Santangelo R,Meli M

    更新日期:2015-05-01 00:00:00

  • Assessment of trough rivaroxaban concentrations on markers of coagulation activation in nonvalvular atrial fibrillation population.

    abstract::Whether trough-phase rivaroxaban concentrations provide sufficient anticoagulation needs more study. We evaluated levels of coagulation activation markers in the trough concentration phase in nonvalvular atrial fibrillation (NVAF) patients, and the correlation between these markers and rivaroxaban concentration. Fifty...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Kitagawa F,Ishii J,Hiramitsu S,Takahashi H,Okuyama R,Kawai H,Muramatsu T,Harada M,Motoyama S,Naruse H,Matsui S,Sarai M,Hayashi M,Watanabe E,Izawa H,Ozaki Y

    更新日期:2017-05-01 00:00:00

  • Taurine prevents beta-glycerophosphate-induced calcification in cultured rat vascular smooth muscle cells.

    abstract::Vascular calcification is an ectopic calcification that commonly occurs in atherosclerosis. Because taurine was previously shown to protect against cardiovascular diseases, the effect of taurine on vascular calcification was evaluated in calcified vascular smooth muscle cells (VSMCs) of rat in vitro in the present stu...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Li J,Zhang B,Huang Z,Wang S,Tang C,Du J

    更新日期:2004-05-01 00:00:00

  • Impact of antiplatelet therapy on tissue prolapse at super acute phase after stenting: serial OCT study in acute coronary syndrome patients.

    abstract::Although drug-eluting stents have improved clinical outcomes, percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) remains a challenging procedure in terms of thrombus management. A new-generation P2Y12 receptor inhibitor, prasugrel, provides more rapid and potent antiplatelet action compared wit...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Naito K,Nakano Y,Waseda K,Takashima H,Ando H,Sakurai S,Suzuki A,Saka Y,Sawada H,Nagahiro S,Suzuki M,Shimoda M,Amano T

    更新日期:2020-09-09 00:00:00

  • Clinicopathological study of myocardial infarction with normal or nearly normal extracardiac coronary arteries. Quantitative analysis of contraction band necrosis, coagulation necrosis, hemorrhage, and infarct size.

    abstract::In order to clarify the pathogenesis of acute myocardial infarction (MI) in hearts with normal coronary arteries, infarct size, and the extent of contraction band necrosis (CBN), coagulation necrosis, and hemorrhage were quantitatively examined using an image analyzer in 5 autopsy cases of MI with normal or nearly nor...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Wu DJ,Fujiwara H,Matsuda M,Ishida M,Kawamura A,Takemura G,Kida M,Uegaito T,Fujiwara T,Kawai C

    更新日期:1990-01-01 00:00:00

  • Regional work of the ventricle: wall tension--area relation.

    abstract::We clarified that the set of the isotropic component (T) of wall tension and the area (A) of a selected region of the left ventricular wall expresses the regional work with sufficient accuracy. The area surrounded by the locus of the T-A relation in the T-A plane is approximately equal to the real work done by that re...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Sugawara M,Tamiya K,Nakano K

    更新日期:1985-08-01 00:00:00

  • Effects of levamisole, an immunomodulator, upon murine encephalomyocarditis virus myocarditis.

    abstract::To test the therapeutic efficacy of levamisole, 5-week-old DBA/2 mice were inoculated intraperitoneally with 10 plaque-forming units of encephalo-myocarditis virus. Levamisole (2.5 mg/kg/per day) was administered intraperitoneally daily, starting simultaneously with the virus inoculation, in experiment I for 14 days, ...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Kishimoto C,Takada H,Hiraoka Y,Kurokawa M,Ochiai H

    更新日期:1997-01-01 00:00:00

  • Aldosterone induces circadian gene expression of clock genes in H9c2 cardiomyoblasts.

    abstract::We examined mRNA expression of the clock genes (Per1, Per2, and Bmal1) and PAI-1 (plasminogen activator inhibitor-1) after aldosterone treatment every 4 h up to 48 h in H9c2 cardiomyoblasts by reverse transcription-polymerase chain reaction. To block the MR (mineralocorticoid receptor), the MR antagonist, spironolacto...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Tanaka K,Ashizawa N,Kawano H,Sato O,Seto S,Nishihara E,Terazono H,Isomoto S,Shinohara K,Yano K

    更新日期:2007-07-01 00:00:00