Is the coronary flow velocity reserve improvement after aortic valve replacement for aortic stenosis transient? Results of a 3-year follow-up.


:The coronary flow velocity reserve (CFR) is decreased in patients with aortic valve stenosis (AS). The aim of the present prospective study was to examine the CFR in AS patients with normal epicardial coronary arteries during a 3-year follow-up of aortic valve replacement (AVR). A total of 30 AS patients (17 women and 13 men) were enrolled in this prospective follow-up study; they all had a normal coronary angiogram and underwent dipyridamole stress transesophageal echocardiography (STEE) for CFR measurement before AVR. Nine of them participated in this 3-year follow-up study, and all patients were examined 16 months and 3 years after AVR by STEE. The CFR of AS patients was decreased before AVR. Different extents of diastolic coronary flow velocity reduction (resting and posthyperaemic) were observed resulting in a significant CFR improvement, despite the low number of patients during the 16-month follow-up. A further posthyperaemic flow velocity reduction was demonstrated after the 3-year follow-up, resulting in a significant CFR impairment. The CFR decreased in 5 cases, but remained practically unchanged in 3 after the first CFR measurement; only the CFR of 1 patient improved minimally. The main finding of the current study is that the CFR improvement 16 months after AVR, which paralleled the regression of the left ventricular hypertrophy, was found to be transient. Coronary flow velocity reserve impairment was demonstrated after the long-term (3-year) follow-up in most of the patients, which could not be explained by extravascular compressive forces.


Heart Vessels


Heart and vessels


Nemes A,Forster T,Kovács Z,Csanády M




Has Abstract


2006-05-01 00:00:00












  • Long-term treatment with angiotensin II type 1 receptor antagonist, CV-11974, restores beta-catenin mRNA expression in volume-overloaded rabbit hearts.

    abstract::This study aimed to search genes altered in expression after long-term treatment with the angiotensin II type 1 receptor (AT1) antagonist, CV-11974, in volume-overloaded hearts. Arteriovenous shunt was made between the common carotid artery and jugular vein in Japanese White rabbits. Shunt-operated rabbits were random...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Itoh M,Takeishi Y,Nakada S,Miyamoto T,Tsunoda Y,Takahashi H,Kubota I,Tomoike H

    更新日期:2002-11-01 00:00:00

  • Aldosterone induces circadian gene expression of clock genes in H9c2 cardiomyoblasts.

    abstract::We examined mRNA expression of the clock genes (Per1, Per2, and Bmal1) and PAI-1 (plasminogen activator inhibitor-1) after aldosterone treatment every 4 h up to 48 h in H9c2 cardiomyoblasts by reverse transcription-polymerase chain reaction. To block the MR (mineralocorticoid receptor), the MR antagonist, spironolacto...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Tanaka K,Ashizawa N,Kawano H,Sato O,Seto S,Nishihara E,Terazono H,Isomoto S,Shinohara K,Yano K

    更新日期:2007-07-01 00:00:00

  • Effects of levamisole, an immunomodulator, upon murine encephalomyocarditis virus myocarditis.

    abstract::To test the therapeutic efficacy of levamisole, 5-week-old DBA/2 mice were inoculated intraperitoneally with 10 plaque-forming units of encephalo-myocarditis virus. Levamisole (2.5 mg/kg/per day) was administered intraperitoneally daily, starting simultaneously with the virus inoculation, in experiment I for 14 days, ...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Kishimoto C,Takada H,Hiraoka Y,Kurokawa M,Ochiai H

    更新日期:1997-01-01 00:00:00

  • Differences in hemodynamic responses between intravenous carperitide and nicorandil in patients with acute heart failure syndromes.

    abstract::While recent guidelines for the treatment of acute heart failure syndromes (AHFS) recommend pharmacotherapy with vasodilators in patients without excessively low blood pressure (BP), few reports have compared the relative efficiency of vasodilators on hemodynamics in AHFS patients. The present study aimed to assess th...

    journal_title:Heart and vessels

    pub_type: 临床试验,杂志文章


    authors: Hattori H,Minami Y,Mizuno M,Yumino D,Hoshi H,Arashi H,Nuki T,Sashida Y,Higashitani M,Serizawa N,Yamada N,Yamaguchi J,Mori F,Shiga T,Hagiwara N

    更新日期:2013-05-01 00:00:00

  • Is pentraxin 3 a biomarker, a player, or both in the context of coronary atherosclerosis and metabolic factors?

    abstract::The objective of this study is to determine whether pentraxin-3 (PTX-3) is clinically a biomarker of inflammation, a player in anti-inflammation, or both with regard to coronary atherosclerosis, we compared levels of PTX-3 with levels of adiponectin in addition to high-sensitivity C-reactive protein (hs-CRP). We enrol...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Nakamura A,Miura S,Shiga Y,Norimatsu K,Miyase Y,Suematsu Y,Mitsutake R,Saku K

    更新日期:2015-11-01 00:00:00

  • Gallic acid induces vascular smooth muscle cell death via hydroxyl radical production.

    abstract::In the present study, we investigated whether gallic acid (GA) can induce death in cultured vascular smooth muscle cells (VSMCs), and whether production of the hydroxyl radical (.OH) is involved in the process of GA action. GA killed cultured VSMCs from rat aorta, in a dosc- and time-dependent manner. Cytoplasmic shri...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Qiu X,Takemura G,Koshiji M,Hayakawa Y,Kanoh M,Maruyama R,Ohno Y,Minatoguchi S,Akao S,Fukuda K,Fujiwara T,Fujiwara H

    更新日期:2000-01-01 00:00:00

  • Cardiac tamponade as an independent condition affecting the relationship between the plasma B-type natriuretic peptide levels and cardiac function.

    abstract::Plasma B-type natriuretic peptide (BNP) is finely regulated by the cardiac function and several extracardiac factors. Therefore, the relationship between the plasma BNP levels and the severity of heart failure sometimes seems inconsistent. The purpose of the present study was to investigate the plasma BNP levels in pa...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Minai K,Komukai K,Arase S,Nagoshi T,Matsuo S,Ogawa K,Kayama Y,Inada K,Tanigawa S,Takemoto T,Sekiyama H,Date T,Ogawa T,Taniguchi I,Yoshimura M

    更新日期:2013-07-01 00:00:00

  • Prognostic impact of mitral L-wave in patients with hypertrophic cardiomyopathy without risk factors for sudden cardiac death.

    abstract::Hypertrophic cardiomyopathy (HCM) with severe diastolic dysfunction is a major cause of heart failure and sudden cardiac death (SCD) associated with lethal arrhythmia. Although various risk factors for cardiac events have been reported in HCM patients, previous studies have reported that some HCM patients exhibit eith...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Sugiura Y,Morimoto R,Aoki S,Yamaguchi S,Haga T,Kuwayama T,Yokoi T,Hiraiwa H,Kondo T,Watanabe N,Kano N,Fukaya K,Sawamura A,Okumura T,Murohara T

    更新日期:2019-12-01 00:00:00

  • Correction to: High-intensity aerobic interval training can lead to improvement in skeletal muscle power among in-hospital patients with advanced heart failure.

    abstract::In the original publication of the article, the unit of hand in Fig. 2 was wrongly given as "N/kg" instead of "kg". ...

    journal_title:Heart and vessels

    pub_type: 杂志文章,已发布勘误


    authors: Taya M,Amiya E,Hatano M,Maki H,Nitta D,Saito A,Tsuji M,Hosoya Y,Minatsuki S,Nakayama A,Fujiwara T,Konishi Y,Yokota K,Watanabe M,Morita H,Haga N,Komuro I

    更新日期:2018-07-01 00:00:00

  • Morphological characteristics of optical coherence tomography defined plaque fissure in patients with acute coronary syndrome.

    abstract::We assessed the plaque disruption in 245 consecutive patients with acute coronary syndrome undergoing percutaneous coronary intervention. The plaque fissure was diagnosed with optical coherence tomography, and intravascular ultrasound was used to determine arterial remodeling. Of them, 26 fissures were found in this s...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Goyal M,Kim SW,Mishra S,Sharmin S,Won H,Cho I,Jung MK,Shin SY,Lee KJ,Kim TH,Kim CJ,Lee WS

    更新日期:2019-03-01 00:00:00

  • Brief myocardial ischemia affects free radical generating and scavenging systems in dogs.

    abstract::This study examined whether brief repeated myocardial ischemia altered free radical generating and scavenging activity in a dog model. In dogs preconditioned with four 5-min left anterior descending coronary artery (LAD) occlusions and reperfusions, we examined transcardiac changes in both the function of neutrophils,...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Hoshida S,Kuzuya T,Yamashita N,Oe H,Fuji H,Hori M,Tada M,Kamada T

    更新日期:1993-01-01 00:00:00

  • Higher body mass index at the time of acute myocardial infarction is associated with a favorable long-term prognosis (8-year follow-up).

    abstract::Obesity is an important public health problem, especially among patients with cardiovascular disease. However, little is known about the impact of obesity on the long-term prognoses of patients with acute myocardial infarction (AMI). Major adverse cardiac and cerebrovascular events (MACCE) consist of all causes of dea...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Ikeda N,Nakajima R,Utsunomiya M,Hori M,Itaya H,Makino K,Ono T,Yamamoto M,Nemoto N,Iijima R,Hara H,Takagi T,Hara H,Nakamura M,Sugi K

    更新日期:2011-09-01 00:00:00

  • Novel contrast-injection protocol for coronary computed tomographic angiography: contrast-injection protocol customized according to the patient's time-attenuation response.

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    journal_title:Heart and vessels

    pub_type: 杂志文章,随机对照试验


    authors: Kidoh M,Nakaura T,Nakamura S,Awai K,Utsunomiya D,Namimoto T,Harada K,Yamashita Y

    更新日期:2014-03-01 00:00:00

  • Immunological features in a case of hypereosinophilic syndrome and myocarditis.

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    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Maisch B,Drude L,Kochsiek K

    更新日期:1990-01-01 00:00:00

  • Effects of dietary sodium on reactive oxygen species formation and endothelial dysfunction in low-density lipoprotein receptor-deficient mice on high-fat diet.

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    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Ketonen J,Mervaala E

    更新日期:2008-11-01 00:00:00

  • Hydrodynamics in the heart modulates work.

    abstract::The hydrostatic pressure (perfusion pressure) of the isovolumic isolated perfused rat heart regulated the hydrodynamics (water movement) of the myocardium. An abrupt (10 s) decrease in hydrostatic pressure caused an immediate decrease in oxygen consumption, left ventricular developed pressure, and wall thickness. Wall...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Watters TA,Bouchard A,Wu ST,Parmley WW,Wikman-Coffelt J

    更新日期:1988-01-01 00:00:00

  • Inhibition of cyclooxygenase-2 modulates phenotypic switching of vascular smooth muscle cells during increased aortic blood flow.

    abstract::This study investigates the interactions between cyclooxygenase (COX-2) and vascular smooth muscle cell (VSMC) phenotypic switching, the two important coupling mechanisms of the vasculature on arterial remodeling in response to high laminal shear stress. High aortic blood flow was induced by creating a fistula in the ...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Roan JN,Tsai YC,Chen IW,Chang SW,Huang CC,Lam CF

    更新日期:2012-05-01 00:00:00

  • Assessment of right heart function in the athlete's heart.

    abstract::It is known that the heart of an athlete has been physiologically adapted by prolonged training. There are a large number of echocardiographic studies which have focused on left ventricular wall thickness and dilatation, but there are few studies concerning right heart function in the athlete's heart. The aim of this ...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Erol MK,Karakelleoglu S

    更新日期:2002-07-01 00:00:00

  • Diffuse fibromuscular dysplasia successfully treated with scoring balloon angioplasty in a 3-year-old boy.

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    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Bonvini RF,Rastan A,Sixt S,Righini M,Hofstetter R,Zeller T

    更新日期:2009-11-01 00:00:00

  • A left ventricular noncompaction in a patient with long QT syndrome caused by a KCNQ1 mutation: a case report.

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    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Nakashima K,Kusakawa I,Yamamoto T,Hirabayashi S,Hosoya R,Shimizu W,Sumitomo N

    更新日期:2013-01-01 00:00:00

  • Effects of drug-eluting stents on systemic inflammatory response in patients with unstable angina pectoris undergoing percutaneous coronary intervention.

    abstract::Inflammatory markers are elevated in acute coronary syndromes, and are also known to play a crucial role in the pathogenesis of neointimal proliferation and stent restenosis. Drug-eluting stents (DESs) have been shown to decrease stent restenosis in different studies. In this study, we aimed to investigate the effect ...

    journal_title:Heart and vessels

    pub_type: 临床试验,杂志文章


    authors: Ozer N,Tangurek B,Firat F,Ozer S,Tartan Z,Ozturk R,Ozay B,Ciloglu F,Yilmaz H,Cam N

    更新日期:2008-03-01 00:00:00

  • The 5352 A allele of the pro-inflammatory caspase-1 gene predicts late-acquired stent malapposition in STEMI patients treated with sirolimus stents.

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    journal_title:Heart and vessels

    pub_type: 杂志文章,随机对照试验


    authors: Bergheanu SC,Pons D,van der Hoeven BL,Liem SS,Siegerink B,Schalij MJ,van der Bom JG,Jukema JW

    更新日期:2011-05-01 00:00:00

  • Successful repair of a large aortic abscess causing apical displacement of the anterior mitral valve.

    abstract::Anatomic continuity between the anterior mitral leaflet and the aortic root may predispose those patients with aortic root pathology to functional changes of the mitral valve without any involvement of this valve. A 34-year-old man presented with aortic valve endocarditis. Transthoracic echocardiograpy showed severe a...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Gunay I,Mert M,Kucukoglu S,Ozkan AA,Okcun B

    更新日期:2005-02-01 00:00:00

  • Serum uric acid levels and long-term outcomes in chronic kidney disease.

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    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Miyaoka T,Mochizuki T,Takei T,Tsuchiya K,Nitta K

    更新日期:2014-07-01 00:00:00

  • Stroke prevention following modified endoscopic ablation and appendectomy for atrial fibrillation.

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    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Ma N,Jiang Z,Chen F,Yin H,Ding F,Mei J

    更新日期:2016-09-01 00:00:00

  • Primary cardiac osteosarcoma in a pregnant woman.

    abstract::Primary cardiac osteosarcomas are uncommon tumors. Their growth pattern is aggressive and the prognosis is poor. A 34-year-old, 7-month pregnant woman with a primary cardiac osteosarcoma associated with the anterior mitral leaflet and connected to the interatrial septum, causing nearly subtotal obstruction of the mitr...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Koçak H,Karapolat S,Gündogdu C,Bozkurt E,Unlü Y

    更新日期:2006-01-01 00:00:00

  • Local delivery of green tea catechins inhibits neointimal formation in the rat carotid artery injury model.

    abstract::It has been shown that green tea catechins (GTC) suppress proliferation of vascular smooth muscle cells (VSMCs) and that epigallocatechin-3-gallate (EGCG), which is a major constituent of GTC, selectively inhibits the platelet-derived growth factor-BB (PDGF-BB)-induced intracellular signaling transduction pathway. Vas...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Kim DW,Park YS,Kim YG,Piao H,Kwon JS,Hwang KK,Youn TJ,Park JB,Yun YP,Sachinidis A,Kim CH,Cho MC,Ahn HY

    更新日期:2004-09-01 00:00:00

  • Beneficial effects of losartan for prevention of paroxysmal atrial fibrillation in patients with sick sinus syndrome: analysis with memory function of pacemaker.

    abstract::Renin-angiotensin system (RAS) inhibitors may be useful in preventing the occurrence of paroxysmal atrial fibrillation (PAF). However, evaluation of such effect is difficult because many PAF episodes are asymptomatic and not all episodes are detected by intermittent electrocardiographic monitoring. A pacemaker has bee...

    journal_title:Heart and vessels

    pub_type: 杂志文章,随机对照试验


    authors: Takii E,Inage T,Yoshida T,Ohe M,Gondo T,Haraguchi G,Ito S,Kumanomido J,Imaizumi T,Fukuomoto Y

    更新日期:2016-03-01 00:00:00

  • Endothelial function estimated by digital reactive hyperemia in patients with atherosclerotic risk factors or coronary artery disease.

    abstract::Due to the complex profile of atherosclerotic risk factors, an integrated analysis of a specific individual is difficult. Endothelial function reflects a composite of various risk factors, and may be used as an optimal tool to estimate the overall atherosclerotic risk. In this study, we investigated the value of digit...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Kang J,Kim HL,Seo JB,Lee JY,Moon MK,Chung WY

    更新日期:2018-07-01 00:00:00

  • Positron emission tomography/computed tomography improves diagnostics of inflammatory arteritis.

    abstract::Based on the unique property of fluorine-18 fluorodeoxyglucose, localization and follow-up of hypermetabolic processes is possible with positron emission tomography (PET). The dual-modality PET/computed tomography (CT) systems provide intrinsically fused morphologic and functional data in a single examination. We repo...

    journal_title:Heart and vessels

    pub_type: 杂志文章


    authors: Kröger K,Antoch G,Goyen M,Freudenberg LS,Veit P,Janicke I,Bockisch A,Forsting M

    更新日期:2005-07-01 00:00:00