Utility of myocardial fractional flow reserve for prediction of restenosis following sirolimus-eluting stent implantation.

Abstract:

:Drug-eluting stents reduce restenosis due to neointimal growth suppression. Considering long-term outcomes, it is both difficult and important to predict drug-eluting stent restenosis. Thus, this study was designed to examine the utility of myocardial fractional flow reserve (FFR) as a predictor of sirolimus-eluting stent (SES) restenosis. Thirty-three patients (35 lesions) were enrolled. Upon completion of SES implantation, FFR was obtained under hyperemia. At 8 months of follow-up, coronary angiography revealed that five lesions had restenosis. Percent diameter stenosis (restenosis 68.7 ± 12.8% vs. non-restenosis 68.7 ± 12.4%, p = 0.78) and lesion length (restenosis 15.8 ± 9.4 mm vs. non-restenosis 14.4 ± 9.2 mm, p = 0.60) were similar. At post-intervention, percent diameter stenosis (restenosis 16.4 ± 6.1% vs. non-restenosis 14.0 ± 7.4%, p = 0.48) and minimum stent area (restenosis 6.01 ± 1.08 mm2 vs. non-restenosis 6.27 ± 1.85 mm2, p = 0.92) were also equivalent. However, proximal edge lumen area was smaller (restenosis 4.24 ± 1.40 mm2 vs. non-restenosis 7.73 ± 2.64 mm2, p = 0.004) and FFR was lower in the restenosis group (restenosis 0.81 ± 0.12 vs. non-restenosis 0.92 ± 0.06, p = 0.029). SES patients with restenosis had a lower FFR post stent deployment, suggesting the decreased FFR may be a useful predictor for SES restenosis.

journal_name

Heart Vessels

journal_title

Heart and vessels

authors

Ishii H,Kataoka T,Kobayashi Y,Tsumori T,Takeshita H,Matsumoto R,Shirai N,Nishioka H,Hasegawa T,Nakata S,Shimada Y,Ehara S,Muro T,Yoshiyama M

doi

10.1007/s00380-010-0105-1

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

572-81

issue

6

eissn

0910-8327

issn

1615-2573

journal_volume

26

pub_type

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