Abstract:
:Previous studies showed that continuous anticoagulation or single antiplatelet therapy during implantations of cardiac implantable electronic devices (CIED) was relatively safe. However, the safety of continuous multi antithrombotic therapy (AT) in patients undergoing CIED interventions has not been clearly defined. We sought to evaluate the safety of this therapy during CIED implantations. A total of 300 consecutive patients (mean 69 years old, 171 males) with CIED implantations were enrolled in this study. The patients were divided into 6 groups [No-AT, oral anticoagulant therapy (OAT), single antiplatelet therapy (SAPT), OAT and SAPT, dual antiplatelet therapy (DAPT), triple AT (TAT)], and the perioperative complications were evaluated. Clinically significant pocket hematomas (PH) were defined as PH needing surgical intervention, prolonged hospitalizations, interruption of AT, or blood product transfusions. There were 129, 89, 49, 20, 10, and 3 patients in No-AT, OAT, SAPT, OAT + SAPT, DAPT, and TAT groups, respectively. The occurrence of clinically significant PH and thromboembolism did not differ among 6 groups (p = 0.145 and p = 0.795, respectively). However, high HAS-BLED score and valvular heart disease (VHD) were associated with clinically significant PH (p = 0.014 and p = 0.015, respectively). Continuous multi AT may be tolerated, but patients with high HAS-BLED score or VHD would require a careful attention during CIED implantations.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Ishibashi K,Miyamoto K,Kamakura T,Wada M,Nakajima I,Inoue Y,Okamura H,Noda T,Aiba T,Kamakura S,Shimizu W,Yasuda S,Akasaka T,Kusano Kdoi
10.1007/s00380-016-0879-xsubject
Has Abstractpub_date
2017-03-01 00:00:00pages
333-340issue
3eissn
0910-8327issn
1615-2573pii
10.1007/s00380-016-0879-xjournal_volume
32pub_type
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