Abstract:
:Downregulation of glucose and fatty acid oxidation occurs in heart failure (HF). Trimetazidine reduces fatty acid oxidation and increases glucose oxidation. In this single-blind study, trimetazidine, 20 mg three times per day (n = 51) or placebo (n = 36) was added to treatment of 87 HF patients receiving optimal HF therapy. Etiology of heart failure was coronary artery disease in 35 patients (68.6%) in the trimetazidine group and 22 (62.9%) in the placebo group. Fourteen (27.5%) patients in the trimetazidine group and 11 (31.4%) patients in the placebo group had diabetes. Peak systolic velocity (Vs), and the peak early diastolic (Vd) and late diastolic (Va) velocities of various segments left and right ventricles (RV) were obtained with tissue Doppler imaging (TDI) and averaged. Patients were re-evaluated three months later. Significant increases in mean left ventricular ejection fraction (LVEF) (33.3% +/- 5.6% to 42.4% +/- 6.3%, P < 0.001 and 30.6% +/- 8.2% to 33.2% +/- 6.6%, P = 0.021) and LV and RV myocardial velocities and mitral and tricuspid annular TDI velocities were observed in both groups. However, compared to placebo, increments in LVEF (9.1% +/- 4.2% vs. 2.5% +/- 1.4%, P < 0.001) and myocardial velocities were significantly higher with trimetazidine (P < 0.001 for LV Vs, Vd, Va; P = 0.035 for RV Vd; and P < 0.001 for RV Va and Vs). Increase in LVEF with trimetazidine was significantly correlated with presence of diabetes (r = 0.524, P < 0.001). With trimetazidine LVEF increased significantly more in diabetic patients compared to nondiabetics (P < 0.001). Also, patients having both diabetes and ischemic HF tended to have greater improvement in LVEF compared to ischemic HF patients without diabetes (P = 0.063). Addition of trimetazidine to current treatment of HF, especially for those who are diabetic, may improve LV and RV functions.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Gunes Y,Guntekin U,Tuncer M,Sahin Mdoi
10.1007/s00380-008-1118-xsubject
Has Abstractpub_date
2009-07-01 00:00:00pages
277-82issue
4eissn
0910-8327issn
1615-2573journal_volume
24pub_type
杂志文章abstract::Peripartum cardiomyopathy (PPCM) is a rare but life-threatening cardiac disorder characterized by maternal systolic heart failure. Although PPCM is a major cause of maternal mortality, little is known about the acute-phase management of PPCM in real-world clinical settings. We retrospectively identified patients hospi...
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pub_type: 杂志文章
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journal_title:Heart and vessels
pub_type: 杂志文章
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journal_title:Heart and vessels
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doi:10.1007/s00380-005-0831-y
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abstract::Two-dimensional echocardiographic measurements of the right and left ventricles from the parasternal long-axis and apical four-chamber views and an estimated right ventricular-left ventricular dimensional ratio were obtained in 173 normal subjects, ranging from 1 day to 15 years of age. The end-diastolic dimensions of...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058684
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journal_title:Heart and vessels
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0486-7
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-008-1129-7
更新日期:2009-09-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01745093
更新日期:1994-01-01 00:00:00
abstract::Existing methods to calculate pre-test probability of obstructive coronary artery disease (CAD) have been established using selected high-risk patients who were referred to conventional coronary angiography. The purpose of this study is to develop and validate our new method for pre-test probability of obstructive CAD...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0515-6
更新日期:2015-09-01 00:00:00
abstract::Although endothelial progenitor cells (EPCs) are considered to be an essential source of vascular endothelial repair, their bidirectional differentiation determines that they play a double-edged role in the restoration of endothelial injury. In this research, we investigated the effect of Kir2.1 ion channel on the tra...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01625-w
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01745868
更新日期:1992-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:2011-03-01 00:00:00
abstract::This study examined whether brief repeated myocardial ischemia altered free radical generating and scavenging activity in a dog model. In dogs preconditioned with four 5-min left anterior descending coronary artery (LAD) occlusions and reperfusions, we examined transcardiac changes in both the function of neutrophils,...
journal_title:Heart and vessels
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