Abstract:
:Although endothelial progenitor cells (EPCs) are considered to be an essential source of vascular endothelial repair, their bidirectional differentiation determines that they play a double-edged role in the restoration of endothelial injury. In this research, we investigated the effect of Kir2.1 ion channel on the transdifferentiation of endothelial progenitor cells (EPCs) under the oscillating shear stress (OSS) and the molecular mechanisms underlying the pathological vascular remodeling. EPCs were treated with OSS (± 3.5 dynes/cm2, 1 Hz) simulated with the parallel flow chamber system. The results have shown that OSS promoted the expression of α-SMA and SM22, markers of mesenchymal cells on EPCs. Moreover, OSS also increased expression of Kir2.1 in EPCs. The down-regulation of Kir2.1 reduced OSS-induced EPC mesenchymal transdifferentiation. The overexpression of Kir2.1 suppressed the angiogenic abilities of EPCs in vitro. In parallel, the overexpression of Kir2.1 on EPCs thickened the carotid tunica intima in rat carotid artery balloon injured model in vivo. Taken together, those data indicated that the OSS could facilitate the transdifferentiation of EPCs by increasing Kir2.1 expression. This study provides a novel insight into the pathogenesis of cardiovascular diseases and gives evidence for Kir2.1 as a potential therapeutic target.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Li J,He Y,Bu H,Wang M,Yu J,Li L,Li H,Zhang X,Cui X,Cheng Mdoi
10.1007/s00380-020-01625-wsubject
Has Abstractpub_date
2020-10-01 00:00:00pages
1473-1482issue
10eissn
0910-8327issn
1615-2573pii
10.1007/s00380-020-01625-wjournal_volume
35pub_type
杂志文章abstract::Gradient-echo T2-star (T2*)-weighted magnetic resonance imaging (MRI) is a sensitive method to detect cerebral microbleeds (CMBs). The presence of CMBs was reported to be a marker of future cardiovascular mortality and is associated with various cardiovascular risk factors, use of antithrombotic drugs, and cognitive d...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01503-0
更新日期:2020-03-01 00:00:00
abstract::Wire crossing of a chronic total coronary occlusion (CTO) is time consuming and limited by the amount of contrast agent and time of radiation exposure. Magnetic wire navigation (MWN) might accelerate wire crossing by maintaining a coaxial vessel orientation. This study compares MWN with the conventional approach for r...
journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-015-0739-0
更新日期:2016-08-01 00:00:00
abstract::Atrial fibrillation (AF) is the most common arrhythmia, characterized by a lack of atrial contraction and an irregular ventricular rhythm. We assessed the effect of fibrillatory wave amplitude on coronary blood flow in patients with AF using the thrombolysis in myocardial infarction (TIMI) frame count. Sixty-one patie...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1121-9
更新日期:2018-07-01 00:00:00
abstract::To elucidate involvement of age-related impairments of right ventricular (RV) distensibility in the elderly congestive heart failure (CHF), we examined the prevalence of less-distensible right ventricle in patients with preserved left ventricular ejection fraction (LVEF) over a wide range of ages. In 893 patients aged...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-1092-2
更新日期:2018-06-01 00:00:00
abstract::Successful restoration of patency of the infarct-related artery is important in management of acute ST-segment elevation myocardial infarction (STEMI); however, it does not necessarily translate into the restoration of perfusion at the tissue level. In this study, we evaluate the prognostic role of qualitative and qua...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-013-0460-9
更新日期:2015-01-01 00:00:00
abstract::To assess left ventricular diastolic properties in response to dynamic exercise, mitral inflow velocity integrals were measured by pulsed-wave Doppler echocardiography in ten patients with myocardial infarction and in ten normal subjects, and simultaneous left ventricular pressure was obtained with micromanometry in t...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Vector flow mapping (VFM) is a novel echocardiographic technology that shows blood flow vectors and vortexes, enabled the hydrokinetic evaluation of hemodynamics within the left ventricle. VFM provides several unique parameters: circulation, vorticity, vortex area, and energy loss. The present study aims to reveal a r...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-1093-1
更新日期:2018-05-01 00:00:00
abstract::The efficacy of second-generation drug-eluting stent (DES) for the treatment of left main disease (LM) and/or three vessel disease (3VD) remains unclear. We compared 2-year outcomes of second- versus first -generation DES implantation among patients with LM and/or 3VD and to assess the differential of risk by complexi...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0824-z
更新日期:2016-12-01 00:00:00
abstract::Due to the complex profile of atherosclerotic risk factors, an integrated analysis of a specific individual is difficult. Endothelial function reflects a composite of various risk factors, and may be used as an optimal tool to estimate the overall atherosclerotic risk. In this study, we investigated the value of digit...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1118-4
更新日期:2018-07-01 00:00:00
abstract::It has been shown that green tea catechins (GTC) suppress proliferation of vascular smooth muscle cells (VSMCs) and that epigallocatechin-3-gallate (EGCG), which is a major constituent of GTC, selectively inhibits the platelet-derived growth factor-BB (PDGF-BB)-induced intracellular signaling transduction pathway. Vas...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-004-0768-6
更新日期:2004-09-01 00:00:00
abstract::Although the number of pregnancies in women with cardiac disease is increasing worldwide, there are few data concerning their clinical characteristics and peripartum outcomes. Using the Diagnosis Procedure Combination database between 2008 and 2014 in Japan, we retrospectively identified pregnant women who underwent h...
journal_title:Heart and vessels
pub_type: 杂志文章,多中心研究
doi:10.1007/s00380-018-1137-1
更新日期:2018-08-01 00:00:00
abstract::Phrenic nerve (PN) stimulation is essential for the elimination of PN palsy during balloon-based pulmonary vein isolation (PVI). Although ultrasound-guided vascular access is safe, insertion of a PN stimulation catheter via central venous access carries a potential risk of the development of mechanical complications. ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01402-4
更新日期:2019-10-01 00:00:00
abstract::The role of inflammation in acute coronary syndrome (ACS) and the mechanism by which statin treats ACS is explored. Serum high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) levels were measured in 50 patients with ACS [including 30 cases with unstable angina (UA) and 20 patients with acute myocardia...
journal_title:Heart and vessels
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00380-004-0776-6
更新日期:2004-11-01 00:00:00
abstract::Complex congenital heart diseases with abnormal formation of the aorticopulmonary septum are also associated with defective large artery elastogenesis. In the current study, we tested the hypothesis that carotid artery elastic function was impaired in patients with tetralogy of Fallot (ToF). The study included 45 Fall...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-010-0095-z
更新日期:2011-09-01 00:00:00
abstract::Percutaneous transvenous mitral commissurotomy (PTMC) increases peak oxygen uptake (VO2) chronically, but not acutely, despite early symptomatic improvements. Analysis of transient VO2 responses to submaximal exercise (an exercise regimen more comparable to the patients' daily activities than that provided by maximal ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02911391
更新日期:1995-01-01 00:00:00
abstract::Ventricular arrhythmias play a critical role in chronic heart failure (CHF) and are associated with adverse clinical outcomes. Sleep-disordered breathing (SDB) is associated with arrhythmias and/or a poor prognosis in CHF. Adaptive servo-ventilation (ASV) is a ventilatory support system designed to normalize ventilati...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-013-0394-2
更新日期:2014-07-01 00:00:00
abstract::Late-acquired stent malapposition (LASM) is a common finding after sirolimus-eluting stent (SES) implantation and may be the cause for late stent thrombosis. Inflammation may play a pivotal role in LASM just as it plays in stent restenosis. We have therefore investigated seven polymorphisms involved in inflammatory pr...
journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-010-0046-8
更新日期:2011-05-01 00:00:00
abstract::Mitral valve morphology after mitral valve surgery affects postoperative intraventricular flow patterns and long-term cardiac performance. We visualized ventricular flow by echocardiography vector flow mapping (VFM) to reveal the impact of different mitral valve procedures. Eleven cases of mechanical mitral valve repl...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0967-6
更新日期:2017-09-01 00:00:00
abstract::Both hypertension and hyperuricemia are closely associated with the morbidity and mortality of heart failure. This study was designed to evaluate the influences of long-term xanthine oxidase inhibitor (febuxostat) prescription on left ventricular hypertrophy (LVH), left ventricular (LV) diastolic function, and new-ons...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01619-8
更新日期:2020-10-01 00:00:00
abstract::Coronary slow flow (CSF) is characterized by delayed opacification of coronary arteries in the absence epicardial occlusive disease. QT duration and dispersion have been reported to be longer in patients with CSF. ACE inhibitors may improve CSF through positive effects on endothelial function. The study included 32 pa...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-010-0058-4
更新日期:2011-07-01 00:00:00
abstract::There is no proven therapy for heart failure with preserved ejection fraction (HFpEF). Research has shown beneficial responses to cardiac rehabilitation (CR) among HF patients. To date, there are no reports comparing those responses between patients with HFpEF and those with reduced ejection fraction (HFrEF). The purp...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1128-2
更新日期:2018-08-01 00:00:00
abstract::Wave intensity analysis is a method of studying intravascular flow wave propagation, calculated as the product of the rate of change in pressure (d P/ t) and the rate of change in velocity (d U/d t). The typical pattern of wave intensity seen during the cardiac cycle has two dominant peaks. The larger first peak (FP) ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-003-0725-9
更新日期:2004-01-01 00:00:00
abstract::A 53-year-old woman with end-stage renal disease and hypertension, who had received regular artificial hemodialysis for 10 years, has been treated with candesartan in a dose of 8 mg/day against her hypertension, but premature ventricular contractions were often observed during the hemodialysis. QT interval was 445 ms ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0865-3
更新日期:2017-01-01 00:00:00
abstract::The thrombotest (TT) technique has been widely used in Japan for monitoring oral anticoagulant therapy (OAT). The therapeutic range was originally recommended to be 10%-25%. However, the International Committee for Standardization in Hematology/International Committee on Thrombosis and Hemostasis (ICSH/ICTH) recommend...
journal_title:Heart and vessels
pub_type: 临床试验,杂志文章
doi:10.1007/pl00007265
更新日期:2000-01-01 00:00:00
abstract::Myocardial fibrosis and microvascular dysfunction are key determinants of outcome in heart failure (HF); we examined their relationship in patients with HF. Our study included 61 consecutive patients with HF but without coronary stenosis. All underwent gadolinium-enhanced cardiac magnetic resonance to evaluate late ga...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0816-z
更新日期:2016-12-01 00:00:00
abstract::The objectives of the study were to evaluate the impact of aortic angulation (AA) on success of transcatheter aortic valve replacement (TAVR) with a new generation self-expandable prosthesis (Medtronic Evolut R®). Specific anatomical conditions, such as for example the presence of a horizontal aorta with elevated AA, ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01436-8
更新日期:2019-12-01 00:00:00
abstract::Atrial fibrillation (AF) is a complex disease with multiple inter-relating causes culminating in rapid atrial activation and atrial structural remodeling. The contribution of endoplasmic reticulum and mitochondria stress to AF has been highlighted. As the class III antiarrhythmic agent, ibutilide are widely used to AF...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0891-1
更新日期:2017-02-01 00:00:00
abstract::In children, up to 10% of the cases of arterial hypertension may be caused by a renovascular disease. The etiology of this renovascular disease is most of the time due to a fibromuscular dysplasia (FMD), which causes a noninflammatory intimal-medial fibroplasia leading to luminal compromise. Percutaneous transluminal ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-009-1147-0
更新日期:2009-11-01 00:00:00
abstract::We developed a new individually customized contrast-injection protocol for coronary computed tomography (CT) angiography based on the time-attenuation response in a test bolus, and investigated its clinical applicability. We scanned 60 patients with suspected coronary diseases using a 64-detector CT scanner, who were ...
journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-013-0338-x
更新日期:2014-03-01 00:00:00
abstract::The objective of this study is to determine whether pentraxin-3 (PTX-3) is clinically a biomarker of inflammation, a player in anti-inflammation, or both with regard to coronary atherosclerosis, we compared levels of PTX-3 with levels of adiponectin in addition to high-sensitivity C-reactive protein (hs-CRP). We enrol...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0553-0
更新日期:2015-11-01 00:00:00